{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:58:49Z","timestamp":1783954729599,"version":"3.55.0"},"reference-count":46,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2015]]},"DOI":"10.1248\/bpb.b14-00583","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T22:05:57Z","timestamp":1422741957000},"page":"228-234","source":"Crossref","is-referenced-by-count":17,"title":["Antifibrotic Compounds from <i>Liriodendron tulipifera<\/i> Attenuating HSC-T6 Proliferation and TNF-\u03b1 Production in RAW264.7 Cells"],"prefix":"10.1248","volume":"38","author":[{"given":"Eun Ju","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Agronomy & Medicinal Plant Resources, College of Life Sciences and Natural Resources, Gyeongnam National University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Doo","family":"Heo","sequence":"additional","affiliation":[{"name":"Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Korea University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Rae","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Oceanography, Kunsan National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Choong","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyun","family":"Sung","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 82<\/b>, 8681\u20138685 (1985).","DOI":"10.1073\/pnas.82.24.8681"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Maher JJ. Interactions between hepatic stellate cells and the immune system. Semin. Liver Dis.<\/i>, 21<\/b>, 417\u2013426 (2001).","DOI":"10.1055\/s-2001-17555"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Sakata R, Ueno T, Nakamura T, Sakamoto M, Torimura T, Sata M. Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90. J. Hepatol.<\/i>, 40<\/b>, 52\u201359 (2004).","DOI":"10.1016\/S0168-8278(03)00477-X"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Chiu CC, Chou HL, Wu PF, Chen HL, Wang HM, Chen CY. Bio-functional constituents from the stems of Liriodendron tulipifera.<\/i> Molecules<\/i>, 17<\/b>, 4357\u20134372 (2012).","DOI":"10.3390\/molecules17044357"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Doskotch RW, el-Feraly FS. Antitumor agents. II. Tulipinolide, a new germacranolide sesquiterpene, and constunolide. Two cytotoxic substances from Liriodendron tulipifera<\/i> L. J. Pharm. Sci.<\/i>, 58<\/b>, 877\u2013880 (1969).","DOI":"10.1002\/jps.2600580720"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Graziose R, Rathinasabapathy T, Lategan C, Poulev A, Smith PJ, Grace M, Lila MA, Raskin I. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera<\/i> L. J. Ethnopharmacol.<\/i>, 133<\/b>, 26\u201330 (2011).","DOI":"10.1016\/j.jep.2010.08.059"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Hufford CD, Funderburk MJ, Morgan JM, Robertson LW. Two antimicrobial alkaloids from heartwood of Liriodendron tulipifera<\/i> L. J. Pharm. Sci.<\/i>, 64<\/b>, 789\u2013792 (1975).","DOI":"10.1002\/jps.2600640512"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Moon MK, Oh HM, Kwon BM, Baek NI, Kim SH, Kim JS, Kim DK. Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera.<\/i> Arch. Pharm. Res.<\/i>, 30<\/b>, 299\u2013302 (2007).","DOI":"10.1007\/BF02977609"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tullberg-Reinert H, Jundt G. In situ<\/i> measurement of collagen synthesis by human bone cells with a sirius red-based colorimetric microassay: effects of transforming growth factor beta2 and ascorbic acid 2-phosphate. Histochem. Cell Biol.<\/i>, 112<\/b>, 271\u2013276 (1999).","DOI":"10.1007\/s004180050447"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Vermes B, Seligmann O, Wagner H. Synthesis of biologically active tetrahydro-furofuranlignan (syringin, pinoresinol)-mono- and bis-glucosides. Phytochemistry<\/i>, 30<\/b>, 3087\u20133089 (1991).","DOI":"10.1016\/S0031-9422(00)98258-X"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Agrawal PK, Thakur RS. 13<\/sup>C-NMR spectroscopy of lignan and neolignan derivatives. Magn. Reson. Chem.<\/i>, 23<\/b>, 389\u2013418 (1985).","DOI":"10.1002\/mrc.1260230602"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Fang J-M, Lee C-K, Cheng Y-S. Lignans from leaves of Juniperus chinensis.<\/i> Phytochemistry<\/i>, 31<\/b>, 3659\u20133661 (1992).","DOI":"10.1016\/0031-9422(92)83753-L"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kim TH, Ito H, Hayashi K, Hasegawa T, Machiguchi T, Yoshida T. Aromatic constituents from the heartwood of Santalum album<\/i> L. Chem. Pharm. Bull.