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Fundamental research for the pharmacological activity of Oriental drugs. IX. On the combined action of several crude drugs consisting in \u201cRokusingan\u201d for the anti-inflammatory effect. Yakugaku Zasshi<\/i>, 88, 135\u2013139 (1968).","DOI":"10.1248\/yakushi1947.88.2_135"},{"key":"2","unstructured":"2) Ma HY, Kou JP, Wang JR, Yu BY. Evaluation of the anti-inflammatory and analgesic activities of Liu-Shen-Wan and its individual fractions. J. Ethnopharmacol.<\/i>, 112, 108\u2013114 (2007)."},{"key":"3","unstructured":"3) Dai XM, Xu F, Guo Y. Experimental study of Liu-shen-wan on inducing leukemia cell apoptosis and correlative gene of control apoptosis. Liaoning Journal of Traditional<\/i> Chin. Med.<\/i>, 30, 431\u2013433 (2003)."},{"key":"4","unstructured":"4) Bensky D, Barolet R. Chinese Herbal Medicine: Formulas and Strategies<\/i>. 2nd ed, Eastland Press, Seattle, p. 87 (1993)."},{"key":"5","unstructured":"5) Liu J, Liang SX, Lu YF, Miao JW, Wu Q, Shi JS. Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate. J. Ethnopharmacol.<\/i>, 134, 26\u201331 (2011)."},{"key":"6","unstructured":"6) Ancient Way Acupuncture Blog. \u201cSix Spirit Pills\/Liu Shen Wan: Is it the Arsenic or Psychedelic Toad Venom that causes skin blistering and peeling?\u201d: \u2039http:\/\/ancientway.com\/blog\/?p=1071\/March 2012\u203a, cited on 7 March, 2012."},{"key":"7","unstructured":"7) Mu\u00f1oz M, Covenas R. Neurokinin-1 receptor: a new promising target in the treatment of cancer. Discov. Med.<\/i>, 10, 305\u2013313 (2010)."},{"key":"8","unstructured":"8) Tang HB, Inoue A, Iwasa M, Hide I, Nakata Y. Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. J. Neurochem.<\/i>, 97, 1412\u20131418 (2006)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Mu\u00f1oz M, Rosso M, Aguilar FJ, Gonzalez-Moles MA, Redondo M, Esteban F. NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2. Invest. New Drugs<\/i>, 26, 111\u2013118 (2008).","DOI":"10.1007\/s10637-007-9087-y"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Mu\u00f1oz M. Rosso M. Coveas R. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett. Drug Des. Discov.<\/i>, 3, 323\u2013329 (2006).","DOI":"10.2174\/157018006777574168"},{"key":"11","unstructured":"11) Rosso M, Robles-Fr\u00edas MJ, Cove\u00f1as R, Salinas-Mart\u00edn MV, Mu\u00f1oz M. The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines. Tumour Biol.<\/i>, 29, 245\u2013254 (2008)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mu\u00f1oz M, Gonz\u00e1lez-Ortega A, Rosso M, Robles-Frias MJ, Carranza A, Salinas-Mart\u00edn MV, Cove\u00f1as R. The substance P\/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists. Peptides<\/i>, 38, 318\u2013325 (2012).","DOI":"10.1016\/j.peptides.2012.09.024"},{"key":"13","unstructured":"13) Cao Y, Liang QL, Zhang HY, Wang YM, Bi KS, Luo GA. Screening and identification of multi-classified components in Liu Shen Wan using multi-dimension high performance liquid chromatography tandem mass spectrometry system. Chinese Journal of Analytical Chemistry<\/i>, 36, 39\u201345 (2008)."},{"key":"14","unstructured":"14) Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J.<\/i>, 22, 659\u2013661 (2007)."},{"key":"15","unstructured":"15) Yoshiyama S, Horinouchi T, Miwa S, Wang HH, Kohama K, Nakamura A. Effect of cigarette smoke components on vascular smooth muscle cell migration toward platelet-derived growth factor BB. J. Pharmacol. Sci.