{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:18Z","timestamp":1785779718495,"version":"3.56.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peritoneal carcinomatosis from lower gastrointestinal malignancies causes debilitating intra-abdominal complications, including bowel obstruction, ascites, and biliary\/ureteral obstruction. Guidelines addressing palliative cytoreductive surgery (CRS) in patient\u2019s ineligible for curative resection remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent CRS for appendiceal cancer (AC)- or colorectal cancer (CRC)-related carcinomatosis not amenable to complete cytoreduction at one referral center (2004\u20132025) were retrospectively reviewed. Tumor grade was dichotomized into low- (well- and well-to-moderately differentiated ACs) versus high-grade (moderately or poorly differentiated\/signet ring ACs, all CRCs). Descriptive statistics summarize patient demographics. Carcinomatosis-related complication-free (CRCFS), obstruction-free (OFS), ascites-free (AFS), and overall survival (OS) were estimated by using the Kaplan-Meier method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 131 patients underwent palliative CRS. The most common reasons for incomplete cytoreduction were high tumor burden\/multiple unresectable areas 62 (47%), portal 20 (15%), small bowel 19 (14%), or pelvic 17 (13%) disease. Common palliative procedures included omentectomy 86 (66%), hyperthermic intraperitoneal chemotherapy 63 (48%), bowel resection 63 (48%), gastrostomy tube\/gastropexy 60 (46%), and intestinal bypass 27 (20%). Twenty-two (17%) patients had major complications, and median length of stay was 11 days (IQR 9\u201314). Median CRCFS, OFS, AFS, and OS were 11, 16, 62, and 13 months for high-grade versus 36, NR, NR, and 37 months for low-grade tumors. The strongest predictor of shortened CRCFS, OFS, AFS, and OS was high-grade histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Palliative CRS for incompletely resectable carcinomatosis is associated with prolonged OFS and AFS for patients with low-grade histology. Palliative surgical intervention should be considered in carefully selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1245\/s10434-026-20210-5","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:25:49Z","timestamp":1785777949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Palliative Cytoreductive Surgery for Patients with Incompletely Resectable Peritoneal Carcinomatosis from Lower Gastrointestinal Cancers"],"prefix":"10.1245","author":[{"given":"Taylor","family":"Neilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J.","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlee","family":"Seldomridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan B.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaDonna","family":"Kearse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Mansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarett","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith F.","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Helmink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Marincola Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"20210_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soi.2025.100150","author":"PM Smith","year":"2025","unstructured":"Smith PM, Seldomridge A, Chiang YJ, et al. Outcomes following diagnostic laparoscopy in patients with peritoneal carcinomatosis deemed ineligible for cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) due to disease burden. Surg Oncol Insight. 2025. https:\/\/doi.org\/10.1016\/j.soi.2025.100150.","journal-title":"Surg Oncol Insight."},{"key":"20210_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102840","author":"MM Harper","year":"2022","unstructured":"Harper MM, Kim J, Pandalai PK. Current trends in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal disease from appendiceal and colorectal malignancies. J Clin Med. 2022. https:\/\/doi.org\/10.3390\/jcm11102840.","journal-title":"J Clin Med."},{"issue":"13","key":"20210_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35874","volume":"131","author":"EL Godfrey","year":"2025","unstructured":"Godfrey EL, Mahoney F, Bansal VV, et al. Consensus guideline for the management of patients with appendiceal tumors, part 2: appendiceal tumors with peritoneal involvement. Cancer. 