{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:46:02Z","timestamp":1792788362149,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Thora og Viggo Grove\u2019s Mindelegat","award":["06022019"],"award-info":[{"award-number":["06022019"]}]},{"name":"Grosserer Georg Bj\u00f8rkner og Hustru Ellen Bj\u00f8rkners Fond","award":["744980"],"award-info":[{"award-number":["744980"]}]},{"DOI":"10.13039\/501100023490","name":"IMK Almene Fond","doi-asserted-by":"publisher","award":["30206-365"],"award-info":[{"award-number":["30206-365"]}],"id":[{"id":"10.13039\/501100023490","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","award":["14112024"],"award-info":[{"award-number":["14112024"]}],"id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","award":["50020"],"award-info":[{"award-number":["50020"]}],"id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006426","name":"Eva og Henry Fr\u00e6nkels Mindefond","doi-asserted-by":"publisher","award":["10092021"],"award-info":[{"award-number":["10092021"]}],"id":[{"id":"10.13039\/501100006426","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grosserer A.V. Lykfeldts og hustrus legat","award":["26012023"],"award-info":[{"award-number":["26012023"]}],"id":[{"id":"https:\/\/ror.org\/00834cd23","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Aarhus Universitet","id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultrastaging of sentinel lymph nodes (SLNs) is standard for nodal assessment in early stage cervical cancer but is limited by sampling constraints and workload. Molecular detection of human papillomavirus (HPV) may identify metastatic disease. This study evaluated next\u00a0generation sequencing (NGS)-based HPV detection in SLNs as a complementary approach to SLN assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included 122 women with early stage cervical cancer treated with primary surgery and SLN mapping. SLNs were assessed by ultrastaging and HPV detection using an NGS-based HPV genotyping panel. A subset of patients additionally underwent polymerase chain reaction (PCR)-based HPV analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 17 patients (13.9%) had SLN metastases identified by ultrastaging, all of which were HPV-positive by NGS. HPV read counts correlated with SLN metastasis size (Spearman\u2019s\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.73,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). NGS additionally identified HPV in 13 patients (10.7%) with ultrastaging-negative SLNs. Compared with patients negative by both methods, these patients had significantly larger tumors (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009) and higher International Federation of Obstetrics and Gynecology (FIGO) stage (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02), while exhibiting significantly lower HPV read counts than patients positive by both ultrastaging and NGS (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). PCR detected HPV in more SLNs than NGS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NGS detected HPV in all ultrastaging-confirmed SLN metastases and identified an additional subgroup of patients with molecular HPV detection despite negative ultrastaging. The association between HPV quantity, metastasis size, and adverse clinicopathological characteristics supports the biological relevance of quantitative HPV detection in SLNs. These findings warrant further evaluation of NGS as a complementary molecular biomarker for SLN assessment in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1245\/s10434-026-20586-4","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:22:16Z","timestamp":1790180536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular HPV Detection in Sentinel Lymph Nodes Using Next Generation Sequencing: Concordance with Ultrastaging and Biological Relevance in Early-Stage Cervical Cancer"],"prefix":"10.1245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-1288","authenticated-orcid":false,"given":"Sara","family":"B\u00f8nl\u00f8kke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-2702","authenticated-orcid":false,"given":"Sara