{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:54:35Z","timestamp":1764330875753},"reference-count":60,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1248\/bpb.b14-00470","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T02:08:48Z","timestamp":1414807728000},"page":"1803-1810","source":"Crossref","is-referenced-by-count":11,"title":["The Therapeutic Effect of rhMK on Osteoarthritis in Mice, Induced by Destabilization of the Medial Meniscus"],"prefix":"10.1248","volume":"37","author":[{"given":"Chuanying","family":"Xu","sequence":"first","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University"},{"name":"School of Pharmacy, Shanghai Jiao Tong University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunying","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Academy of Agricultural Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Schaible H-G. Mechanisms of chronic pain in osteoarthritis. <i>Curr. Rheumatol. Rep.<\/i>, <b>14<\/b>, 549\u2013556 (2012).","DOI":"10.1007\/s11926-012-0279-x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Dray A, Read SJ. Arthritis and pain. Future targets to control osteoarthritis pain. <i>Arthritis Res. Ther.<\/i>, <b>9<\/b>, 212\u2013225 (2007).","DOI":"10.1186\/ar2178"},{"key":"3","unstructured":"3) Enobumab KO, Imarengiaye CO. Pain in osteoarthritis: A review of literature. <i>South. Afr. J. Anaesth. Analg.<\/i>, <b>14<\/b>, 29\u201333 (2008)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, Im H-J. A current review of molecular mechanisms regarding osteoarthritis and pain. <i>Gene<\/i>, <b>527<\/b>, 440\u2013447 (2013).","DOI":"10.1016\/j.gene.2013.05.069"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Sofat N, Ejindu V, Kiely P. What makes osteoarthritis painful? The evidence for local and central pain processing. <i>Rheumatology<\/i>, <b>50<\/b>, 2157\u20132165 (2011).","DOI":"10.1093\/rheumatology\/ker283"},{"key":"6","unstructured":"6) Winkler C, Yao S. The midkine family of growth factors: diverse roles in nervous system formation and maintenance. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 905\u2013912 (2014)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Liedert A, Schinke T, Ignatius A, Amling M. The role of midkine in skeletal remodelling. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 870\u2013878 (2014).","DOI":"10.1111\/bph.12412"},{"key":"8","unstructured":"8) Ishiguro H, Horiba M, Takenaka H, Sumida A, Opthof T, Ishiguro YS, Kadomatsu K, Murohara T, Kodama I. Frontiers: A single intracoronary injection of midkine reduces ischemia\/reperfusion injury in swine hearts: a novel therapeutic approach for acute coronary syndrome. <i>Front. Physiol.<\/i>, <b>2<\/b>, 27 (2011)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Lee JK, Murohara T, Kadomatsu K, Kodama I. Midkine gene transfer ameliorates ischemic cardiomyopathy through enhancements of neovascularization <i>via<\/i> Akt\/PI3 kinase and ERK pathways and anti-apoptosis by regulating bcl-2 and bax. <i>Circulation<\/i>, <b>118<\/b>, S352 (2008).","DOI":"10.1161\/circ.118.suppl_18.S_352-b"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Ooboshi H, Opthof T, Kadomatsu K, Kodama I. Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction. <i>Cardiovasc. Res.<\/i>, <b>86<\/b>, 113\u2013121 (2010).","DOI":"10.1093\/cvr\/cvp386"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Takada J, Ooboshi H, Ago T, Kitazono T, Yao H, Kadomatsu K, Muramatsu T, Ibayashi S, Iida M. Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. <i>Gene Ther.<\/i>, <b>12<\/b>, 487\u2013493 (2005).","DOI":"10.1038\/sj.gt.3302434"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ishikawa E, Ooboshi H, Kumai Y, Takada J, Nakamura K, Ago T, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M. Midkine gene transfer protects against focal brain ischemia and augments neurogenesis. <i>J. Neurol. Sci.<\/i>, <b>285<\/b>, 78\u201384 (2009).","DOI":"10.1016\/j.jns.2009.05.026"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Ohta S, Muramatsu H, Senda T, Zou K, Iwata H, Muramatsu T. Midkine is expressed during repair of bone fracture and promotes chondrogenesis. <i>J. Bone Miner. Res.