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This study aims to share our preliminary clinical experience with respect to the safety and efficacy of TmLER in treating paraganglioma of the urinary bladder (PUB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The clinical and pathological data of eight patients with PUB who underwent TmLER under general anesthesia at our urology center between January 2020 and April 2024 were retrospectively collected and analyzed. Detailed documentation was maintained regarding intraoperative blood pressure fluctuations, the incidence of perioperative complications, changes in postoperative catecholamine hormone levels, and tumor recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight patients successfully underwent TmLER without the need for conversion to conventional transurethral resection. The operation duration ranged from 25 to 37 min, with an average of 28.9 min. During TmLER, systolic blood pressure fluctuated between 8 and 20 mmHg, averaging 13.5 mmHg. No significant perioperative complications were observed. Postoperatively, bladder irrigation was discontinued on average after 18.75 h, and the urinary catheter was removed after 3\u20135 days. Hospital stays ranged from 4 to 6 days, with an average of 4.91 days. At the 1-month follow-up, there was no significant fluctuation in systolic blood pressure before and after urination, and plasma catecholamine hormone levels had normalized. Furthermore, no tumor recurrence was detected at the 12-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For the treatment of PUB, the TmLER technique can effectively reduce intraoperative bleeding and blood pressure fluctuations, and it is a safe and efficient minimally invasive surgical option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1245\/s10434-025-18692-w","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T18:04:08Z","timestamp":1769364248000},"page":"4806-4811","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary Experience of Transurethral Thulium Laser En Bloc Resection of Paraganglioma of the Urinary Bladder"],"prefix":"10.1245","volume":"33","author":[{"given":"Yongjun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"issue":"4","key":"18692_CR1","doi-asserted-by":"publisher","first-page":"bvaf036","DOI":"10.1210\/jendso\/bvaf036","volume":"9","author":"S Agarwal","year":"2025","unstructured":"Agarwal S, Alkaissi H, Pacak K, Mosquera Izurieta JE, Dackiw AP, Oltmann SC, et al. 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