<\/i>, 115, 532\u2013535 (2011)."},{"key":"16","unstructured":"16) Li YS, Wang JX, Jia MM, Liu M, Li XJ, Tang HB. Dragon\u2019s blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats. J. Pharmacol. Sci.<\/i>, 118, 43\u201354 (2012)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Gerard NP, Garraway LA, Eddy RL Jr, Shows TB, Iijima H, Paquet JL, Gerard C. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry<\/i>, 30, 10640\u201310646 (1991).","DOI":"10.1021\/bi00108a006"},{"key":"18","unstructured":"18) Tang HB, Li YS, Arihiro K, Nakata Y. Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons. Mol. Pain<\/i>, 3, 42 (2007)."},{"key":"19","unstructured":"19) Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem.<\/i>, 193, 265\u2013275 (1951)."},{"key":"20","unstructured":"20) Niu M, Sun Y, Liu X, Tang L, Qiu R. Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. J. Pharmacol. Sci.<\/i>, 121, 17\u201324 (2013)."},{"key":"21","unstructured":"21) Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev.<\/i>, 13, 1899\u20131911 (1999)."},{"key":"22","unstructured":"22) Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell<\/i>, 21, 92\u2013101 (2011)."},{"key":"23","unstructured":"23) Castaneda F, Rosin-Steiner S. Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways. Int. J. Med. Sci.<\/i>, 3, 160\u2013167 (2006)."},{"key":"24","unstructured":"24) Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S. Quercetin induces apoptosis via<\/i> caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase\/Akt and ERK pathways in a human hepatoma cell line (HepG2). J. Nutr.<\/i>, 136, 2715\u20132721 (2006)."},{"key":"25","unstructured":"25) Huang SP, Chen JC, Wu CC, Chen CT, Tang NY, Ho YT, Lo C, Lin JP, Chung JG, Lin JG. Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res.<\/i>, 29, 165\u2013174 (2009)."},{"key":"26","unstructured":"26) Ji YB, Gao SY, Ji CF, Zou X. Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein. J. Ethnopharmacol.<\/i>, 115, 194\u2013202 (2008)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Chen Y, Li GW, Wang C, Gu Y, Huang LY. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain<\/i>, 119, 38\u201348 (2005).","DOI":"10.1016\/j.pain.2005.09.007"},{"key":"28","unstructured":"28) Ma J. Influence of Liushenwan on Inducing Apoptosis in Leukemia Cells and Apoptosis-Related Genes, Tianjin College of Traditional Chinese Medicine thesis<\/i>, 2003."},{"key":"29","unstructured":"29) Li W, Meng Y, Zhao L, Ding S, Sun L. Experiment research of the reversed effect of Liushenwan on the inhibiton effect of Erigeron breviscapus<\/i> injection on tumor cell apotosis. Hebei J. TCM<\/i>, 28, 940\u2013942 (2006)."},{"key":"30","unstructured":"30) Qi F, Li A, Inagaki Y, Xu H, Wang D, Cui X, Zhang L, Kokudo N, Du G, Tang W. Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells. Food Chem. Toxicol.<\/i>, 50, 295\u2013302 (2012)."},{"key":"31","unstructured":"31) Qi F, Li A, Zhao L, Xu H, Inagaki Y, Wang D, Cui X, Gao B, Kokudo N, Nakata M, Tang W. Cinobufacini, an aqueous extract from Bufo bufo<\/i> gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J. Ethnopharmacol.<\/i>, 128, 654\u2013661 (2010)."},{"key":"32","unstructured":"32) Qi FH, Li AY, Lv H, Zhao L, Li JJ, Gao B, Tang W. Apoptosis-inducing effect of cinobufacini, Bufo bufo<\/i> gargarizans Cantor skin extract, on human hepatoma cell line BEL-7402. Drug Discov. 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