<\/i>, <b>14<\/b>, 1132\u20131144 (1999).","DOI":"10.1359\/jbmr.1999.14.7.1132"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Ochiai K, Muramatsu H, Yamamoto S, Ando H, Muramatsu T. The role of midkine and pleiotrophin in liver regeneration. <i>Liver Int.<\/i>, <b>24<\/b>, 484\u2013491 (2004).","DOI":"10.1111\/j.1478-3231.2004.0990.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ikutomo M, Sakakima H, Matsuda F, Yoshida Y. Midkine-deficient mice delayed degeneration and regeneration after skeletal muscle injury. <i>Acta Histochem.<\/i>, <b>116<\/b>, 319\u2013326 (2014).","DOI":"10.1016\/j.acthis.2013.08.009"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. <i>Nat. Med.<\/i>, <b>16<\/b>, 475\u2013482 (2010).","DOI":"10.1038\/nm.2119"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Gela A, Jovic S, Nordin SL, Egesten A. Midkine in host defence. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 859\u2013869 (2014).","DOI":"10.1111\/bph.12402"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Weckbach LT, Muramatsu T, Walzog B. Midkine in inflammation. <i>The Scientific World Journal<\/i>, <b>11<\/b>, 2491\u20132505 (2011).","DOI":"10.1100\/2011\/517152"},{"key":"19","unstructured":"19) Yaz\u0131han N, Ko\u00e7ak M, Ak\u00e7\u0131l E. Midkine in Inflammation and Inflammatory Diseases. <i>Midkine: From Embryogenesis to Pathogenesis and Therapy<\/i>. (Erg\u00fcven M, Muramatsu T, Bilir A eds.) Springer, Netherlands, pp. 89\u2013101 (2012)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) G\u00fcng\u00f6r C, Hofmann BT, Wolters-Eisfeld G, Bockhorn M. Pancreatic cancer. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 849\u2013858 (2014).","DOI":"10.1111\/bph.12401"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kishida S, Kadomatsu K. Involvement of midkine in neuroblastoma tumourigenesis. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 896\u2013904 (2014).","DOI":"10.1111\/bph.12442"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kadomatsu K, Muramatsu T. Midkine and pleiotrophin in neural development and cancer. <i>Cancer Lett.<\/i>, <b>204<\/b>, 127\u2013143 (2004).","DOI":"10.1016\/S0304-3835(03)00450-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Yoshida Y, Sakakima H, Matsuda F, Ikutomo M. Midkine in repair of the injured nervous system. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 924\u2013930 (2014).","DOI":"10.1111\/bph.12497"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Zhang ZH, Li HX, Qi YP, Du LJ, Zhu SY, Wu MY, Lu HL, Yu Y, Han W. Recombinant human midkine stimulates proliferation of articular chondrocytes. <i>Cell Prolif.<\/i>, <b>43<\/b>, 184\u2013194 (2010).","DOI":"10.1111\/j.1365-2184.2010.00668.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Xu C, Zhang Z, Wu M, Zhu S, Gao J, Zhang J, Yuan Y, Zhang K, Yu Y, Han W. Recombinant human midkine stimulates proliferation and decreases dedifferentiation of auricular chondrocytes <i>in vitro.<\/i> <i>Exp. Biol. Med.<\/i> (Maywood), <b>236<\/b>, 1254\u20131262 (2011).","DOI":"10.1258\/ebm.2011.011022"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse. <i>Osteoarthritis Cartilage<\/i>, <b>15<\/b>, 1061\u20131069 (2007).","DOI":"10.1016\/j.joca.2007.03.006"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Inglis JJ, McNamee KE, Chia S-L, Essex D, Feldmann M, Williams RO, Hunt SP, Vincent T. Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system. <i>Arthritis Rheum.<\/i>, <b>58<\/b>, 3110\u20133119 (2008).","DOI":"10.1002\/art.23870"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Dixon WJ. Efficient analysis of experimental observations. <i>Annu. Rev. Pharmacol. Toxicol.<\/i>, <b>20<\/b>, 441\u2013462 (1980).","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Zhang ZH, Du LJ, Xiang D, Zhu SY, Wu MY, Lu HL, Yu Y, Han W. Expression and purification of bioactive high-purity human midkine in <i>Escherichia coli.