{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:30:48Z","timestamp":1764131448730},"reference-count":30,"publisher":"Pharmaceutical Society of Japan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1248\/bpb.b15-00849","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T22:07:22Z","timestamp":1450735642000},"page":"409-414","source":"Crossref","is-referenced-by-count":25,"title":["Anti-obesity Effect of &lt;i&gt;Dioscorea oppositifolia&lt;\/i&gt; Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization"],"prefix":"10.1248","volume":"39","author":[{"given":"Eun Ju","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Agronomy & Medicinal Plant Resources, College of Life Sciences and Natural Resources, Gyeongnam National University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghwan","family":"Jegal","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongmin","family":"Ahn","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwoong","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Hye","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Guyenet SJ, Schwartz MW. Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. <i>J. Clin. Endocrinol. Metab.<\/i>, <b>97<\/b>, 745\u2013755 (2012).","DOI":"10.1210\/jc.2011-2525"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. <i>JAMA<\/i>, <b>298<\/b>, 2028\u20132037 (2007).","DOI":"10.1001\/jama.298.17.2028"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Nikolopoulou A, Kadoglou NP. Obesity and metabolic syndrome as related to cardiovascular disease. <i>Expert Rev. Cardiovasc. Ther.<\/i>, <b>10<\/b>, 933\u2013939 (2012).","DOI":"10.1586\/erc.12.74"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Okifuji A, Hare BD. The association between chronic pain and obesity. <i>J. Pain Res.<\/i>, <b>8<\/b>, 399\u2013408 (2015).","DOI":"10.2147\/JPR.S55598"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Yun JW. Possible anti-obesity therapeutics from nature\u2014A review. <i>Phytochemistry<\/i>, <b>71<\/b>, 1625\u20131641 (2010).","DOI":"10.1016\/j.phytochem.2010.07.011"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Vasudeva N, Yadav N, Sharma SK. Natural products: a safest approach for obesity. <i>Chin. J. Integr. Med.<\/i>, <b>18<\/b>, 473\u2013480 (2012).","DOI":"10.1007\/s11655-012-1120-0"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Williams DJ, Edwards D, Hamernig I, Jian L, James AP, Johnson SK, Tapsell LC. Vegetables containing phytochemicals with potential anti-obesity properties: A review. <i>Food Res. Int.<\/i>, <b>52<\/b>, 323\u2013333 (2013).","DOI":"10.1016\/j.foodres.2013.03.015"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Yang MH, Chin YW, Yoon KD, Kim J. Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (<i>Dioscorea opposita<\/i>). <i>J. Enzyme Inhib. Med. Chem.<\/i>, <b>29<\/b>, 1\u20136 (2014).","DOI":"10.3109\/14756366.2012.742517"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yang MH, Chin YW, Chae HS, Yoon KD, Kim J. Anti-adipogenic constituents from <i>Dioscorea opposita<\/i> in 3T3-L1 Cells. <i>Biol. Pharm. Bull.<\/i>, <b>37<\/b>, 1683\u20131688 (2014).","DOI":"10.1248\/bpb.b14-00216"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kwon CS, Sohn HY, Kim SH, Kim JH, Son KH, Lee JS, Lim JK, Kim JS. Anti-obesity effect of <i>Dioscorea nipponica<\/i> MAKINO with lipase-inhibitory activity in rodents. <i>Biosci. Biotechnol. Biochem.<\/i>, <b>67<\/b>, 1451\u20131456 (2003).","DOI":"10.1271\/bbb.67.1451"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Maithili V, Dhanabal SP, Mahendran S, Vadivelan R. Antidiabetic activity of ethanolic extract of tubers of <i>Dioscorea alata<\/i> in alloxan induced diabetic rats. <i>Indian J. Pharmacol.<\/i>, <b>43<\/b>, 455\u2013459 (2011).","DOI":"10.4103\/0253-7613.83121"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Zhao HL, Cho KH, Ha YW, Jeong TS, Lee WS, Kim YS. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. <i>Eur. J. Pharmacol.<\/i>, <b>537<\/b>, 166\u2013173 (2006).","DOI":"10.1016\/j.ejphar.2006.03.032"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Son IS, Kim JH, Sohn HY, Son KH, Kim JS, Kwon CS. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (<i>Dioscorea<\/i> spp.), on high-cholesterol fed rats. <i>Biosci. Biotechnol. Biochem.<\/i>, <b>71<\/b>, 3063\u20133071 (2007).","DOI":"10.1271\/bbb.70472"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. <i>Clin. Chem.