{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:02:55Z","timestamp":1773824575558,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pressurized intraperitoneal aerosol chemotherapy (PIPAC) improves local drug delivery and has shown promising results for treating peritoneal surface malignancies (PSMs); however, comparative data on the performance of different PIPAC nozzles in disease-bearing models are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the therapeutic efficacy of three PIPAC nozzles in a rabbit model of PSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nine immunocompetent New Zealand rabbits received intraperitoneal injections of VX2 tumor cells to induce PSM. The animals were randomized into three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03) and treated with oxaliplatin-based PIPAC using CapnoPen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , HurriChem\u2122, or MCR-4 TOPOL\n                      <jats:sup>\u00ae<\/jats:sup>\n                      nozzles on days 8, 15, and 21. Evaluations included the Peritoneal Cancer Index (PCI), tumor weight, histopathology (Peritoneal Regression Grading Score [PRGS]), imaging, and markers of proliferation (Ki-67) and apoptosis (TUNEL). The final results, including autopsy, were obtained on day 26.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CapnoPen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      showed a trend toward improved tumor regression, with significantly lower PCI scores at euthanasia. After the third PIPAC, the mean PCI was lower in the CapnoPen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group compared with MCR-4 TOPOL\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (6.33 vs. 13.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041). Tumor weights were also lowest in the CapnoPen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group. Mean PRGS values were 2.14 (CapnoPen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ), 2.75 (HurriChem\u2122), and 3.49 (MCR-4), with a significant difference between CapnoPen\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and MCR-4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.033). All devices significantly reduced PCI compared with controls from a previous study (no chemotherapy: 21.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This initial study suggests that the type of PIPAC nebulizer may influence therapeutic efficacy in a rabbit model with peritoneal metastasis, highlighting the need for further controlled studies to confirm these preliminary findings<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1245\/s10434-025-18002-4","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T17:33:33Z","timestamp":1754415213000},"page":"2161-2168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Three Nebulizer Nozzles Used During Pressurized Intraperitoneal Aerosol Chemotherapy Procedures in a Rabbit Model with Peritoneal Surface Malignancies: NOMOS Project"],"prefix":"10.1245","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-6474","authenticated-orcid":false,"given":"Abdelkader","family":"Taibi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Yardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Usseglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvaine","family":"Durand Fontanier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia M.","family":"Bardet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"issue":"1","key":"18002_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41572-021-00326-6","volume":"7","author":"D Cort\u00e9s-Guiral","year":"2021","unstructured":"Cort\u00e9s-Guiral D, H\u00fcbner M, Alyami M, Bhatt A, Ceelen W, Glehen O, et al. 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