<\/i> <i>J. Zhejiang Univ. Sci. B<\/i>, <b>10<\/b>, 79\u201386 (2009).","DOI":"10.1631\/jzus.B0820385"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Salo PT, Hogervorst T, Seerattan RA, Rucker D, Bray RC. Selective joint denervation promotes knee osteoarthritis in the aging rat. <i>J. Orthop. Res.<\/i>, <b>20<\/b>, 1256\u20131264 (2002).","DOI":"10.1016\/S0736-0266(02)00045-1"},{"key":"31","unstructured":"31) Jones DR. Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases. <i>Br. J. Pharmacol.<\/i>, <b>171<\/b>, 2925\u20132939 (2014)."},{"key":"32","unstructured":"32) Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. <i>Ann. Rheum. Dis.<\/i>, <b>60<\/b>, 91\u201397 (2001)."},{"key":"33","unstructured":"33) Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL, Laslett LL, Jones G, Cicuttini F, Osborne R, Vos T, Buchbinder R, Woolf A, March L. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. <i>Ann. Rheum. Dis.<\/i>, <b>73<\/b>, 1323\u20131330 (2014)."},{"key":"34","unstructured":"34) Dekker J, Boot B, van der Woude LV, Bijlsma JWJ. Pain and disability in osteoarthritis: A review of biobehavioral mechanisms. <i>J. Behav. Med.<\/i>, <b>15<\/b>, 189\u2013214 (1992)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Houard X, Goldring M, Berenbaum F. Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. <i>Curr. Rheumatol. Rep.<\/i>, <b>15<\/b>, 375\u2013384 (2013).","DOI":"10.1007\/s11926-013-0375-6"},{"key":"36","unstructured":"36) Shen Y, Jin H, Tong P, Xiao L. Research development of the induced animal model of osteoarthritis. <i>Zhongguo Gu Shang<\/i>, <b>21<\/b>, 716\u2013718 (2008)."},{"key":"37","unstructured":"37) Ameye LG, Young MF. Animal models of osteoarthritis: lessons learned while seeking the \u201cHoly Grail.\u201d <i>Curr. Opin. Rheumatol.<\/i>, <b>18<\/b>, 537\u2013547 (2006)."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Little C, Smith M. Animal models of osteoarthritis. <i>Curr. Rheumatol. Rev.<\/i>, <b>4<\/b>, 175\u2013182 (2008).","DOI":"10.2174\/157339708785133523"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang ZY, Majumdar MK, Morris EA. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. <i>Nature<\/i>, <b>434<\/b>, 644\u2013648 (2005).","DOI":"10.1038\/nature03369"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) McNamee KE, Burleigh A, Gompels LL, Feldmann M, Allen SJ, Williams RO, Dawbarn D, Vincent TL, Inglis JJ. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. <i>Pain<\/i>, <b>149<\/b>, 386\u2013392 (2010).","DOI":"10.1016\/j.pain.2010.03.002"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren DJ, Miller RJ, Malfait AM. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>109<\/b>, 20602\u201320607 (2012).","DOI":"10.1073\/pnas.1209294110"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Kim BJ, Choi BH, Jin LH, Park SR, Min BH. Comparison between subchondral bone change and cartilage degeneration in collagenase- and DMM-induced osteoarthritis (OA) models in mice. <i>Tissue Eng. Regen. Med.<\/i>, <b>10<\/b>, 211\u2013217 (2013).","DOI":"10.1007\/s13770-013-0008-1"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan M, Ferguson C, Fetrow JS. Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. <i>PLoS ONE<\/i>, <b>8<\/b>, e54633 (2013).","DOI":"10.1371\/journal.pone.0054633"},{"key":"44","unstructured":"44) Flicker M, Handschuh S, Glosmann M, Erben R. \u03bc-CT evaluation of osteoarthritic changes in the tibia plateau of rats after destabilization of the medial meniscus. <i>J. Tissue Eng. Regen. Med.<\/i>, <b>6<\/b>, 320\u2013320 (2012)."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Moodie JP, Stok KS, Muller R, Vincent TL, Shefelbine SJ. Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity. <i>Osteoarthritis Cartilage<\/i>, <b>19<\/b>, 163\u2013170 (2011).","DOI":"10.1016\/j.joca.2010.11.006"},{"key":"46","unstructured":"46) Miller RE, Tran P, Ghoreishi-Haack N, Das R, Malfait AM. Destabilization of the medial meniscus as a model to study the relationship between joint degeneration and pain. <i>Arthritis Rheum.<\/i>, <b>63<\/b>, S694\u2013S695 (2011)."