{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:42:35Z","timestamp":1772660555939,"version":"3.50.1"},"reference-count":149,"publisher":"Pharmaceutical Society of Japan","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1248\/bpb.b16-00453","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T22:12:41Z","timestamp":1472681561000},"page":"1397-1411","source":"Crossref","is-referenced-by-count":18,"title":["Diagnostic Approach to Disease Using Non-invasive Samples Based on Derivatization and LC-ESI-MS\/MS"],"prefix":"10.1248","volume":"39","author":[{"given":"Toshimasa","family":"Toyo\u2019oka","sequence":"first","affiliation":[{"name":"Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Imai K, Toyo\u2019oka T, Watanabe Y. A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate. Anal. Biochem.<\/i>, 128<\/b>, 471\u2013473 (1983).","DOI":"10.1016\/0003-2697(83)90404-9"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Toyo\u2019oka T, Imai K. High-performance liquid chromatography and fluorometric detection of biologically important thiols derivatized with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate (SBD-F). J. Chromatogr. A<\/i>, 282<\/b>, 495\u2013500 (1983).","DOI":"10.1016\/S0021-9673(00)91626-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Toyo\u2019oka T, Imai K. Fluorescence analysis of thiols with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate. Analyst<\/i>, 109<\/b>, 1003\u20131007 (1984).","DOI":"10.1039\/an9840901003"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Toyo\u2019oka T, Imai K, Kawahara Y. Determination of total captopril in dog plasma by HPLC after prelabeling with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate (SBD-F). J. Pharm. Biomed. Anal.<\/i>, 2<\/b>, 473\u2013479 (1984).","DOI":"10.1016\/0731-7085(84)80050-3"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Toyo\u2019oka T. Recent advances in separation and detection methods for thiol compounds in biological samples. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 877<\/b>, 3318\u20133330 (2009).","DOI":"10.1016\/j.jchromb.2009.03.034"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Imai K, Toyo\u2019oka T. Fluorometric assay of thiols with fluorobenzoxadiazole. Methods in Enzymol<\/i>., Vol. 143, Academic Press, New York, pp. 67\u201375 (1987).","DOI":"10.1016\/0076-6879(87)43014-0"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Sueyoshi T, Miyata T, Iwanaga S, Toyo\u2019oka T, Imai K. Application of a fluorogenic reagent, ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate for detection of cysteine-containing peptides. J. Biochem.<\/i>, 97<\/b>, 1811\u20131813 (1985).","DOI":"10.1093\/oxfordjournals.jbchem.a135241"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Toyo\u2019oka T, Okudaira K, Kurihara M, Miyata N, Takahashi A, Suzuki T, Saito Y. Determination of N<\/i>-acetyl-S<\/i>-carbethoxycysteine in rat and mouse urines by high-performance liquid chromatography with fluorescence detection. Anal. Chim. Acta<\/i>, 226<\/b>, 109\u2013119 (1989).","DOI":"10.1016\/S0003-2670(00)80908-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Inoue K, Nishimura M, Tsutsui H, Min JZ, Todoroki K, Kauffmann JM, Toyo\u2019oka T. Foodomics platform for the assay of thiols in wines with fluorescence derivatization and ultra performance liquid chromatography mass spectrometry using multivariate statistical analysis. J. Agric. Food Chem.<\/i>, 61<\/b>, 1228\u20131234 (2013).","DOI":"10.1021\/jf304822t"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Toyo\u2019oka T, Imai K. New fluorogenic reagent having halogenobenzofurazan structure for thiols: 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole. Anal. Chem.<\/i>, 56<\/b>, 2461\u20132464 (1984).","DOI":"10.1021\/ac00277a044"},{"key":"11","unstructured":"11) Toyo\u2019oka T, Miyano H, Imai K. Application of fluorogenic reagents (ABD-F and NBD-F) to analysis of proteins and peptides. Peptide Chem.