{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:57:51Z","timestamp":1776376671172,"version":"3.51.2"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Oncol"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1245\/s10434-022-12312-7","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T13:06:09Z","timestamp":1659704769000},"page":"7528-7537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Impact of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer with Peritoneal Carcinomatosis: A Systematic Review and Meta-analysis"],"prefix":"10.1245","volume":"29","author":[{"given":"Mariana","family":"Martins","sequence":"first","affiliation":[]},{"given":"Hugo","family":"Santos-Sousa","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Nogueiro","sequence":"additional","affiliation":[]},{"given":"Bernardo","family":"Sousa-Pinto","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"issue":"3","key":"12312_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin."},{"key":"12312_CR2","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.21037\/jgo-20-284","volume":"12","author":"T Boerner","year":"2021","unstructured":"Boerner T, Piso P. A narrative review of intraperitoneal chemotherapy and cytoreductive surgery (CRS) for peritoneal metastases in gastric cancer. J Gastrointest Oncol. 2021;12:S59\u201367.","journal-title":"J Gastrointest Oncol."},{"issue":"3","key":"12312_CR3","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3748\/wjg.v22.i3.1114","volume":"22","author":"RA Seshadri","year":"2016","unstructured":"Seshadri RA, Glehen O. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer. World J Gastroenterol. 2016;22(3):1114\u201330.","journal-title":"World J Gastroenterol."},{"issue":"2","key":"12312_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3109\/02656736.2015.1111432","volume":"32","author":"K Polom","year":"2016","unstructured":"Polom K, Marano L, Roviello G, et al. Evolution and emerging future of cytoreducxtive surgery and hyperthermic intraperitoneal chemoperfusion in gastric cancer: From treating the incurable to preventing recurrence. Int J Hyperthermia. 2016;32(2):173\u20139.","journal-title":"Int J Hyperthermia."},{"issue":"1","key":"12312_CR5","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1245\/s10434-020-08739-5","volume":"28","author":"B Badgwell","year":"2021","unstructured":"Badgwell B, Ikoma N, Murphy MB, et al. A phase II trial of cytoreduction, gastrectomy, and hyperthermic intraperitoneal perfusion with chemotherapy for patients with gastric cancer and carcinomatosis or positive cytology. Ann Surg Oncol. 2021;28(1):258\u201364.","journal-title":"Ann Surg Oncol."},{"issue":"1","key":"12312_CR6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/jso.26718","volume":"125","author":"B Badgwell","year":"2022","unstructured":"Badgwell B. Regional therapy trials in peritoneal metastases: The path to standardization of care for gastric cancer. J Surg Oncol. 2022;125(1):64\u20138.","journal-title":"J Surg Oncol."},{"issue":"3","key":"12312_CR7","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/ijc.28373","volume":"134","author":"I Thomassen","year":"2014","unstructured":"Thomassen I, van Gestel YR, van Ramshorst B, et al. Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors. Int J Cancer. 2014;134(3):622\u20138.","journal-title":"Int J Cancer."},{"issue":"6","key":"12312_CR8","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1080\/02656736.2016.1190987","volume":"32","author":"Y Tu","year":"2016","unstructured":"Tu Y, Tian Y, Fang Z, et al. Cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion for the treatment of gastric cancer: a single-centre retrospective study. Int J Hyperthermia. 2016;32(6):587\u201394.","journal-title":"Int J Hyperthermia."},{"issue":"8","key":"12312_CR9","doi-asserted-by":"publisher","first-page":"4130","DOI":"10.1245\/s10434-021-09927-7","volume":"28","author":"SP Dineen","year":"2021","unstructured":"Dineen SP, Pimiento JM. The Landmark Series: cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) for treatment of gastric cancer metastatic to peritoneum. Ann Surg Oncol. 2021;28(8):4130\u20137.","journal-title":"Ann Surg Oncol."},{"issue":"Suppl 1","key":"12312_CR10","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.21037\/jgo-2020-04","volume":"12","author":"A Brandl","year":"2021","unstructured":"Brandl A, Prabhu A. Intraperitoneal chemotherapy in the treatment of gastric cancer peritoneal metastases: an overview of common therapeutic regimens. J Gastrointest Oncol. 2021;12(Suppl 1):S32\u201344.","journal-title":"J Gastrointest Oncol."},{"issue":"31","key":"12312_CR11","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.1200\/JCO.2006.06.8429","volume":"24","author":"E Van Cutsem","year":"2006","unstructured":"Van Cutsem E, Moiseyenko VM, Tjulandin S, et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol. 2006;24(31):4991\u20137.","journal-title":"J Clin Oncol."},{"key":"12312_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-1-4613-1247-5_4","volume":"82","author":"P Jacquet","year":"1996","unstructured":"Jacquet P, Sugarbaker PH. Peritoneal-plasma barrier. Cancer Treat Res. 1996;82:53\u201363.","journal-title":"Cancer Treat Res."