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS. Hypoxia-inducible factor-2 alpha regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. <i>Cell Death Differ.<\/i>, <b>19<\/b>, 440\u2013450 (2012).","DOI":"10.1038\/cdd.2011.111"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T. Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. <i>Arthritis Rheum.<\/i>, <b>60<\/b>, 2019\u20132027 (2009).","DOI":"10.1002\/art.24654"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Xu L, Servais J, Polur I, Kim D, Lee PL, Chung K, Li YF. Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice. <i>Arthritis Rheum.<\/i>, <b>62<\/b>, 2736\u20132744 (2010).","DOI":"10.1002\/art.27582"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Daans M, Luyten FP, Lories RJU. GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes. <i>Ann. Rheum. Dis.<\/i>, <b>70<\/b>, 208\u2013213 (2011).","DOI":"10.1136\/ard.2010.134619"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Sondergaard BC, Catala-Lehnen P, Huebner AK, Bay-Jensen AC, Schinke T, Henriksen K, Schilling S, Haberland M, Nielsen RH, Amling M, Karsdal MA. Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus. <i>Osteoarthritis Cartilage<\/i>, <b>20<\/b>, 136\u2013143 (2012).","DOI":"10.1016\/j.joca.2011.11.004"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Mi M, Shi SS, Li TF, Holz J, Lee YJ, Sheu TJ, Liao QD, Xiao T. TIMP2 deficient mice develop accelerated osteoarthritis <i>via<\/i> promotion of angiogenesis upon destabilization of the medial meniscus. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>423<\/b>, 366\u2013372 (2012).","DOI":"10.1016\/j.bbrc.2012.05.132"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Oh H, Chun CH, Chun JS. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. <i>Arthritis Rheum.<\/i>, <b>64<\/b>, 2568\u20132578 (2012).","DOI":"10.1002\/art.34481"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Valverde-Franco G, Pelletier JP, Fahmi H, Hum D, Matsuo K, Lussier B, Kapoor M, Martel-Pelletier J. <i>In vivo<\/i> bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis. <i>Arthritis Rheum.<\/i>, <b>64<\/b>, 3614\u20133625 (2012).","DOI":"10.1002\/art.34638"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Ma HL, Blanchet TJ, Peluso D, Hopkins B, Morris EA, Glasson SS. Osteoarthritis severity is sex dependent in a surgical mouse model. <i>Osteoarthritis Cartilage<\/i>, <b>15<\/b>, 695\u2013700 (2007).","DOI":"10.1016\/j.joca.2006.11.005"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Suri S, Gill SE, Massena de Camin S, Wilson D, McWilliams DF, Walsh DA. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. <i>Ann. Rheum. Dis.<\/i>, <b>66<\/b>, 1423\u20131428 (2007).","DOI":"10.1136\/ard.2006.063354"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Suri S, Walsh DA. Osteochondral alterations in osteoarthritis. <i>Bone<\/i>, <b>51<\/b>, 204\u2013211 (2012).","DOI":"10.1016\/j.bone.2011.10.010"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Sakakima H, Yoshida Y, Yamazaki Y, Matsuda F, Ikutomo M, Ijiri K, Muramatsu H, Muramatsu T, Kadomatsu K. Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve. <i>J. Neurosci. Res.<\/i>, <b>87<\/b>, 2908\u20132915 (2009).","DOI":"10.1002\/jnr.22127"},{"key":"59","unstructured":"59) Ezquerra L, Alguacil LF, Nguyen T, Deuel TF, Silos-Santiago I, Herradon G. Different pattern of pleiotrophin and midkine expression in neuropathic pain: Correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain. <i>Growth Factors<\/i>, <b>26<\/b>, 44\u201348 (2008)."},{"key":"60","unstructured":"60) Chevalier X, Eymard F, Richette P. Biologic agents in osteoarthritis: hopes and disappointments. <i>Nat. Rev. Rheumatol.<\/i>, <b>9<\/b>, 400\u2013410 (2013)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/11\/37_b14-00470\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T01:17:16Z","timestamp":1650503836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/11\/37_b14-00470\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b14-00470","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}