Elizabeth","family":"Sponholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-6040","authenticated-orcid":false,"given":"Pernille Tine","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-3555","authenticated-orcid":false,"given":"Torben","family":"Steiniche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-9120","authenticated-orcid":false,"given":"Algirdas","family":"Markauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-2394","authenticated-orcid":false,"given":"Else","family":"Mejlgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-0589","authenticated-orcid":false,"given":"Jan","family":"Blaak\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-1173","authenticated-orcid":false,"given":"Katrine","family":"Fuglsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"20586_CR1","unstructured":"NCCN Clinical Practice Guidelines in Oncology, Cervical Cancer, 2024, NCCN Clinical Practice Guidelines in Oncology, Accessed 31.03.2026"},{"issue":"15","key":"20586_CR2","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1056\/NEJMoa2506267","volume":"393","author":"H Tu","year":"2025","unstructured":"Tu H, Huang H, Li Y, Chen X, Wang C, Zheng M, et al. Sentinel-lymph-node biopsy alone or with lymphadenectomy in cervical cancer. N Engl J Med. 2025;393(15):1463\u201374.","journal-title":"N Engl J Med."},{"issue":"9","key":"20586_CR3","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/s43018-025-01016-y","volume":"6","author":"D Cibula","year":"2025","unstructured":"Cibula D, Marnitz S, Jarkovsky J, Kocian R, Dundr P, Klat J, et al. Sentinel lymph node biopsy without systematic pelvic lymphadenectomy in females with early-stage cervical cancer: final outcome of the SENTIX prospective, single-arm, noninferiority, international trial. Nat Cancer. 2025;6(9):1585\u201394.","journal-title":"Nat Cancer."},{"issue":"2","key":"20586_CR4","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ygyno.2021.12.015","volume":"164","author":"B Guani","year":"2022","unstructured":"Guani B, Mahiou K, Crestani A, Cibula D, Buda A, Gaillard T, et al. Clinical impact of low-volume lymph node metastases in early-stage cervical cancer: a comprehensive meta-analysis. Gynecol Oncol. 2022;164(2):446\u201354.","journal-title":"Gynecol Oncol."},{"issue":"3","key":"20586_CR5","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ygyno.2012.08.035","volume":"127","author":"D Cibula","year":"2012","unstructured":"Cibula D, Abu-Rustum NR, Dusek L, Slama J, Zikan M, Zaal A, et al. Bilateral ultrastaging of sentinel lymph node in cervical cancer: lowering the false-negative rate and improving the detection of micrometastasis. Gynecol Oncol. 2012;127(3):462\u20136.","journal-title":"Gynecol Oncol."},{"issue":"6","key":"20586_CR6","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.3390\/cancers12061438","volume":"12","author":"R Kocian","year":"2020","unstructured":"Kocian R, Slama J, Fischerova D, Germanova A, Burgetova A, Dusek L, Dundr P, Nemejcova K, Jarkovsky J, Sebestova S, Fruhauf F. Micrometastases in sentinel lymph nodes represent a significant negative prognostic factor in early-stage cervical cancer: a single-institutional retrospective cohort study. Cancers. 2020;12(6):1438.","journal-title":"Cancers"},{"issue":"3","key":"20586_CR7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ygyno.2011.11.037","volume":"124","author":"D Cibula","year":"2012","unstructured":"Cibula D, Abu-Rustum NR, Dusek L, Zikan M, Zaal A, Sevcik L, et al. Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. Gynecol Oncol. 2012;124(3):496\u2013501.","journal-title":"Gynecol Oncol."},{"issue":"3","key":"20586_CR8","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1136\/ijgc-2018-000089","volume":"29","author":"B Guani","year":"2019","unstructured":"Guani B, Dorez M, Magaud L, Buenerd A, Lecuru F, Mathevet P. Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL trial. Int J Gynecol Cancer. 2019;29(3):447\u201352.","journal-title":"Int J Gynecol Cancer."