<\/i>, <b>18<\/b>, 499\u2013502 (1972).","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Aziz N, Mehmood MH, Mandukhal SR, Bashir S, Raoof S, Giliani AH. Antihypertensive, antioxidant, antidyslipidemic and endothelial modulating activities of a polyherbal formulation (POL-10). <i>Vascul. Pharmacol.<\/i>, <b>50<\/b>, 57\u201364 (2009).","DOI":"10.1016\/j.vph.2008.09.003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. <i>Can. J. Biochem. Physiol.<\/i>, <b>37<\/b>, 911\u2013917 (1959).","DOI":"10.1139\/o59-099"},{"key":"17","unstructured":"17) Kinosian B, Glick H, Preiss L, Puder KL. Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios. <i>J. Investig. Med.<\/i>, <b>43<\/b>, 443\u2013450 (1995)."},{"key":"18","unstructured":"18) Yoon KD, Yang MH, Nam SI, Park JH, Kim YC, Kim J. Phenanthrene derivatives, 3,5-dimethoxyphenanthrene-2,7-diol and batatasin-1, as non-polar standard marker compounds for <i>Dioscorea<\/i> Rhizoma. <i>Nat. Prod. Sci.<\/i>, <b>13<\/b>, 378\u2013383 (2007)."},{"key":"19","unstructured":"19) Burton BT, Foster WR, Hirsch J, Van Itallie TB. Health implications of obesity: NIH consensus development conference. <i>Int. J. Obes. Relat. Metab. Disord.<\/i>, <b>9<\/b>, 155\u2013170 (1985)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kotchen TA, Kotchen JM, Boegehold MA. Nutrition and hypertension prevention. <i>Hypertension<\/i>, <b>18<\/b> (Suppl.), I115\u2013I120 (1991).","DOI":"10.1161\/01.HYP.18.3_Suppl.I115"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. <i>JAMA<\/i>, <b>282<\/b>, 1523\u20131529 (1999).","DOI":"10.1001\/jama.282.16.1523"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Hu CC, Qing K, Chen Y. Diet-induced changes in stearoyl-CoA desatturase 1 expression in obesity-prone and -resistant mice. <i>Obes. Res.<\/i>, <b>12<\/b>, 1264\u20131270 (2004).","DOI":"10.1038\/oby.2004.160"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Vaanholt LM, Jonas I, Doornbos M, Schubert KA, Nyakas C, Garland T, Visser GH, van Dijk G. Metabolic and behavioral responses to high-fat feeding in mice selectively bred for high wheel-running activity. <i>Int. J. Obes.<\/i>, <b>32<\/b>, 1566\u20131575 (2008).","DOI":"10.1038\/ijo.2008.136"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Atangwho IJ, Edet EE, Uti DE, Obi AU, Asmawi MZ, Ahmad M. Biochemical and histological impact of <i>Vernonia amygdalina<\/i> supplemented diet in obese rats. <i>Saudi J. Biol. Sci.<\/i>, <b>19<\/b>, 385\u2013392 (2012).","DOI":"10.1016\/j.sjbs.2012.05.003"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) de Melo CL, Queiroz MG, Fonseca SG, Bizerra AM, Lemos TL, Melo TS, Santos FA, Rao VS. Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. <i>Chem. Biol. Interact.<\/i>, <b>185<\/b>, 59\u201365 (2010).","DOI":"10.1016\/j.cbi.2010.02.028"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Shi Y, Burn P. Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. <i>Nat. Rev. Drug Discov.<\/i>, <b>3<\/b>, 695\u2013710 (2004).","DOI":"10.1038\/nrd1469"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Birari RB, Bhutani KK. Pancreatic lipase inhibitors from natural sources: unexplored potential. <i>Drug Discov. Today<\/i>, <b>12<\/b>, 879\u2013889 (2007).","DOI":"10.1016\/j.drudis.2007.07.024"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Yamamoto M, Shimura S, Itoh Y, Ohsaka T, Egawa M, Inoue S. Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, <i>Nomame<\/i> Herba, on rats fed a high-fat diet. <i>Int. J. Obes. Relat. Metab. Disord.<\/i>, <b>24<\/b>, 758\u2013764 (2000).","DOI":"10.1038\/sj.ijo.0801222"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Yoshikawa M, Shimoda H, Nishida N, Takada M, Matsuda H. <i>Salacia reticulata<\/i> and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. <i>J. Nutr.<\/i>, <b>132<\/b>, 1819\u20131824 (2002).","DOI":"10.1093\/jn\/132.7.1819"},{"key":"30","unstructured":"30) Yoon KD, Yang MH, Chin YW, Kim Y, Kim H, Choi K, Park JH, Kim J. Development of gradient centrifugal partition chromatography method and its application for the isolation of 3,5-dimethoxyphenanthrene-2,7-diol and batatasin-I from <i>Dioscorea oppositifolia.<\/i> <i>Nat. Prod. Sci.<\/i>, <b>15<\/b>, 144\u2013150 (2009)."}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/39\/3\/39_b15-00849\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T02:21:52Z","timestamp":1599963712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/39\/3\/39_b15-00849\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b15-00849","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}