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Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity. Bioorg. Med. Chem. Lett.<\/i>, 18<\/b>, 2272–2276 (2008).","DOI":"10.1016\/j.bmcl.2008.03.009"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Checker R, Sharma D, Sandur SK, Subrahmanyam G, Krishnan S, Poduval TB, Sainis KB. Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols. J. Cell. Biochem.<\/i>, 110<\/b>, 1082–1093 (2010).","DOI":"10.1002\/jcb.22620"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Fournet A, Angelo A, Muñoz V, Roblot F, Hocquemiller R, Cavé A. Biological and chemical studies of Pera benensis<\/i>, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis. J. Ethnopharmacol.<\/i>, 37<\/b>, 159–164 (1992).","DOI":"10.1016\/0378-8741(92)90074-2"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Kapadia GJ, Balasubramanian V, Tokuda H, Konoshima T, Takasaki M, Koyama J, Tagahaya K, Nishino H. Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein–Barr early antigen activation assay and in mouse skin carcinogenesis. Cancer Lett.<\/i>, 113<\/b>, 47–53 (1997).","DOI":"10.1016\/S0304-3835(96)04582-X"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Parimala R, Sachdanandam P. Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma. Mol. Cell. Biochem.<\/i>, 125<\/b>, 59–63 (1993).","DOI":"10.1007\/BF00926835"},{"key":"6","unstructured":"6) Isaac-Márquez AP, Lezama-Dávila CM, Satoskar AR. Immunobiology of visceral leishmaniasis. Current status and future perspectives. Kala Azar Emerging perspectives and prospects in South Asia<\/i>. (Thakur HP ed.) Mittal Publications, India, Chapter 17, pp. 289–310 (2011)."},{"key":"7","unstructured":"7) Ronet C, Beverley SM, Fasel N. Muco-cutaneous leishmaniasis in the New World: the ultimate subversion. Virulence<\/i>, 2<\/b>, 547–552 (2011)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lezama-Dávila CM, Isaac-Márquez AP, Zamora-Crescencio P, Uc-Encalada M del R, Justiniano-Apolinar SY, del Angel-Robles L, Satoskar A, Hernández-Rivero L. Leishmanicidal activity of Pentalinon andrieuxii<\/i>. Fitoterapia<\/i>, 78<\/b>, 255–257 (2007).","DOI":"10.1016\/j.fitote.2006.12.005"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Croft SL, Coombs GH. Leishmaniasis—current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol.<\/i>, 19<\/b>, 502–508 (2003).","DOI":"10.1016\/j.pt.2003.09.008"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Prasad N, Ghiya BC, Bumb RA, Kaushal H, Saboskar AA, Lezama-Davila CM, Salotra P, Satoskar AR. 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Leishmanicidal activity of racemic +\/− 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline. Nat. Prod. Commun.<\/i>, 5<\/b>, 387–390 (2010).","DOI":"10.1177\/1934578X1000500309"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kayser O, Kiderlen AF, Laatsch H, Croft SL. In vitro<\/i> leishmanicidal activity of monomeric and dimeric naphthoquinones. Acta Trop.<\/i>, 76<\/b>, 131–138 (2000).","DOI":"10.1016\/S0001-706X(00)00078-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Lezama-Dávila CM, Satoskar AR, Úc-Encalada M, Isaac-Márquez R, Isaac-Márquez AP. Leishmanicidal Activity of Artemisinin, Deoxoartemisinin, Artemether and Arteether. Nat. Prod. Commun.<\/i>, 1<\/b>, 1–4 (2007).","DOI":"10.1177\/1934578X0700200101"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ng LG, Hsu A, Mandell MA, Roediger B, Hoeller C, Mrass P, Iparraguirre A, Cavanagh LL, Triccas JA, Beverley SM, Scott P, Weninger W. 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