},{"issue":"10","key":"12312_CR13","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.ejso.2014.01.006","volume":"40","author":"B Xiong","year":"2014","unstructured":"Xiong B, Ma L, Cheng Y, Zhang C. Clinical effectiveness of neoadjuvant chemotherapy in advanced gastric cancer: an updated meta-analysis of randomized controlled trials. Eur J Surg Oncol. 2014;40(10):1321\u201330.","journal-title":"Eur J Surg Oncol."},{"issue":"6","key":"12312_CR14","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3109\/00365521.2014.907337","volume":"49","author":"J Cao","year":"2014","unstructured":"Cao J, Qi F, Liu T. Adjuvant chemotherapy after curative resection for gastric cancer: a meta-analysis. Scand J Gastroenterol. 2014;49(6):690\u2013704.","journal-title":"Scand J Gastroenterol."},{"issue":"12","key":"12312_CR15","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.ejso.2014.04.009","volume":"40","author":"JW Liang","year":"2014","unstructured":"Liang JW, Zheng ZC, Yu T, Wang X, Zhang JJ. Is postoperative adjuvant chemoradiotherapy efficacious and safe for gastric cancer patients with D2 lymphadenectomy? A meta-analysis of the literature. Eur J Surg Oncol. 2014;40(12):1614\u201321.","journal-title":"Eur J Surg Oncol."},{"issue":"5","key":"12312_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1056\/NEJMoa0707035","volume":"359","author":"M Sasako","year":"2008","unstructured":"Sasako M, Sano T, Yamamoto S, et al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. N Engl J Med. 2008;359(5):453\u201362.","journal-title":"N Engl J Med."},{"issue":"3","key":"12312_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1200\/JCO.2011.39.1953","volume":"30","author":"J Lee","year":"2012","unstructured":"Lee J, Lim DH, Kim S, et al. Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial. J Clin Oncol. 2012;30(3):268\u201373.","journal-title":"J Clin Oncol."},{"issue":"9","key":"12312_CR18","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/bjs.4164","volume":"90","author":"F Roviello","year":"2003","unstructured":"Roviello F, Marrelli D, de Manzoni G, et al. Prospective study of peritoneal recurrence after curative surgery for gastric cancer. Br J Surg. 2003;90(9):1113\u20139.","journal-title":"Br J Surg."},{"issue":"7","key":"12312_CR19","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s00595-020-02180-7","volume":"51","author":"T Kitai","year":"2021","unstructured":"Kitai T. The role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis: a systematic review including evidence from Japan. Surg Today. 2021;51(7):1085\u201398.","journal-title":"Surg Today."},{"issue":"2","key":"12312_CR20","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/1097-0142(19880115)61:2<232::AID-CNCR2820610205>3.0.CO;2-U","volume":"61","author":"S Koga","year":"1988","unstructured":"Koga S, Hamazoe R, Maeta M, Shimizu N, Murakami A, Wakatsuki T. Prophylactic therapy for peritoneal recurrence of gastric cancer by continuous hyperthermic peritoneal perfusion with mitomycin C. Cancer. 1988;61(2):232\u20137.","journal-title":"Cancer."},{"issue":"1","key":"12312_CR21","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00000658-198807000-00005","volume":"208","author":"S Fujimoto","year":"1988","unstructured":"Fujimoto S, Shrestha RD, Kokubun M, et al. Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding. Ann Surg. 1988;208(1):36\u201341.","journal-title":"Ann Surg."},{"key":"12312_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejca.2017.03.030","volume":"79","author":"J Desiderio","year":"2017","unstructured":"Desiderio J, Chao J, Melstrom L, et al. The 30-year experience\u2014a meta-analysis of randomised and high-quality non-randomised studies of hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer. Eur J Cancer. 2017;79:1\u201314.","journal-title":"Eur J Cancer."},{"issue":"6","key":"12312_CR23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1053\/ctrv.2001.0232","volume":"27","author":"AJ Witkamp","year":"2001","unstructured":"Witkamp AJ, de Bree E, Van Goethem R, Zoetmulder FA. Rationale and techniques of intra-operative hyperthermic intraperitoneal chemotherapy. Cancer Treat Rev. 2001;27(6):365\u201374.","journal-title":"Cancer Treat Rev."},{"issue":"23","key":"12312_CR24","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1200\/JCO.18.01688","volume":"37","author":"PE Bonnot","year":"2019","unstructured":"Bonnot PE, Piessen G, Kepenekian V, et al. Cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastases (CYTO-CHIP study): a propensity score analysis. J Clin Oncol. 2019;37(23):2028\u201340.","journal-title":"J Clin Oncol."},{"key":"12312_CR25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.","journal-title":"BMJ."},{"issue":"9","key":"12312_CR26","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","volume":"73","author":"K Slim","year":"2003","unstructured":"Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J. Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg. 2003;73(9):712\u20136.","journal-title":"ANZ J Surg."