{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:25:59Z","timestamp":1790702759397,"version":"4.1.0"},"reference-count":21,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2001]]},"DOI":"10.1248\/bpb.24.678","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:52:08Z","timestamp":1030380728000},"page":"678-682","source":"Crossref","is-referenced-by-count":18,"title":["Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities."],"prefix":"10.1248","volume":"24","author":[{"given":"Takayuki","family":"ASANO","sequence":"first","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"KUSHIDA","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"SADAKANE","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"ISHIHARA","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"WAKUI","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"YANAGISAWA","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"KIMURA","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"KAMEI","sequence":"additional","affiliation":[{"name":"New Drug Discovery Laboratories R&D Division, Tsumura & Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takemi","family":"YOSHIDA","sequence":"additional","affiliation":[{"name":"Department of Biochemical Toxicology School of Pharmaceutical Sciences Showa University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/014107689108400113","volume":"84","author":"Saetta J.P., Quinton D.N.","year":"1991","journal-title":"J.R. Soc. Med.","ISSN":"https:\/\/id.crossref.org\/issn\/0141-0768","issn-type":"print"},{"key":"2","unstructured":"2) a) Asano T., Ishihara K., Yanagisawa T., Kimura M., Kamei H., Yoshida T., Kuroiwa Y., Fujii Y., Yamashita M., Kuramochi T., Tomisawa H., Tateishi M., submitting to J. Pharm. Pharmacol."},{"key":"3","unstructured":" b) Asano T., Watanabe J., Sadakane C., Ishihara K., Hirakura K., Wakui Y., Yanagisawa T., Kimura M., Kamei H., Yoshida T., Fujii Y., Yamashita M., submitting to J. Pharm. Pharmacol."},{"key":"4","doi-asserted-by":"crossref","unstructured":"3) Yamashita M., Azuma J., Takeda Y., Utagawa K., Iwasaki M., Fujii Y., Asano T,. Sadakane C., Ishihara K., Yamashita M., The 1st International Conference of Asian Society of Toxicology, 1997, p. 179.","DOI":"10.2131\/jts.22.5_409"},{"key":"5","unstructured":"4) The Japanese Pharmacopoeia, 13th Ed., D-774."},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00361-1"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1248\/cpb.33.583","volume":"33","author":"FUJII T","year":"1985","journal-title":"Chem. Pharm. Bull.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"issue":"3","key":"8","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1248\/cpb.33.1023","volume":"33","author":"FUJII T","year":"1985","journal-title":"Chem. Pharm. Bull.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"issue":"12","key":"9","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1248\/cpb.33.5264","volume":"33","author":"FUJII T","year":"1985","journal-title":"Chem. Pharm. Bull.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"issue":"3","key":"10","first-page":"912","volume":"276","year":"1996","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"issue":"1","key":"11","first-page":"442","volume":"252","year":"1990","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"issue":"5","key":"12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/clpt.1985.213","volume":"38","author":"Meier U.T., Dayer P., Male P.J., Kr","year":"1985","journal-title":"Clin. Pharmacol. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9236","issn-type":"print"},{"issue":"1","key":"13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0003-2697(87)90006-6","volume":"162","author":"Kronbach T., Mathys D., Gut J., Cat","year":"1987","journal-title":"Anal. Biochem.","ISSN":"https:\/\/id.crossref.org\/issn\/0003-2697","issn-type":"print"},{"key":"14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0076-6879(91)06114-I","volume":"206","author":"Arlotto M.P., Trant J.M., Estabrook","year":"1991","journal-title":"Methods Enzymol.","ISSN":"https:\/\/id.crossref.org\/issn\/0076-6879","issn-type":"print"},{"issue":"12","key":"15","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/j.1552-4604.1994.tb04735.x","volume":"34","year":"1994","journal-title":"J. Clin. Pharmacol.","ISSN":"https:\/\/id.crossref.org\/issn\/0091-2700","issn-type":"print"},{"issue":"2","key":"16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1592\/phco.20.3.229.34774","volume":"20","author":"BRACKETT C C","year":"2000","journal-title":"Pharmacotherapy","ISSN":"https:\/\/id.crossref.org\/issn\/0277-0008","issn-type":"print"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050588"},{"issue":"2","key":"18","first-page":"370","volume":"276","year":"1996","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1080\/004982597240082"},{"issue":"6","key":"20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2165\/00003088-199733060-00004","volume":"33","year":"1997","journal-title":"Clin. Pharmacokinet.","ISSN":"https:\/\/id.crossref.org\/issn\/0312-5963","issn-type":"print"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026317929335"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/bpb\/24\/6\/24_6_678\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T05:02:25Z","timestamp":1614142945000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/bpb\/24\/6\/24_6_678\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.24.678","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001]]}}}