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Propensity score matching and multivariate Cox regression analyses were performed to mitigate the influence of selection bias and control for potential confounding variables.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of 1950 patients with NMIBC, 1353 underwent LND, of which 58 (4.2%) exhibited positive LNs. LND were associated with better prognosis in the whole cohort (<jats:italic>P<\/jats:italic> &lt; 0.001). Patients who had positive lymph nodes were found to have the worst prognosis (<jats:italic>P<\/jats:italic> &lt; 0.001). Restricted cubic spline (RCS) found that patients with at least 8 LNs examined show longer survival than those with nLNE &lt; 8, which was further validated in multivariable Cox regression [HR 0.66 (0.59, 0.76)]. Subgroup analysis indicated that nLNE \u2265 8 was associated with significantly improved overall survival in T1 and Tis patients both before and after PSM, while for Ta patients, the impact of LND or nLNE \u2265 8 on prognosis was insignificant. Additionally, for patients with negative lymph node, nLNE \u2265 8 still resulted in better prognosis [HR 0.73 (0.61, 0.87)]. Furthermore, sensitivity analyses replicated the same results in patients more than 80 years old and found that patients with nLNE \u2265 8 demonstrated superior prognosis than those with less than 8 lymph nodes retrieved.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Among patients with NMIBC, it is crucial to remove eight or more lymph node effectively during cystectomy, except in Ta subgroup.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1245\/s10434-025-17654-6","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T14:29:23Z","timestamp":1752157763000},"page":"9432-9444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of the Extent of Lymphadenectomy for Overall Survival Among Patients with Non-muscle Invasive Bladder Cancer, A Retrospective Cohort Study"],"prefix":"10.1245","volume":"32","author":[{"given":"Jiaxiang","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Hui","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shicong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingrui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haopu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runfeng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"1","key":"17654_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.eururo.2021.08.010","volume":"81","author":"M Babjuk","year":"2022","unstructured":"Babjuk M, Burger M, Capoun O, Cohen D, Comperat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH, et al. 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