2025;131(13):e35874. https:\/\/doi.org\/10.1002\/cncr.35874.","journal-title":"Cancer."},{"issue":"13","key":"20210_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35869","volume":"131","author":"KS Schultz","year":"2025","unstructured":"Schultz KS, Bansal VV, Wach MM, et al. Consensus guideline for the management of colorectal cancer with peritoneal metastases. Cancer. 2025;131(13):e35869. https:\/\/doi.org\/10.1002\/cncr.35869.","journal-title":"Cancer."},{"issue":"13","key":"20210_CR5","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1245\/s10434-020-08844-5","volume":"27","author":"CA Munoz-Zuluaga","year":"2020","unstructured":"Munoz-Zuluaga CA, King MC, Diaz-Sarmiento VS, et al. Defining \u201ccomplete cytoreduction\u201d after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) for the histopathologic spectrum of appendiceal carcinomatosis. Ann Surg Oncol. 2020;27(13):5026\u201336. https:\/\/doi.org\/10.1245\/s10434-020-08844-5.","journal-title":"Ann Surg Oncol."},{"issue":"4","key":"20210_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/s1470-2045(04)01425-1","volume":"5","author":"O Glehen","year":"2004","unstructured":"Glehen O, Mohamed F, Gilly FN. Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia. Lancet Oncol. 2004;5(4):219\u201328. https:\/\/doi.org\/10.1016\/s1470-2045(04)01425-1.","journal-title":"Lancet Oncol."},{"key":"20210_CR7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-025-17362-1","author":"VV Bansal","year":"2025","unstructured":"Bansal VV, Godfrey EL, Sadjadi J, et al. Consensus guideline for the management of malignant gastrointestinal obstruction in patients with peritoneal surface malignancies. Ann Surg Oncol. 2025. https:\/\/doi.org\/10.1245\/s10434-025-17362-1.","journal-title":"Ann Surg Oncol."},{"issue":"4","key":"20210_CR8","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/jso.21068","volume":"98","author":"AG Portilla","year":"2008","unstructured":"Portilla AG, Shigeki K, Dario B, Marcello D. The intraoperative staging systems in the management of peritoneal surface malignancy. J Surg Oncol. 2008;98(4):228\u201331. https:\/\/doi.org\/10.1002\/jso.21068.","journal-title":"J Surg Oncol."},{"issue":"2","key":"20210_CR9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187\u201396. https:\/\/doi.org\/10.1097\/SLA.0b013e3181b13ca2.","journal-title":"Ann Surg."},{"issue":"9","key":"20210_CR10","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1245\/s10434-010-0984-5","volume":"17","author":"SC Bruin","year":"2010","unstructured":"Bruin SC, Verwaal VJ, Vincent A, van\u2019t Veer LJ, van Velthuysen ML. A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin. Ann Surg Oncol. 2010;17(9):2330\u201340. https:\/\/doi.org\/10.1245\/s10434-010-0984-5.","journal-title":"Ann Surg Oncol."},{"issue":"6","key":"20210_CR11","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1097\/SLA.0b013e318269d680","volume":"257","author":"MJ Overman","year":"2013","unstructured":"Overman MJ, Fournier K, Hu CY, et al. Improving the AJCC\/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade. Ann Surg. 2013;257(6):1072\u20138. https:\/\/doi.org\/10.1097\/SLA.0b013e318269d680.","journal-title":"Ann Surg."},{"issue":"3","key":"20210_CR12","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1245\/s10434-022-12753-0","volume":"30","author":"EW Beal","year":"2023","unstructured":"Beal EW, Srinivas S, Shen C, et al. Conditional survival following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies: an analysis from the US HIPEC Collaborative. Ann Surg Oncol. 2023;30(3):1840\u20139. https:\/\/doi.org\/10.1245\/s10434-022-12753-0.","journal-title":"Ann Surg Oncol."},{"issue":"9","key":"20210_CR13","doi-asserted-by":"publisher","first-page":"354","DOI":"10.4251\/wjgo.v9.i9.354","volume":"9","author":"TE Grotz","year":"2017","unstructured":"Grotz TE, Royal RE, Mansfield PF, et al. Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade. World J Gastrointest Oncol. 2017;9(9):354\u201362. https:\/\/doi.org\/10.4251\/wjgo.v9.i9.354.","journal-title":"World J Gastrointest Oncol."