{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:06:41Z","timestamp":1765728401439},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T00:00:00Z","timestamp":1302307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1245\/s10434-011-1703-6","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T16:52:36Z","timestamp":1302281556000},"page":"2937-2945","source":"Crossref","is-referenced-by-count":47,"title":["Prognostic Impact of CD133 mRNA Expression in 48 Glioblastoma Patients Treated with Concomitant Radiochemotherapy: A Prospective Patient Cohort at a Single Institution"],"prefix":"10.1245","volume":"18","author":[{"given":"Philippe","family":"Metellus","sequence":"first","affiliation":[]},{"given":"Isabelle","family":"Nanni-Metellus","sequence":"additional","affiliation":[]},{"given":"Christine","family":"Delfino","sequence":"additional","affiliation":[]},{"given":"Carole","family":"Colin","sequence":"additional","affiliation":[]},{"given":"Aurelie","family":"Tchogandjian","sequence":"additional","affiliation":[]},{"given":"Bema","family":"Coulibaly","sequence":"additional","affiliation":[]},{"given":"Frederic","family":"Fina","sequence":"additional","affiliation":[]},{"given":"Anderson","family":"Loundou","sequence":"additional","affiliation":[]},{"given":"Marylin","family":"Barrie","sequence":"additional","affiliation":[]},{"given":"Olivier","family":"Chinot","sequence":"additional","affiliation":[]},{"given":"L\u2019Houcine","family":"Ouafik","sequence":"additional","affiliation":[]},{"given":"Dominique","family":"Figarella-Branger","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,4,9]]},"reference":[{"key":"1703_CR1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1470-2045(04)01531-1","volume":"5","author":"F Berger","year":"2004","unstructured":"Berger F, Gay E, Pelletier L, Tropel P, Wion D. Development of gliomas: potential role of asymmetrical cell division of neural stem cells. Lancet Oncol. 2004;5:511\u20134.","journal-title":"Lancet Oncol"},{"key":"1703_CR2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJMra043666","volume":"353","author":"N Sanai","year":"2005","unstructured":"Sanai N, Alvarez-Buylla A, Berger MS. Neural stem cells and the origin of gliomas. N Engl J Med. 2005;353:811\u201322.","journal-title":"N Engl J Med"},{"key":"1703_CR3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1750-3639.2008.00130.x","volume":"18","author":"D Beier","year":"2008","unstructured":"Beier D, Wischhusen J, Dietmaier W, Hau P, Proescholdt M, Brawanski A, et al. CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors. Brain Pathol. 2008;18:370\u20137.","journal-title":"Brain Pathol"},{"key":"1703_CR4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrc1889","volume":"6","author":"AL Vescovi","year":"2006","unstructured":"Vescovi AL, Galli R, Reynolds BA. Brain tumour stem cells. Nat Rev Cancer. 2006;6:425\u201336.","journal-title":"Nat Rev Cancer"},{"key":"1703_CR5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumour initiating cells. Nature. 2004;432:396\u2013401.","journal-title":"Nature"},{"key":"1703_CR6","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1158\/0008-5472.CAN-08-1079","volume":"68","author":"S Bao","year":"2008","unstructured":"Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, et al. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 2008;68:6043\u20138.","journal-title":"Cancer Res"},{"key":"1703_CR7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1227\/01.neu.0000316019.28421.95","volume":"62","author":"AT Ogden","year":"2008","unstructured":"Ogden AT, Waziri AE, Lochhead RA, Fusco D, Lopez K, Ellis JA, et al. Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery. 2008;62:505\u2013514; discussion 514\u20135.","journal-title":"Neurosurgery"},{"key":"1703_CR8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1750-3639.2009.00269.x","volume":"20","author":"A Tchoghandjian","year":"2010","unstructured":"Tchoghandjian A, Baeza N, Colin C, Cayre M, Metellus P, Beclin C, et al. A2B5 cells from human glioblastoma have cancer stem cell properties. Brain Pathol. 2010;20:211\u201321.","journal-title":"Brain Pathol"},{"key":"1703_CR9","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/sj.cdd.4401872","volume":"13","author":"A Eramo","year":"2006","unstructured":"Eramo A, Ricci-Vitiani L, Zeuner A, Pallini R, Lotti F, Sette G, et al. Chemotherapy resistance of glioblastoma stem cells. Cell Death Differ. 