{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:00:46Z","timestamp":1791284446396,"version":"4.1.0"},"reference-count":42,"publisher":"Pharmaceutical Society of Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2013]]},"DOI":"10.1248\/bpb.b12-00968","type":"journal-article","created":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T23:25:12Z","timestamp":1360106712000},"page":"592-601","source":"Crossref","is-referenced-by-count":8,"title":["Corticosterone Suppresses the Proliferation of RAW264.7 Macrophage Cells via Glucocorticoid, But Not Mineralocorticoid, Receptor"],"prefix":"10.1248","volume":"36","author":[{"given":"Yoshihiko","family":"Nakatani","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, International University of Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, International University of Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.49.030187.002145"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(72)90053-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Reul JM, de Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. <i>Endocrinology<\/i>, 117, 2505\u20132511 (1985).","DOI":"10.1210\/endo-117-6-2505"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91351-R"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Beato M. Transcriptional control by nuclear receptors. <i>FASEB J.<\/i>, 5, 2044\u20132051 (1991).","DOI":"10.1096\/fasebj.5.7.2010057"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.34.21213"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.13.7358"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1101\/gad.827900"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406568200"},{"key":"10","unstructured":"10) Krstic MD, Rogatsky I, Yamamoto KR, Garabedian MJ. Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. <i>Mol. Cell. Biol.<\/i>, 17, 3947\u20133954 (1997)."},{"key":"11","unstructured":"11) Imai E, Miner JN, Mitchell JA, Yamamoto KR, Granner DK. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. <i>J. Biol. Chem.<\/i>, 268, 5353\u20135356 (1993)."},{"key":"12","unstructured":"12) Smoak KA, Cidlowski JA. Mechanisms of glucocorticoid receptor signaling during inflammation. <i>Mech. Ageing Dev.<\/i>, 125, 697\u2013706 (2004)."},{"key":"13","unstructured":"13) Sapolsky RM, Krey LC, McEwen BS. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. <i>J. Neurosci.<\/i>, 5, 1222\u20131227 (1985)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zhu MY, Wang WP, Bissette G. Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons. <i>Neuroscience<\/i>, 141, 2019\u20132027 (2006).","DOI":"10.1016\/j.neuroscience.2006.05.011"},{"key":"15","unstructured":"15) Murray F, Smith DW, Hutson PH. Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. <i>Eur. J. Pharmacol.<\/i>, 583, 115\u2013127 (2008)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Cz\u00e9h B, M\u00fcller-Keuker JI, Rygula R, Abumaria N, Hiemke C, Domenici E, Fuchs E. Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. <i>Neuropsychopharmacology<\/i>, 32, 1490\u20131503 (2007).","DOI":"10.1038\/sj.npp.1301275"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2687"},{"key":"18","unstructured":"18) Cheng GJ, Morrow-Tesch JL, Beller DI, Levy EM, Black PH. Immunosuppression in mice induced by cold water stress. <i>Brain Behav. Immun.<\/i>, 4, 278\u2013291 (1990)."},{"key":"19","unstructured":"19) Sesti-Costa R, Ignacchiti MD, Chedraoui-Silva S, Marchi LF, Mantovani B. Chronic cold stress in mice induces a regulatory phenotype in macrophages: correlation with increased 11\u03b2-hydroxysteroid dehydrogenase expression. <i>Brain Behav. Immun.<\/i>, 26, 50\u201360 (2012)."},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812671106"},{"key":"21","unstructured":"21) Katyare SS, Balasubramanian S, Parmar DV. Effect of corticosterone treatment on mitochondrial oxidative energy metabolism in developing rat brain. <i>Exp. Neurol.<\/i>, 183, 241\u2013248 (2003)."},{"key":"22","unstructured":"22) Arnould T, Vankoningsloo S, Renard P, Houbion A, Ninane N, Demazy C, Remacle J, Raes M. CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation. <i>EMBO J.<\/i>, 21, 53\u201363 (2002)."