{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:53:48Z","timestamp":1787320428392,"version":"build-2736575974"},"reference-count":26,"publisher":"Pharmaceutical Society of Japan","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b14-00408","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T21:10:47Z","timestamp":1412111447000},"page":"1650-1654","source":"Crossref","is-referenced-by-count":3,"title":["ORI2 Inhibits Coxsackievirus Replication and Myocardial Inflammation in Experimental Murine Myocarditis"],"prefix":"10.1248","volume":"37","author":[{"given":"Byung-Kwan","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Jungwon University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Herbal Bio-Industry, Daegu Haany University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. <i>J. Clin. Invest.<\/i>, <b>118<\/b>, 2758\u20132770 (2008).","DOI":"10.1172\/JCI34777"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Feldman AM, McNamara D. Myocarditis. <i>N. Engl. J. Med.<\/i>, <b>343<\/b>, 1388\u20131398 (2000).","DOI":"10.1056\/NEJM200011093431908"},{"key":"3","unstructured":"3) Herskowitz A, Beisel KW, Wolfgram LJ, Rose NR. Coxsackievirus B3 murine myocarditis: wide pathologic spectrum in genetically defined inbred strains. <i>Hum. Pathol.<\/i>, <b>16<\/b>, 671\u2013673 (1985)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Knowlton KU, Jeon ES, Berkley N, Wessely R, Huber S. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. <i>J. Virol.<\/i>, <b>70<\/b>, 7811\u20137818 (1996).","DOI":"10.1128\/JVI.70.11.7811-7818.1996"},{"key":"5","unstructured":"5) Knowlton KU, Badorff C. The immune system in viral myocarditis: maintaining the balance. <i>Circ. Res.<\/i>, <b>85<\/b>, 559\u2013561 (1999)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Martino TA, Liu P, Sole MJ. Viral infection and the pathogenesis of dilated cardiomyopathy. <i>Circ. Res.<\/i>, <b>74<\/b>, 182\u2013188 (1994).","DOI":"10.1161\/01.RES.74.2.182"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton KU. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. <i>Circulation<\/i>, <b>115<\/b>, 94\u2013102 (2007).","DOI":"10.1161\/CIRCULATIONAHA.106.631093"},{"key":"8","unstructured":"8) Woodruff JF. Viral myocarditis. A review. <i>Am. J. Pathol.<\/i>, <b>101<\/b>, 425\u2013484 (1980)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yun SH, Lee WG, Kim YC, Ju ES, Lim BK, Choi JO, Kim DK, Jeon ES. Antiviral activity of coxsackievirus B3 3C protease inhibitor in experimental murine myocarditis. <i>J. Infect. Dis.<\/i>, <b>205<\/b>, 491\u2013497 (2012).","DOI":"10.1093\/infdis\/jir745"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Jeong HJ, Chang LC, Kim HK, Kim IH, Kinghorn AD, Pezzuto JM. Aromatase inhibitors from <i>Isodon excisus<\/i> var. <i>coreanus<\/i>. <i>Arch. Pharm. Res.<\/i>, <b>23<\/b>, 243\u2013245 (2000).","DOI":"10.1007\/BF02976453"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Lim BK, Choi JH, Nam JH, Gil CO, Shin JO, Yun SH, Kim DK, Jeon ES. Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis. <i>Cardiovasc. Res.<\/i>, <b>71<\/b>, 517\u2013526 (2006).","DOI":"10.1016\/j.cardiores.2006.05.016"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Lee C, Kim J, Lee H, Lee S, Kho Y. Two new constituents of <i>Isodon excisus<\/i> and their evaluation in an apoptosis inhibition assay. <i>J. Nat. Prod.<\/i>, <b>64<\/b>, 659\u2013660 (2001).","DOI":"10.1021\/np000604g"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Lim BK, Yun SH, Gil CO, Ju ES, Choi JO, Kim DK, Jeon ES. Foreign gene transfer to cardiomyocyte using a replication-defective recombinant coxsackievirus B3 without cytotoxicity. <i>Intervirology<\/i>, <b>55<\/b>, 201\u2013209 (2012).","DOI":"10.1159\/000324541"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Lim BK, Yun SH, Ju ES, Gil CO, Kim DK, Jeon ES. Role of the myristoylation site in expressing exogenous functional proteins in coxsackieviral vector. <i>Biosci. Biotechnol. Biochem.