{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:26:50Z","timestamp":1791178010058,"version":"4.1.0"},"reference-count":38,"publisher":"Pharmaceutical Society of Japan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b13-00763","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T23:13:07Z","timestamp":1393629187000},"page":"409-416","source":"Crossref","is-referenced-by-count":6,"title":["Adhesion of Enterohemorrhagic &lt;i&gt;Escherichia coli&lt;\/i&gt; O157:H7 to the Intestinal Epithelia Is Essential for Inducing Secretory IgA Antibody Production in the Intestine of Mice"],"prefix":"10.1248","volume":"37","author":[{"given":"Keiji","family":"Nagano","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Department of Public Health Pharmacy, Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Department of Public Health Pharmacy, Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Tokoro","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Department of Public Health Pharmacy, Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Tatsuno","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Department of Public Health Pharmacy, Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Nataro JP, Kaper JB. Diarrheagenic <i>Escherichia coli.<\/i> <i>Clin. Microbiol. Rev.<\/i>, 11, 142\u2013201 (1998)."},{"key":"2","unstructured":"2) Melton-Celsa A, Mohawk K, Teel L, O\u2019Brien A. Pathogenesis of Shiga-toxin producing <i>Escherichia coli.<\/i> <i>Curr. Top. Microbiol. Immunol.<\/i>, 357, 67\u2013103 (2012)."},{"key":"3","unstructured":"3) Mota LJ, Sorg I, Cornelis GR. Type III secretion: the bacteria-eukaryotic cell express. <i>FEMS Microbiol. Lett.<\/i>, 252, 1\u201310 (2005)."},{"key":"4","unstructured":"4) Frankel G, Phillips AD. Attaching effacing <i>Escherichia coli<\/i> and paradigms of Tir-triggered actin polymerization: getting off the pedestal. <i>Cell. Microbiol.<\/i>, 10, 549\u2013556 (2008)."},{"key":"5","unstructured":"5) Louie M, de Azavedo JC, Handelsman MY, Clark CG, Ally B, Dytoc M, Sherman P, Brunton J. Expression and characterization of the <i>eaeA<\/i> gene product of <i>Escherichia coli<\/i> serotype O157:H7. <i>Infect. Immun.<\/i>, 61, 4085\u20134092 (1993)."},{"key":"6","unstructured":"6) Liu H, Magoun L, Luperchio S, Schauer DB, Leong JM. The Tir-binding region of enterohaemorrhagic <i>Escherichia coli<\/i> intimin is sufficient to trigger actin condensation after bacterial-induced host cell signalling. <i>Mol. Microbiol.<\/i>, 34, 67\u201381 (1999)."},{"key":"7","unstructured":"7) Ebel F, Podzadel T, Rohde M, Kresse AU, Kramer S, Deibel C, Guzman CA, Chakraborty T. Initial binding of Shiga toxin-producing <i>Escherichia coli<\/i> to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. <i>Mol. Microbiol.<\/i>, 30, 147\u2013161 (1998)."},{"key":"8","unstructured":"8) Yip CK, Finlay BB, Strynadka NC. Structural characterization of a type III secretion system filament protein in complex with its chaperone. <i>Nat. Struct. Mol. Biol.<\/i>, 12, 75\u201381 (2005)."},{"key":"9","unstructured":"9) Kresse AU, Beltrametti F, Muller A, Ebel F, Guzman CA. Characterization of SepL of enterohemorrhagic <i>Escherichia coli.<\/i> <i>J. Bacteriol.<\/i>, 182, 6490\u20136498 (2000)."},{"key":"10","unstructured":"10) Tatsuno I, Kimura H, Okutani A, Kanamaru K, Abe H, Nagai S, Makino K, Shinagawa H, Yoshida M, Sato K, Nakamoto J, Tobe T, Sasakawa C. Isolation and characterization of mini-Tn<i>5<\/i>Km2 insertion mutants of enterohemorrhagic <i>Escherichia coli<\/i> O157:H7 deficient in adherence to Caco-2 cells. <i>Infect. Immun.<\/i>, 68, 5943\u20135952 (2000)."},{"key":"11","unstructured":"11) Nagano K, Taguchi K, Hara T, Yokoyama S, Kawada K, Mori H. Adhesion and colonization of enterohemorrhagic <i>Escherichia coli<\/i> O157:H7 in cecum of mice. <i>Microbiol. Immunol.