{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:55:04Z","timestamp":1791309304590,"version":"4.3.1"},"reference-count":32,"publisher":"Pharmaceutical Society of Japan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b13-00459","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T18:13:07Z","timestamp":1393611187000},"page":"347-354","source":"Crossref","is-referenced-by-count":102,"title":["Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-\u03b1), IL-6 and IL-1\u03b2 Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice"],"prefix":"10.1248","volume":"37","author":[{"given":"Mengjun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Third Military Medical University & Institute of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Science & Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjuan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Sugita K, Kabashima K, Atarashi K, Shimauchi T, Kobayashi M, Tokura Y. Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin. <i>Clin. Exp. Immunol.<\/i>, 147, 176\u2013183 (2007)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Gr\u00f6ne A. Keratinocytes and cytokines. <i>Vet. Immunol. Immunopathol.<\/i>, 88, 1\u201312 (2002).","DOI":"10.1016\/S0165-2427(02)00136-8"},{"key":"3","unstructured":"3) Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: Mechanisms and clinical consequences. <i>Nat. Rev. Immunol.<\/i>, 4, 211\u2013222 (2004)."},{"key":"4","unstructured":"4) Bonifati C, Ameglio F, Carducci M, Sacerdoti G, Pietravalle M, Fazio M. Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved and uninolved skin and in sera of psoriatic patients. <i>Acta Derm. Venereol. Suppl.<\/i> (Stockh.), 186, 23\u201324 (1994)."},{"key":"5","unstructured":"5) Nickoloff BJ, Turka LA. Keratinocytes: key immunocytes of the integument. <i>Am. J. Pathol.<\/i>, 143, 325\u2013331 (1993)."},{"key":"6","unstructured":"6) Mazza J, Rossi A, Weinberg JM. Innovative uses of tumor necrosis factor alpha inhibitors. <i>Dermatol. Clin.<\/i>, 28, 559\u2013575 (2010)."},{"key":"7","unstructured":"7) Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B. The essential role of MEKK3 in TNF-induced NFkappaB activation. <i>Nat. Immunol.<\/i>, 2, 620\u2013624 (2001)."},{"key":"8","unstructured":"8) Bell S, Degitz K, Quirling M, Jilg N, Page S, Brand K. Involvement of NF-kappaB signalling in skin physiology and disease. <i>Cell. Signal.<\/i>, 15, 1\u20137 (2003)."},{"key":"9","unstructured":"9) Fern\u00e1ndez MA, Saenz MT, Garcia MD. Anti-inflammatory activity in rats and mice of phenolic acids isolated from <i>Scrophularia frutescens<\/i>. <i>J. Pharm. Pharmacol.<\/i>, 50, 1183\u20131186 (1998)."},{"key":"10","unstructured":"10) Moon MK, Lee YJ, Kim JS, Kang DG, Lee HS. Effect of caffeic acid on tumor necrosis factor-alpha-induced vascular inflammation in human umbilical vein endothelial cells. <i>Biol. Pharm. Bull.<\/i>, 32, 1371\u20131377 (2009)."},{"key":"11","unstructured":"11) Tsai SJ, Chao CY, Yin MC. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. <i>Eur. J. Pharmacol.<\/i>, 670, 441\u2013447 (2011)."},{"key":"12","unstructured":"12) Chao PC, Hsu CC, Yin MC. Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. <i>Nutr. Metab.<\/i> (London), 6, 33 (2009)."},{"key":"13","unstructured":"13) Khan AQ, Khan R, Qamar W, Lateef A, Ali F, Tahir M, Muneeb-U-Rehman, Sultana S. Caffeic acid attenuates 12-<i>O<\/i>-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-kappaB and COX-2 expression in mouse skin: abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production. <i>Food Chem. Toxicol.<\/i>, 50, 175\u2013183 (2012)."},{"key":"14","unstructured":"14) Song HS, Park TW, Sohn UD, Shin YK, Choi BC, Kim CJ, Sim SS. The effect of caffeic acid on wound healing in skin-incised mice. <i>Korean J. Physiol. Pharmacol.<\/i>, 12, 343\u2013347 (2008)."},{"key":"15","unstructured":"15) Stanley PL, Steiner S, Havens M, Tramposch KM. Mouse skin inflammation induced by multiple topical applications of 12-<i>O<\/i>-tetradecanoylphorbol-13-acetate. <i>Skin Pharmacol.<\/i>, 4, 262\u2013271 (1991)."},{"key":"16","unstructured":"16) Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. <i>J. Invest. Dermatol.<\/i>, 78, 206\u2013209 (1982)."