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Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential. Int. J. Mol. Med.<\/i>, 25<\/b>, 231–236 (2010).","DOI":"10.3892\/ijmm_00000335"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.1828"},{"key":"14","doi-asserted-by":"crossref","unstructured":"15) Zhang Z, Gao J, Wang Y, Song T, Zhang J, Wu G, Zhang T, Du G. Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding. Biochem. Pharmacol.<\/i>, 78<\/b>, 1316–1322 (2009).","DOI":"10.1016\/j.bcp.2009.06.110"},{"key":"15","doi-asserted-by":"crossref","unstructured":"17) Sung HJ, Choi SM, Yoon Y, An KS. Tanshinone IIA, an ingredient of Salvia miltiorrhiza<\/i> BUNGE<\/small>, induces apoptosis in human leukemia cell lines through the activation of caspase-3. Exp. Mol. 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