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A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. <i>Gastroenterology<\/i>, 128, 1172\u20131178 (2005).","DOI":"10.1053\/j.gastro.2005.03.020"},{"key":"5","unstructured":"5) Kato N, Mashita Y, Kato S, Mitsufuji S, Yoshikawa T, Takeuchi K. Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats <i>via<\/i> a NO\/cGMP-dependent mechanism. <i>Dig. Dis. Sci.<\/i>, 54, 2346\u20132356 (2009)."},{"key":"6","unstructured":"6) Kato S, Ohkawa F, Ito Y, Amagase K, Takeuchi K. Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats. <i>J. Physiol. Pharmacol.<\/i>, 60, 147\u2013155 (2009)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Nagai N, Fukuhata T, Ito Y, Usui S, Hirano K. Involvement of interleukin 18 in indomethacin-induced lesions of the gastric mucosa in adjuvant-induced arthritis rat. <i>Toxicology<\/i>, 255, 124\u2013130 (2009).","DOI":"10.1016\/j.tox.2008.10.005"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Bjarnason I. Gastrointestinal safety of NSAIDs and over-the-counter analgesics. <i>Int. J. Clin. Pract. Suppl.<\/i>, 67 (Suppl. 178), 37\u201342 (2013).","DOI":"10.1111\/ijcp.12048"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Fries JF, Miller SR, Spitz PW, Williams CA, Hubert HB, Bloch DA. Toward an epidemiology of gastropathy associated with non-steroidal antiinflammatory drug use. <i>Gastroenterology<\/i>, 96 (Suppl.), 647\u2013655 (1989).","DOI":"10.1016\/S0016-5085(89)80061-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. <i>Nat. 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