},{"key":"23","unstructured":"23) Sheikh MS, Huang Y. Death receptor activation complexes: it takes two to activate TNF receptor 1. <i>Cell Cycle<\/i>, 2, 550\u2013552 (2003)."},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.10.4260"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Baccan GC, Sesti-Costa R, Chedraoui-Silva S, Mantovani B. Effects of cold stress, corticosterone and catecholamines on phagocytosis in mice: differences between resting and activated macrophages. <i>Neuroimmunomodulation<\/i>, 17, 379\u2013385 (2010).","DOI":"10.1159\/000292058"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Sesti-Costa R, Baccan GC, Chedraoui-Silva S, Mantovani B. Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone. <i>Neuroimmunomodulation<\/i>, 17, 79\u201387 (2010).","DOI":"10.1159\/000258690"},{"key":"27","unstructured":"27) Du Q, Min S, Chen LY, Ma YD, Guo XL, Wang Z, Wang ZG. Major stress hormones suppress the response of macrophages through down-regulation of TLR2 and TLR4. <i>J. Surg. Res.<\/i>, 173, 354\u2013361 (2012)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Stark JL, Avitsur R, Padgett DA, Campbell KA, Beck FM, Sheridan JF. Social stress induces glucocorticoid resistance in macrophages. <i>Am. J. Physiol. Regul. Integr. Comp. Physiol.<\/i>, 280, R1799\u2013R1805 (2001).","DOI":"10.1152\/ajpregu.2001.280.6.R1799"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Bailey MT, Engler H, Powell ND, Padgett DA, Sheridan JF. Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway. <i>Am. J. Physiol. Regul. Integr. Comp. Physiol.<\/i>, 293, R1180\u2013R1190 (2007).","DOI":"10.1152\/ajpregu.00307.2007"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Miller AH, Spencer RL, Husain A, Rhee R, McEwen BS, Stein M. Differential expression of type I adrenal steroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone. <i>Endocrinology<\/i>, 133, 2133\u20132140 (1993).","DOI":"10.1210\/endo.133.5.8404663"},{"key":"31","unstructured":"31) Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM. A Nuclear Receptor Atlas: macrophage activation. <i>Mol. Endocrinol.<\/i>, 19, 2466\u20132477 (2005)."},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02611.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199705)20:1<23::AID-GLIA3>3.0.CO;2-6"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.07.010"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.08.019"},{"key":"36","unstructured":"36) Vijayan VK, Cotman CW. Hydrocortisone administration alters glial reaction to entorhinal lesion in the rat dentate gyrus. <i>Exp. Neurol.<\/i>, 96, 307\u2013320 (1987)."},{"key":"37","unstructured":"37) Ganter S, Northoff H, M\u00e4nnel D, Gebicke-H\u00e4rter PJ. Growth control of cultured microglia. <i>J. Neurosci. Res.<\/i>, 33, 218\u2013230 (1992)."},{"key":"38","unstructured":"38) Hoeck W, Rusconi S, Groner B. Down-regulation and phosphorylation of glucocorticoid receptors in cultured cells. Investigations with a monospecific antiserum against a bacterially expressed receptor fragment. <i>J. Biol. Chem.<\/i>, 264, 14396\u201314402 (1989)."},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0395"},{"key":"40","unstructured":"40) Bird AD, Tan KH, Olsson PF, Zieba M, Flecknoe SJ, Liddicoat DR, Mollard R, Hooper SB, Cole TJ. Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development. <i>J. Physiol.<\/i>, 585, 187\u2013201 (2007)."},{"key":"41","unstructured":"41) Wang X, Li Y, Zhu X, Wang Y, Diao F, Lu J. Signal regulatory protein alpha1 is involved in the inhibitory effect of glucocorticoid receptor on the proliferation of murine macrophage RAW264.7 cell and mouse peritoneal macrophage. <i>J. Mol. Endocrinol.<\/i>, 41, 393\u2013403 (2008)."},{"key":"42","unstructured":"42) Peeters BW, Ruigt GS, Craighead M, Kitchener P. Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line. <i>Ann. N. Y. Acad. Sci.<\/i>, 1148, 536\u2013541 (2008)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/36\/4\/36_b12-00968\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T04:56:55Z","timestamp":1615870615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/36\/4\/36_b12-00968\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b12-00968","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}