{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:26:34Z","timestamp":1790364394395,"version":"4.1.0"},"reference-count":28,"publisher":"Pharmaceutical Society of Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b13-00619","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T22:55:10Z","timestamp":1388530510000},"page":"178-183","source":"Crossref","is-referenced-by-count":21,"title":["Topical Application of <i>Rosa multiflora<\/i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC\/Nga Mice"],"prefix":"10.1248","volume":"37","author":[{"given":"Kwan Hee","family":"Park","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Sook","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Medicine, Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Jun","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Wook","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Jun","family":"Seo","sequence":"additional","affiliation":[{"name":"College of Medicine, Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Won","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Leung DYM. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J. Allergy Clin. Immunol.<\/i>, 105, 860\u2013876 (2000)."},{"key":"2","unstructured":"2) Leung AK, Barber KA. Managing childhood atopic dermatitis. Adv. Ther.<\/i>, 20, 129\u2013137 (2003)."},{"key":"3","unstructured":"3) Kim CM, Shin MK, Ahn DK, Lee KS. An Unabridged Dictionary of Chinese Herbs.<\/i> Jeongdam Publishing House, Seoul, pp. 4735\u20134738 (1998)."},{"key":"4","unstructured":"4) Park KH, Kim SK, Choi SE, Kwon JH, Oh MH, Lee MW. Three new stereoisomers of condensed tannins from the roots of Rosa multiflora.<\/i> Chem. Pharm. Bull.<\/i>, 58, 1227\u20131231 (2010)."},{"key":"5","unstructured":"5) Park KH, Choi SE, Choi YW, Lee DI, Joo SS, Jeong MS, Bang HW, Lee CS, Lee MK, Seo SJ, Lee MW. Topical application of two condensed tannins from the root of Rosa multiflora<\/i> THUNBERG for the treatment of atopic dermatitis (AD) in NC\/Nga mice. Phytother. Res.<\/i>, 25, 1564\u20131569 (2011)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kunz B, Oranje AP, Labr\u00e8ze L, Stalder JF, Ring J, Ta\u00efeb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology<\/i>, 195, 10\u201319 (1997).","DOI":"10.1159\/000245677"},{"key":"7","unstructured":"7) Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, Willoughby DA. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 91, 2046\u20132050 (1994)."},{"key":"8","unstructured":"8) Rousset F, Robert J, Andary M, Bonnin JP, Souillet G, Chr\u00e9tien I, Bri\u00e8re F, P\u00e8ne J, de Vries JE. Shifts in interleukin-4 and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J. Allergy Clin. Immunol.<\/i>, 87, 58\u201369 (1991)."},{"key":"9","unstructured":"9) Akdis CA, Akdis M, Trautmann A, Blaser K. Immune regulation in atopic dermatitis. Curr. Opin. Immunol.<\/i>, 12, 641\u2013646 (2000)."},{"key":"10","unstructured":"10) Grewe M, Bruijnzeel-Koomen CA, Sch\u00f6pf E, Thepen T, Langeveld-Wildschut AG, Ruzicka T, Krutmann J. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol. Today<\/i>, 19, 359\u2013361 (1998)."},{"key":"11","unstructured":"11) Tupker RA, De Monchy JG, Coenraads PJ, Homan A, van der Meer JB. Induction of atopic dermatitis by inhalation of house dust mite. J. Allergy Clin. Immunol.<\/i>, 97, 1064\u20131070 (1996)."},{"key":"12","unstructured":"12) Steenkamp JA, Steynberg JP, Brandt EV, Ferreira D, Roux DG. Phlobatannins, A novel class of ring-isomerized condensed tannins. J. Chem. Soc. Chem. Commun.<\/i>, 23, 1678\u20131679 (1985)."},{"key":"13","unstructured":"13) Shiohara T, Hayakawa J, Mizukawa Y. Animal models for atopic dermatitis: are they relevant to human disease? J. Dermatol. Sci.