{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:33:14Z","timestamp":1761708794405},"reference-count":30,"publisher":"Pharmaceutical Society of Japan","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2012]]},"DOI":"10.1248\/bpb.b12-00069","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T22:32:14Z","timestamp":1343773934000},"page":"1269-1274","source":"Crossref","is-referenced-by-count":4,"title":["Multidrug Resistance Associated Protein 1 together with Glutathione Plays a Protective Role against 4-Hydroxy-2-nonenal-Induced Oxidative Stress in Bovine Aortic Endothelial Cells"],"prefix":"10.1248","volume":"35","author":[{"given":"Kyohei","family":"Takahashi","sequence":"first","affiliation":[{"name":"School of Pharmacy, Hokkaido Pharmaceutical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Tatsunami","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hokkaido Pharmaceutical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sato","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hokkaido Pharmaceutical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Tampo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hokkaido Pharmaceutical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Witztum JL, Steinberg D. The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc. Med.<\/i>, 11<\/b>, 93–102 (2001)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer\u2019s disease. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 101<\/b>, 2070–2075 (2004).","DOI":"10.1073\/pnas.0305799101"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med.<\/i>, 11<\/b>, 81–128 (1991).","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Lesgards JF, Gauthier C, Iovanna J, Vidal N, Dolla A, Stocker P. Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes. Chem. Biol. Interact.<\/i>, 190<\/b>, 28–34 (2011).","DOI":"10.1016\/j.cbi.2010.12.028"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Am. J. Physiol. Heart Circ. Physiol.<\/i>, 290<\/b>, H1777–H1787 (2006).","DOI":"10.1152\/ajpheart.01087.2005"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kai H, Mori T, Tokuda K, Takayama N, Tahara N, Takemiya K, Kudo H, Sugi Y, Fukui D, Yasukawa H, Kuwahara F, Imaizumi T. Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II. Hypertens. Res.<\/i>, 29<\/b>, 711–718 (2006).","DOI":"10.1291\/hypres.29.711"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Arakawa M, Ishimura A, Arai Y, Kawabe K, Suzuki S, Ishige K, Ito Y. N<\/i>-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death. Neurosci. Res.<\/i>, 57<\/b>, 220–229 (2007).","DOI":"10.1016\/j.neures.2006.10.011"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Zhang Y, Sano M, Shinmura K, Tamaki K, Katsumata Y, Matsuhashi T, Morizane S, Ito H, Hishiki T, Endo J, Zhou H, Yuasa S, Kaneda R, Suematsu M, Fukuda K. 4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via<\/i> the Nrf2-dependent pathway. J. Mol. Cell. Cardiol.<\/i>, 49<\/b>, 576–586 (2010).","DOI":"10.1016\/j.yjmcc.2010.05.011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Ballatori N, Krance SM, Marchan R, Hammond CL. Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology. Mol. Aspects Med.<\/i>, 30<\/b>, 13–28 (2009).","DOI":"10.1016\/j.mam.2008.08.004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yan F, Jiang Y, Li YM, Zhen X, Cen J, Fang WR. Reversal of P-glycoprotein and multidrug resistance-associated protein 1 mediated multidrug resistance in cancer cells by HZ08 Isomers, tetrataisohydroquinolin derivatives. Biol. Pharm. Bull.<\/i>, 31<\/b>, 1258–1264 (2008).","DOI":"10.1248\/bpb.31.1258"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Renes J, de Vries EG, Nienhuis EF, Jansen PL, Müller M. ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br. J. Pharmacol.<\/i>, 126<\/b>, 681–688 (1999).","DOI":"10.1038\/sj.bjp.0702360"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mookerjee A, Basu JM, Majumder S, Chatterjee S, Panda GS, Dutta P, Pal S, Mukherjee P, Efferth T, Roy S, Choudhuri SK. A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis<\/i> carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo<\/i>. BMC Cancer<\/i>, 6<\/b>, 267 (2006).","DOI":"10.1186\/1471-2407-6-267"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Parthasarathy S, Barnett J, Fong LG. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim. Biophys. Acta<\/i>, 1044<\/b>, 275–283 (1990).","DOI":"10.1016\/0005-2760(90)90314-N"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Connolly DT, Knight MB, Harakas NK, Wittwer AJ, Feder J. Determination of the number of endothelial cells in culture using an acid phosphatase assay. Anal. Biochem.