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Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells. <i>Pharmacol. Rep.<\/i>, <b>60<\/b>, 12\u201320 (2008)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Burnstock G. Purinergic regulation of vascular tone and remodelling. <i>Auton. Autacoid Pharmacol.<\/i>, <b>29<\/b>, 63\u201372 (2009).","DOI":"10.1111\/j.1474-8673.2009.00435.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Cekic C, Linden J. Purinergic regulation of the immune system. <i>Nat. Rev. Immunol.<\/i>, <b>16<\/b>, 177\u2013192 (2016).","DOI":"10.1038\/nri.2016.4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ferrari D, Vitiello L, Idzko M, la Sala A. Purinergic signaling in atherosclerosis. <i>Trends Mol. Med.<\/i>, <b>21<\/b>, 184\u2013192 (2015).","DOI":"10.1016\/j.molmed.2014.12.008"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Fuentes E, Palomo I. Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules. <i>Vascul. Pharmacol.<\/i>, <b>75<\/b>, 1\u20136 (2015).","DOI":"10.1016\/j.vph.2015.05.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Hechler B, Gachet C. Purinergic receptors in thrombosis and inflammation. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, <b>35<\/b>, 2307\u20132315 (2015).","DOI":"10.1161\/ATVBAHA.115.303395"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Idzko M, Ferrari D, Riegel AK, Eltzschig HK. Extracellular nucleotide and nucleoside signaling in vascular and blood disease. <i>Blood<\/i>, <b>124<\/b>, 1029\u20131037 (2014).","DOI":"10.1182\/blood-2013-09-402560"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lohman AW, Billaud M, Isakson BE. Mechanisms of ATP release and signalling in the blood vessel wall. <i>Cardiovasc. 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Mechanisms underlying reduced P2Y(1)-receptor-mediated relaxation in superior mesenteric arteries from long-term streptozotocin-induced diabetic rats. <i>Acta Physiol.<\/i>, <b>207<\/b>, 130\u2013141 (2013).","DOI":"10.1111\/j.1748-1716.2012.02469.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Matsumoto T, Tostes RC, Webb RC. Alterations in vasoconstrictor responses to the endothelium-derived contracting factor uridine adenosine tetraphosphate are region specific in DOCA-salt hypertensive rats. <i>Pharmacol. Res.<\/i>, <b>65<\/b>, 81\u201390 (2012).","DOI":"10.1016\/j.phrs.2011.09.005"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Matsumoto T, Tostes RC, Webb RC. Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. <i>Am. J. Physiol. Heart Circ. 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