},{"issue":"6","key":"12312_CR27","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1245\/s10434-011-1631-5","volume":"18","author":"XJ Yang","year":"2011","unstructured":"Yang XJ, Huang CQ, Suo T, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol. 2011;18(6):1575\u201381.","journal-title":"Ann Surg Oncol."},{"issue":"5","key":"12312_CR28","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/(SICI)1097-0142(19970301)79:5<884::AID-CNCR3>3.0.CO;2-C","volume":"79","author":"S Fujimoto","year":"1996","unstructured":"Fujimoto S, Takahashi M, Mutou T, et al. Improved mortality rate of gastric carcinoma patients with peritoneal carcinomatosis treated with intraperitoneal hyperthermic chemoperfusion combined with surgery. Cancer. 1996;79(5):884\u201391.","journal-title":"Cancer."},{"issue":"5","key":"12312_CR29","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/00000658-199011000-00005","volume":"212","author":"S Fujimoto","year":"1989","unstructured":"Fujimoto S, Shrestha RD, Kokubun M, et al. Positive results of combined therapy of surgery and intraperitoneal hyperthermic perfusion for far-advanced gastric cancer. Ann Surg. 1989;212(5):592\u20136.","journal-title":"Ann Surg."},{"issue":"2","key":"12312_CR30","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000012016","volume":"57","author":"K Hirose","year":"1999","unstructured":"Hirose K, Katayama K, Iida A, et al. Efficacy of continuous hyperthermic peritoneal perfusion for the prophylaxis and treatment of peritoneal metastasis of advanced gastric cancer: evaluation by multivariate regression analysis. Oncology. 1999;57(2):106\u201314.","journal-title":"Oncology."},{"issue":"10","key":"12312_CR31","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1093\/bjs\/znab200","volume":"108","author":"PE Bonnot","year":"2021","unstructured":"Bonnot PE, Lintis A, Mercier F, et al. Prognosis of poorly cohesive gastric cancer after complete cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (CYTO-CHIP study). Br J Surg. 2021;108(10):1225\u201335.","journal-title":"Br J Surg."},{"key":"12312_CR32","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.suronc.2019.01.005","volume":"28","author":"T Hotopp","year":"2019","unstructured":"Hotopp T. HIPEC and CRS in peritoneal metastatic gastric cancer\u2014who really benefits? Surg Oncol. 2019;28:159\u201366.","journal-title":"Surg Oncol."},{"issue":"8","key":"12312_CR33","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1245\/s10434-019-07450-4","volume":"26","author":"I Manzanedo","year":"2019","unstructured":"Manzanedo I, Pereira F, Rihuete Caro C, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for gastric cancer with peritoneal carcinomatosis: multicenter study of Spanish Group Of Peritoneal Oncologic Surgery (GECOP). Ann Surg Oncol. 2019;26(8):2615\u201321.","journal-title":"Ann Surg Oncol."},{"issue":"6","key":"12312_CR34","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1245\/s10434-015-5081-3","volume":"23","author":"CS Chia","year":"2016","unstructured":"Chia CS, You B, Decullier E, et al. Patients with peritoneal carcinomatosis from gastric cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: is cure a possibility? Ann Surg Oncol. 2016;23(6):1971\u20139.","journal-title":"Ann Surg Oncol."},{"issue":"11","key":"12312_CR35","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1016\/j.ejso.2021.05.016","volume":"47","author":"S Granieri","year":"2021","unstructured":"Granieri S, Bonomi A, Frassini S, et al. Prognostic impact of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer patients: a meta-analysis of randomized controlled trials. Eur J Surg Oncol. 2021;47(11):2757\u201367.","journal-title":"Eur J Surg Oncol."},{"key":"12312_CR36","unstructured":"Peritoneal Surface Oncology International (PSOGI). International recommendations for the management of peritoneal metastases. 2022. http:\/\/www.psogi.com\/psogi\/international-recommendations-for-the-management-of-peritoneal-metastases\/. Accessed 10 Mar 2022."},{"issue":"4","key":"12312_CR37","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S1470-2045(04)01425-1","volume":"5","author":"O Glehen","year":"2004","unstructured":"Glehen O, Mohamed F, Gilly FN. Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia. Lancet Oncol. 2004;5(4):219\u201328.","journal-title":"Lancet Oncol."}],"container-title":["Annals of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-022-12312-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1245\/s10434-022-12312-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1245\/s10434-022-12312-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T10:03:14Z","timestamp":1665482594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1245\/s10434-022-12312-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["12312"],"URL":"https:\/\/doi.org\/10.1245\/s10434-022-12312-7","relation":{},"ISSN":["1068-9265","1534-4681"],"issn-type":[{"value":"1068-9265","type":"print"},{"value":"1534-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"5 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declared no potential conflicts of interest or financial support with respect to the research, authorship, and\/or publication of this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}