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Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet<\/i>, 370<\/b>, 851\u2013858 (2007).","DOI":"10.1016\/S0140-6736(07)61415-9"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Racagni G, Popoli M. The pharmacological properties of antidepressants. Int. Clin. Psychopharmacol.<\/i>, 25<\/b>, 117\u2013131 (2010).","DOI":"10.1097\/YIC.0b013e3283311acd"},{"key":"3","unstructured":"3) Butler L, Pilkington K. Chinese herbal medicine and depression: the research evidence. eCAM<\/i>, 2013<\/b>, 739716 (2013)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Pilkington K, Rampes H, Richardson J. Complementary medicine for depression. Expert Rev. Neurother.<\/i>, 6<\/b>, 1741\u20131751 (2006).","DOI":"10.1586\/14737175.6.11.1741"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Schrader E. Equivalence of St John\u2019s wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Int. Clin. Psychopharmacol.<\/i>, 15<\/b>, 61\u201368 (2000).","DOI":"10.1097\/00004850-200015020-00001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Gaffney BT, Hugel HM, Rich PA. The effects of Eleutherococcus senticosus<\/i> and Panax ginseng<\/i> on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci.<\/i>, 70<\/b>, 431\u2013442 (2001).","DOI":"10.1016\/S0024-3205(01)01394-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol. Biochem. Behav.<\/i>, 75<\/b>, 547\u2013555 (2003).","DOI":"10.1016\/S0091-3057(03)00110-2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Mei M, Ruan JQ, Wu WJ, Zhou RN, Lei JP, Zhao HY, Yan R, Wang YT. In vitro<\/i> pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba<\/i> L.), and its bacterial metabolite oxyresveratrol in traditional oral use. J. Agric. Food Chem.<\/i>, 60<\/b>, 2299\u20132308 (2012).","DOI":"10.1021\/jf204495t"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Geng CA, Ma YB, Zhang XM, Yao SY, Xue DQ, Zhang RP, Chen JJ. Mulberrofuran G and isomulberrofuran G from Morus alba<\/i> L.: anti-hepatitis B virus activity and mass spectrometric fragmentation. J. Agric. Food Chem.<\/i>, 60<\/b>, 8197\u20138202 (2012).","DOI":"10.1021\/jf302639b"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Fukai T, Hano Y, Hirakura K, Nomura T, Uzawa J, Fukushima K. Structures of two natural hypotensive Diels\u2013Alder type adducts, mulberrofurans F and G, from the cultivated mulberry tree (Morus lhou<\/i> KOIDZ.). Chem. Pharm. Bull.<\/i>, 33<\/b>, 3195\u20133204 (1985).","DOI":"10.1248\/cpb.33.3195"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Singab AN, El-Beshbishy HA, Yonekawa M, Nomura T, Fukai T. Hypoglycemic effect of Egyptian Morus alba<\/i> root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats. J. Ethnopharmacol.<\/i>, 100<\/b>, 333\u2013338 (2005).","DOI":"10.1016\/j.jep.2005.03.013"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Oh H, Ko EK, Jun JY, Oh MH, Park SU, Kang KH, Lee HS, Kim YC. Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba<\/i>. Planta Med.<\/i>, 68<\/b>, 932\u2013934 (2002).","DOI":"10.1055\/s-2002-34930"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kang TH, Oh HR, Jung SM, Ryu JH, Park MW, Park YK, Kim SY. Enhancement of neuroprotection of mulberry leaves (Morus alba<\/i> L.) prepared by the anaerobic treatment against ischemic damage. Biol. Pharm. Bull.<\/i>, 29<\/b>, 270\u2013274 (2006).","DOI":"10.1248\/bpb.29.270"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Kim HM, Han SB, Lee KH, Lee CW, Kim CY, Lee EJ, Huh H. Immunomodulating activity of a polysaccharide isolated from Mori Cortex Radicis. Arch. Pharm. Res.