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Identification of etoposide glucuronide as a major metabolite of etoposide in the rat and rabbit. Cancer Res.<\/i>, 48, 1829\u20131834 (1988)."},{"key":"2","unstructured":"2) Machavaram KK, Gundu J, Yamsani MR. Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats. Pharmazie<\/i>, 59, 957\u2013960 (2004)."},{"key":"3","unstructured":"3) Kawashiro T, Yamashita K, Zhao XJ, Koyama E, Tani M, Chiba K, Ishizaki T. A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J. Pharmacol. Exp. Ther.<\/i>, 286, 1294\u20131300 (1998)."},{"key":"4","unstructured":"4) Cordon-Cardo C, O\u2019Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem.<\/i>, 38, 1277\u20131287 (1990)."},{"key":"5","unstructured":"5) Nishimura T, Kato Y, Amano N, Ono M, Kubo Y, Kimura Y, Fujita H, Tsuji A. Species difference in intestinal absorption mechanism of etoposide and digoxin between cynomolgus monkey and rat. Pharm. Res.<\/i>, 25, 2467\u20132476 (2008)."},{"key":"6","unstructured":"6) Lee CK, Ki SH, Choi JS. Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats: possible role of intestinal CYP3A and P-gp inhibition by curcumin. Biopharm. Drug Dispos.<\/i>, 32, 245\u2013251 (2011)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Wandel C, Kim R, Wood M, Wood A. Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology<\/i>, 96, 913\u2013920 (2002).","DOI":"10.1097\/00000542-200204000-00019"},{"key":"8","unstructured":"8) Sakaeda T, Nakamura T, Okumura K. MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol. Pharm. Bull.<\/i>, 25, 1391\u20131400 (2002)."},{"key":"9","unstructured":"9) Akaike H. Information theory and an extension of the maximum likelihood principle, 2nd International Symposium on Information Theory<\/i> (Petrow BN, Csaki F eds.), Akademiai Kiado, Buqdapest, pp. 267\u2013281 (1973)."},{"key":"10","unstructured":"10) Colombo T, Broggini M, Torti L, Erba E, D\u2019Incalci M. Pharmacokinetics of VP16-213 in Lewis lung carcinoma bearing mice. Cancer Chemother. Pharmacol.<\/i>, 7, 127\u2013131 (1982)."},{"key":"11","unstructured":"11) Kakemi M. Pharmacokinetics<\/i>, 1 ed. (Kakemi M ed.), Kyoto-Hirokawa, Tokyo, p. 269. (2009)"},{"key":"12","unstructured":"12) Joel SP, Clark PI, Heap L, Webster L, Robbins S, Craft H, Slevin ML. Pharmacological attempts to improve the bioavailability of oral etoposide. Cancer Chemother. Pharmacol.<\/i>, 37, 125\u2013133 (1995)."},{"key":"13","unstructured":"13) Yuan CS, Foss JF, O\u2019Connor M, Roizen MF, Moss J. Effects of low-dose morphine on gastric emptying in healthy volunteers. J. Clin. Pharmacol.<\/i>, 38, 1017\u20131020 (1998)."},{"key":"14","unstructured":"14) Fujita-Hamabe W, Nishida M, Nawa A, Kobori T, Nakamoto K, Kishioka S, Tokuyama S. Etoposide modulates the effects of oral morphine analgesia by targeting the intestinal P-glycoprotein. J. Pharm. Pharmacol.<\/i>, 64, 496\u2013504 (2012)."},{"key":"15","unstructured":"15) Shah AK, Brundage RC, Gratwohl A, Sawchuk RJ. Pharmacokinetic model for subcutaneous absorption of cyclosporine in the rabbit during chronic treatment. J. Pharm. Sci.<\/i>, 81, 491\u2013495 (1992)."},{"key":"16","unstructured":"16) Shah JC, Chen JR, Chow D. Oral bioavailability and in situ<\/i> absorption of etoposide in rat. Int. J. 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