{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:05Z","timestamp":1790774405527,"version":"4.1.0"},"reference-count":23,"publisher":"Pharmaceutical Society of Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2013]]},"DOI":"10.1248\/bpb.b12-00460","type":"journal-article","created":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T22:38:58Z","timestamp":1364769538000},"page":"509-514","source":"Crossref","is-referenced-by-count":12,"title":["Cetylpyridinium Chloride Inhibits Receptor Activator of Nuclear Factor-\u03baB Ligand-Induced Osteoclast Formation"],"prefix":"10.1248","volume":"36","author":[{"given":"Ting","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Long Sae Mi","family":"Noh","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijung","family":"Yim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science<\/i>, 289, 1508\u20131514 (2000).","DOI":"10.1126\/science.289.5484.1508"},{"key":"2","unstructured":"2) Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol.<\/i>, 20, 795\u2013823 (2002)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone<\/i>, 40, 251\u2013264 (2007).","DOI":"10.1016\/j.bone.2006.09.023"},{"key":"4","unstructured":"4) Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol.<\/i>, 7, 292\u2013304 (2007)."},{"key":"5","unstructured":"5) Kobayashi N, Kadono Y, Naito A, Matsumoto K, Yamamoto T, Tanaka S, Inoue J. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J.<\/i>, 20, 1271\u20131280 (2001)."},{"key":"6","unstructured":"6) Hotokezaka H, Sakai E, Kanaoka K, Saito K, Matsuo K, Kitaura H, Yoshida N, Nakayama K. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem.<\/i>, 277, 47366\u201347372 (2002)."},{"key":"7","unstructured":"7) Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EF. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J. Biol. Chem.<\/i>, 279, 26475\u201326480 (2004)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Han SY, Lee NK, Kim KH, Jang IW, Yim M, Kim JH, Lee WJ, Lee SY. Transcriptional induction of cyclooxygenase-2 in osteoclast precursors is involved in RANKL-induced osteoclastogenesis. Blood<\/i>, 106, 1240\u20131245 (2005).","DOI":"10.1182\/blood-2004-12-4975"},{"key":"9","unstructured":"9) Wagner EF, Eferl R. Fos\/AP-1 proteins in bone and the immune system. Immunol. Rev.<\/i>, 208, 126\u2013140 (2005)."},{"key":"10","unstructured":"10) Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E, Takayanagi H. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med.<\/i>, 202, 1261\u20131269 (2005)."},{"key":"11","unstructured":"11) Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell<\/i>, 3, 889\u2013901 (2002)."},{"key":"12","unstructured":"12) Pitten FA, Kramer A. Efficacy of cetylpyridinium chloride used as oropharyngeal antiseptic. Arzneimittelforschung<\/i>, 51, 588\u2013595 (2001)."},{"key":"13","unstructured":"13) Scheie AA. Modes of action of currently known chemical antiplaque agents other than chlorhexidine. Dent. Res.<\/i>, 68, 1609\u20131616 (1989)."},{"key":"14","unstructured":"14) Mankodi S, Bauroth K, Witt JJ, Bsoul S, He T, Gibb R, Dunavent J, Hamilton A. A 6-month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque. Am. J. Dent.<\/i>, 18 (Spec. No.), 9A\u201314A (2005)."},{"key":"15","unstructured":"15) Park H, Young Lee S, Lee DS, Yim M. Phosphodiesterase 4 inhibitor regulates the TRANCE\/OPG ratio via<\/i> COX-2 expression in a manner similar to PTH in osteoblasts. Biochem. Biophys. Res. Commun.<\/i>, 354, 178\u2013183 (2007)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity<\/i>, 13, 155\u2013165 (2000).","DOI":"10.1016\/S1074-7613(00)00016-9"},{"key":"17","unstructured":"17) Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves DR, Engel JD, Yamamoto M, Takahashi S. MafB is essential for renal development and F4\/80 expression in macrophages. Mol. Cell. Biol.<\/i>, 26, 5715\u20135727 (2006)."},{"key":"18","unstructured":"18) Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-\u03baB signaling pathways. Nat. Immunol.<\/i>, 12, 695\u2013708 (2011)."},{"key":"19","unstructured":"19) Haps S, Slot DE, Berchier CE, Van der Weijden GA. The effect of cetylpyridinium chloride-containing mouth rinses as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review. Int. J. Dent. Hyg.<\/i>, 6, 290\u2013303 (2008)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Cochran DL. Inflammation and bone loss in periodontal disease. J. Periodontol.<\/i>, 79 (Suppl.), 1569\u20131576 (2008).","DOI":"10.1902\/jop.2008.080233"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature<\/i>, 423, 337\u2013342 (2003).","DOI":"10.1038\/nature01658"},{"key":"22","unstructured":"22) Kim YJ, Rossa C Jr, Kirkwood KL. Prostaglandin production by human gingival fibroblasts inhibited by triclosan in the presence of cetylpyridinium chloride. J. Periodontol.<\/i>, 76, 1735\u20131742 (2005)."},{"key":"23","unstructured":"23) Ross FP. M-CSF, c-Fms, and signaling in osteoclasts and their precursors. Ann. N. Y. Acad. Sci.<\/i>, 1068, 110\u2013116 (2006)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/36\/4\/36_b12-00460\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T04:40:39Z","timestamp":1615869639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/36\/4\/36_b12-00460\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b12-00460","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}