{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:54:05Z","timestamp":1717523645978},"reference-count":18,"publisher":"Pharmaceutical Society of Japan","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2012]]},"DOI":"10.1248\/bpb.b12-00426","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T22:32:14Z","timestamp":1343773934000},"page":"1379-1383","source":"Crossref","is-referenced-by-count":8,"title":["Clionosterol and Ethyl Cholestan-22-enol Isolated from the Rhizome of &lt;i&gt;Polygala tenuifolia&lt;\/i&gt; Inhibit Phosphatidylinositol 3-Kinase\/Akt Pathway"],"prefix":"10.1248","volume":"35","author":[{"given":"Thi Kim Van","family":"Le","sequence":"first","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, College of Pharmacy, Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, College of Pharmacy, Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, College of Pharmacy, Kyung Hee University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","unstructured":"1)&#8195;Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. <i>Genes Dev.<\/i>, <b>13<\/b>, 2905&#8211;2927 (1999)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2)&#8195;Xuan Nguyen TL, Choi JW, Lee SB, Ye K, Woo SD, Lee KH, Ahn JY. Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>349<\/b>, 789&#8211;798 (2006).","DOI":"10.1016\/j.bbrc.2006.08.120"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3)&#8195;Noh KH, Kang TH, Kim JH, Pai SI, Lin KY, Hung CF, Wu TC, Kim TW. Activation of Akt as a mechanism for tumor immune evasion. <i>Mol. Ther.<\/i>, <b>17<\/b>, 439&#8211;447 (2009).","DOI":"10.1038\/mt.2008.255"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4)&#8195;Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G. HIV-1-Tat protein activates phosphatidylinositol 3-kinase\/Akt-dependent survival pathways in Kaposi\u2019s sarcoma cells. <i>J. Biol. Chem.<\/i>, <b>277<\/b>, 25195&#8211;25202 (2002).","DOI":"10.1074\/jbc.M200921200"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5)&#8195;Chugh P, Bradel-Tretheway B, Monteiro-Filho CM, Planelles V, Maggirwar SB, Dewhurst S, Kim B. Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. <i>Retrovirology<\/i>, <b>5<\/b>, 11&#8211;23 (2008).","DOI":"10.1186\/1742-4690-5-11"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6)&#8195;Kim N, Kukkonen S, Gupta S, Aldovini A. Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD<sup>4+<\/sup> T cells. <i>PLoS Pathog.<\/i>, <b>6<\/b>, e1001103 (2010).","DOI":"10.1371\/journal.ppat.1001103"},{"key":"7","unstructured":"7)&#8195;Fert&eacute; C, Andr&eacute; F, Soria JC. Molecular circuits of solid tumors: prognostic and predictive tools for bedside use. <i>Nat. Rev. Clin. Oncol.<\/i>, <b>7<\/b>, 367&#8211;380 (2010)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8)&#8195;Chugh P, Fan S, Planelles V, Maggirwar SB, Dewhurst S, Kim B. Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. <i>J. Mol. Biol.<\/i>, <b>366<\/b>, 67&#8211;81 (2007).","DOI":"10.1016\/j.jmb.2006.11.011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9)&#8195;Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. <i>Science<\/i>, <b>233<\/b>, 1089&#8211;1093 (1986).","DOI":"10.1126\/science.3016903"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10)&#8195;Cosenza MA, Zhao ML, Lee SC. HIV-1 expression protects macrophages and microglia from apoptotic death. <i>Neuropathol. Appl. Neurobiol.<\/i>, <b>30<\/b>, 478&#8211;490 (2004).","DOI":"10.1111\/j.1365-2990.2004.00563.x"},{"key":"11","unstructured":"11)&#8195;Irish BP, Khan ZK, Jain P, Nonnemacher MR, Pirrone V, Rahman S, Rajagopalan N, Suchitra JB, Mostoller K, Wigdahl B. Molecular mechanisms of neurodegenerative diseases induced by human retroviruses: A review. <i>Am. J. Infect. Dis.<\/i>, <b>5<\/b>, 231&#8211;258 (2009)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12)&#8195;Li C, Yang J, Yu S, Chen N, Xue W, Hu J, Zhang D. Triterpenoid saponins with neuroprotective effects from the roots of <i>Polygala tenuifolia<\/i>. <i>Planta Med.<\/i>, <b>74<\/b>, 133&#8211;141 (2008).","DOI":"10.1055\/s-2008-1034296"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13)&#8195;Jiang Y, Zhang W, Tu P, Xu X. Xanthone glycosides from <i>Polygala tenuifolia<\/i> and their conformational analyses. <i>J. Nat. Prod.<\/i>, <b>68<\/b>, 875&#8211;879 (2005).","DOI":"10.1021\/np050026+"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14)&#8195;Patterson GW, Krauss RW. Sterols of chlorella. I. The naturally occurring sterols of <i>Chlorella vulgaris<\/i>, <i>C. ellipsoidea<\/i>, and <i>C. saccharophila<\/i>. <i>Plant Cell Physiol.<\/i>, <b>6<\/b>, 211&#8211;220 (1965).","DOI":"10.1093\/oxfordjournals.pcp.a079095"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15)&#8195;Santalova EA, Makarieva TN, Gorshkova IA, Dmitrenok AS, Krasokhin VB, Stonik VA. Sterols from six marine sponges. <i>Biochem. Syst. Ecol.<\/i>, <b>32<\/b>, 153&#8211;167 (2004).","DOI":"10.1016\/S0305-1978(03)00143-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16)&#8195;Akihisa T, Shimizu N, Ghosh P, Thakur S, Rosenstein FU, Tamura T, Matsumoto T. Sterols of the cucurbitaceae. <i>Phytochemistry<\/i>, <b>26<\/b>, 1693&#8211;1700 (1987).","DOI":"10.1016\/S0031-9422(00)82270-0"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17)&#8195;Kim Y, Hollenbaugh JA, Kim DH, Kim B. Novel PI3K\/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. <i>PLoS ONE<\/i>, <b>6<\/b>, e21781 (2011).","DOI":"10.1371\/journal.pone.0021781"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18)&#8195;Lucas A, Kim Y, Rivera-Pabon O, Chae S, Kim DH, Kim B. Targeting the PI3K\/Akt cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds. <i>PLoS ONE<\/i>, <b>5<\/b>, e13121 (2010).","DOI":"10.1371\/journal.pone.0013121"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/35\/8\/35_b12-00426\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T04:39:14Z","timestamp":1615869554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/35\/8\/35_b12-00426\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b12-00426","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}