2006;13:1238\u201341.","journal-title":"Cell Death Differ"},{"key":"1703_CR10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1476-4598-5-67","volume":"5","author":"G Liu","year":"2006","unstructured":"Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 2006;5:67.","journal-title":"Mol Cancer"},{"key":"1703_CR11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","volume":"444","author":"S Bao","year":"2006","unstructured":"Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756\u201360.","journal-title":"Nature"},{"key":"1703_CR12","doi-asserted-by":"crossref","first-page":"8205","DOI":"10.1158\/1078-0432.CCR-08-0644","volume":"14","author":"R Pallini","year":"2008","unstructured":"Pallini R, Ricci-Vitiani L, Banna GL, Signore M, Lombardi D, Todaro M, et al. Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin Cancer Res. 2008;14:8205\u201312.","journal-title":"Clin Cancer Res"},{"key":"1703_CR13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1158\/1078-0432.CCR-07-0932","volume":"14","author":"F Zeppernick","year":"2008","unstructured":"Zeppernick F, Ahmadi R, Campos B, Dictus C, Helmke BM, Becker N, et al. Stem cell marker CD133 affects clinical outcome in glioma patients. Clin Cancer Res. 2008;14:123\u20139.","journal-title":"Clin Cancer Res"},{"key":"1703_CR14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97\u2013109.","journal-title":"Acta Neuropathol"},{"key":"1703_CR15","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1200\/JCO.1990.8.7.1277","volume":"8","author":"DR Macdonald","year":"1990","unstructured":"Macdonald DR, Cascino TL, Schold SC Jr, Cairncross JG. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol. 1990;8:1277\u201380.","journal-title":"J Clin Oncol"},{"key":"1703_CR16","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1002\/cncr.24546","volume":"115","author":"P Metellus","year":"2009","unstructured":"Metellus P, Coulibaly B, Nanni I, Fina F, Eudes N, Giorgi R, et al. Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort. Cancer. 2009;115:4783\u201394.","journal-title":"Cancer"},{"key":"1703_CR17","first-page":"5821","volume":"63","author":"SK Singh","year":"2003","unstructured":"Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003;63:5821\u20138.","journal-title":"Cancer Res"},{"key":"1703_CR18","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/stem.15","volume":"27","author":"DR Laks","year":"2009","unstructured":"Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, et al. Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells. 2009;27:980\u20137.","journal-title":"Stem Cells"},{"key":"1703_CR19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mcn.2008.07.022","volume":"43","author":"N Thon","year":"2010","unstructured":"Thon N, Damianoff K, Hegermann J, Grau S, Krebs B, Schnell O, et al. Presence of pluripotent CD133(+) cells correlates with malignancy of gliomas. Mol Cell Neurosci. 2010;43:51\u20139.","journal-title":"Mol Cell Neurosci"},{"key":"1703_CR20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1756-9966-27-85","volume":"27","author":"M Zhang","year":"2008","unstructured":"Zhang M, Song T, Yang L, Chen R, Wu L, Yang Z, et al. Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients. J Exp Clin Cancer Res. 2008;27:85.","journal-title":"J Exp Clin Cancer Res"},{"key":"1703_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ccr.2006.02.019","volume":"9","author":"HS Phillips","year":"2006","unstructured":"Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell. 2006;9:157\u201373.","journal-title":"Cancer Cell"},{"key":"1703_CR22","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200011093431901","volume":"343","author":"M Esteller","year":"2000","unstructured":"Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med. 2000;343:1350\u20134.","journal-title":"N Engl J Med"},{"key":"1703_CR23","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","volume":"352","author":"ME Hegi","year":"2005","unstructured":"Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352:997\u20131003.","journal-title":"N Engl J Med"},{"key":"1703_CR24","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1158\/0008-5472.CAN-07-6878","volume":"68","author":"D Beier","year":"2008","unstructured":"Beier D, Rohrl S, Pillai DR, Schwarz S, Kunz-Schughart LA, Leukel P, et al. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res. 2008;68:5706\u201315.","journal-title":"Cancer Res"}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-011-1703-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1245\/s10434-011-1703-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-011-1703-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T11:42:20Z","timestamp":1572954140000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1245\/s10434-011-1703-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,9]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["1703"],"URL":"https:\/\/doi.org\/10.1245\/s10434-011-1703-6","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,9]]}}}