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Guidelines for management of atopic dermatitis. <i>J. Dermatol.<\/i>, 36, 563\u2013577 (2009)."},{"key":"2","unstructured":"2) Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O\u2019Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. <i>Nat. Genet.<\/i>, 38, 441\u2013446 (2006)."},{"key":"3","unstructured":"3) Marenholz I, Nickel R, R\u00fcschendorf F, Schulz F, Esparza-Gordillo J, Kerscher T, Gr\u00fcber C, Lau S, Worm M, Keil T, Kurek M, Zaluga E, Wahn U, Lee YA. Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. <i>J. Allergy Clin. Immunol.<\/i>, 118, 866\u2013871 (2006)."},{"key":"4","unstructured":"4) Kamata Y, Taniguchi A, Yamamoto M, Nomura J, Ishihara K, Takahara H, Hibino T, Takeda A. Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids. <i>J. Biol. Chem.<\/i>, 284, 12829\u201312836 (2009)."},{"key":"5","unstructured":"5) Wahlgren CF. Itch and atopic dermatitis: an overview. <i>J. Dermatol.<\/i>, 26, 770\u2013779 (1999)."},{"key":"6","unstructured":"6) Kobayashi H, Takahashi K, Mizuno N, Kutsuna H, Ishii M. An alternative approach to atopic dermatitis: Part I-Case-series presentation. <i>Evid. Based Complement. Alternat. Med.<\/i>, 1, 49\u201362 (2004)."},{"key":"7","unstructured":"7) Kobayashi H, Takahashi K, Mizuno N, Kutsuna H, Ishii M. An alternative approach to atopic dermatitis: Part II-Summary of cases and discussion. <i>Evid. Based Complement. Alternat. Med.<\/i>, 1, 145\u2013155 (2004)."},{"key":"8","unstructured":"8) Katayama I, Kohno Y, Akiyama K, Ikezawa Z, Kondo N, Tamaki K, Kouro O; Japanese Society of Allergology. Japanese guideline for atopic dermatitis. <i>Allergol. Int.<\/i>, 60, 205\u2013220 (2011)."},{"key":"9","unstructured":"9) Kijima A, Murota H, Takahashi A, Arase N, Yang L, Nishioka M, Yamaoka T, Kitaba S, Yamauchi-Takihara K, Katayama I. Prevalence and impact of past history of food allergy in atopic dermatitis. <i>Allergol. Int.<\/i>, 62, 105\u2013112 (2013)."},{"key":"10","unstructured":"10) Lod\u00e9n M, Andersson AC, Lindberg M. Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm). <i>Br. J. Dermatol.<\/i>, 140, 264\u2013267 (1999)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E. The human glucocorticoid receptor: molecular basis of biologic function. <i>Steroids<\/i>, 75, 1\u201312 (2010).","DOI":"10.1016\/j.steroids.2009.09.002"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos\/Jun) activity by glucocorticoid hormone. <i>Cell<\/i>, 62, 1189\u20131204 (1990).","DOI":"10.1016\/0092-8674(90)90395-U"},{"key":"13","unstructured":"13) Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, Barnes PJ. Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. <i>PLoS Med.<\/i>, 6, e1000076 (2009)."},{"key":"14","unstructured":"14) Akabane H, Murata M, Kubota M, Takashima E, Tanaka H, Inagaki N, Horiba M, Nagai H. Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. <i>Allergol. Int.<\/i>, 55, 387\u2013393 (2006)."},{"key":"15","unstructured":"15) Sears HW, Bailer JW, Yeadon A. Efficacy and safety of hydrocortisone buteprate 0.1% cream in patients with atopic dermatitis. <i>Clin. Ther.<\/i>, 19, 710\u2013719 (1997)."},{"key":"16","unstructured":"16) Sher LG, Chang J, Patel IB, Balkrishnan R, Fleischer AB Jr. Relieving the pruritus of atopic dermatitis: a meta-analysis. <i>Acta Derm. Venereol.<\/i>, 92, 455\u2013461 (2012)."},{"key":"17","unstructured":"17) Furue M, Terao H, Rikihisa W, Urabe K, Kinukawa N, Nose Y, Koga T. Clinical dose and adverse effects of topical steroids in daily management of atopic dermatitis. <i>Br. J. Dermatol.<\/i>, 148, 128\u2013133 (2003)."},{"key":"18","unstructured":"18) Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. <i>Proc. Natl. Acad. Sci. 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The effects of anti-asthma drugs on mediator release from cultured human mast cells. <i>Clin. Exp. Allergy<\/i>, 28, 1228\u20131236 (1998)."},{"key":"28","unstructured":"28) Kamei H, Isaji A, Noda Y, Ishikawa K, Senzaki K, Yamada K, Sugiura K, Tomita Y, Nabeshima T. Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. <i>Arch. Dermatol. Res.<\/i>, 304, 263\u2013272 (2012)."},{"key":"29","unstructured":"29) Kawashima M, Tango T, Noguchi T, Inagi M, Nakagawa H, Harada S. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study. <i>Br. J. Dermatol.<\/i>, 148, 1212\u20131221 (2003)."},{"key":"30","unstructured":"30) Kamiyama H, Takano S, Ishikawa E, Tsuboi K, Matsumura A. 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