},{"issue":"4","key":"20586_CR9","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1136\/ijgc-2019-000332","volume":"29","author":"FR Lecuru","year":"2019","unstructured":"Lecuru FR, McCormack M, Hillemanns P, Anota A, Leitao M, Mathevet P, Zweemer R, Fujiwara K, Zanagnolo V, Eriksson AGZ, Hudson E. SENTICOL III: an international validation study of sentinel node biopsy in early cervical cancer. A GINECO, ENGOT, GCIG and multicenter study. Int J Gynecol Cancer. 2019;29(4):829\u201334.","journal-title":"Int J Gynecol Cancer"},{"issue":"10","key":"20586_CR10","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1002\/cncr.24268","volume":"115","author":"R Riber-Hansen","year":"2009","unstructured":"Riber-Hansen R, Nyengaard JR, Hamilton-Dutoit SJ, Steiniche T. Stage migration after minor changes in histologic estimation of tumor burden in sentinel lymph nodes: the protocol trap. Cancer. 2009;115(10):2177\u201387.","journal-title":"Cancer."},{"issue":"5","key":"20586_CR11","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/CCO.0000000000001061","volume":"36","author":"D Viveros-Carreno","year":"2024","unstructured":"Viveros-Carreno D, Mora-Soto N, Pareja R. Value of sentinel node ultrastaging and pathologic techniques in tumoral detection. Curr Opin Oncol. 2024;36(5):376\u201382.","journal-title":"Curr Opin Oncol."},{"issue":"1","key":"20586_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ygyno.2021.10.074","volume":"164","author":"V Balaya","year":"2022","unstructured":"Balaya V, Guani B, Morice P, Querleu D, Fourchotte V, Leblanc E, et al. Long-term oncological safety of sentinel lymph node biopsy in early-stage cervical cancer: a post-hoc analysis of SENTICOL I and SENTICOL II cohorts. Gynecol Oncol. 2022;164(1):53\u201361.","journal-title":"Gynecol Oncol."},{"issue":"5","key":"20586_CR13","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1002\/cncr.31165","volume":"124","author":"GA Taarnhoj","year":"2018","unstructured":"Taarnhoj GA, Christensen IJ, Lajer H, Fuglsang K, Jeppesen MM, Kahr HS, et al. Risk of recurrence, prognosis, and follow-up for Danish women with cervical cancer in 2005\u20132013: a national cohort study. Cancer. 2018;124(5):943\u201351.","journal-title":"Cancer."},{"issue":"5","key":"20586_CR14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc798","volume":"2","author":"H Zur Hausen","year":"2002","unstructured":"Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2(5):342\u201350.","journal-title":"Nat Rev Cancer"},{"key":"20586_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pvr.2018.12.001","volume":"7","author":"K Fuglsang","year":"2019","unstructured":"Fuglsang K, Blaakaer J, Petersen LK, Mejlgaard E, Hammer A, Steiniche T. Detection of high-risk human papillomavirus DNA in tissue from primary cervical cancer tumor, pelvic lymph nodes and recurrent disease. Papillomavirus Res. 2019;7:15\u201320.","journal-title":"Papillomavirus Res."},{"key":"20586_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155672","volume":"264","author":"S Bonlokke","year":"2024","unstructured":"Bonlokke S, Stougaard M, Blaakaer J, Bertelsen J, Andersen K, Fuglsang K, et al. HPV is an essential driver in recurrence of cervical cancer. Pathol Res Pract. 2024;264:155672.","journal-title":"Pathol Res Pract."},{"key":"20586_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2023.105418","volume":"161","author":"R Montero-Macias","year":"2023","unstructured":"Montero-Macias R, Veyer D, Bruneau T, Robillard N, Le Frere-Belda MA, Rigolet P, et al. TRANSLACOL project: Nodal human papillomavirus tumoral DNA detection by ddPCR for survival prediction in early cervical cancer patients without pelvic lymph node invasion. J Clin Virol. 2023;161:105418.","journal-title":"J Clin Virol."},{"issue":"9","key":"20586_CR18","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1093\/annonc\/mdm192","volume":"18","author":"C Coutant","year":"2007","unstructured":"Coutant C, Barranger E, Cortez A, Dabit D, Uzan S, Bernaudin JF, et al. Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer. Ann Oncol. 2007;18(9):1513\u20137.","journal-title":"Ann Oncol."