{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:21:25Z","timestamp":1790396485705,"version":"4.1.0"},"reference-count":37,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2015]]},"DOI":"10.1248\/bpb.b15-00199","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T22:05:56Z","timestamp":1431122756000},"page":"1054-1062","source":"Crossref","is-referenced-by-count":13,"title":["Adjuvant Effect of an Alternative Plasticizer, Diisopropyl Adipate, on a Contact Hypersensitivity Mouse Model: Link with Sensory Ion Channel TRPA1 Activation"],"prefix":"10.1248","volume":"38","author":[{"given":"Kohta","family":"Kurohane","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Kimura","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Terasawa","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurina","family":"Sahara","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiyu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Laboratory of Food Chemistry, School of Food and Nutritional Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Imai","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Wormuth M, Scheringer M, Vollenweider M, Hungerb\u00fchler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? <i>Risk Anal.<\/i>, <b>26<\/b>, 803\u2013824 (2006).","DOI":"10.1111\/j.1539-6924.2006.00770.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Schecter A, Lorber M, Guo Y, Wu Q, Yun SH, Kannan K, Hommel M, Imran N, Hynan LS, Cheng D, Colacino JA, Birnbaum LS. Phthalate concentrations and dietary exposure from food purchased in New York State. <i>Environ. Health Perspect.<\/i>, <b>121<\/b>, 473\u2013494 (2013).","DOI":"10.1289\/ehp.1206367"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Bornehag C-G, Sundell J, Weschler CJ, Sigsgaard T, Lundgren B, Hasselgren M, H\u00e4gerhed-Engman L. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. <i>Environ. Health Perspect.<\/i>, <b>112<\/b>, 1393\u20131397 (2004).","DOI":"10.1289\/ehp.7187"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Kolarik B, Naydenov K, Larsson M, Bornehag C-G, Sundell J. The association between phthalates in dust and allergic diseases among Bulgarian children. <i>Environ. Health Perspect.<\/i>, <b>116<\/b>, 98\u2013103 (2008).","DOI":"10.1289\/ehp.10498"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Chowdhury MMU, Statham BN. Allergic contact dermatitis from dibutyl phthalate and benzalkonium chloride in Timodine cream. <i>Contact Dermatitis<\/i>, <b>46<\/b>, 57 (2002).","DOI":"10.1034\/j.1600-0536.2002.460115.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Levi K, Kwan A, Rhines AS, Gorcea M, Moore DJ, Dauskardt RH. Emollient molecule effects on the drying stresses in human stratum corneum. <i>Br. J. Dermatol.<\/i>, <b>163<\/b>, 695\u2013703 (2010).","DOI":"10.1111\/j.1365-2133.2010.09937.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Remitz A, Reitamo S, Erkko P, Granlund H, Lauerma AI. Tacrolimus ointment improves psoriasis in a microplaque assay. <i>Br. J. Dermatol.<\/i>, <b>141<\/b>, 103\u2013107 (1999).","DOI":"10.1046\/j.1365-2133.1999.02927.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Takahashi K, Sakano H, Numata N, Kuroda S, Mizuno N. Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin. <i>Drug Dev. Ind. Pharm.<\/i>, <b>28<\/b>, 1285\u20131294 (2002).","DOI":"10.1081\/DDC-120015362"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Shirai MA, Grossmann MVE, Mali S, Yamashita F, Garcia PS, M\u00fcller CMO. Development of biodegradable flexible films of starch and poly(lactic acid) plasticized with adipate or citrate esters. <i>Carbohydr. Polym.<\/i>, <b>92<\/b>, 19\u201322 (2013).","DOI":"10.1016\/j.carbpol.2012.09.038"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Lanigan RS. Final report on the safety assessment of Stearamide DIBA-Stearate. <i>Int. J. Toxicol.<\/i>, <b>20<\/b> (Suppl. 3), 91\u201397 (2001).","DOI":"10.1080\/10915810152630765"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Andersen A. Amended final report of the safety assessment of dibutyl adipate as used in cosmetics. <i>Int. J. Toxicol.