<\/i>, 23<\/b>, 240\u2013242 (2000).","DOI":"10.1007\/BF02976452"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Nade VS, Yadav AV. Anti-stress effect of ethyl acetate soluble fraction of Morus alba<\/i> in chronic restraint stress. Pharmaceutical Biology<\/i>, 48<\/b>, 1038\u20131046 (2010).","DOI":"10.3109\/13880200903473741"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Lee MS, Park WS, Kim YH, Kwon SH, Jang YJ, Han D, Morita K, Her S. Antidepressant-like effects of Cortex Mori Radicis extract via<\/i> bidirectional phosphorylation of glucocorticoid receptors in the hippocampus. Behav. Brain Res.<\/i>, 236<\/b>, 56\u201361 (2013).","DOI":"10.1016\/j.bbr.2012.08.028"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Nade VS, Kawale LA, Naik RA, Yadav AV. Adaptogenic effect of Morus alba<\/i> on chronic footshock-induced stress in rats. Indian J. Pharmacol.<\/i>, 41<\/b>, 246\u2013251 (2009).","DOI":"10.4103\/0253-7613.59921"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Lim DW, Kim YT, Park JH, Baek NI, Han D. Antidepressant-like effects of the ethyl acetate soluble fraction of the root bark of Morus alba<\/i> on the immobility behavior of rats in the forced swim test. Molecules<\/i>, 19<\/b>, 7981\u20137989 (2014).","DOI":"10.3390\/molecules19067981"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci.<\/i>, 23<\/b>, 238\u2013245 (2002).","DOI":"10.1016\/S0165-6147(02)02017-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Pechnick RN, Chesnokova VM, Kariagina A, Price S, Bresee CJ, Poland RE. Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) gene. Neuropsychopharmacology<\/i>, 29<\/b>, 770\u2013776 (2004).","DOI":"10.1038\/sj.npp.1300402"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) de Medeiros MA, Carlos Reis L, Eugenio Mello L. Stress-induced c-Fos expression is differentially modulated by dexamethasone, diazepam and imipramine. Neuropsychopharmacology<\/i>, 30<\/b>, 1246\u20131256 (2005).","DOI":"10.1038\/sj.npp.1300694"},{"key":"22","unstructured":"22) Twardowska K, Rybakowski J. Limbic\u2013hypothalamic\u2013pituitary\u2013adrenal axis in depression: literature review. Psychiatr. Pol.<\/i>, 30<\/b>, 741\u2013755 (1996)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Aihara M, Ida I, Yuuki N, Oshima A, Kumano H, Takahashi K, Fukuda M, Oriuchi N, Endo K, Matsuda H, Mikuni M. HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic\/paralimbic regions. Psychiatry Res.<\/i>, 155<\/b>, 245\u2013256 (2007).","DOI":"10.1016\/j.pscychresns.2006.11.002"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Pariante CM, Miller AH. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry<\/i>, 49<\/b>, 391\u2013404 (2001).","DOI":"10.1016\/S0006-3223(00)01088-X"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Jankord R, Herman JP. Limbic regulation of hypothalamo\u2013pituitary\u2013adrenocortical function during acute and chronic stress. Ann. N. Y. Acad. Sci.<\/i>, 1148<\/b>, 64\u201373 (2008).","DOI":"10.1196\/annals.1410.012"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology<\/i>, 177<\/b>, 245\u2013255 (2005).","DOI":"10.1007\/s00213-004-2048-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Renard CE, Dailly E, David DJ, Hascoet M, Bourin M. Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension test. Fundam. Clin. Pharmacol.<\/i>, 17<\/b>, 449\u2013455 (2003).","DOI":"10.1046\/j.1472-8206.2003.00160.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology<\/i>, 121<\/b>, 66\u201372 (1995).","DOI":"10.1007\/BF02245592"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Detke MJ, Johnson J, Lucki I. Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Exp. Clin. Psychopharmacol.