},{"issue":"6","key":"20210_CR14","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1097\/sla.0000000000001593","volume":"263","author":"R Kwakman","year":"2016","unstructured":"Kwakman R, Schrama AM, van Olmen JP, et al. Clinicopathological parameters in patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer metastases: a meta-analysis. Ann Surg. 2016;263(6):1102\u201311. https:\/\/doi.org\/10.1097\/sla.0000000000001593.","journal-title":"Ann Surg."},{"issue":"5","key":"20210_CR15","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1245\/s10434-015-5037-7","volume":"23","author":"PL Wagner","year":"2016","unstructured":"Wagner PL, Austin F, Zenati M, et al. Oncologic risk stratification following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for appendiceal carcinomatosis. Ann Surg Oncol. 2016;23(5):1587\u201393. https:\/\/doi.org\/10.1245\/s10434-015-5037-7.","journal-title":"Ann Surg Oncol."},{"issue":"6","key":"20210_CR16","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.16161","volume":"6","author":"JP Shen","year":"2023","unstructured":"Shen JP, Yousef AM, Zeineddine FA, et al. Efficacy of systemic chemotherapy in patients with low-grade mucinous appendiceal adenocarcinoma: a randomized crossover trial. JAMA Netw Open. 2023;6(6):e2316161. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.16161.","journal-title":"JAMA Netw Open."},{"issue":"2","key":"20210_CR17","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/cncr.29744","volume":"122","author":"EA Asare","year":"2016","unstructured":"Asare EA, Compton CC, Hanna NN, et al. The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base. Cancer. 2016;122(2):213\u201321. https:\/\/doi.org\/10.1002\/cncr.29744.","journal-title":"Cancer."},{"issue":"12","key":"20210_CR18","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/s1470-2045(16)30500-9","volume":"17","author":"J Franko","year":"2016","unstructured":"Franko J, Shi Q, Meyers JP, et al. Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the analysis and research in cancers of the digestive system (ARCAD) database. Lancet Oncol. 2016;17(12):1709\u201319. https:\/\/doi.org\/10.1016\/s1470-2045(16)30500-9.","journal-title":"Lancet Oncol."},{"key":"20210_CR19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2026.1929","author":"EC Gootjes","year":"2026","unstructured":"Gootjes EC, Bakkerus L, Adhin AA, et al. Tumor debulking in combination with chemotherapy in multiorgan metastatic colorectal cancer: The ORCHESTRA randomized clinical trial. JAMA. 2026. https:\/\/doi.org\/10.1001\/jama.2026.1929.","journal-title":"JAMA."},{"issue":"11","key":"20210_CR20","doi-asserted-by":"publisher","first-page":"6581","DOI":"10.1245\/s10434-022-11894-6","volume":"29","author":"E Baron","year":"2022","unstructured":"Baron E, Sardi A, King MC, et al. Systemic Chemotherapy for high-grade mucinous appendiceal cancer with peritoneal spread after unsuccessful CRS\/HIPEC. Ann Surg Oncol. 2022;29(11):6581\u20139. https:\/\/doi.org\/10.1245\/s10434-022-11894-6.","journal-title":"Ann Surg Oncol."},{"issue":"Pt A","key":"20210_CR21","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ijsu.2015.09.074","volume":"23","author":"SJ Valle","year":"2015","unstructured":"Valle SJ, Alzahrani NA, Alzahrani SE, Liauw W, Morris DL. Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) for refractory malignant ascites in patients unsuitable for cytoreductive surgery. Int J Surg. 2015;23(Pt A):176\u201380. https:\/\/doi.org\/10.1016\/j.ijsu.2015.09.074.","journal-title":"Int J Surg."},{"issue":"5","key":"20210_CR22","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1245\/s10434-013-3224-y","volume":"21","author":"RW Randle","year":"2014","unstructured":"Randle RW, Swett KR, Swords DS, et al. Efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in the management of malignant ascites. Ann Surg Oncol. 2014;21(5):1474\u20139. https:\/\/doi.org\/10.1245\/s10434-013-3224-y.","journal-title":"Ann Surg Oncol."},{"issue":"1","key":"20210_CR23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3978\/j.issn.2078-6891.2015.132","volume":"7","author":"LA Lambert","year":"2016","unstructured":"Lambert LA, Harris A. Palliative cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion: current clinical practice or misnomer? J Gastrointest Oncol. 