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Pharmacological studies of sodium alginate. I. Protective effect of sodium alginate on mucous membranes of upper-gastrointestinal tract. <i>Yakugaku Zasshi<\/i>, 101, 452\u2013457 (1981).","DOI":"10.1248\/yakushi1947.101.5_452"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Daigo K, Yamada C, Wada Y, Yamaji M, Okuda S, Okada M, Miyazato T. Pharmacological studies of sodium alginate. II. Hemostatic effect of sodium alginate on gastrointestinal bleeding. <i>Yakugaku Zasshi<\/i>, 101, 458\u2013463 (1981).","DOI":"10.1248\/yakushi1947.101.5_458"},{"key":"3","unstructured":"3) Poynard T, Vernisse B, Agostini H. Randomized, multicentre comparison of sodium alginate and cisapride in the symptomatic treatment of uncomplicated gastro-oesophageal reflux. <i>Aliment. Pharmacol. Ther.<\/i>, 12, 159\u2013165 (1998)."},{"key":"4","unstructured":"4) Dettmar PW, Sykes J, Little SL, Bryan J. Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes. <i>Int. J. Clin. Pract.<\/i>, 60, 275\u2013283 (2006)."},{"key":"5","unstructured":"5) Mirshafiey A, Khodadadi A, Rehm BH, Khorramizadeh MR, Eslami MB, Razavi A, Saadat F. Sodium alginate as a novel therapeutic option in experimental colitis. <i>Scand. J. Immunol.<\/i>, 61, 316\u2013321 (2005)."},{"key":"6","unstructured":"6) Razavi A, Khodadadi A, Eslami MB, Eshraghi S, Mirshafiey A. Therapeutic effect of sodium alginate in experimental chronic ulcerative colitis. <i>Iran. J. Allergy Asthma Immunol.<\/i>, 7, 13\u201318 (2008)."},{"key":"7","unstructured":"7) Nakatsugawa S, Yukawa Y, Abe M. Radioprotective effects of sodium alginate on radiation induced intestinal damage. <i>Nippon Gan Chiryo Gakkai Shi<\/i>, 23, 1025\u20131030 (1988)."},{"key":"8","unstructured":"8) Oshitani T, Okada K, Kushima T, Suematsu T, Obayashi K, Hirata Y, Takada Y, Ishida T, Yoshida M, Narabayashi I, Kimura S, Mizojiri G, Akazawa N, Inoue K, Tenshin M. Clinical evaluation of sodium alginate on oral mucositis associated with radiotherapy. <i>Nippon Gan Chiryo Gakkai Shi<\/i>, 25, 1129\u20131137 (1990)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Humphreys ER, Triffitt JT. Absorption by the rat of alginate labelled with carbon-14. <i>Nature<\/i>, 14, 1172\u20131173 (1968).","DOI":"10.1038\/2191172a0"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Pico JL, Avila-Garavito A, Naccache P. Mucositis: Its occurrence, consequences, and treatment in the oncology setting. <i>Oncologist<\/i>, 3, 446\u2013451 (1998).","DOI":"10.1634\/theoncologist.3-6-446"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Rubenstein EB, Peterson DE, Schubert M, Keefe D, McGuire D, Epstein J, Elting LS, Fox PC, Cooksley C, Sonis ST, Mucositis Study Section of the Multinational Association for Supportive Care in Cancer International Society for Oral Oncology. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. <i>Cancer<\/i>, 100 (Suppl.), 2026\u20132046 (2004).","DOI":"10.1002\/cncr.20163"},{"key":"12","unstructured":"12) Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA. The pharmacology and clinical use of methotrexate. <i>N. Engl. J. Med.<\/i>, 3, 1094\u20131104 (1983)."},{"key":"13","unstructured":"13) Margolis S, Philips FS, Sternberg SS. The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis. <i>Cancer Res.<\/i>, 31, 2037\u20132046 (1971)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Altmann GG. Changes in the mucosa of the small intestine following methotrexate administration or abdominal X-irradiation. <i>Am. J. Anat.<\/i>, 140, 263\u2013279 (1974).","DOI":"10.1002\/aja.1001400210"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Taminiau JA, Gall DG, Hamilton JR. Response of the rat small-intestine epithelium to methotrexate. <i>Gut<\/i>, 21, 486\u2013492 (1980).","DOI":"10.1136\/gut.21.6.486"},{"key":"16","unstructured":"16) Alam SS, Hafiz NA, Abd El-Rahim AH. Protective role of taurine against genotoxic damage in mice treated with methotrexate and tamoxfine. <i>Environ. Toxicol. Pharmacol.<\/i>, 31, 143\u2013152 (2011)."},{"key":"17","unstructured":"17) Kimura H, Ogawa S, Katsube T, Jisaka M, Yokota K. Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut (<i>Aesculus turbinata<\/i> BLUME) after treatment with wood ashes. <i>J. Agric. Food Chem.<\/i>, 25, 4783\u20134788 (2008)."},{"key":"18","unstructured":"18) Howarth GS, Francis GL, Cool JC, Xu X, Byard RW, Read LC. Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. <i>J. Nutr.<\/i>, 126, 2519\u20132530 (1996)."},{"key":"19","unstructured":"19) Hirotani Y, Yamamoto K, Ikeda K, Arakawa Y, Li J, Kitamura K, Kurokawa N, Tanaka K. Correlation between plasma glucagon-like peptide 2 levels and proliferative makers in small intestinal injury in rats induced by methotrexate administration. <i>Biol. Pharm. Bull.<\/i>, 29, 2327\u20132330 (2006)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Potten CS, Kellett M, Roberts SA, Rew DA, Wilson GD. Measurement of <i>in vivo<\/i> proliferation in human colorectal mucosa using bromodeoxyuridine. <i>Gut<\/i>, 33, 71\u201378 (1992).","DOI":"10.1136\/gut.33.1.71"},{"key":"21","unstructured":"21) Wilson MS, Schofield PF. Markers to study human colonic cell proliferation. <i>Gut<\/i>, 36, 152 (1995)."},{"key":"22","unstructured":"22) Kawaguchi M, Fukushima T, Hayakawa T, Nakashima N, Inoue Y, Takeda S, Okamura K, Taniguchi K. Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering. <i>Dent. Mater. J.<\/i>, 25, 719\u2013725 (2006)."},{"key":"23","unstructured":"23) Kim JO, Choi JY, Park JK, Kim JH, Jin SG, Chang SW, Li DX, Hwang MR, Woo JS, Kim JA, Lyoo WS, Yong CS, Choi HG. Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate. <i>Biol. Pharm. 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