{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:07:30Z","timestamp":1787893650919,"version":"build-2784847793"},"reference-count":19,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b14-00278","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T23:20:38Z","timestamp":1410304838000},"page":"1816-1819","source":"Crossref","is-referenced-by-count":11,"title":["Transdermal Administration of Aqueous Pregabalin Solution as a Potential Treatment Option for Patients with Neuropathic Pain to Avoid Central Nervous System-Mediated Side Effects"],"prefix":"10.1248","volume":"37","author":[{"given":"Hiroshi","family":"Fukasawa","sequence":"first","affiliation":[{"name":"Research Foundation ITSUU Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Muratake","sequence":"additional","affiliation":[{"name":"Research Foundation ITSUU Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Nagae","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacokinetics, Hoshi University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacokinetics, Hoshi University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Shudo","sequence":"additional","affiliation":[{"name":"Research Foundation ITSUU Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Jensen TS, Baron R, Haanpaa M, Kalso E, Loeser JD, Rice AS, Treede RD. A new definition of neuropathic pain. <i>Pain<\/i>, <b>152<\/b>, 2204\u20132205 (2011).","DOI":"10.1016\/j.pain.2011.06.017"},{"key":"2","unstructured":"2) Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J. Neuropathic pain: redefinition and a grading system for clinical and research purposes. <i>Neurology<\/i>, <b>70<\/b>, 1630\u20131635 (2008)."},{"key":"3","unstructured":"3) Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. <i>Lancet Neurol.<\/i>, <b>9<\/b>, 807\u2013819 (2010)."},{"key":"4","unstructured":"4) O\u02bcConnor AB, Dworkin RH. Treatment of neuropathic pain: an overview of recent guidelines. <i>Am. J. Med.<\/i>, <b>122<\/b> (Suppl.), S22\u2013S32 (2009)."},{"key":"5","unstructured":"5) Dworkin RH, O\u02bcConnor AB, Audette J, Baron R, Gourlay GK, Haanpaa ML, Kent JL, Krane EJ, Lebel AA, Levy RM, Mackey SC, Mayer J, Miaskowski C, Raja SN, Rice AS, Schmader KE, Stacey B, Stanos S, Treede RD, Turk DC, Walco GA, Wells CD. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. <i>Mayo Clin. Proc.<\/i>, <b>85<\/b> (Suppl.), S3\u2013S14 (2010)."},{"key":"6","unstructured":"6) Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. <i>J. Med. Chem.<\/i>, <b>34<\/b>, 2295\u20132298 (1991)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Taylor CP, Vartanian MG, Yuen PW, Bigge C, Suman-Chauhan N, Hill DR. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to <i>in vitro<\/i> binding at a novel site labeled by tritiated gabapentin. <i>Epilepsy Res.<\/i>, <b>14<\/b>, 11\u201315 (1993).","DOI":"10.1016\/0920-1211(93)90070-N"},{"key":"8","unstructured":"8) Stahl SM, Porreca F, Taylor CP, Cheung R, Thorpe AJ, Clair A. The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities? <i>Trends Pharmacol. Sci.<\/i>, <b>34<\/b>, 332\u2013339 (2013)."},{"key":"9","unstructured":"9) Zaccara G, Gangemi P, Perucca P, Specchio L. The adverse event profile of pregabalin: a systematic review and meta-analysis of randomized controlled trials. <i>Epilepsia<\/i>, <b>52<\/b>, 826\u2013836 (2011)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Muratake H, Ito A, Toda T, Suzuki H, Fukasawa H, Tsuda M, Inoue K, Sugiyama K, Shudo K. (<i>R<\/i>)- and (<i>S<\/i>)-4-Amino-3-(trimethylsilyl)-methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects. <i>Bioorg. Med. Chem. Lett.<\/i>, <b>22<\/b>, 7602\u20137604 (2012).","DOI":"10.1016\/j.bmcl.2012.10.001"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. <i>Pain<\/i>, <b>43<\/b>, 205\u2013218 (1990).","DOI":"10.1016\/0304-3959(90)91074-S"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. <i>Pain<\/i>, <b>50<\/b>, 355\u2013363 (1992).","DOI":"10.1016\/0304-3959(92)90041-9"},{"key":"13","unstructured":"13) Tuchman M, Barrett JA, Donevan S, Hedberg TG, Taylor CP. Central sensitization and Ca(V)alpha(2)delta ligands in chronic pain syndromes: pathologic processes and pharmacologic effect. <i>J. Pain<\/i>, <b>11<\/b>, 1241\u20131249 (2010)."},{"key":"14","unstructured":"14) Bryans JS, Wustrow DJ. 3-Substituted GABA analogs with central nervous system activity: a review. <i>Med. Res. Rev.<\/i>, <b>19<\/b>, 149\u2013177 (1999)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Fukasawa H, Muratake H, Ito A, Suzuki H, Amano Y, Nagae M, Sugiyama K, Shudo K. Silicon-containing GABA derivatives, silagaba compounds, as orally effective agents for treating neuropathic pain without central-nervous-system-related side effects. <i>ACS Chem. Neurosci.<\/i>, <b>5<\/b>, 525\u2013532 (2014).","DOI":"10.1021\/cn500053d"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Chen SR, Xu Z, Pan HL. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. <i>Anesthesiology<\/i>, <b>95<\/b>, 1473\u20131479 (2001).","DOI":"10.1097\/00000542-200112000-00029"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Plaza-Villegas F, Heir G, Markman S, Khan J, Noma N, Benoliel R, Patel J, Eliav E. Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. <i>Oral Surg. Oral Med. Oral Pathol. Oral Radiol.<\/i>, <b>114<\/b>, 449\u2013456 (2012).","DOI":"10.1016\/j.oooo.2012.05.002"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Field MJ, Cox PJ, Stott E, Melrose H, Offord J, Su TZ, Bramwell S, Corradini L, England S, Winks J, Kinloch RA, Hendrich J, Dolphin AC, Webb T, Williams D. Identification of the \u03b12-\u03b4-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>103<\/b>, 17537\u201317542 (2006).","DOI":"10.1073\/pnas.0409066103"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Li Z, Taylor CP, Weber M, Piechan J, Prior F, Bian F, Cui M, Hoffman D, Donevan S. Pregabalin is a potent and selective ligand for \u03b1<sub>2<\/sub>\u03b4-1 and \u03b1<sub>2<\/sub>\u03b4-2 calcium channel subunits. <i>Eur. J. Pharmacol.<\/i>, <b>667<\/b>, 80\u201390 (2011).","DOI":"10.1016\/j.ejphar.2011.05.054"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/11\/37_b14-00278\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T06:04:35Z","timestamp":1615874675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/11\/37_b14-00278\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b14-00278","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}