<\/i>, 403\u2013408 (1986)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Toyo\u2019oka T, Miyano H, Imai K. Amino acid composition analysis of minute amounts of cysteine-containing proteins using 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole and 4-fluoro-7-nitro-2,1,3-benzoxadiazole in combination with HPLC. Biomed. Chromatogr.<\/i>, 1<\/b>, 15\u201320 (1986).","DOI":"10.1002\/bmc.1130010105"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Toyo\u2019oka T, Uchiyama S, Saito Y, Imai K. Simultaneous determination of thiols and disulfides by HPLC with fluorescence detection. Anal. Chim. Acta<\/i>, 205<\/b>, 29\u201341 (1988).","DOI":"10.1016\/S0003-2670(00)82313-2"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Toyo\u2019oka T, Furukawa F, Suzuki T, Saito Y, Takahashi M, Hayashi Y, Uzu S, Imai K. Determination of thiols and disulfides in normal rat tissues and hamster pancreas treated with N<\/i>-nitrosobis(2-oxopropyl)amine using 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole and ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate. Biomed. Chromatogr.<\/i>, 3<\/b>, 166\u2013172 (1989).","DOI":"10.1002\/bmc.1130030406"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Toyo\u2019oka T, Imai K. Isolation and characterization of cysteine containing regions of proteins using 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole and high-performance liquid chromatography. Anal. Chem.<\/i>, 57<\/b>, 1931\u20131937 (1985).","DOI":"10.1021\/ac00286a032"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Toyo\u2019oka T, Suzuki T, Saito Y, Uzu S, Imai K. 4-(N<\/i>,N<\/i>-dimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole: A new fluorogenic reagent for thiols. Analyst<\/i>, 114<\/b>, 413\u2013419 (1989).","DOI":"10.1039\/AN9891400413"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Toyo\u2019oka T, Suzuki T, Saito Y, Uzu S, Imai K. Evaluation of benzofurazan derivatives as fluorogenic reagents for thiols and amines using high-performance liquid chromatography. Analyst<\/i>, 114<\/b>, 1233\u20131240 (1989).","DOI":"10.1039\/an9891401233"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Toyo\u2019oka T, Ishibashi M, Terao T. Sensitive determination of N-terminal prolyl-peptides by high-performance liquid chromatography with laser-induced fluorescence detection. J. Chromatogr. A<\/i>, 661<\/b>, 105\u2013112 (1994).","DOI":"10.1016\/0021-9673(94)85182-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Toyo\u2019oka T, Ishibashi M, Takeda Y, Imai K. 4-(Aminosulfonyl)-2,1,3-benzoxadiazole derivatives as pre-column fluorogenic tagging reagents for carboxylic acids in high-performance liquid chromatography. Analyst<\/i>, 116<\/b>, 609\u2013613 (1991).","DOI":"10.1039\/an9911600609"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Toyo\u2019oka T, Ishibashi M, Takeda Y, Nakashima K, Akiyama S, Uzu S, Imai K. Precolumn fluorescence tagging reagent for carboxylic acid in high-performance liquid chromatography: 4-Substituted-7-aminoalkylamino-2,1,3-benzoxadiazoles. J. Chromatogr. A<\/i>, 588<\/b>, 61\u201371 (1991).","DOI":"10.1016\/0021-9673(91)85008-4"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Toyo\u2019oka T, Ishibashi M, Terao T, Imai K. Sensitive fluorometric detection of prostaglandins by high-performance liquid chromatography after pre-column labeling with 4-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-7-(1-piperazinyl)-2,1,3-benzoxadiazole (DBD-PZ). Biomed. Chromatogr.<\/i>, 6<\/b>, 143\u2013148 (1992).","DOI":"10.1002\/bmc.1130060310"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Imai K, Toyo\u2019oka T, Miyano H. Fluorogenic reagents for primary and secondary amines and thiols in high-performance liquid chromatography. A review. Analyst<\/i>, 109<\/b>, 1365\u20131373 (1984).","DOI":"10.1039\/an9840901365"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Imai K, Uzu S, Toyo\u2019oka T. Fluorogenic reagent, having benzofurazan structere, in liquid chromatography. J. Pharm. Biomed. Anal.