<\/i>, 53<\/b>, 641\u2013644 (2005).","DOI":"10.1248\/cpb.53.641"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Chang JY, Chang CY, Kuo CC, Chen LT, Wein YS, Kuo YH. Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae<\/i> unge (anshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells. Mol. Pharmacol.<\/i>, 65<\/b>, 77\u201384 (2004).","DOI":"10.1124\/mol.65.1.77"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sinkkonen J, Karonen M, Liimatainen J, Pihlaja K. Lignans from the bark extract of Pinus sylrestin\u2019s<\/i> L. Magn. Reson. Chem.<\/i>, 44<\/b>, 633\u2013636 (2006).","DOI":"10.1002\/mrc.1780"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Lourith N, Katayama T, Suzuki T. Stereochemistry and biosynthesis of 8-O<\/i>-4\u2032 neolignans in Eucommia ulmoides<\/i>: diastereoselective formation of guaiacylglycerol-8-O<\/i>-4\u2032-(sinapyl alcohol) ether. J. Wood Sci.<\/i>, 51<\/b>, 370\u2013378 (2005).","DOI":"10.1007\/s10086-004-0660-0"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Mac\u00edas FA, Lopez A, Varela RM, Torres A, Molinillo JM. Bioactive lignans from a cultivar of Helianthus annuus<\/i>. J. Agric. Food Chem.<\/i>, 52<\/b>, 6443\u20136447 (2004).","DOI":"10.1021\/jf048945d"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Abe F, Yamauchi T. Tanegosides A. B and C, lignan glycosides from Trachelospermum liukiuense<\/i>. Chem. Pharm. Bull.<\/i>, 38<\/b>, 2143\u20132145 (1990).","DOI":"10.1248\/cpb.38.2143"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Rosiak A, Frey W, Christoffers J. Synthesis of tetrahydropyran-4-ones and thiopyran-4-ones from donor-substituted \u03b1-bromostyrene derivatives. Eur. J. Org. Chem.<\/i>, 2006<\/b>, 4044\u20134054 (2006).","DOI":"10.1002\/ejoc.200600372"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Allevi P, Ciuffreda P, Longo A, Anastasia M. Lipase-catalysed chemoselective monoacetylation of hydroxyalkylphenols and chemoselective removal of a single acetyl group from their diacetates. Tetrahedron Asymmetry<\/i>, 9<\/b>, 2915\u20132924 (1998).","DOI":"10.1016\/S0957-4166(98)00285-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Nagao Y, Fujita E, Kohno T, Yagi M. An efficient method for selective acetylation of alcoholic hydroxylgroups. Chem. Pharm. Bull.<\/i>, 29<\/b>, 3202\u20133207 (1981).","DOI":"10.1248\/cpb.29.3202"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ruangrungsi N, Likhitwitaya-wuid K, Kasiwong S, Lange GL, Decicco CP. Constituents of Michelia rajaniana<\/i>. Two new germacranolide amides. J. Nat. Prod.<\/i>, 51<\/b>, 1220\u20131225 (1988).","DOI":"10.1021\/np50060a027"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) \u00c7ali\u015f \u0130, Kuru\u00fcz\u00fcm-UzA, Lorenzetto PA, R\u00fcedi P. (6S<\/i>)-Hydroxy-3-oxo-\u03b1-ionol glucosides from Capparis spinosa<\/i> fruits. Phytochemistry<\/i>, 59<\/b>, 451\u2013457 (2002).","DOI":"10.1016\/S0031-9422(01)00399-5"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kiso K, Ueno S, Fukuda M, Ichi I, Kobayashi K, Sakai T, Fukui K, Kojo S. The role of Kupffer cells in carbon tetrachloride intoxication in mice. Biol. Pharm. Bull.<\/i>, 35<\/b>, 980\u2013983 (2012).","DOI":"10.1248\/bpb.35.980"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Shi J, Aisaki K, Ikawa Y, Wake K, Shi J1. Aisaki K, Ikawa Y, Wake K. Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride. Am. J. Pathol.<\/i>, 153<\/b>, 515\u2013525 (1998).","DOI":"10.1016\/S0002-9440(10)65594-0"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Friedman SL. Hepatic fibrosis\u2014overview. Toxicology<\/i>, 254<\/b>, 120\u2013129 (2008).","DOI":"10.1016\/j.tox.2008.06.013"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Gieling RG, Burt AD, Mann DA. Fibrosis and cirrhosis reversibility\u2014molecular mechanisms. Clin. Liver Dis.<\/i>, 12<\/b>, 915\u2013937, xi (2008).","DOI":"10.1016\/j.cld.2008.07.001"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kisseleva T, Brenner DA. Mechanisms of fibrogenesis. Exp. Biol. Med.<\/i>, 233<\/b>, 109\u2013122 (2008).","DOI":"10.3181\/0707-MR-190"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology<\/i>, 50<\/b>, 1294\u20131306 (2009).","DOI":"10.1002\/hep.23123"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Friedman SL. Liver fibrosis\u2014from bench to beside. J. Hepatol.