{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:55:32Z","timestamp":1778702132483,"version":"3.51.4"},"reference-count":30,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2011]]},"DOI":"10.1248\/bpb.34.1696","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T06:10:30Z","timestamp":1320127830000},"page":"1696-1701","source":"Crossref","is-referenced-by-count":52,"title":["Antihypertensive Effects of Continuous Oral Administration of Nattokinase and Its Fragments in Spontaneously Hypertensive Rats"],"prefix":"10.1248","volume":"34","author":[{"given":"Mitsugu","family":"Fujita","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Hiroshima International University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Japan Bio Science Laboratory Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsaku","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Japan Bio Science Laboratory Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Japan Bio Science Laboratory Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Hiroshima International University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Nakamuta","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Hiroshima International University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2624"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Fujita M., Ito Y., Hong K., Nishimuro S., <i>Fibrinolysis<\/i>, <b>9<\/b>, 157&mdash;164 (1995).","DOI":"10.1016\/S0268-9499(95)80005-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.18.1387"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1583"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.18.1194"},{"issue":"4","key":"6","first-page":"79","volume":"12","author":"OGASAWARA KAZUYA","year":"2008","journal-title":"Food Style 21","ISSN":"https:\/\/id.crossref.org\/issn\/1343-9502","issn-type":"print"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1756"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.24.1057"},{"key":"9","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/00004872-199207005-00010","volume":"10","author":"Zannad F., Stoltz J. F.","year":"1992","journal-title":"Journal of Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"key":"10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0895-7061(98)00056-9","volume":"11","author":"Lominadze D., Joshua I. G., Schusch","year":"1998","journal-title":"American Journal of Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0895-7061","issn-type":"print"},{"key":"11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/01.HYP.5.5.757","volume":"5","author":"Letcher R. L., Chien S., Pickering","year":"1983","journal-title":"Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02575-9"},{"key":"13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/mvre.1993.1021","volume":"45","author":"Mchedlishvili G., Gobejishvili L.,","year":"1993","journal-title":"Microvascular Research","ISSN":"https:\/\/id.crossref.org\/issn\/0026-2862","issn-type":"print"},{"key":"14","first-page":"139","volume":"35","author":"Pais E., Alexy T., Holsworth R. E.","year":"2006","journal-title":"Clinical Hemorheology and Microcirculation","ISSN":"https:\/\/id.crossref.org\/issn\/1386-0291","issn-type":"print"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70.1118"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(95)76689-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(95)76745-5"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1387(199907)5:7<289::AID-PSC196>3.0.CO;2-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.51.1581"},{"key":"20","unstructured":"20) Yonekura M., Ichimura T., Nishikawa M., <i>Soy Protein Res. Japan<\/i>, <b>8<\/b>, 97&mdash;102 (2005)."},{"key":"21","first-page":"677","volume":"21","author":"Sultana A., Nabi A. H., Nasir U. M.","year":"2008","journal-title":"International Journal of Molecular Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1107-3756","issn-type":"print"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106724"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/JB.160.1.442-444.1984","volume":"160","year":"1984","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/JB.139.2.583-590.1979","volume":"139","author":"Uehara H., Yamane K., Maruo B.","year":"1979","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"issue":"12","key":"25","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1128\/jb.170.12.5557-5563.1988","volume":"170","year":"1988","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"issue":"2","key":"26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1128\/jb.172.2.1024-1029.1990","volume":"172","year":"1990","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"issue":"21","key":"27","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1128\/jb.173.21.6889-6895.1991","volume":"173","year":"1991","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"issue":"3","key":"28","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1128\/jb.172.3.1470-1477.1990","volume":"172","year":"1990","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0050408"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.13.5355"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/bpb\/34\/11\/34_11_1696\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T03:42:29Z","timestamp":1615866149000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/bpb\/34\/11\/34_11_1696\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.34.1696","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}