<\/i>, 7<\/b>, 1395\u20131403 (1989).","DOI":"10.1016\/0731-7085(89)80144-X"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Toyo\u2019oka T. Development of chiral derivatization reagents having benzofurazan (2,1,3-benzoxadiazole) fluorophore for HPLC analysis and their application to the sensitive detection of biologically important compounds. Bunseki Kagaku<\/i>, 51<\/b>, 339\u2013358 (2002).","DOI":"10.2116\/bunsekikagaku.51.339"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Toyo\u2019oka T. Fluorescent tagging of physiologically important carboxylic acids, including fatty acids, for their detection in liquid chromatography. Anal. Chim. Acta<\/i>, 465<\/b>, 111\u2013130 (2002).","DOI":"10.1016\/S0003-2670(02)00398-7"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Toyo\u2019oka T. The use of derivatization to improve the chromatographic properties and detection selectivity of physiologically important carboxylic acids. J. Chromatogr. B Biomed. Appl.<\/i>, 671<\/b>, 91\u2013112 (1995).","DOI":"10.1016\/0378-4347(94)00559-N"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Imai K, Toyo\u2019oka T. Design and choice of suitable labelling reagents for liquid chromatography (Chapter 4) in selective sample handling and detection in high-performance liquid chromatography. J. Chromatogr. Lib.<\/i>, 39<\/b>, 209\u2013288 (1988).","DOI":"10.1016\/S0301-4770(08)60380-2"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Toyo\u2019oka T. Recent progress in liquid chromatographic enantioseparation based upon diastereomer formation with fluorescent chiral derivatization reagents. Biomed. Chromatogr.<\/i>, 10<\/b>, 265\u2013277 (1996).","DOI":"10.1002\/(SICI)1099-0801(199611)10:6<265::AID-BMC602>3.0.CO;2-A"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Toyo\u2019oka T. Resolution of chiral drugs by liquid chromatography based upon diastereomer formation with chiral derivatization reagents. J. Biochem. Biophys. Methods<\/i>, 54<\/b>, 25\u201356 (2002).","DOI":"10.1016\/S0165-022X(02)00127-6"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Toyo\u2019oka T. Fluorescent chiral derivatization reagents possessing benzofurazan structure for the resolution of optical isomers in HPLC: The synthesis, characteristics and application. Current Pharmaceutical Analysis<\/i>, 1<\/b>, 57\u201364 (2005).","DOI":"10.2174\/1573412052953364"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Toyo\u2019oka T. Development of benzofurazan-bearing fluorescence labeling reagents for separation and detection in high-performance liquid chromatography. Chromatography<\/i>, 33<\/b>, 1\u201317 (2012).","DOI":"10.15583\/jpchrom.2012.001"},{"key":"32","unstructured":"32) Toyo\u2019oka T. Derivatization for resolution of chiral compounds (Chapter 6). Modern Derivatization Methods for Separation Sciences<\/i>. (Toyo\u2019oka T ed.) John Wiley & Sons, Chichester, England, pp. 217\u2013289 (1999)."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Toyo\u2019oka T. Indirect Enantioseparation by HPLC Using Chiral Benzofurazan-Bearing Reagents. Methods in Molecular Biology<\/i>. Chiral Separations: Methods and Protocols. (Gubitz G, Schmid MG eds.) Vol. 243, Humana Press, Totawa, NJ, pp. 231\u2013246 (2003).","DOI":"10.1385\/1-59259-648-7:231"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Toyo\u2019oka T. Chiral Benzofurazan-Derived Derivatization Reagents for Indirect Enantioseparations by HPLC (Chapter 14). Chiral Separations: Methods and Protocols<\/i>, 2nd Ed. (Gerhard KE ed.) Methods in Molecular Biology<\/i>, Vol. 970, Humana Press Totawa, NJ, pp. 233\u2013248 (2013).","DOI":"10.1007\/978-1-62703-263-6_14"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Toyo\u2019oka T, Liu YM. Development of optically active fluorescent \u201cEdman-type\u201d reagents. Analyst<\/i>, 120<\/b>, 385\u2013390 (1995).","DOI":"10.1039\/an9952000385"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Toyo\u2019oka T, Liu YM. High-performance liquid chromatographic resolution of amino acid enantiomers derivatized with fluorescent chiral Edman reagents. J. Chromatogr. A<\/i>, 689<\/b>, 23\u201330 (1995).","DOI":"10.1016\/0021-9673(94)00978-I"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Liu YM, Miao JR, Toyo\u2019oka T. Enantiomeric separation of di- and tri-peptides with chiral