2016;7(1):112\u201321. https:\/\/doi.org\/10.3978\/j.issn.2078-6891.2015.132.","journal-title":"J Gastrointest Oncol."},{"issue":"2","key":"20210_CR24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/s1470-2045(20)30599-4","volume":"22","author":"F Qu\u00e9net","year":"2021","unstructured":"Qu\u00e9net F, Elias D, Roca L, et al. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(2):256\u201366. https:\/\/doi.org\/10.1016\/s1470-2045(20)30599-4.","journal-title":"Lancet Oncol."},{"issue":"10","key":"20210_CR25","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/s2468-1253(23)00191-7","volume":"8","author":"RS Krouse","year":"2023","unstructured":"Krouse RS, Anderson GL, Arnold KB, et al. Surgical versus non-surgical management for patients with malignant bowel obstruction (S1316): a pragmatic comparative effectiveness trial. Lancet Gastroenterol Hepatol. 2023;8(10):908\u201318. https:\/\/doi.org\/10.1016\/s2468-1253(23)00191-7.","journal-title":"Lancet Gastroenterol Hepatol."},{"issue":"1","key":"20210_CR26","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1245\/s10434-018-6992-6","volume":"26","author":"P Piso","year":"2019","unstructured":"Piso P, Nedelcut SD, Rau B, et al. Morbidity and mortality following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: data from the DGAV StuDoQ registry with 2149 consecutive patients. Ann Surg Oncol. 2019;26(1):148\u201354. https:\/\/doi.org\/10.1245\/s10434-018-6992-6.","journal-title":"Ann Surg Oncol."},{"issue":"3","key":"20210_CR27","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.amjsurg.2019.09.017","volume":"219","author":"EW Beal","year":"2020","unstructured":"Beal EW, Ahmed A, Grotz T, et al. Trends in the indications for and short-term outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Am J Surg. 2020;219(3):478\u201383. https:\/\/doi.org\/10.1016\/j.amjsurg.2019.09.017.","journal-title":"Am J Surg."},{"issue":"5","key":"20210_CR28","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1245\/s10434-022-11323-8","volume":"29","author":"C Zhang","year":"2022","unstructured":"Zhang C, Patel A, Hegeholz D, et al. Cytoreductive surgery with HIPEC is a safe and effective palliative option in chemorefractory symptomatic peritoneal metastasis. Ann Surg Oncol. 2022;29(5):3337\u201346. https:\/\/doi.org\/10.1245\/s10434-022-11323-8.","journal-title":"Ann Surg Oncol."},{"key":"20210_CR29","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-025-18421-3","author":"P Marincola Smith","year":"2025","unstructured":"Marincola Smith P, Lie JJ, Seldomridge A, et al. Repeat cytoreductive surgery for colorectal cancer metastatic to the peritoneal cavity. Ann Surg Oncol. 2025. https:\/\/doi.org\/10.1245\/s10434-025-18421-3.","journal-title":"Ann Surg Oncol."},{"issue":"8","key":"20210_CR30","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1245\/s10434-016-5172-9","volume":"23","author":"Y Huang","year":"2016","unstructured":"Huang Y, Alzahrani NA, Chua TC, Huo YR, Liauw W, Morris DL. Impacts of preoperative serum albumin level on outcomes of cytoreductive surgery and perioperative intraperitoneal chemotherapy. Ann Surg Oncol. 2016;23(8):2411\u20138. https:\/\/doi.org\/10.1245\/s10434-016-5172-9.","journal-title":"Ann Surg Oncol."},{"issue":"5","key":"20210_CR31","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.amjsurg.2016.11.023","volume":"214","author":"CP Meyer","year":"2017","unstructured":"Meyer CP, Rios-Diaz AJ, Dalela D, et al. The association of hypoalbuminemia with early perioperative outcomes - a comprehensive assessment across 16 major procedures. Am J Surg. 2017;214(5):871\u201383. https:\/\/doi.org\/10.1016\/j.amjsurg.2016.11.023.","journal-title":"Am J Surg."},{"issue":"6","key":"20210_CR32","doi-asserted-by":"publisher","first-page":"cd011129","DOI":"10.1002\/14651858.CD011129.pub2","volume":"6","author":"MW Haun","year":"2017","unstructured":"Haun MW, Estel S, R\u00fccker G, et al. Early palliative care for adults with advanced cancer. Cochrane Database Syst Rev. 2017;6(6):cd011129. https:\/\/doi.org\/10.1002\/14651858.CD011129.pub2.","journal-title":"Cochrane Database Syst Rev."