},{"key":"17","unstructured":"17) Murakawa M, Yamaoka K, Tanaka Y, Fukuda Y. Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-<i>O<\/i>-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice. <i>Biochem. Pharmacol.<\/i>, 71, 1331\u20131336 (2006)."},{"key":"18","unstructured":"18) De Vry CG, Valdez M, Lazarov M, Muhr E, Buelow R, Fong T, Iyer S. Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model. <i>J. Invest. Dermatol.<\/i>, 125, 473\u2013481 (2005)."},{"key":"19","unstructured":"19) Moon MK, Lee YJ, Kim JS, Kang DG, Lee HS. Effect of caffeic acid on tumor necrosis factor-alpha-induced vascular inflammation in human umbilical vein endothelial cells. <i>Biol. Pharm. Bull.<\/i>, 32, 1371\u20131377 (2009)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yang Y, Li Y, Wang K, Wang Y, Yin W, Li L. P38\/NF-kB\/snail pathway is involved in caffeic acid-induced inhibition of cancer stem cells-like properties and migratory capacity in malignant human keratinocyte. <i>PLoS ONE<\/i>, 8, e58915 (2013).","DOI":"10.1371\/journal.pone.0058915"},{"key":"21","unstructured":"21) Hossen MA, Inoue T, Shinmei Y, Minami K, Fujii Y, Kamei C. Caffeic acid inhibits compound 48\/80-induced allergic symptoms in mice. <i>Biol. Pharm. Bull.<\/i>, 29, 64\u201366 (2006)."},{"key":"22","unstructured":"22) Kadoshima-Yamaoka K, Goto M, Murakawa M, Yoshioka R, Tanaka Y, Inoue H, Murafuji H, Kanki S, Hayashi Y, Nagahira K, Ogata A, Nakatsuka T, Fukuda Y. ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-<i>O<\/i>-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice. <i>Eur. J. Pharmacol.<\/i>, 613, 163\u2013166 (2009)."},{"key":"23","unstructured":"23) Kalyan Kumar G, Dhamotharan R, Kulkarni NM, Mahat MY, Gunasekaran J, Ashfaque M. Embelin reduces cutaneous TNF-alpha level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. <i>Eur. J. Pharmacol.<\/i>, 662, 63\u201369 (2011)."},{"key":"24","unstructured":"24) Ha HY, Kim Y, Ryoo ZY, Kim TY. Inhibition of the TPA-induced cutaneous inflammation and hyperplasia by EC-SOD. <i>Biochem. Biophys. Res. Commun.<\/i>, 348, 450\u2013458 (2006)."},{"key":"25","unstructured":"25) Kristensen M, Chu CQ, Eedy DJ, Feldmann M, Brennan FM, Breathnach SM. Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor. <i>Clin. Exp. Immunol.<\/i>, 94, 354\u2013362 (1993)."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Postal M, Appenzeller S. The role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus. <i>Cytokine<\/i>, 56, 537\u2013543 (2011).","DOI":"10.1016\/j.cyto.2011.08.026"},{"key":"27","unstructured":"27) Schottelius AJ, Moldawer LL, Dinarello CA, Asadullah K, Sterry W, Edwards CK 3rd. Biology of tumor necrosis factor-alpha-implications for psoriasis. <i>Exp. Dermatol.<\/i>, 13, 193\u2013222 (2004)."},{"key":"28","unstructured":"28) Zepter K, Haffner A, Soohoo LF, De Luca D, Tang HP, Fisher P, Chavinson J, Elmets CA. Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes by inflammatory and immunologic stimuli. <i>J. Immunol.<\/i>, 159, 6203\u20136208 (1997)."},{"key":"29","unstructured":"29) Hirano T. Interleukin 6 and its receptor: ten years later. <i>Int. Rev. Immunol.<\/i>, 16, 249\u2013284 (1998)."},{"key":"30","unstructured":"30) Kupper TS, Min K, Sehgal P, Mizutani H, Birchall N, Ray A, May L. Production of IL-6 by keratinocytes. Implications for epidermal inflammation and immunity. <i>Ann. N. Y. Acad. Sci.<\/i>, 557, 454\u2013465 (1989)."},{"key":"31","unstructured":"31) Jeon YJ, Kim BH, Kim S, Oh I, Lee S, Shin J, Kim TY. Rhododendrin ameliorates skin inflammation through inhibition of NF-\u03baB, MAPK, and PI3K\/Akt signaling. <i>Eur. J. Pharmacol.<\/i>, 714, 7\u201314 (2013)."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Gougerot-Pocidalo MA. The neutrophil and systemic inflammation. <i>Joint Bone Spine<\/i>, 79, 209\u2013211 (2012).","DOI":"10.1016\/j.jbspin.2011.12.008"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/3\/37_b13-00459\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T01:26:28Z","timestamp":1615857988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/3\/37_b13-00459\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b13-00459","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}