fluorescence labelling reagents by liquid chromatography. Anal. Chim. Acta<\/i>, 314<\/b>, 169\u2013173 (1995).","DOI":"10.1016\/0003-2670(95)00270-A"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Jin D, Toyo\u2019oka T. Indirect resolution of thiol enantiomers by high-performance liquid chromatography with a fluorescent chiral tagging reagent. Analyst<\/i>, 123<\/b>, 1271\u20131277 (1998).","DOI":"10.1039\/a800712h"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Liu YM, Schneider M, Sticha CM, Toyo\u2019oka T, Sweedler JV. Separation of amino acid and peptide stereoisomers by nonionic micelle-mediated capillary electrophoresis after chiral derivatization. J. Chromatogr. A<\/i>, 800<\/b>, 345\u2013354 (1998).","DOI":"10.1016\/S0021-9673(97)01137-0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Jin D, Nagakura K, Murofushi S, Miyahara T, Toyo\u2019oka T. Total resolution of 17 DL-amino acids labelled with a fluorescent chiral reagent, R<\/i>(\u2212)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, by high-performance liquid chromatography. J. Chromatogr. A<\/i>, 822<\/b>, 215\u2013224 (1998).","DOI":"10.1016\/S0021-9673(98)00617-7"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Min JZ, Toyo\u2019oka T, Fukushima T, Kato M. Synthesis and evaluation of new fluorescent derivatization reagents for resolution of chiral amines by RP-HPLC. Anal. Chim. Acta<\/i>, 515<\/b>, 243\u2013253 (2004).","DOI":"10.1016\/j.aca.2004.03.097"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Min JZ, Toyo\u2019oka T, Kato M, Fukushima T. Synthesis of fluorescent label, DBD-\u03b2-proline, and the resolution efficiency for chiral amines by reversed-phase chromatography. Biomed. Chromatogr.<\/i>, 19<\/b>, 43\u201350 (2005).","DOI":"10.1002\/bmc.414"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Inagaki S, Taniguchi S, Hirashima H, Higashi T, Min JZ, Kikura-Hanajiri R, Goda Y, Toyo\u2019oka T. HPLC enantioseparation of \u03b1,\u03b1-diphenyl-2-pyrrolidinemethanol and methylphenidate using a chiral fluorescent derivatization reagent and its application to the analysis of rat plasma. J. Sep. Sci.<\/i>, 33<\/b>, 3137\u20133143 (2010).","DOI":"10.1002\/jssc.201000479"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Iizuka H, Hirasa Y, Kubo K, Ishii K, Toyo\u2019oka T, Fukushima T. Enantiomeric separation of D,L-tryptophan and D,L-kynurenine by HPLC using pre-column fluorescence derivatization with R<\/i>(\u2212)-DBD-PyNCS. Biomed. Chromatogr.<\/i>, 25<\/b>, 743\u2013747 (2011).","DOI":"10.1002\/bmc.1525"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Toyo\u2019oka T, Ishibashi M, Terao T, Imai K. 4-(N<\/i>,N<\/i>-Dimethylaminosulfonyl)-7-(2-chroloformylpyrrolidine-1-yl)-2,1,3-benzoxadiazole: Novel fluorescent chiral derivatization reagents for the resolution of alcohol enantiomers by high-performance liquid chromatography. Analyst<\/i>, 118<\/b>, 759\u2013763 (1993).","DOI":"10.1039\/an9931800759"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Toyo\u2019oka T, Liu YM, Hanioka N, Jinno H, Ando M. Determination of hydroxyls and amines, labelled with 4-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole, by high-performance liquid chromatography with fluorescence and laser-induced fluorescence detection. Anal. Chim. Acta<\/i>, 285<\/b>, 343\u2013351 (1994).","DOI":"10.1016\/0003-2670(94)80074-X"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Toyo\u2019oka T, Liu YM, Hanioka N, Jinno H, Ando M, Imai K. Resolution of enantiomers of alcohols and amines by high-performance liquid chromatography after derivatization with a novel fluorescent chiral reagent. J. Chromatogr. A<\/i>, 675<\/b>, 79\u201388 (1994).","DOI":"10.1016\/0021-9673(94)85262-6"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Toyo\u2019oka T, Liu YM. Enantioseparation of carbonyl compounds by high-performance liquid chromatography based on diastereomer formation. Anal. Proc.