<\/i>, 38<\/b> (Suppl. 1), S38\u2013S53 (2003).","DOI":"10.1016\/S0168-8278(02)00429-4"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Gin\u00e8s P, Cabrera J, Guevara M, Morillas R, Ruiz del \u00c1rbol L, Sol\u00e0 R, Soriano G. Consensus document on the treatment of ascites, dilutional hyponatremia and hepatorenal syndrome in liver cirrhosis. Gastroenterol. Hepatol.<\/i>, 27<\/b>, 535\u2013544 (2004).","DOI":"10.1157\/13068140"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Wu J, Zern MA. Hepatic stellate cells: a target for the treatment of liver fibrosis. J. Gastroenterol.<\/i>, 35<\/b>, 665\u2013672 (2000).","DOI":"10.1007\/s005350070045"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Chen YW, Li DG, Wu JX, Chen YW, Lu HM. Tetrandrine inhibits activation of rat hepatic stellate cells stimulated by transforming growth factor-b in vitro via<\/i> upregulation of Smad 7. J. Ethnopharmacol.<\/i>, 100<\/b>, 299\u2013305 (2005).","DOI":"10.1016\/j.jep.2005.03.027"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Laskin DL, Sunil VR, Gardner CR, Laskin JD. Macrophages and tissue injury: agents of defense or destruction? Annu. Rev. Pharmacol. Toxicol.<\/i>, 51<\/b>, 267\u2013288 (2011).","DOI":"10.1146\/annurev.pharmtox.010909.105812"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kudlow BA, Stanfel MN, Burtner CR, Johnston ED, Kennedy BK. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol. Biol. Cell<\/i>, 19<\/b>, 5238\u20135248 (2008).","DOI":"10.1091\/mbc.E08-05-0492"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Zhang YQ, Sarge KD. Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J. Cell Biol.<\/i>, 182<\/b>, 35\u201339 (2008).","DOI":"10.1083\/jcb.200712124"},{"key":"37","unstructured":"37) Negi AS, Kumar JK, Luqman S, Saikia D, Khanuja SPS. Antitubercular potential of plants: a brief account of some important molecules. Med. Res. Rev.<\/i>, 30<\/b>, 603\u2013645 (2010)."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Canel C, Moraes RM, Dayan FE, Ferreira D. Podophyllotoxin. Phytochemistry<\/i>, 54<\/b>, 115\u2013120 (2000).","DOI":"10.1016\/S0031-9422(00)00094-7"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Srivastava V, Negi AS, Kumar JK, Gupta MM, Khanuja SPS. Plant-based anticancer molecules: a chemical and biological profile of some important leads. Bioorg. Med. Chem.<\/i>, 13<\/b>, 5892\u20135908 (2005).","DOI":"10.1016\/j.bmc.2005.05.066"},{"key":"40","unstructured":"40) Desb\u00e8ne S, Giorgi-Renault S. Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues. Curr. Med. Chem. Anticancer Agents<\/i>, 2<\/b>, 71\u201390 (2002)."},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Lee KH. Novel antitumor agents from higher plants. Med. Res. Rev.<\/i>, 19<\/b>, 569\u2013596 (1999).","DOI":"10.1002\/(SICI)1098-1128(199911)19:6<569::AID-MED7>3.0.CO;2-9"},{"key":"42","unstructured":"42) Hammerich L, Tacke F. Interleukins in chronic liver disease: lessons learned from experimental mouse models. Clin. Exp. Gastroenterol.<\/i>, 7<\/b>, 297\u2013306 (2014)."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Manuelpillai U, Lourensz D, Vaghjiani V, Tchongue J, Lacey D, Tee JY, Murthi P, Chan J, Hodge A, Sievert W. Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis. PLoS ONE<\/i>, 7<\/b>, e38631 (2012).","DOI":"10.1371\/journal.pone.0038631"},{"key":"44","unstructured":"44) Aggarwal BB, Natarajan K. Tumor necrosis factors: developments during the last decade. Eur. Cytokine Netw.<\/i>, 7<\/b>, 93\u2013124 (1996)."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB, Brenner DA. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hepatology<\/i>, 27<\/b>, 1285\u20131295 (1998).","DOI":"10.1002\/hep.510270514"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Robinson SM, Mann DA. Role of nuclear factor kappaB in liver health and disease. Clin. Sci.<\/i> (London), 118<\/b>, 691\u2013705 (2010).","DOI":"10.1042\/CS20090549"}],"container-title":["Biological & Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/38\/2\/38_b14-00583\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T11:42:31Z","timestamp":1566301351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/38\/2\/38_b14-00583\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b14-00583","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}