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Shuttle vectors for Candida albicans<\/i>. control of plasmid copy number and elevated expression of cloned genes. Curr. Genet.<\/i>, 45, 390\u2013398 (2004)."},{"key":"7","unstructured":"7) \u2003Jia XM, Ma ZP, Jia Y, Gao PH, Zhang JD, Wang Y, Xu Y, Wang L, Cao YY, Cao YB, Zhang LX, Jiang YY. RTA2, a novel gene involved in azole resistance in Candida albicans.<\/i> Biochem. Biophys. Res. Commun.<\/i>, 373, 631\u2013636 (2008)."},{"key":"8","unstructured":"8) \u2003Jia XM, Wang Y, Jia Y, Gao PH, Xu YG, Wang L, Cao YY, Cao YB, Zhang LX, Jiang YY. RTA2<\/sub> is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans.<\/i> Cell. Mol. Life Sci.<\/i>, 66, 122\u2013134 (2009)."},{"key":"9","unstructured":"9) \u2003Prasad R, De Wergifosse P, Goffeau A, Balzi E. Molecular cloning and characterization of a novel gene of Candida albicans<\/i>, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet.<\/i>, 27, 320\u2013329 (1995)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) \u2003Sanglard D, Ischer F, Monod M, Bille J. Cloning of Candida albicans<\/i> genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology<\/i>, 143, 405\u2013416 (1997).","DOI":"10.1099\/00221287-143-2-405"},{"key":"11","unstructured":"11) \u2003Wirsching S, Michel S, Morschhauser J. Targeted gene disruption in Candida albicans<\/i> wild-type strains. the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans<\/i> isolates. Mol. Microbiol.<\/i>, 36, 856\u2013865 (2000)."},{"key":"12","unstructured":"12) \u2003Yan L, Li M, Cao Y, Gao P, Cao Y, Wang Y, Jiang Y. The alternative oxidase of Candida albicans<\/i> causes reduced fluconazole susceptibility. J. Antimicrob. Chemother.<\/i>, 64, 764\u2013773 (2009)."},{"key":"13","unstructured":"13) \u2003Krishnamurthy S, Gupta V, Snehlata P, Prasad R. Characterisation of human steroid hormone transport mediated by Cdr1p, a multidrug transporter of Candida albicans<\/i>, belonging to the ATP binding cassette super family. FEMS Microbiol. Lett.<\/i>, 158, 69\u201374 (1998)."},{"key":"14","unstructured":"14) \u2003Maesaki S, Marichal P, Vanden Bossche H, Sanglard D, Kohno S. Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans<\/i> strains. J. Antimicrob. Chemother.<\/i>, 44, 27\u201331 (1999)."},{"key":"15","unstructured":"15) \u2003de Micheli M, Bille J, Schueller C, Sanglard D. A common drug-responsive element mediates the upregulation of the Candida albicans<\/i> ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol. Microbiol.<\/i>, 43, 1197\u20131214 (2002)."},{"key":"16","unstructured":"16) \u2003Coste AT, Karababa M, Ischer F, Bille J, Sanglard D. TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans<\/i> ABC transporters CDR1 and CDR2. Eukaryot. Cell<\/i>, 3, 1639\u20131652 (2004)."},{"key":"17","unstructured":"17) \u2003MacPherson S, Larochelle M, Turcotte B. A fungal family of transcriptional regulators. the zinc cluster proteins. Microbiol. Mol. Biol. Rev.<\/i>, 70, 583\u2013604 (2006)."},{"key":"18","unstructured":"18) \u2003Mantena SK, Sharma SD, Katiyar SK. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol. Cancer Ther.<\/i>, 5, 296\u2013308 (2006)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) \u2003Ficker CE, Arnason JT, Vindas PS, Alvarez LP, Akpagana K, Gbeassor M, De Souza C, Smith ML. Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses<\/i>, 46, 29\u201337 (2003).","DOI":"10.1046\/j.1439-0507.2003.00838.x"},{"key":"20","unstructured":"20) \u2003Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris<\/i> and its active constituent, berberine. Phytother. Res.<\/i>, 22, 999\u20131012 (2008)."},{"key":"21","unstructured":"21) \u2003Han Y, Lee JH. Berberine synergy with amphotericin B against disseminated candidiasis in mice. Biol. Pharm. Bull.<\/i>, 28, 541\u2013544 (2005)."},{"key":"22","unstructured":"22) \u2003Wei G-X, Xu X, Wu CD. In vitro<\/i> synergism between berberine and miconazole against planktonic and biofilm Candida<\/i> cultures. Arch. Oral Biol.<\/i>, 56, 565\u2013572 (2011)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) \u2003Iwazaki RS, Endo EH, Ueda-Nakamura T, Nakamura CV, Garcia LB, Filho BP. In vitro<\/i> antifungal activity of the berberine and its synergism with fluconazole. 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Biophys.<\/i>, 26, 201\u2013208 (1989)."},{"key":"27","unstructured":"27) \u2003Saran A, Srivastava S, Coutinho E, Maiti M. 1H NMR investigation of the interaction of berberine and sanguinarine with DNA. Indian J. Biochem. Biophys.<\/i>, 32, 74\u201377 (1995)."},{"key":"28","unstructured":"28) \u2003Bhadra K, Maiti M, Kumar GS. Berberine-DNA complexation: New insights into the cooperative binding and energetic aspects. Biochim. Biophys. Acta<\/i>, 1780, 1054\u20131061 (2008)."},{"key":"29","unstructured":"29) \u2003Saidane S, Weber S, De Deken X, St-Germain G, Raymond M. PDR16-mediated azole resistance in Candida albicans.<\/i> Mol. Microbiol.<\/i>, 60, 1546\u20131562 (2006)."},{"key":"30","unstructured":"30) \u2003Yan L, Cote P, Li XX, Jiang YY, Whiteway M. PalI domain proteins of Saccharomyces cerevisiae<\/i> and Candida albicans.<\/i> Microbiol. 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