<\/i>, 31<\/b>, 265\u2013268 (1994).","DOI":"10.1039\/ai9943100265"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Toyo\u2019oka T, Liu YM. Fluorescence determination of aldehydes labelled with 4-(2-carbazoylpyrrolidin-1-yl)-7-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-2,1,3-benzoxadiazole by high-performance liquid chromatography. J. Chromatogr. A<\/i>, 695<\/b>, 11\u201318 (1995).","DOI":"10.1016\/0021-9673(94)01130-7"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Liu YM, Miao JR, Toyo\u2019oka T. Determination of 4-hydroxy-2-nonenal by precolumn derivatization and liquid chromatography with laser fluorescence detection. J. Chromatogr. A<\/i>, 719<\/b>, 450\u2013456 (1996).","DOI":"10.1016\/0021-9673(95)00733-4"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Toyo\u2019oka T, Kuze A. Determination of saccarides labelled with a fluorescent reagent, DBD-ProCZ, by liquid chromatography. Biomed. Chromatogr.<\/i>, 11<\/b>, 132\u2013136 (1997).","DOI":"10.1002\/(SICI)1099-0801(199705)11:3<132::AID-BMC633>3.3.CO;2-E"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Toyo\u2019oka T, Ishibashi M, Terao T. Fluorescenct chiral derivatization reagents for carboxylic acid enantiomers in high-performance liquid chromatography. Analyst<\/i>, 117<\/b>, 727\u2013733 (1992).","DOI":"10.1039\/an9921700727"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Toyo\u2019oka T, Ishibashi M, Terao T. Resolution of carboxylic acid enantiomers by high-performance liquid chromatography with highly sensitive laser-induced fluorescence detection. J. Chromatogr. A<\/i>, 625<\/b>, 357\u2013361 (1992).","DOI":"10.1016\/0021-9673(92)85221-E"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Toyo\u2019oka T, Ishibashi M, Terao T. Resolution of carboxylic acid enantiomers by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection. J. Chromatogr. A<\/i>, 627<\/b>, 75\u201386 (1992).","DOI":"10.1016\/0021-9673(92)87188-E"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Inoue K, Prayoonhan N, Tsutsui H, Sakamoto T, Nishimura M, Toyo\u2019oka T. Use of chiral derivatization for the determination of dichlorprop in tea samples by ultra performance LC with fluorescence detection. J. Sep. Sci.<\/i>, 36<\/b>, 1356\u20131361 (2013).","DOI":"10.1002\/jssc.201201187"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Toyo\u2019oka T, Ishibashi M, Terao T. Further studies on the resolution of carboxylic acid enantiomers by liquid chromatography with fluorescence and laser-induced fluorescence detection. Anal. Chim. Acta<\/i>, 278<\/b>, 71\u201381 (1993).","DOI":"10.1016\/0003-2670(93)80086-Z"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Toyo\u2019oka T, Toriumi M, Ishii Y. Enantioseparation of \u03b2-blockers labelled with a chiral fluorescent reagent, R<\/i>(\u2212)-DBD-PyNCS, by reversed-phase liquid chromatography. J. Pharm. Biomed. Anal.<\/i>, 15<\/b>, 1467\u20131476 (1997).","DOI":"10.1016\/S0731-7085(96)02026-2"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Jin D, Miyahara T, Oe T, Toyo\u2019oka T. Determination of D-amino acids labelled with fluorescent chiral reagents, R<\/i>(\u2212)- and S<\/i>(+)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in biological and food samples by liquid chromatography. Anal. Biochem.<\/i>, 269<\/b>, 124\u2013132 (1999).","DOI":"10.1006\/abio.1998.3090"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Toyo\u2019oka T, Suzuki T, Watanabe T, Liu YM. Sequential analysis of D\/L-amino acid in peptide with a novel chiral Edman degradation method. Anal. Sci.<\/i>, 12<\/b>, 779\u2013782 (1996).","DOI":"10.2116\/analsci.12.779"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Suzuki T, Watanabe T, Toyo\u2019oka T. Descrimination of D\/L-amino acid in peptide sequences based on fluorescent chiral derivatization by reversed-phase liquid chromatography. Anal. Chim. Acta<\/i>, 352<\/b>, 357\u2013363 (1997).","DOI":"10.1016\/S0003-2670(97)00087-1"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Toyo\u2019oka T, Tomoi N, Oe T, Miyahara T. Separation of 17 DL-amino acids and chiral sequential analysis of peptides by reversed-phase liquid chromatography after labeling with R<\/i>(\u2212)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N<\/i>,N<\/i>-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole. Anal. Biochem.