},{"issue":"9930","key":"20210_CR33","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/s0140-6736(13)62416-2","volume":"383","author":"C Zimmermann","year":"2014","unstructured":"Zimmermann C, Swami N, Krzyzanowska M, et al. Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet. 2014;383(9930):1721\u201330. https:\/\/doi.org\/10.1016\/s0140-6736(13)62416-2.","journal-title":"Lancet."},{"issue":"8","key":"20210_CR34","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1056\/NEJMra1404684","volume":"373","author":"AS Kelley","year":"2015","unstructured":"Kelley AS, Morrison RS. Palliative care for the seriously ill. N Engl J Med. 2015;373(8):747\u201355. https:\/\/doi.org\/10.1056\/NEJMra1404684.","journal-title":"N Engl J Med."},{"issue":"8","key":"20210_CR35","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1056\/NEJMoa1000678","volume":"363","author":"JS Temel","year":"2010","unstructured":"Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363(8):733\u201342. https:\/\/doi.org\/10.1056\/NEJMoa1000678.","journal-title":"N Engl J Med."},{"issue":"10","key":"20210_CR36","doi-asserted-by":"publisher","first-page":"7124","DOI":"10.1245\/s10434-025-18152-5","volume":"32","author":"S Dineen","year":"2025","unstructured":"Dineen S, O\u2019Leary C, Rajasekhara S, Mullinax J. Implementation of a palliative surgical oncology rotation to complex general surgical oncology fellowship training. Ann Surg Oncol. 2025;32(10):7124\u201330. https:\/\/doi.org\/10.1245\/s10434-025-18152-5.","journal-title":"Ann Surg Oncol."},{"issue":"1","key":"20210_CR37","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jamcollsurg.2020.03.036","volume":"231","author":"CP Scally","year":"2020","unstructured":"Scally CP, Robinson K, Blumenthaler AN, Bruera E, Badgwell BD. Identifying core principles of palliative care consultation in surgical patients and potential knowledge gaps for surgeons. J Am Coll Surg. 2020;231(1):179\u201385. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2020.03.036.","journal-title":"J Am Coll Surg."},{"issue":"9","key":"20210_CR38","doi-asserted-by":"publisher","first-page":"103581","DOI":"10.1016\/j.jsurg.2025.103581","volume":"82","author":"A Lifrieri","year":"2025","unstructured":"Lifrieri A, Schmidt L, Kline T, et al. Beyond the incision: a palliative care curriculum for general surgery residents. J Surg Educ. 2025;82(9):103581. https:\/\/doi.org\/10.1016\/j.jsurg.2025.103581.","journal-title":"J Surg Educ."},{"issue":"1","key":"20210_CR39","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1245\/s10434-019-07626-y","volume":"27","author":"MY Zaidi","year":"2020","unstructured":"Zaidi MY, Lee RM, Gamboa AC, et al. Preoperative risk score for predicting incomplete cytoreduction: a 12-institution study from the US HIPEC Collaborative. Ann Surg Oncol. 2020;27(1):156\u201364. https:\/\/doi.org\/10.1245\/s10434-019-07626-y.","journal-title":"Ann Surg Oncol."},{"issue":"1","key":"20210_CR40","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/sla.0000000000002253","volume":"267","author":"EJ Lilley","year":"2018","unstructured":"Lilley EJ, Cooper Z, Schwarze ML, Mosenthal AC. Palliative care in surgery: defining the research priorities. Ann Surg. 2018;267(1):66\u201372. https:\/\/doi.org\/10.1097\/sla.0000000000002253.","journal-title":"Ann Surg."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-026-20210-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-026-20210-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-026-20210-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:25:51Z","timestamp":1785777951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-026-20210-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":40,"alternative-id":["20210"],"URL":"https:\/\/doi.org\/10.1245\/s10434-026-20210-5","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"10 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"John-Paul Shen - Consulting: Engine Biosciences, NaDeNo Nanoscience; Patent- Siegel D, Schweer J, Abagyan R, Shen JP. Small molecule for treatment of cancer of the appendix. Filed July 17, 2023, PCT\/US2023\/027939.","order":1,"name":"Ethics","label":"Disclosure","group":{"name":"EthicsHeading","label":"Ethics"}}]}}