{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:26:00Z","timestamp":1741238760639,"version":"3.38.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018950","name":"Centre Hospitalier Universitaire de Rennes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018950","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Hepatocellular carcinoma (HCC) associated with major vasculature tumor extension is considered an advanced stage of disease to which palliative radiotherapy or chemotherapy is proposed.<jats:sup>1,2<\/jats:sup> Surgical resection associated with chemotherapy or chemoembolization could be an opportunity to improve overall survival and recurrence-free survival in selected cases in a high-volume hepatobiliary center.<jats:sup>3,4<\/jats:sup> Moreover, it has been 25 years since Couinaud described the entity of a posterior liver located behind an axial plane crossing the portal bifurcation.<jats:sup>5<\/jats:sup> The aim of this video was to show how to reproduce such a resection technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We report the case of a 72-year-old male presenting with a 6\u00a0cm HCC developed in a well-compensated Child\u2013Pugh A alcohol-related cirrhosis and localized in the dorsal liver sector. The tumor invaded the retrohepatic inferior vena cava (IVC) as well as segment 2 and the right posterior section glissonean pedicles. The initial management of the patient was performed outside of a reference center for hepatobiliary surgery and the tumor was initially considered unresectable. Transarterial chemoembolization was judged ineffective due to the size and location of the tumor. Initial treatment included 6 months of atezolizumab\u2013bevacizumab, permitting tumor volume stability and enabling surgical resection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The procedure included an en\u00a0bloc posterior hepatectomy (H1267)<jats:sup>6<\/jats:sup> with IVC resection and polytetrafluoroethylene (PTFE) graft replacement. A well-tolerated intermittent pedicle and IVC clamping of 30\u00a0min in total was used. The duration of surgery was 240\u00a0min, with 30\u00a0min of total vascular liver exclusion, and total blood loss was 650\u00a0mL. The patient was discharged on postoperative day 8. R0 resection was achieved and the patient was free of disease at 1\u00a0year post-surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>To our knowledge, this video reports the first posterior hepatectomy performed in clinical practice and demonstrates liver anatomy as described by Couinaud in 1999.<jats:sup>5<\/jats:sup> Moreover, complex vascular resections for HCC should be considered a valid therapeutic option in selected cases and high-volume hepatobiliary centers.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1245\/s10434-024-16855-9","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T16:52:48Z","timestamp":1737823968000},"page":"2472-2473","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posterior Hepatectomy and Inferior Vena Cava Graft Reconstruction for En Bloc Resection of a Hepatocellular Carcinoma: A Tribute to Couinaud\u2019s Liver Anatomy Description"],"prefix":"10.1245","volume":"32","author":[{"given":"Bastien","family":"Le Floc\u2019h","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Livin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Tzedakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Robin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heithem","family":"Jeddou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-8767","authenticated-orcid":false,"given":"Karim","family":"Boudjema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"issue":"10127","key":"16855_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","volume":"391","author":"A Forner","year":"2018","unstructured":"Forner A, Reig M, Bruix J. Hepatocellular carcinoma. The Lancet. 2018;391(10127):1301\u201314.","journal-title":"The Lancet."},{"issue":"7","key":"16855_CR2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/S1470-2045(21)00151-0","volume":"22","author":"PR Galle","year":"2021","unstructured":"Galle PR, Finn RS, Qin S, Ikeda M, Zhu AX, Kim TY, et al. Patient-reported outcomes with atezolizumab plus bevacizumab versus sorafenib in patients with unresectable hepatocellular carcinoma (IMbrave150): an open-label, randomised, phase 3 trial. The Lancet Oncology. 2021;22(7):991\u20131001.","journal-title":"The Lancet Oncology."},{"issue":"2","key":"16855_CR3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S1072-7515(02)01616-2","volume":"196","author":"S Arii","year":"2003","unstructured":"Arii S, Teramoto K, Kawamura T, Takamatsu S, Sato E, Nakamura N, et al. Significance of hepatic resection combined with inferior vena cava resection and its reconstruction with expanded polytetrafluoroethylene for treatment of liver tumors. J Am College Surg. 2003;196(2):243\u20139.","journal-title":"J Am College Surg"},{"issue":"5","key":"16855_CR4","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jamcollsurg.2011.01.002","volume":"212","author":"H Yoshidome","year":"2011","unstructured":"Yoshidome H, Takeuchi D, Kimura F, Shimizu H, Ohtsuka M, Kato A, et al. Treatment strategy for hepatocellular carcinoma with major portal vein or inferior vena cava invasion: a single institution experience. J Am College Surg. 2011;212(5):796\u2013803.","journal-title":"J Am College Surg"},{"issue":"1","key":"16855_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S0001-4001(98)80033-0","volume":"123","author":"C Couinaud","year":"1999","unstructured":"Couinaud C. Secteur dorsal du foie. Chirurgie. 1999;123(1):8\u201315.","journal-title":"Chirurgie."},{"issue":"1","key":"16855_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/SLA.0000000000004808","volume":"274","author":"M Nagino","year":"2021","unstructured":"Nagino M, DeMatteo R, Lang H, Cherqui D, Malago M, Kawakatsu S, et al. Proposal of a new comprehensive notation for hepatectomy: the \u201cnew world\u201d terminology. Ann Surg. 2021;274(1):1\u20133.","journal-title":"Ann Surg."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16855-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-024-16855-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-024-16855-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T17:28:12Z","timestamp":1741195692000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-024-16855-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,25]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["16855"],"URL":"https:\/\/doi.org\/10.1245\/s10434-024-16855-9","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"type":"print","value":"1068-9265"},{"type":"electronic","value":"1534-4681"}],"subject":[],"published":{"date-parts":[[2025,1,25]]},"assertion":[{"value":"12 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}