<\/i>, 276<\/b>, 48\u201358 (1999).","DOI":"10.1006\/abio.1999.4307"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Toyo\u2019oka T, Jin D, Tomoi N, Oe T, Hiranuma H. R<\/i>(\u2212)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-(N<\/i>,N<\/i>-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole, a fluorescent chiral tagging reagent: Sensitive resolution of chiral amines and amino acids by reversed-phase liquid chromatography. Biomed. Chromatogr.<\/i>, 15<\/b>, 56\u201367 (2001).","DOI":"10.1002\/bmc.53"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Toyo\u2019oka T, Liu YM. Determination of D- and L-amino acid residues in peptides with fluorescent chiral tagging reagents by high-performance liquid chromatography. Chromatographia<\/i>, 40<\/b>, 645\u2013651 (1995).","DOI":"10.1007\/BF02315131"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo\u2019oka T. Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-\u03b2 in Alzheimer\u2019s brain tissues by covalent chiral derivatized ultra-performance liquid chromatography tandem mass spectrometry. Anal. Chem.<\/i>, 86<\/b>, 797\u2013804 (2014).","DOI":"10.1021\/ac403315h"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo\u2019oka T. Blood-based diagnosis of Alzheimer\u2019s disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 974<\/b>, 24\u201334 (2015).","DOI":"10.1016\/j.jchromb.2014.10.022"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Toyo\u2019oka T. Determination methods for biologically active compounds by ultra-performance liquid chromatography coupled with mass spectrometry: Application to the analyses of pharmaceuticals, foods, plants, environments, metabonomics and metabolomics. J. Chromatogr. Sci.<\/i>, 46<\/b>, 233\u2013247 (2008).","DOI":"10.1093\/chromsci\/46.3.233"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Toyo\u2019oka T. LC-MS determination of bioactive molecules based upon stable isotope-coded derivatization method. J. Pharm. Biomed. Anal.<\/i>, 69<\/b>, 174\u2013184 (2012).","DOI":"10.1016\/j.jpba.2012.04.018"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68) Inoue K, Ozawa Y, Toyo\u2019oka T. Application of liquid chromatography coupled with electrospray ionization tandem mass spectrometry for therapeutic drug monitoring of sedative medicine in clinical stage. Chromatography<\/i>, 36<\/b>, 81\u201392 (2015).","DOI":"10.15583\/jpchrom.2015.020"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Higashi T, Shimada K, Toyo\u2019oka T. Advances in determination of vitamin D related compounds in biological samples using liquid chromatography-mass spectrometry: A review. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 878<\/b>, 1654\u20131661 (2010).","DOI":"10.1016\/j.jchromb.2009.11.026"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Inoue K, Sakamoto T, Fujita Y, Yoshizawa S, Tomita M, Min JZ, Todoroki K, Sobue K, Toyo\u2019oka T. Development of a stable isotope dilution UPLC-MS\/MS method for quantification of dexmedetomidine in a small amount of human plasma. Biomed. Chromatogr.<\/i>, 27<\/b>, 853\u2013858 (2013).","DOI":"10.1002\/bmc.2870"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71) Inagaki S, Hirashima H, Esaka Y, Higashi T, Min JZ, Toyo\u2019oka T. Screening DNA adducts by LC-ESI-MS-MS: Application to screening new adducts formed from acrylamide. Chromatographia<\/i>, 72<\/b>, 1043\u20131048 (2010).","DOI":"10.1365\/s10337-010-1783-7"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Inoue K, Tanada C, Sakamoto T, Tsutsui H, Akiba T, Min JZ, Todoroki K, Yamano Y, Toyo\u2019oka T. Metabolomics approach of infant formula for the evaluation of contamination and degradation using hydrophilic interaction liquid chromatography coupled with mass spectrometry. Food Chem.<\/i>, 181<\/b>, 318\u2013324 (2015).","DOI":"10.1016\/j.foodchem.2015.02.117"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Inoue K, Sakamoto T, Min JZ, Todoroki K, Toyo\u2019oka T. Determination of dicyandiamide in infant formula by stable isotope dilution hydrophilic interaction liquid chromatography with tandem mass spectrometry. Food Chem.