<\/i>, 47, 125\u2013132 (2003)."},{"key":"12","unstructured":"12) Jenkins C, Chart H, Smith HR, Hartland EL, Batchelor M, Delahay RM, Dougan G, Frankel G. Antibody response of patients infected with verocytotoxin-producing <i>Escherichia coli<\/i> to protein antigens encoded on the LEE locus. <i>J. Med. Microbiol.<\/i>, 49, 97\u2013101 (2000)."},{"key":"13","unstructured":"13) Srimanote P, Paton AW, Paton JC. Characterization of a novel type IV pilus locus encoded on the large plasmid of locus of enterocyte effacement-negative Shiga-toxigenic <i>Escherichia coli<\/i> strains that are virulent for humans. <i>Infect. Immun.<\/i>, 70, 3094\u20133100 (2002)."},{"key":"14","unstructured":"14) Li Y, Frey E, Mackenzie AM, Finlay BB. Human response to <i>Escherichia coli<\/i> O157:H7 infection: antibodies to secreted virulence factors. <i>Infect. Immun.<\/i>, 68, 5090\u20135095 (2000)."},{"key":"15","unstructured":"15) Conlan JW, Perry MB. Susceptibility of three strains of conventional adult mice to intestinal colonization by an isolate of <i>Escherichia coli<\/i> O157:H7. <i>Can. J. Microbiol.<\/i>, 44, 800\u2013805 (1998)."},{"key":"16","unstructured":"16) Mohawk KL, O\u2019Brien AD. Mouse models of <i>Escherichia coli<\/i> O157:H7 infection and shiga toxin injection. <i>J. Biomed. Biotechnol.<\/i>, 2011, 258185 (2011)."},{"key":"17","unstructured":"17) Itoh S, Kariya M, Nagano K, Yokoyama S, Fukao T, Yamazaki Y, Mori H. New rapid enzyme-linked immunosorbent assay to detect antibodies against bacterial surface antigens using filtration plates. <i>Biol. Pharm. Bull.<\/i>, 25, 986\u2013990 (2002)."},{"key":"18","unstructured":"18) Nagano K, Sugisaki T, Taguchi K, Hara T, Naiki M, Mori H. A murine model of enterohemorrhagic <i>Escherichia coli<\/i> O157:H7 infection to assess immunopotentiating activity of drugs on mucosal immunity: effect of drugs. <i>J. Pharmacol. Sci.<\/i>, 91, 219\u2013228 (2003)."},{"key":"19","unstructured":"19) Camara LM, Carbonare SB, Silva ML, Carneiro-Sampaio MM. Inhibition of enteropathogenic <i>Escherichia coli<\/i> (EPEC) adhesion to HeLa cells by human colostrum: detection of specific sIgA related to EPEC outer-membrane proteins. <i>Int. Arch. Allergy Immunol.<\/i>, 103, 307\u2013310 (1994)."},{"key":"20","unstructured":"20) Russel MW, Kilian M, Lamm ME. Biological activities of IgA. <i>Mucosal Immunology<\/i>. (Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR eds.) Academic Press, New York, pp. 225\u2013240 (1999)."},{"key":"21","unstructured":"21) McGhee JR, Czerkinsky C, Mestecky J. Mucosal vaccines: An overview. <i>Mucosal Immunology<\/i>. (Ogra PL, Mestecky J, Lamm ME, Sakakibara J, Batchelor M, Mackenzie AM eds.) Academic Press, New York, pp. 741\u2013757 (1999)."},{"key":"22","unstructured":"22) Mestecky J, Moro I, Underdown BJ. Mucosal Immunoglobulins. <i>Mucosal Immunology<\/i>. (Ogra PL, Mestecky J, Lamm ME, Sakakibara J, Batchelor M, Mackenzie AM eds.) Academic Press, New York, pp. 133\u2013152 (1999)."},{"key":"23","unstructured":"23) Izumiya H, Terajima J, Wada A, Inagaki Y, Itoh KI, Tamura K, Watanabe H. Molecular typing of enterohemorrhagic <i>Escherichia coli<\/i> O157:H7 isolates in Japan by using pulsed-field gel electrophoresis. <i>J. Clin. Microbiol.<\/i>, 35, 1675\u20131680 (1997)."},{"key":"24","unstructured":"24) Tatsuno I, Nagano K, Taguchi K, Rong L, Mori H, Sasakawa C. Increased adherence to Caco-2 cells caused by disruption of the <i>yhiE<\/i> and <i>yhiF<\/i> genes in enterohemorrhagic <i>Escherichia coli<\/i> O157:H7. <i>Infect. Immun.<\/i>, 71, 2598\u20132606 (2003)."},{"key":"25","unstructured":"25) Wadolkowski EA, Burris JA, O\u2019Brien AD. Mouse model for colonization and disease caused by enterohemorrhagic <i>Escherichia coli<\/i> O157:H7. <i>Infect. Immun.<\/i>, 58, 2438\u20132445 (1990)."