<\/i>, 36, 1\u20139 (2004)."},{"key":"14","unstructured":"14) Sasakawa T, Higashi Y, Sakuma S, Hirayama Y, Sasakawa Y, Ohkubo Y, Goto T, Matsumoto M, Matsuda H. Atopic dermatitis-like skin lesions induced by topical application of mite antigens in NC\/Nga mice. Int. Arch. Allergy Immunol.<\/i>, 126, 239\u2013247 (2001)."},{"key":"15","unstructured":"15) Vella A, Teague TK, Ihle J, Kappler J, Marrack P. Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: Stat-6 is probably not required for the effect of IL-4. J. Exp. Med.<\/i>, 186, 325\u2013330 (1997)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Romagnani S. Regulation and deregulation of human IgE synthesis. Immunol. Today<\/i>, 11, 316\u2013321 (1990).","DOI":"10.1016\/S0167-5699(10)80004-0"},{"key":"17","unstructured":"17) Schleimer RP, Sterbinsky SA, Kaiser J, Bickel CA, Klunk DA, Tomioka K, Newman W, Luscinskas FW, Gimbrone MA Jr, Mclntyre BW, Bochner BS. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAM-1. J. Immunol.<\/i>, 148, 1086\u20131092 (1992)."},{"key":"18","unstructured":"18) Zurawski G, de Vries JE. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today<\/i>, 15, 19\u201326 (1994)."},{"key":"19","unstructured":"19) Baatjes AJ, Sehmi R, Saito H, Cyr MM, Dorman SC, Inman MD, O'Byrne PM, Denburg JA. Anti-allergic therapies: effects on eosinophil progenitors. Pharmacol. Ther.<\/i>, 95, 63\u201372 (2002)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Weiss E, Mamelak AJ, La Morgia S, Wang B, Feliciani C, Tulli A, Sauder DN. The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases. J. Am. Acad. Dermatol.<\/i>, 50, 657\u2013675, quiz, 676\u2013678 (2004).","DOI":"10.1016\/j.jaad.2003.11.075"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Borish LC, Steinke JW. 2. Cytokines and chemokines. J. Allergy Clin. Immunol.<\/i>, 111 (Suppl.), S460\u2013S475 (2003).","DOI":"10.1067\/mai.2003.108"},{"key":"22","unstructured":"22) Ding Y, Chen D, Tarcsafalvi A, Su R, Qin L, Bromberg JS. Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses. J. Immunol.<\/i>, 170, 1383\u20131391 (2003)."},{"key":"23","unstructured":"23) Schottelius AJ, Mayo MW, Sartor RB, Baldwin AS Jr. Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J. Biol. Chem.<\/i>, 274, 31868\u201331874 (1999)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Souquet J, Cheynier V, Brossaud F, Michel M. Polymeric proanthocyanidins from grape skins. Phytochemistry<\/i>, 43, 509\u2013512 (1996).","DOI":"10.1016\/0031-9422(96)00301-9"},{"key":"25","unstructured":"25) Zhang WY, Liu HQ, Xie KQ, Yin LL, Li Y, Kwik-Uribe CL, Zhu XZ. Procyanidin dimer B2 [epicatechin-(4\u03b2\u21928)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. Biochem. Biophys. Res. Commun.<\/i>, 345, 508\u2013515 (2006)."},{"key":"26","unstructured":"26) Tamura S, Yoshihira K, Fujiwara K, Murakami N. New inhibitors for expression of IgE receptor on human mast cell. Bioorg. Med. Chem. Lett.<\/i>, 20, 2299\u20132302 (2010)."},{"key":"27","unstructured":"27) Takano F, Takata T, Yoshihara A, Nakamura Y, Arima Y, Ohta T. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol. Pharm. Bull.<\/i>, 30, 922\u2013927 (2007)."},{"key":"28","unstructured":"28) Wong CP, Nguyen LP, Noh SK, Bray TM, Bruno RS, Ho E. Induction of regulatory T cells by green tea polyphenol EGCG. Immunol. Lett.<\/i>, 139, 7\u201313 (2011)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/1\/37_b13-00619\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T05:33:35Z","timestamp":1615872815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/1\/37_b13-00619\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b13-00619","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}