<\/i>, <b>25<\/b> (Suppl. 1), 129\u2013134 (2006).","DOI":"10.1080\/10915810600716679"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kripke ML, Munn CG, Jeevan A, Tang JM, Bucana C. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. <i>J. Immunol.<\/i>, <b>145<\/b>, 2833\u20132838 (1990).","DOI":"10.4049\/jimmunol.145.9.2833"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Sato K, Imai Y, Irimura T. Contribution of dermal macrophage trafficking in the sensitization phase of contact hypersensitivity. <i>J. Immunol.<\/i>, <b>161<\/b>, 6835\u20136844 (1998).","DOI":"10.4049\/jimmunol.161.12.6835"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Imai Y, Kondo A, Iizuka H, Maruyama T, Kurohane K. Effects of phthalate esters on the sensitization phase of contact hypersensitivity induced by fluorescein isothiocyanate. <i>Clin. Exp. Allergy<\/i>, <b>36<\/b>, 1462\u20131468 (2006).","DOI":"10.1111\/j.1365-2222.2006.02574.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Denda-Nagai K, Kubota N, Tsuiji M, Kamata M, Irimura T. Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens. <i>Glycobiology<\/i>, <b>12<\/b>, 443\u2013450 (2002).","DOI":"10.1093\/glycob\/cwf061"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Chun KH, Imai Y, Higashi N, Irimura T. Migration of dermal cells expressing a macrophage C-type lectin during the sensitization phase of delayed-type hypersensitivity. <i>J. Leukoc. Biol.<\/i>, <b>68<\/b>, 471\u2013478 (2000).","DOI":"10.1189\/jlb.68.4.471"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Shiba T, Maruyama T, Kurohane K, Iwasaki Y, Watanabe T, Imai Y. TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. <i>J. Neuroimmunol.<\/i>, <b>207<\/b>, 66\u201374 (2009).","DOI":"10.1016\/j.jneuroim.2008.12.001"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Clapham DE. TRP channels as cellular sensors. <i>Nature<\/i>, <b>426<\/b>, 517\u2013524 (2003).","DOI":"10.1038\/nature02196"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Shiba T, Tamai T, Sahara Y, Kurohane K, Watanabe T, Imai Y. Transient receptor potential ankyrin 1 activation enhances hapten sensitization in a T-helper type 2-driven fluorescein isothiocyanate-induced contact hypersensitivity mouse model. <i>Toxicol. Appl. Pharmacol.<\/i>, <b>264<\/b>, 370\u2013376 (2012).","DOI":"10.1016\/j.taap.2012.08.012"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kurohane K, Sahara Y, Kimura A, Narukawa M, Watanabe T, Daimon T, Imai Y. Lack of transient receptor potential melastatin 8 activation by phthalate esters that enhance contact hypersensitivity in mice. <i>Toxicol. Lett.<\/i>, <b>217<\/b>, 192\u2013196 (2013).","DOI":"10.1016\/j.toxlet.2012.12.025"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Maruyama T, Iizuka H, Tobisawa Y, Shiba T, Matsuda T, Kurohane K, Imai Y. Influence of local treatments with capsaicin or allyl isothiocyanate in the sensitization phase of a fluorescein-isothiocyanate-induced contact sensitivity model. <i>Int. Arch. Allergy Immunol.<\/i>, <b>143<\/b>, 144\u2013154 (2007).","DOI":"10.1159\/000099081"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Maruyama T, Shiba T, Iizuka H, Matsuda T, Kurohane K, Imai Y. Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity. <i>Microbiol. Immunol.<\/i>, <b>51<\/b>, 321\u2013326 (2007).","DOI":"10.1111\/j.1348-0421.2007.tb03914.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Matsuda T, Kurohane K, Imai Y. Di-(2-ethylhexyl)phthalate enhances skin sensitization to isocyanate haptens in mice. <i>Toxicol. Lett.<\/i>, <b>192<\/b>, 97\u2013100 (2010).","DOI":"10.1016\/j.toxlet.2009.10.009"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kobayashi C, Kurohane K, Imai Y. High dose dietary pyridoxine induces T-helper type 1 polarization and decreases contact hypersensitivity response to fluorescein isothiocyanate in mice. <i>Biol. Pharm. Bull.