},{"issue":"2","key":"20586_CR19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ygyno.2006.12.016","volume":"105","author":"YS Lee","year":"2007","unstructured":"Lee YS, Rhim CC, Lee HN, Lee KH, Park JS, Namkoong SE. HPV status in sentinel nodes might be a prognostic factor in cervical cancer. Gynecol Oncol. 2007;105(2):351\u20137.","journal-title":"Gynecol Oncol."},{"issue":"26","key":"20586_CR20","doi-asserted-by":"publisher","first-page":"23015","DOI":"10.18632\/oncotarget.4132","volume":"6","author":"M Durst","year":"2015","unstructured":"Durst M, Hoyer H, Altgassen C, Greinke C, Hafner N, Fishta A, et al. Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status. Oncotarget. 2015;6(26):23015\u201325.","journal-title":"Oncotarget."},{"issue":"3","key":"20586_CR21","first-page":"2317","volume":"19","author":"Y Lu","year":"2020","unstructured":"Lu Y, Xu X, Nong XH, Yao DS. Detection of high-risk human papillomavirus DNA in sentinel lymph nodes of patients with cervical cancer. Oncol Lett. 2020;19(3):2317\u201325.","journal-title":"Oncol Lett."},{"issue":"3\u20134","key":"20586_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000150429","volume":"38","author":"E Beyer-Finkler","year":"1995","unstructured":"Beyer-Finkler E, Girardi F, Sillem M, Pfister H. Human papillomavirus DNA in genital cancers, metastases, and lymph nodes. Intervirology. 1995;38(3\u20134):173\u201380.","journal-title":"Intervirology."},{"issue":"16","key":"20586_CR23","doi-asserted-by":"publisher","first-page":"9236","DOI":"10.1073\/pnas.96.16.9236","volume":"96","author":"B Vogelstein","year":"1999","unstructured":"Vogelstein B, Kinzler KW. Digital PCR. Proc Natl Acad Sci U S A. 1999;96(16):9236\u201341.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"20586_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2020.104568","volume":"118","author":"J Lippert","year":"2021","unstructured":"Lippert J, B\u00f8nl\u00f8kke S, Utke A, Knudsen BR, Sorensen BS, Steiniche T, et al. Targeted next generation sequencing panel for HPV genotyping in cervical cancer. Exp Mol Pathol. 2021;118:104568.","journal-title":"Exp Mol Pathol."},{"issue":"3","key":"20586_CR25","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jmoldx.2023.11.007","volume":"26","author":"S Naegele","year":"2024","unstructured":"Naegele S, Ruiz-Torres DA, Zhao Y, Goss D, Faden DL. Comparing the diagnostic performance of quantitative PCR, digital droplet PCR, and next-generation sequencing liquid biopsies for human papillomavirus-associated cancers. J Mol Diagn. 2024;26(3):179\u201390.","journal-title":"J Mol Diagn."},{"issue":"12","key":"20586_CR26","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1038\/s41416-020-01111-0","volume":"123","author":"LS Arroyo Muhr","year":"2020","unstructured":"Arroyo Muhr LS, Lagheden C, Lei J, Eklund C, Nordqvist Kleppe S, Sparen P, et al. Deep sequencing detects human papillomavirus (HPV) in cervical cancers negative for HPV by PCR. Br J Cancer. 2020;123(12):1790\u20135.","journal-title":"Br J Cancer."},{"issue":"7","key":"20586_CR27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s00705-023-05810-w","volume":"168","author":"R Jitvaropas","year":"2023","unstructured":"Jitvaropas R, Thongpoom U, Sawaswong V, Khongnomnan K, Poomipak W, Praianantathavorn K, et al. Development of a simplified and cost-effective sample preparation method for genotyping of human papillomavirus by next-generation sequencing. Arch Virol. 2023;168(7):185.","journal-title":"Arch Virol."},{"issue":"5","key":"20586_CR28","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/1878-0261.13538","volume":"18","author":"S Bonlokke","year":"2024","unstructured":"Bonlokke S, Steiniche T, Sorensen BS, Nyvang GB, Lindegaard JC, Blaakaer J, et al. Circulating cell-free HPV DNA is a strong marker for disease severity in cervical cancer. Mol Oncol. 2024;18(5):1231\u201344.","journal-title":"Mol Oncol."},{"issue":"1","key":"20586_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/jalm\/jfad091","volume":"9","author":"MY Tjota","year":"2024","unstructured":"Tjota MY, Segal JP, Wang P. Clinical utility and benefits of comprehensive genomic profiling in cancer. J Appl Lab Med. 2024;9(1):76\u201391.","journal-title":"J Appl Lab Med."