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Studies on the constituents of the leaves of Trachelospermum asiaticum<\/i> var. intermedium<\/i>. I. Isolation of flavones and flavone glycoside. Yakugaku Zasshi<\/i>, 93<\/b>, 1231\u20131234 (1973).","DOI":"10.1248\/yakushi1947.93.9_1231"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Nishibe S, Hisada S, Inagaki I. Lignans of Trachelospermum asiaticum<\/i> var. intermedium<\/i>. VII. Chemical proof of the position of D-glucose linkage in trachedloside and discussion of trachelogenin derivatives. Yakugaku Zasshi<\/i>, 93<\/b>, 541\u2013545 (1973).","DOI":"10.1248\/yakushi1947.93.4_541"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Li L, Meng F, Guo J, Sun L, Yu N, Zhao Y. Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography\/tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 879<\/b>, 1033\u20131037 (2011).","DOI":"10.1016\/j.jchromb.2011.02.021"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) S\u00f3lyomv\u00e1ry A, Mervai Z, Moln\u00e1r-Perl I, Boldizs\u00e1r I. Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides<\/i> (WILLD.) DC. Nat. Prod. Res.<\/i>, 28<\/b>, 732\u2013739 (2014).","DOI":"10.1080\/14786419.2013.879473"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yoo HH, Park JH, Kwon SW. Kwon, S. W. An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius<\/i>. Biosci. Biotechnol. Biochem.<\/i>, 70<\/b>, 2783\u20132785 (2006).","DOI":"10.1271\/bbb.60290"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tanabe S. Epitope peptides and immunotherapy. Curr. Protein Pept. Sci.<\/i>, 8<\/b>, 109\u2013118 (2007).","DOI":"10.2174\/138920307779941569"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Shin HS, Bae MJ, Jung SY, Shon DH. Inhibitory effect of skullcap (Scutellaria baicalensis<\/i>) extract on ovalbumin permeation in vitro<\/i> and in vivo.<\/i> Food Chem.<\/i>, 140<\/b>, 22\u201330 (2013).","DOI":"10.1016\/j.foodchem.2013.01.042"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nakane PK, Kawaoi A. Peroxidase-labeled antibody. A new method of conjugation. J. Histochem. Cytochem.<\/i>, 22<\/b>, 1084\u20131091 (1974).","DOI":"10.1177\/22.12.1084"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) O\u2019Neill RA, Bhamidipati A, Bi X, Deb-Basu D, Cahill L, Ferrante J, Gentalen E, Glazer M, Gossett J, Hacker K, Kirby C, Knittle J, Loder R, Mastroieni C, Maclaren M, Mills T, Nguyen U, Parker N, Rice A, Roach D, Suich D, Voehringer D, Voss K, Yang J, Yang T, Vander Horn PB. 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