<\/i>, 152<\/b>, 136–140 (1986).","DOI":"10.1016\/0003-2697(86)90131-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tsukamoto M, Tampo Y, Sawada M, Yonaha M. Paraquat-induced oxidative stress and dysfunction of the glutathione redox cycle in pulmonary microvascular endothelial cells. Toxicol. Appl. Pharmacol.<\/i>, 178<\/b>, 82–92 (2002).","DOI":"10.1006\/taap.2001.9325"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem.<\/i>, 106<\/b>, 207–212 (1980).","DOI":"10.1016\/0003-2697(80)90139-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Arakawa M, Ushimaru N, Osada N, Oda T, Ishige K, Ito Y. N<\/i>-Acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death. Neurosci. Res.<\/i>, 55<\/b>, 255–263 (2006).","DOI":"10.1016\/j.neures.2006.03.008"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med.<\/i>, 11<\/b>, 81–128 (1991).","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) McGrath LT, McGleenon BM, Brennan S, McColl D, McILroy S, Passmore AP. Increased oxidative stress in Alzheimer\u2019s disease as assessed with 4-hydroxynonenal but not malondialdehyde. QJM<\/i>, 94<\/b>, 485–490 (2001).","DOI":"10.1093\/qjmed\/94.9.485"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Liu RM, Borok Z, Forman HJ. 4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol.<\/i>, 24<\/b>, 499–505 (2001).","DOI":"10.1165\/ajrcmb.24.4.4307"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Pettazzoni P, Ciamporcero E, Medana C, Pizzimenti S, Dal Bello F, Minero VG, Toaldo C, Minelli R, Uchida K, Dianzani MU, Pili R, Barrera G. Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells. Free Radic. Biol. Med.<\/i>, 51<\/b>, 1610–1618 (2011).","DOI":"10.1016\/j.freeradbiomed.2011.07.009"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Sadzuka Y, Sugiyama T, Suzuki T, Sonobe T. Enhancement of the activity of doxorubicin by inhibition of glutamate transporter. Toxicol. Lett.<\/i>, 123<\/b>, 159–167 (2001).","DOI":"10.1016\/S0378-4274(01)00391-5"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Majumder S, Dutta P, Mookerjee A, Choudhuri SK. The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites<\/i> carcinoma cells in vivo<\/i>. Chem. Biol. Interact.<\/i>, 159<\/b>, 90–103 (2006).","DOI":"10.1016\/j.cbi.2005.10.044"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Takahashi K, Shibata T, Oba T, Ishikawa T, Yoshikawa M, Tatsunami R, Takahashi K, Tampo Y. Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. Life Sci.<\/i>, 84<\/b>, 211–217 (2009).","DOI":"10.1016\/j.lfs.2008.11.021"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Tatebe S, Sinicrope FA, Kuo MT. Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem. Biophys. Res. Commun.<\/i>, 290<\/b>, 1427–1433 (2002).","DOI":"10.1006\/bbrc.2002.6367"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Nakajima A, Yamada K, Zou LB, Yan Y, Mizuno M, Nabeshima T. Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels. Free Radic. Biol. Med.<\/i>, 32<\/b>, 1324–1332 (2002).","DOI":"10.1016\/S0891-5849(02)00845-6"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Cao Z, Hardej D, Trombetta LD, Li Y. The role of chemically induced glutathione and glutathione S<\/i>-transferase in protecting against 4-hydroxy-2-nonenal-mediated cytotoxicity in vascular smooth muscle cells. Cardiovasc. Toxicol.<\/i>, 3<\/b>, 165–177 (2003).","DOI":"10.1385\/CT:3:2:165"},{"key":"28","unstructured":"28) Singhal SS, Yadav S, Roth C, Singhal J. RLIP76: A novel glutathione-conjugate and multi-drug transporter. Biochem. Pharmacol.<\/i>, 77<\/b>, 761–769 (2009)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Cheng JZ, Sharma R, Yang Y, Singhal SS, Sharma A, Saini MK, Singh SV, Zimniak P, Awasthi S, Awasthi YC. Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. J. Biol. Chem.<\/i>, 276<\/b>, 41213–41223 (2001).","DOI":"10.1074\/jbc.M106838200"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sharma R, Sharma A, Yang Y, Awasthi S, Singhal SS, Zimniak P, Awasthi YC. Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal. Acta Biochim. Pol.<\/i>, 49<\/b>, 693–701 (2002).","DOI":"10.18388\/abp.2002_3778"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/35\/8\/35_b12-00069\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T04:25:18Z","timestamp":1615868718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/35\/8\/35_b12-00069\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b12-00069","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}