<\/i>, <b>76<\/b>, 1173\u20131176 (2012).","DOI":"10.1271\/bbb.120045"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Lim BK, Choe SC, Shin JO, Ho SH, Kim JM, Yu SS, Kim S, Jeon ES. Local expression of interleukin-1 receptor antagonist by plasmid DNA improves mortality and decreases myocardial inflammation in experimental coxsackieviral myocarditis. <i>Circulation<\/i>, <b>105<\/b>, 1278\u20131281 (2002).","DOI":"10.1161\/circ.105.11.1278"},{"key":"16","unstructured":"16) Xiong D, Lee GH, Badorff C, Dorner A, Lee S, Wolf P, Knowlton KU. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. <i>Nat. Med.<\/i>, <b>8<\/b>, 872\u2013877 (2002)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Esfandiarei M, Luo H, Yanagawa B, Suarez A, Dabiri D, Zhang J, McManus BM. Protein kinase B\/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. <i>J. Virol.<\/i>, <b>78<\/b>, 4289\u20134298 (2004).","DOI":"10.1128\/JVI.78.8.4289-4298.2004"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Chen TC, Weng KF, Chang SC, Lin JY, Huang PN, Shih SR. Development of antiviral agents for enteroviruses. <i>J. Antimicrob. Chemother.<\/i>, <b>62<\/b>, 1169\u20131173 (2008).","DOI":"10.1093\/jac\/dkn424"},{"key":"19","unstructured":"19) Wang SM, Liu CC. Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine. <i>Expert Rev. Anti Infect. Ther.<\/i>, <b>12<\/b>, 447\u2013456 (2014)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kim JM, Lim BK, Ho SH, Yun SH, Shin JO, Park EM, Kim DK, Kim S, Jeon ES. TNFR-Fc fusion protein expressed by <i>in vivo<\/i> electroporation improves survival rates and myocardial injury in coxsackievirus induced murine myocarditis. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>344<\/b>, 765\u2013771 (2006).","DOI":"10.1016\/j.bbrc.2006.03.170"},{"key":"21","unstructured":"21) Liu P, Martino T, Opavsky MA, Penninger J. Viral myocarditis: balance between viral infection and immune response. <i>Can. J. Cardiol.<\/i>, <b>12<\/b>, 935\u2013943 (1996)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Badorff C, Berkely N, Mehrotra S, Talhouk JW, Rhoads RE, Knowlton KU. Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. <i>J. Biol. Chem.<\/i>, <b>275<\/b>, 11191\u201311197 (2000).","DOI":"10.1074\/jbc.275.15.11191"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Gui MY, Aoyagi Y, Jin YR, Li XW, Hasuda T, Takeya K. Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from <i>Rabdosia excisa<\/i>. <i>J. Nat. Prod.<\/i>, <b>67<\/b>, 373\u2013376 (2004).","DOI":"10.1021\/np030357r"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Han QB, Zhao AH, Zhang JX, Lu Y, Zhang LL, Zheng QT, Sun HD. Cytotoxic constituents of <i>Isodon rubescens<\/i> var. <i>lushiensis<\/i>. <i>J. Nat. Prod.<\/i>, <b>66<\/b>, 1391\u20131394 (2003).","DOI":"10.1021\/np030165w"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Osawa K, Yasuda H, Maruyama T, Morita H, Takeya K, Itokawa H. Antibacterial trichorabdal diterpenes from <i>Rabdosia trichocarpa<\/i>. <i>Phytochemistry<\/i>, <b>36<\/b>, 1287\u20131291 (1994).","DOI":"10.1016\/S0031-9422(00)89653-3"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Zhao AH, Han QB, Li RT, Li SH, Qing C, Zhang YL, Zhao QS, Wang FS, Sun HD. Diterpenoids from <i>Isodon melissoides<\/i>. <i>J. Nat. Prod.<\/i>, <b>67<\/b>, 1441\u20131444 (2004).","DOI":"10.1021\/np030418l"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/10\/37_b14-00408\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T02:12:42Z","timestamp":1615860762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/10\/37_b14-00408\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b14-00408","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}