<\/i>, 5<\/b>, 107\u2013112 (1997).","DOI":"10.1037\/1064-1297.5.2.107"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Bain MJ, Dwyer SM, Rusak B. Restraint stress affects hippocampal cell proliferation differently in rats and mice. Neurosci. Lett.<\/i>, 368<\/b>, 7\u201310 (2004).","DOI":"10.1016\/j.neulet.2004.04.096"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Navarro JF, Rivera A, Maldonado E, Cavas M, de la Calle A. Anxiogenic-like activity of 3,4-methylenedioxy-methamphetamine (\u201cEcstasy\u201d) in the social interaction test is accompanied by an increase of c-fos expression in mice amygdala. Prog. Neuropsychopharmacol. Biol. Psychiatry<\/i>, 28<\/b>, 249\u2013254 (2004).","DOI":"10.1016\/j.pnpbp.2003.10.016"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Choi SH, Chung S, Cho JH, Cho YH, Kim JW, Kim JM, Kim HJ, Kim HJ, Shin KH. Changes in c-Fos expression in the forced swimming test: Common and distinct modulation in rat brain by desipramine and citalopram. Korean J. Physiol. Pharmacol.<\/i>, 17<\/b>, 321\u2013329 (2013).","DOI":"10.4196\/kjpp.2013.17.4.321"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev.<\/i>, 19<\/b>, 269\u2013301 (1998).","DOI":"10.1210\/er.19.3.269"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Seckl JR, Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo<\/i>. Neuroendocrinology<\/i>, 55<\/b>, 621\u2013626 (1992).","DOI":"10.1159\/000126180"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Savitz J, Lucki I, Drevets WC. 5-HT(1A) receptor function in major depressive disorder. Prog. Neurobiol.<\/i>, 88<\/b>, 17\u201331 (2009).","DOI":"10.1016\/j.pneurobio.2009.01.009"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Pietranera L, Saravia FE, Roig P, Lima A, De Nicola AF. Protective effects of estradiol in the brain of rats with genetic or mineralocorticoid-induced hypertension. Psychoneuroendocrinology<\/i>, 33<\/b>, 270\u2013281 (2008).","DOI":"10.1016\/j.psyneuen.2007.11.009"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Chalmers DT, Kwak SP, Mansour A, Akil H, Watson SJ. Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. J. Neurosci.<\/i>, 13<\/b>, 914\u2013923 (1993).","DOI":"10.1523\/JNEUROSCI.13-03-00914.1993"},{"key":"38","unstructured":"38) Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem.<\/i>, 40<\/b>, 288\u2013295 (1994)."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Celada P, Bortolozzi A, Artigas F. Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research. CNS Drugs<\/i>, 27<\/b>, 703\u2013716 (2013).","DOI":"10.1007\/s40263-013-0071-0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Mayorga AJ, Dalvi A, Page ME, Zimov-Levinson S, Hen R, Lucki I. Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice. J. Pharmacol. Exp. Ther.<\/i>, 298<\/b>, 1101\u20131107 (2001).","DOI":"10.1016\/S0022-3565(24)29479-9"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Wieland S, Lucki I. Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test. Psychopharmacology<\/i>, 101<\/b>, 497\u2013504 (1990).","DOI":"10.1007\/BF02244228"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) O\u2019Neill MF, Conway MW. Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology<\/i>, 24<\/b>, 391\u2013398 (2001).","DOI":"10.1016\/S0893-133X(00)00196-2"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Chen HX, Jin ZL, Zhang LM, Xue R, Xu XD, Zhao N, Qiu ZK, Wang XW, Zhang YZ, Yang RF, Li YF. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PLoS ONE<\/i>, 8<\/b>, e83271 (2013).","DOI":"10.1371\/journal.pone.0083271"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Leitch MM, Ingram CD, Young AH, McQuade R, Gartside SE. Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. 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