{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:22:40Z","timestamp":1771554160094,"version":"3.50.1"},"reference-count":19,"publisher":"Pharmaceutical Society of Japan","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b14-00297","type":"journal-article","created":{"date-parts":[[2014,8,31]],"date-time":"2014-08-31T23:36:23Z","timestamp":1409528183000},"page":"1505-1509","source":"Crossref","is-referenced-by-count":34,"title":["Chloroquine Improved Carbon Tetrachloride-Induced Liver Fibrosis through Its Inhibition of the Activation of Hepatic Stellate Cells: Role of Autophagy"],"prefix":"10.1248","volume":"37","author":[{"given":"Wei","family":"He","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, the Third Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the Third Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the Third Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the Third Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the Third Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Schuppan D, Afdhal NH. Liver cirrhosis. <i>Lancet<\/i>, 371, 838\u2013851 (2008).","DOI":"10.1016\/S0140-6736(08)60383-9"},{"key":"2","unstructured":"2) Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. <i>Physiol. Rev.<\/i>, 88, 125\u2013172 (2008)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. <i>Cell<\/i>, 147, 728\u2013741 (2011).","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"4","unstructured":"4) Thoen LFR, Guimar\u00e3es ELM, Doll\u00e9 L, Mannaerts I, Najimi M, Sokal E, van Grunsven LA. A role for autophagy during hepatic stellate cell activation. <i>J. Hepatol.<\/i>, 55, 1353\u20131360 (2011)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Hern\u00e1ndez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, Czaja MJ, Friedman SL. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. <i>Gastroenterology<\/i>, 142, 938\u2013946 (2012).","DOI":"10.1053\/j.gastro.2011.12.044"},{"key":"6","unstructured":"6) Wolf R, Wolf D, Ruocco V. Antimalarials: unapproved uses or indications. <i>Clin. Dermatol.<\/i>, 18, 17\u201335 (2000)."},{"key":"7","unstructured":"7) Hacking D, Smyth R, Shaw N, Kokia G, Carty H, Heaf D. Idiopathic pulmonary fibrosis in infants: good prognosis with conservative management. <i>Arch. Dis. Child.<\/i>, 83, 152\u2013157 (2000)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Zhong W, Shen WF, Ning BF, Hu PF, Lin Y, Yue HY, Yin C, Hou JL, Chen YX, Zhang JP, Zhang X, Xie WF. Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats. <i>Hepatology<\/i>, 50, 1524\u20131536 (2009).","DOI":"10.1002\/hep.23189"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Anthony B, Allen JT, Li YS, McManus DP. Hepatic stellate cells and parasite-induced liver fibrosis. <i>Parasites &amp; Vectors<\/i>, 3, 60\u201366 (2010).","DOI":"10.1186\/1756-3305-3-60"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. <i>J. Biol. Chem.<\/i>, 275, 2247\u20132250 (2000).","DOI":"10.1074\/jbc.275.4.2247"},{"key":"11","unstructured":"11) Lu C, Wang W, Jia Y, Liu X, Tong Z, Li B. Inhibition of AMPK\/autophagy potentiates parthenolide-induced apoptosis in human breast cancer cells. <i>J. Cell. Biochem.<\/i>, 115, 1458\u20131466 (2014)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Das S, Seth RK, Kumar A, Kadiiska MB, Michelotti G, Diehl AM, Chatterjee S. Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, 305, G950\u2013G963 (2013).","DOI":"10.1152\/ajpgi.00235.2013"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Huang H, Kang R, Wang J, Luo G, Yang W, Zhao Z. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. <i>Autophagy<\/i>, 9, 175\u2013195 (2013).","DOI":"10.4161\/auto.22791"},{"key":"14","unstructured":"14) Guo XL, Hu F, Zhang SS, Zhao QD, Zong C, Ye F, Guo SW, Zhang JW, Li R, Wu MC, Wei LX. Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy. <i>Cancer Lett.<\/i>, 346, 278\u2013284 (2014)."},{"key":"15","unstructured":"15) Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. The role of TGFbeta1 in initiating hepatic stellate cell activation <i>in vivo<\/i>. <i>J. Hepatol.<\/i>, 30, 77\u201387 (1999)."},{"key":"16","unstructured":"16) Lee BS, Kim NJ, Jeong HY, Lee HY, Kang DY, Noh SM. Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in rats. <i>Korean J. Intern. Med.<\/i>, 18, 6\u201312 (2003)."},{"key":"17","unstructured":"17) Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. <i>J. Clin. Invest.<\/i>, 96, 447\u2013455 (1995)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Nouchi T, Tanaka Y, Tsukada T, Sato C, Marumo F. Appearance of alpha-smooth-muscle-actin-positive cells in hepatic fibrosis. <i>Liver<\/i>, 11, 100\u2013105 (1991).","DOI":"10.1111\/j.1600-0676.1991.tb00499.x"},{"key":"19","unstructured":"19) Ueno T, Sata M, Sakata R, Torimura T, Sakamoto M, Sugawara H, Tanikawa K. Hepatic stellate cells and intralobular innervation in human liver cirrhosis. <i>Hum. Pathol.<\/i>, 28, 953\u2013959 (1997)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/9\/37_b14-00297\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T06:05:56Z","timestamp":1615874756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/9\/37_b14-00297\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b14-00297","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}