},{"issue":"1","key":"20586_CR30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ijgo.12749","volume":"145","author":"N Bhatla","year":"2019","unstructured":"Bhatla N, Berek JS, Cuello Fredes M, Denny LA, Grenman S, Karunaratne K, et al. Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet. 2019;145(1):129\u201335.","journal-title":"Int J Gynaecol Obstet."},{"issue":"1","key":"20586_CR31","first-page":"S43","volume":"95","author":"MBJ Quinn","year":"2006","unstructured":"Quinn MBJ, Odicino FMP, Beller UCW, Heintz ANH, Pecorelli S. Carcinoma of the cervix uteri. Int J Gynaecol Obstet. 2006;95(1):S43.","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"20586_CR32","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1006\/gyno.1999.5387","volume":"73","author":"A Sedlis","year":"1999","unstructured":"Sedlis A, Bundy BN, Rotman MZ, Lentz SS, Muderspach LI, Zaino RJ. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a Gynecologic Oncology Group Study. Gynecol Oncol. 1999;73(2):177\u201383.","journal-title":"Gynecol Oncol."},{"issue":"8","key":"20586_CR33","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1200\/JCO.2000.18.8.1606","volume":"18","author":"WA Peters 3rd","year":"2000","unstructured":"Peters WA 3rd, Liu PY, Barrett RJ 2nd, Stock RJ, Monk BJ, Berek JS, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 2000;18(8):1606\u201313.","journal-title":"J Clin Oncol."},{"issue":"3","key":"20586_CR34","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.ygyno.2021.06.018","volume":"162","author":"SE Sponholtz","year":"2021","unstructured":"Sponholtz SE, Mogensen O, Hildebrandt MG, Schledermann D, Parner E, Markauskas A, et al. Sentinel lymph node mapping in early-stage cervical cancer - A national prospective multicenter study (SENTIREC trial). Gynecol Oncol. 2021;162(3):546\u201354.","journal-title":"Gynecol Oncol."},{"issue":"3","key":"20586_CR35","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3390\/cancers14030652","volume":"14","author":"K Andersen","year":"2022","unstructured":"Andersen K, Holm K, Tranberg M, Pedersen CL, B\u00f8nl\u00f8kke S, Steiniche T, Andersen B, Stougaard M. Targeted next generation sequencing for human papillomavirus genotyping in cervical liquid-based cytology samples. Cancers. 2022;14(3):652.","journal-title":"Cancers"},{"issue":"5","key":"20586_CR36","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.jmig.2016.03.003","volume":"23","author":"C Kohler","year":"2016","unstructured":"Kohler C, Le X, Dogan NU, Pfiffer T, Schneider A, Marnitz S, et al. Molecular diagnosis for nodal metastasis in endoscopically managed cervical cancer: the accuracy of the APTIMA test to detect high-risk human papillomavirus messenger rna in sentinel lymph nodes. J Minim Invasive Gynecol. 2016;23(5):748\u201352.","journal-title":"J Minim Invasive Gynecol."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-026-20586-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-026-20586-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-026-20586-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:22:19Z","timestamp":1790180539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-026-20586-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":36,"alternative-id":["20586"],"URL":"https:\/\/doi.org\/10.1245\/s10434-026-20586-4","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"8 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Disclosure","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Central Denmark Region Committees on Health Research Ethics (journal number: 1-10-72-217-18) and was registered in the Central Denmark Region\u2019s internal registry of research projects (case no. 628332).","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"All analyses were performed with the written informed consent of each participant. Participants gave permission to publish the relevant data and findings.","order":3,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Ethics"}}]}}