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Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C\/EBP) and C\/EBP-like proteins interact with sequences required for differentiation-dependent expression. J. Biol. Chem.<\/i>, 267, 7185\u20137193 (1992)."},{"key":"2","unstructured":"2) Williams PM, Chang DJ, Danesch U, Ringold GM, Heller RA. CCAAT\/enhancer binding protein expression is rapidly extinguished in TA1 adipocyte cells treated with tumor necrosis factor. Mol. Endocrinol.<\/i>, 6, 1135\u20131141 (1992)."},{"key":"3","unstructured":"3) Liang L, Zhao M, Xu Z, Yokoyama KK, Li T. Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family. Biochem. J.<\/i>, 370, 195\u2013203 (2003)."},{"key":"4","unstructured":"4) Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, Chouinard M, Chakladar A, Czech MP. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J. Biol. Chem.<\/i>, 282, 34213\u201334218 (2007)."},{"key":"5","unstructured":"5) Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, Okamura H, Fushiki T, Kasuga M. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J. Clin. Invest.<\/i>, 118, 2808\u20132821 (2008)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Toh SY, Gong J, Du G, Li JZ, Yang S, Ye J, Yao H, Zhang Y, Xue B, Li Q, Yang H, Wen Z, Li P. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS ONE<\/i>, 3, e2890 (2008).","DOI":"10.1371\/journal.pone.0002890"},{"key":"7","unstructured":"7) Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J. Clin. Invest.<\/i>, 111, 737\u2013747 (2003)."},{"key":"8","unstructured":"8) Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab.<\/i>, 7, 302\u2013311 (2008)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Okumura T. Role of lipid droplet proteins in liver steatosis. J. Physiol. Biochem.<\/i>, 67, 629\u2013636 (2011).","DOI":"10.1007\/s13105-011-0110-6"},{"key":"10","unstructured":"10) Satoh H, Ide N, Kagawa Y, Maeda T. Hepatic steatosis with relation to increased expression of peroxisome proliferator-activated receptor-\u03b3 in insulin resistant mice. Biol. Pharm. Bull.<\/i>, 36, 616\u2013623 (2013)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, 298, G283\u2013G294 (2010).","DOI":"10.1152\/ajpgi.00296.2009"},{"key":"12","unstructured":"12) Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H. Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am. J. Physiol. Heart Circ. Physiol.<\/i>, 297, H1069\u2013H1077 (2009)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology<\/i>, 40, 972\u2013980 (2004).","DOI":"10.1002\/hep.20399"},{"key":"14","unstructured":"14) Hebbard L, George J. Animal models of nonalcoholic fatty liver disease. Nat. Rev. Gastroenterol. Hepatol.<\/i>, 8, 35\u201344 (2011)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA. Peroxisome proliferator-activated receptor (PPAR) gamma. adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology<\/i>, 135, 798\u2013800 (1994).","DOI":"10.1210\/endo.135.2.8033830"},{"key":"16","unstructured":"16) Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev.<\/i>, 8, 1224\u20131234 (1994)."},{"key":"17","unstructured":"17) Lefebvre AM, Chen I, Desreumaux P, Najib J, Fruchart JC, Geboes K, Briggs M, Heyman R, Auwerx J. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL\/6J-APCMin\/+ mice. Nat. Med.<\/i>, 4, 1053\u20131057 (1998)."},{"key":"18","unstructured":"18) Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, Thomazy VA, Evans RM. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat. Med.<\/i>, 4, 1058\u20131061 (1998)."},{"key":"19","unstructured":"19) Moore KJ, Fitzgerald ML, Freeman MW. Peroxisome proliferator-activated receptors in macrophage biology: friend or foe? Curr. Opin. Lipidol.<\/i>, 12, 519\u2013527 (2001)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell<\/i>, 83, 813\u2013819 (1995).","DOI":"10.1016\/0092-8674(95)90194-9"},{"key":"21","unstructured":"21) Vila-Brau A, De Sousa-Coelho AL, Goncalves JF, Haro D, Marrero PF. Fsp27\/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. J. Lipid Res.<\/i>, 54, 592\u2013601 (2013)."},{"key":"22","unstructured":"22) Roth Flach RJ, Zhang L, Qin H, Bennett A. Loss of MAP kinase phosphatase-1 protects from hepatic steatosis by repression of CIDEC\/fat-specific protein 27. J. Biol. Chem.<\/i>, 286, 22195\u201322202 (2011)."},{"key":"23","unstructured":"23) Burns KA, Vanden Heuvel JP. Modulation of PPAR activity via<\/i> phosphorylation. Biochim. Biophys. Acta<\/i>, 1771, 952\u2013960 (2007)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Hu E, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science<\/i>, 274, 2100\u20132103 (1996).","DOI":"10.1126\/science.274.5295.2100"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, Czaja MJ. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology<\/i>, 43, 163\u2013172 (2006).","DOI":"10.1002\/hep.20999"},{"key":"26","unstructured":"26) Min AK, Kim MK, Kim HS, Seo HY, Lee KU, Kim JG, Park KG, Lee IK. Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL\/6 mice. Life Sci.<\/i>, 90, 200\u2013205 (2012)."},{"key":"27","unstructured":"27) Yonezawa T, Kurata R, Kimura M, Inoko H. Which CIDE are you on? Apoptosis and energy metabolism. Mol. 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