{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:09:29Z","timestamp":1778872169015,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1245\/s10434-026-19342-5","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:10:50Z","timestamp":1772219450000},"page":"5558-5566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Omission of Axillary Surgery in Patients with Negative Axillary Evaluation Integrated with LymphPET: A Prospective Clinical Study"],"prefix":"10.1245","volume":"33","clinical-trial-number":[{"clinical-trial-number":"nct04072653","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Fei-Lin","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Yong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Da","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen-Hong","family":"Di","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"issue":"9069","key":"19342_CR1","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1016\/S0140-6736(97)01004-0","volume":"349","author":"U Veronesi","year":"1997","unstructured":"Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet (London, Engl). 1997;349(9069):1864\u20137.","journal-title":"Lancet (London, Engl)."},{"issue":"10","key":"19342_CR2","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S1470-2045(10)70207-2","volume":"11","author":"DN Krag","year":"2010","unstructured":"Krag DN, Anderson SJ, Julian TB, et al. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol. 2010;11(10):927\u201333.","journal-title":"Lancet Oncol."},{"issue":"6","key":"19342_CR3","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1056\/NEJMoa012782","volume":"349","author":"U Veronesi","year":"2003","unstructured":"Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349(6):546\u201353.","journal-title":"N Engl J Med."},{"issue":"27","key":"19342_CR4","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1200\/JCO.21.00934","volume":"39","author":"M Brackstone","year":"2021","unstructured":"Brackstone M, Baldassarre FG, Perera FE, et al. Management of the axilla in early-stage breast cancer: Ontario Health (Cancer Care Ontario) and ASCO Guideline. J Clin Oncol Off J Am Soc Clin Oncol. 2021;39(27):3056\u201382.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol."},{"issue":"9","key":"19342_CR5","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1093\/annonc\/mdt303","volume":"24","author":"A Goldhirsch","year":"2013","unstructured":"Goldhirsch A, Winer EP, Coates AS, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol Off J Eur Soc Med Oncol. 2013;24(9):2206\u201323.","journal-title":"Ann Oncol Off J Eur Soc Med Oncol."},{"key":"19342_CR6","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.breast.2023.01.002","volume":"67","author":"T Reimer","year":"2023","unstructured":"Reimer T. Omission of axillary sentinel lymph node biopsy in early invasive breast cancer. Breast (Edinburgh, Scotland). 2023;67:124\u20138.","journal-title":"Breast (Edinburgh, Scotland)."},{"issue":"11","key":"19342_CR7","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1001\/jamaoncol.2023.3759","volume":"9","author":"OD Gentilini","year":"2023","unstructured":"Gentilini OD, Botteri E, Sangalli C, et al. Sentinel lymph node biopsy vs no axillary surgery in patients with small breast cancer and negative results on ultrasonography of axillary lymph nodes: the SOUND randomized clinical trial. JAMA Oncol. 2023;9(11):1557\u201364.","journal-title":"JAMA Oncol."},{"issue":"11","key":"19342_CR8","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1056\/NEJMoa2412063","volume":"392","author":"T Reimer","year":"2025","unstructured":"Reimer T, Stachs A, Veselinovic K, et al. Axillary surgery in breast cancer-primary results of the INSEMA trial. N Engl J Med. 2025;392(11):1051\u201364.","journal-title":"N Engl J Med."},{"key":"19342_CR9","doi-asserted-by":"publisher","first-page":"103673","DOI":"10.1016\/j.breast.2024.103673","volume":"73","author":"OD Gentilini","year":"2024","unstructured":"Gentilini OD, Cardoso MJ, Senkus E, Poortmans P. De-escalation of loco-regional treatments: time to find a balance. Breast (Edinburgh, Scotland). 2024;73:103673.","journal-title":"Breast (Edinburgh, Scotland)."},{"issue":"4","key":"19342_CR10","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1245\/ASO.2006.05.013","volume":"13","author":"LG Wilke","year":"2006","unstructured":"Wilke LG, McCall LM, Posther KE, et al. Surgical complications associated with sentinel lymph node biopsy: results from a prospective international cooperative group trial. Ann Surg Oncol. 2006;13(4):491\u2013500.","journal-title":"Ann Surg Oncol."},{"issue":"4","key":"19342_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/cancers14040950","volume":"14","author":"J Cheng","year":"2022","unstructured":"Cheng J, Ren C, Liu G, et al. Development of high-resolution dedicated pet-based radiomics machine learning model to predict axillary lymph node status in early-stage breast cancer. Cancers. 2022;14(4):63.","journal-title":"Cancers."},{"issue":"7","key":"19342_CR12","first-page":"1100","volume":"19","author":"J Li","year":"2022","unstructured":"Li J, Cheng J, Liu G, et al. Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial. Science. 2022;19(7):1100\u20138.","journal-title":"Science"},{"issue":"24","key":"19342_CR13","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1200\/JCO.20.03613","volume":"39","author":"SM Tolaney","year":"2021","unstructured":"Tolaney SM, Garrett-Mayer E, White J, et al. Updated Standardized definitions for efficacy end points (STEEP) in adjuvant breast cancer clinical trials: STEEP Version 2.0. J Clin Oncol Off J Am Soc Clin Oncol. 2021;39(24):2720\u201331.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol."},{"issue":"10","key":"19342_CR14","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1001\/jama.2017.11470","volume":"318","author":"AE Giuliano","year":"2017","unstructured":"Giuliano AE, Ballman KV, McCall L, et al. Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA. 2017;318(10):918\u201326.","journal-title":"JAMA."},{"issue":"14","key":"19342_CR15","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1200\/JCO-25-00099","volume":"43","author":"KU Park","year":"2025","unstructured":"Park KU, Somerfield MR, Anne N, et al. Sentinel lymph node biopsy in early-stage breast cancer: ASCO guideline update. J Clin Oncol Off J Am Soc Clin Oncol. 2025;43(14):1720\u201341.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol."},{"issue":"3","key":"19342_CR16","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/SLA.0b013e3181f08f32","volume":"252","author":"AE Giuliano","year":"2010","unstructured":"Giuliano AE, McCall L, Beitsch P, et al. Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial. Ann Surg. 2010;252(3):426\u201332.","journal-title":"Ann Surg."},{"issue":"1","key":"19342_CR17","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s12885-017-3443-x","volume":"17","author":"LM van Roozendaal","year":"2017","unstructured":"van Roozendaal LM, Vane MLG, van Dalen T, et al. Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013\u201308). BMC Cancer. 2017;17(1):459.","journal-title":"BMC Cancer."},{"issue":"1","key":"19342_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12885-022-09273-1","volume":"22","author":"JG Jung","year":"2022","unstructured":"Jung JG, Ahn SH, Lee S, et al. No axillary surgical treatment for lymph node-negative patients after ultra-sonography [NAUTILUS]: protocol of a prospective randomized clinical trial. BMC Cancer. 2022;22(1):189.","journal-title":"BMC Cancer."},{"issue":"12","key":"19342_CR19","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.annonc.2022.09.159","volume":"33","author":"CE Geyer Jr","year":"2022","unstructured":"Geyer CE Jr, Garber JE, Gelber RD, et al. Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1\/2 and high-risk, early breast cancer. Ann Oncol Off J Eur Soc Med Oncol. 2022;33(12):1250\u201368.","journal-title":"Ann Oncol Off J Eur Soc Med Oncol."},{"issue":"1","key":"19342_CR20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S1470-2045(22)00694-5","volume":"24","author":"SRD Johnston","year":"2023","unstructured":"Johnston SRD, Toi M, O\u2019Shaughnessy J, et al. Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial. Lancet Oncol. 2023;24(1):77\u201390.","journal-title":"Lancet Oncol."},{"issue":"2","key":"19342_CR21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.prro.2023.11.001","volume":"14","author":"SF Shaitelman","year":"2024","unstructured":"Shaitelman SF, Anderson BM, Arthur DW, et al. Partial breast irradiation for patients with early-stage invasive breast cancer or ductal carcinoma in situ: an ASTRO clinical practice guideline. Pract Radiat Oncol. 2024;14(2):112\u201332.","journal-title":"Pract Radiat Oncol."},{"issue":"1","key":"19342_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1470-2045(24)00661-2","volume":"26","author":"I Meattini","year":"2025","unstructured":"Meattini I, De Santis MC, Visani L, et al. Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial. Lancet Oncol. 2025;26(1):37\u201350.","journal-title":"Lancet Oncol."},{"issue":"4","key":"19342_CR23","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1200\/JCO.23.02270","volume":"42","author":"R Jagsi","year":"2024","unstructured":"Jagsi R, Griffith KA, Harris EE, et al. Omission of radiotherapy after breast-conserving surgery for women with breast cancer with low clinical and genomic risk: 5-year outcomes of IDEA. J Clin Oncol Off J Am Soc Clin Oncol. 2024;42(4):390\u20138.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-026-19342-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-026-19342-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-026-19342-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:27:21Z","timestamp":1778869641000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-026-19342-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["19342"],"URL":"https:\/\/doi.org\/10.1245\/s10434-026-19342-5","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"30 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Authors declare no Competing Financial or Non-Financial Interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}