},{"key":"26","unstructured":"26) Lindgren SW, Melton AR, O\u2019Brien AD. Virulence of enterohemorrhagic <i>Escherichia coli<\/i> O91:H21 clinical isolates in an orally infected mouse model. <i>Infect. Immun.<\/i>, 61, 3832\u20133842 (1993)."},{"key":"27","unstructured":"27) Ismaili A, Philpott DJ, McKay DM, Perdue MH, Sherman PM. Epitherial cell responses to Shiga toxin-producing <i>Escherichia coli<\/i> infection. <i>Escherichia coli O157:H7 and Shiga Toxin-Producing E. coli Strains<\/i>. (J.B. K, A.D. OB eds.) American Society for Microbiology, Washington, D.C., pp. 213\u2013225 (1998)."},{"key":"28","unstructured":"28) Berin MC, Darfeuille-Michaud A, Egan LJ, Miyamoto Y, Kagnoff MF. Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-\u03baB and MAP kinase pathways and the upregulated expression of interleukin 8. <i>Cell. Microbiol.<\/i>, 4, 635\u2013648 (2002)."},{"key":"29","unstructured":"29) Ismaili A, Philpott DJ, Dytoc MT, Sherman PM. Signal transduction responses following adhesion of verocytotoxin-producing <i>Escherichia coli.<\/i> <i>Infect. Immun.<\/i>, 63, 3316\u20133326 (1995)."},{"key":"30","unstructured":"30) Ismaili A, McWhirter E, Handelsman MY, Brunton JL, Sherman PM. Divergent signal transduction responses to infection with attaching and effacing <i>Escherichia coli.<\/i> <i>Infect. Immun.<\/i>, 66, 1688\u20131696 (1998)."},{"key":"31","unstructured":"31) Sherman P, Soni R, Petric M, Karmali M. Surface properties of the Vero cytotoxin-producing <i>Escherichia coli<\/i> O157:H7. <i>Infect. Immun.<\/i>, 55, 1824\u20131829 (1987)."},{"key":"32","unstructured":"32) McKee ML, O&apos;Brien AD. Investigation of enterohemorrhagic <i>Escherichia coli<\/i> O157:H7 adherence characteristics and invasion potential reveals a new attachment pattern shared by intestinal <i>E. coli.<\/i> <i>Infect. Immun.<\/i>, 63, 2070\u20132074 (1995)."},{"key":"33","unstructured":"33) Donnenberg MS, Donohue-Rolfe A, Keusch GT. Epithelial cell invasion: an overlooked property of enteropathogenic <i>Escherichia coli<\/i> (EPEC) associated with the EPEC adherence factor. <i>J. Infect. Dis.<\/i>, 160, 452\u2013459 (1989)."},{"key":"34","unstructured":"34) Dibb-Fuller MP, Best A, Stagg DA, Cooley WA, Woodward MJ. An <i>in-vitro<\/i> model for studying the interaction of <i>Escherichia coli<\/i> O157:H7 and other enteropathogens with bovine primary cell cultures. <i>J. Med. Microbiol.<\/i>, 50, 759\u2013769 (2001)."},{"key":"35","unstructured":"35) Oelschlaeger TA, Barrett TJ, Kopecko DJ. Some structures and processes of human epithelial cells involved in uptake of enterohemorrhagic <i>Escherichia coli<\/i> O157:H7 strains. <i>Infect. Immun.<\/i>, 62, 5142\u20135150 (1994)."},{"key":"36","unstructured":"36) Uhlich GA, Keen JE, Elder RO. Variations in the <i>csgD<\/i> promoter of <i>Escherichia coli<\/i> O157:H7 associated with increased virulence in mice and increased invasion of HEp-2 cells. <i>Infect. Immun.<\/i>, 70, 395\u2013399 (2002)."},{"key":"37","unstructured":"37) Kelsall B, Strober W. Gut-associated lymphoid tissue. <i>Mucosal Immunology<\/i>. (Ogra PL, Mestecky J, Lamm ME, Sakakibara J, Batchelor M, Mackenzie AM eds.) Academic Press, New York, pp. 293\u2013317 (1999)."},{"key":"38","unstructured":"38) M\u00e9nard R, Sansonetti PJ, Parsot C. Nonpolar mutagenesis of the <i>ipa<\/i> genes defines IpaB, IpaC, and IpaD as effectors of <i>Shigella flexneri<\/i> entry into epithelial cells. <i>J. Bacteriol.<\/i>, 175, 5899\u20135906 (1993)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/3\/37_b13-00763\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T05:39:36Z","timestamp":1615873176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/3\/37_b13-00763\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b13-00763","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}