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Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. <i>Pharm. Res.<\/i>, <b>21<\/b>, 1263\u20131273 (2004).","DOI":"10.1023\/B:PHAM.0000033015.84146.4c"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Zhang S, Yang X, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. <i>Mol. Pharmacol.<\/i>, <b>65<\/b>, 1208\u20131216 (2004).","DOI":"10.1124\/mol.65.5.1208"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Temerk YM, Ibrahim MS, Kotb M. Voltammetric and spectroscopic studies on binding of antitumor Morin, Morin\u2013Cu complex and Morin\u2013beta-cyclodextrin with DNA. <i>Spectrochim. Acta A Mol. Biomol. Spectrosc.<\/i>, <b>71<\/b>, 1830\u20131836 (2009).","DOI":"10.1016\/j.saa.2008.07.001"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hsiu SL, Tsao CW, Tsai YC, Ho HJ, Chao PD. 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Preparation, characterization, and <i>in vivo<\/i> evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin\u2013phospholipid complex. <i>Int. J. Nanomedicine<\/i>, <b>6<\/b>, 3405\u20133414 (2011).","DOI":"10.2147\/IJN.S25824"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tian XJ, Yang XW, Yang X, Wang K. Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model. <i>Int. J. Pharm.<\/i>, <b>367<\/b>, 58\u201364 (2009).","DOI":"10.1016\/j.ijpharm.2008.09.023"},{"key":"14","unstructured":"14) Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting P-glycoprotein. <i>Cancer Contr.<\/i>, <b>10<\/b>, 159\u2013165 (2003)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Leslie EM, Deeley RG, Cole SP. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. <i>Toxicol. Appl. 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