<\/i>, <b>35<\/b>, 532\u2013538 (2012).","DOI":"10.1248\/bpb.35.532"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Takeshita K, Yamasaki T, Akira S, Gantner F, Bacon KB. Essential role of MHC II-independent CD4<sup>+<\/sup> T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse. <i>Int. Immunol.<\/i>, <b>16<\/b>, 685\u2013695 (2004).","DOI":"10.1093\/intimm\/dxh073"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Dearman RJ, Kimber I. Role of CD4<sup>+<\/sup> T helper 2-type cells in cutaneous inflammatory responses induced by fluorescein isothiocyanate. <i>Immunology<\/i>, <b>101<\/b>, 442\u2013451 (2000).","DOI":"10.1046\/j.1365-2567.2000.01126.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Larson RP, Zimmerli SC, Comeau MR, Itano A, Omori M, Iseki M, Hauser C, Ziegler SF. Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses. <i>J. Immunol.<\/i>, <b>184<\/b>, 2974\u20132984 (2010).","DOI":"10.4049\/jimmunol.0803478"},{"key":"28","unstructured":"28) Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. <i>J. Allergy Clin. Immunol.<\/i>, <b>133<\/b>, 448\u2013460.e7 (2014)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Chun KH, Imai Y, Higashi N, Irimura T. Involvement of cytokines in the skin-to-lymph node trafficking of cells of the monocyte-macrophage lineage expressing a C-type lectin. <i>Int. Immunol.<\/i>, <b>12<\/b>, 1695\u20131703 (2000).","DOI":"10.1093\/intimm\/12.12.1695"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Saarnilehto M, Chapman H, Savinko T, Lindstedt K, Lauerma AI, Koivisto A. Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist. <i>Allergy<\/i>, <b>69<\/b>, 1424\u20131427 (2014).","DOI":"10.1111\/all.12488"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Matsuda T, Maruyama T, Iizuka H, Kondo A, Tamai T, Kurohane K, Imai Y. Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice. <i>Food Chem. Toxicol.<\/i>, <b>48<\/b>, 1704\u20131708 (2010).","DOI":"10.1016\/j.fct.2010.03.049"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Liu B, Escalera J, Balakrishna S, Fan L, Caceres AI, Robinson E, Sui A, McKay MC, McAlexander MA, Herrick CA, Jordt SE. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. <i>FASEB J.<\/i>, <b>27<\/b>, 3549\u20133563 (2013).","DOI":"10.1096\/fj.13-229948"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, H\u00f6gest\u00e4tt ED, Julius D, Jordt S-E, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>102<\/b>, 12248\u201312252 (2005).","DOI":"10.1073\/pnas.0505356102"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Mikami N, Matsushita H, Kato T, Kawasaki R, Sawazaki T, Kishimoto T, Ogitani Y, Watanabe K, Miyagi Y, Sueda K, Fukada S, Yamamoto H, Tsujikawa K. Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions. <i>J. Immunol.<\/i>, <b>186<\/b>, 6886\u20136893 (2011).","DOI":"10.4049\/jimmunol.1100028"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kueseng P, Thavarungkul P, Kanatharana P. Trace phthalate and adipate esters contaminated in packaged food. <i>J. Environ. Sci. Health B<\/i>, <b>42<\/b>, 569\u2013576 (2007).","DOI":"10.1080\/03601230701389488"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Zhou SN, Moody RP, Aikawa B, Yip A, Wang B, Zhu J. <i>In vitro<\/i> dermal absorption of di(2-ethylhexyl)adipate (DEHA) in a roll-on deodorant using human skin. <i>J. Toxicol. Environ. Health A<\/i>, <b>76<\/b>, 157\u2013166 (2013).","DOI":"10.1080\/15287394.2012.738598"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Simonsson C, Stenfeldt A-L, Karlberg A-T, Ericson MB, Jonsson CAM. The pilosebaceous unit\u2014a phthalate-induced pathway to skin sensitization. <i>Toxicol. Appl. Pharmacol.<\/i>, <b>264<\/b>, 114\u2013120 (2012).","DOI":"10.1016\/j.taap.2012.07.023"}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/38\/7\/38_b15-00199\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T07:26:58Z","timestamp":1691652418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/38\/7\/38_b15-00199\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b15-00199","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}