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Novel drug delivery systems: potential in improving topical delivery of antiacne agents. Skin Pharmacol. Physiol.<\/i>, 19<\/b>, 2–16 (2006)."},{"key":"2","unstructured":"4) Bergstrom KG. Beyond tretinoin: cosmeceuticals for aging skin. J. Drugs Dermatol.<\/i>, 8<\/b>, 674–677 (2009)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"5) Fu JJJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide\/peptide\/retinyl propionate product regimen vs.<\/i> a prescription 0.02% tretinoin product regimen. Br. J. Dermatol.<\/i>, 162<\/b>, 647–654 (2010).","DOI":"10.1111\/j.1365-2133.2009.09436.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"8) Pople PV, Singh KK. Development and evaluation of topical formulation containing solid lipid nanoparticles of vitamin A. 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Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne. J. Microencapsul.<\/i>, 24<\/b>, 395–407 (2007).","DOI":"10.1080\/02652040701288519"},{"key":"16","doi-asserted-by":"crossref","unstructured":"22) Küchler S, Abdel-Mottaleb M, Lamprecht A, Radowski MR, Haag R, Schäfer-Korting M. Influence of nanocarrier type and size on skin delivery of hydrophilic agents. Int. J. Pharm.<\/i>, 377<\/b>, 169–172 (2009).","DOI":"10.1016\/j.ijpharm.2009.04.046"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.08.020"},{"key":"18","doi-asserted-by":"crossref","unstructured":"24) Wu Y, Fassihi R. Stability of metronidazole, tetracycline HCl and famotidine alone and in combination. Int. J. Pharm.<\/i>, 290<\/b>, 1–13 (2005).","DOI":"10.1016\/j.ijpharm.2004.10.015"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.05.008"},{"key":"20","unstructured":"26) Shah KA, Date AA, Joshi MD, Patravale VB. 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