<\/i>, 156<\/b>, 390\u2013393 (2014).","DOI":"10.1016\/j.foodchem.2014.01.124"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Yokoyama Y, Tomatsuri M, Hayashi H, Hirai K, Ono Y, Yamada Y, Todoroki K, Toyo\u2019oka T, Yamada H, Itoh K. Simultaneous micro determination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography\/tandem mass spectrometry for pediatric patients with pulmonary arterial hypertension. J. Pharm. Biomed. Anal.<\/i>, 89<\/b>, 227\u2013232 (2014).","DOI":"10.1016\/j.jpba.2013.11.007"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Yamaguchi H, Hirakura Y, Shirai H, Mimura H, Toyo\u2019oka T. Quantitative evaluation of protein conformation in pharmaceuticals using cross-linking reactions coupled with LC-MS\/MS analysis. J. Pharm. Biomed. Anal.<\/i>, 55<\/b>, 574\u2013582 (2011).","DOI":"10.1016\/j.jpba.2011.01.038"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Fujita Y, Inoue K, Sakamoto T, Yoshizawa S, Tomita M, Maeda Y, Taka H, Muramatsu A, Hattori Y, Hirate H, Toyo\u2019oka T, Sobue K. A comparison between dosages and plasma concentrations of dexmedetomidine in clinically ill patients: a prospective, observational, cohort study in Japan. J. Intensive Care<\/i>, 1<\/b>, 15 (2013).","DOI":"10.1186\/2052-0492-1-15"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Inoue K, Tsutsui H, Akatsu H, Hashizume Y, Matsukawa N, Yamamoto T, Toyo\u2019oka T. Metabolic profiling of Alzheimer\u2019s disease brains. Sci. Rep.<\/i>, 3<\/b>, 2364 (2013).","DOI":"10.1038\/srep02364"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78) Kato M, Onda Y, Sekimoto M, Degawa M, Toyo\u2019oka T. A capillary electrochromatography-electron spray ionization-mass spectrometry method for simultaneous analysis of charged and neutral constituents of a hepatocarcinoma cell metabolome. J. Chromatogr. A<\/i>, 1216<\/b>, 8277\u20138282 (2009).","DOI":"10.1016\/j.chroma.2009.06.074"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Ohkubo T, Inagaki S, Min JZ, Kamiya D, Toyo\u2019oka T. Rapid determination of oxidized methionine residues in recombinant human basic fibroblast growth factor by ultra-performance liquid chromatography and electrospray ionization quadrupole time-of-flight mass spectrometry with in-source collision-induced dissociation. Rapid Commun. Mass Spectrom.<\/i>, 23<\/b>, 2053\u20132060 (2009).","DOI":"10.1002\/rcm.4119"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Kato M, Yamamoto T, Sekimoto M, Degawa M, Toyo\u2019oka T. An easy cell-based microchip assay method for a CYP1A1-mediated drug metabolism using adhesive cells, HepG2. J. Appl. Phys.<\/i>, 105<\/b>, 102019 (2009).","DOI":"10.1063\/1.3116123"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81) Johnson DW. Contemporary clinical usage of LC\/MS: Analysis of biologically important carboxylic acids. Clin. Biochem.<\/i>, 38<\/b>, 351\u2013361 (2005).","DOI":"10.1016\/j.clinbiochem.2005.01.007"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82) Gagn\u00e9 S, Crane S, Huang Z, Li CS, Bateman KP, L\u00e9vesque JF. Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS. J. Lipid Res.<\/i>, 48<\/b>, 252\u2013259 (2007).","DOI":"10.1194\/jlr.D600037-JLR200"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83) Cartwright AJ, Jones P, Wolff JC, Evans EH. Derivatization of carboxylic acid groups in pharmaceuticals for enhanced detection using liquid chromatography with electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom.<\/i>, 19<\/b>, 1058\u20131062 (2005).","DOI":"10.1002\/rcm.1883"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84) Higashi T, Ichikawa T, Inagaki S, Min JZ, Fukushima T, Toyo\u2019oka T. Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal.<\/i>, 52<\/b>, 809\u2013818 (2010).","DOI":"10.1016\/j.jpba.2010.03.001"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85) Higashi T, Shibayama Y, Ichikawa T, Ito K, Toyo\u2019oka T, Shimada K, Mitamura K, Ikegawa S, Chiba H. Salivary chenodeoxycholic acid and its glycine-conjugate: Their determination method using LC-MS\/MS and variation of their concentrations with increased saliva flow rate. Steroids<\/i>, 75<\/b>, 338\u2013345 (2010).","DOI":"10.1016\/j.steroids.2010.01.015"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86) Higashi T, Ito K, Narushima M, Sugiura T, Inagaki S, Min JZ, Toyo\u2019oka T. Development and validation of stable-isotope dilution liquid chromatography-tandem mass spectrometric method for determination of salivary progesterone. Biomed. Chromatogr.<\/i>, 25<\/b>, 1175\u20131180 (2011).","DOI":"10.1002\/bmc.1586"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87) Higashi T, Takekawa M, Min JZ, Toyo\u2019oka T. Diels\u2013Alder-derivatization for sensitive detection and characterization of conjugated linoleic acids using LC\/ESI-MS\/MS. Anal. Bioanal. Chem.<\/i>, 403<\/b>, 495\u2013502 (2012).","DOI":"10.1007\/s00216-012-5819-8"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88) Inagaki S, Tano Y, Yamakata Y, Higashi T, Min JZ, Toyo\u2019oka T. Highly sensitive and positively charged precolumn derivatization reagent for amines and amino acids in liquid chromatography\/electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom.<\/i>, 24<\/b>, 1358\u20131364 (2010).","DOI":"10.1002\/rcm.4521"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89) Inagaki S, Toyo\u2019oka T. Amino acid analysis via<\/i> LC-MS method after derivatization with quaternary phosphonium (Chapter 5). Amino Acid Analysis, Methods and Protocols, Methods in Molecular Biology<\/i>, Vol. 828, Humana Press, pp. 47\u201354 (2012).","DOI":"10.1007\/978-1-61779-445-2_5"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90) Mochizuki Y, Inagaki S, Suzuki M, Min JZ, Inoue K, Todoroki K, Toyo\u2019oka T. A novel derivatization reagent possessing a bromoquinolinium structure for biological carboxylic acids in HPLC-ESI-MS\/MS. J. Sep. Sci.<\/i>, 36<\/b>, 1883\u20131889 (2013).","DOI":"10.1002\/jssc.201300083"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91) Nagao R, Tsutsui H, Mochizuki T, Takayama T, Kuwabara T, Min JZ, Inoue K, Todoroki K, Toyo\u2019oka T. Novel chiral derivatization reagents possessing a pyridylthiourea structure for enantiospecific determination of amines and carboxylic acids in high-throughput liquid chromatography and electrospray-ionization mass spectrometry for chiral metabolomics identification. J. Chromatogr. A<\/i>, 1296<\/b>, 111\u2013118 (2013).","DOI":"10.1016\/j.chroma.2013.03.019"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92) Tsutsui H, Fujii S, Sakamoto T, Min JZ, Todoroki K, Toyo\u2019oka T. Chiral amines as reagents for HPLC-MS enantioseparation of chiral carboxylic acids. J. Sep. Sci.<\/i>, 35<\/b>, 1551\u20131559 (2012).","DOI":"10.1002\/jssc.201200091"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93) Tsutsui H, Mochizuki T, Maeda T, Noge I, Kitagawa Y, Min JZ, Todoroki K, Inoue K, Toyo\u2019oka T. Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS\/MS. Anal. Bioanal. Chem.<\/i>, 404<\/b>, 1925\u20131934 (2012).","DOI":"10.1007\/s00216-012-6320-0"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94) Higashi T, Kawasaki M, Tadokoro H, Ogawa S, Tsutsui H, Fukushima T, Toyo\u2019oka T. Derivatization of chiral carboxylic acids with (S<\/i>)-anabashine for increasing detectability and enantiomeric separation in LC\/ESI-MS\/MS. J. Sep. Sci.<\/i>, 35<\/b>, 2840\u20132846 (2012).","DOI":"10.1002\/jssc.201200585"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95) Uno K, Takayama T, Todoroki K, Inoue K, Min JZ, Mizuno H, Toyo\u2019oka T. Evaluation of a novel positively-charged pyrrolidine-based chiral derivatization reagent for the enantioseparation of carboxylic acids by LC-ESI-MS\/MS. Chromatography<\/i>, 36<\/b>, 57\u201360 (2015).","DOI":"10.15583\/jpchrom.2015.023"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96) Takayama T, Kuwabara T, Maeda T, Noge I, Kitagawa Y, Inoue K, Todoroki K, Min JZ, Toyo\u2019oka T. Profiling of chiral and achiral carboxylic acid metabolomics: Synthesis and evaluation of triazine-type chiral derivatization reagents for carboxylic acids by LC-ESI-MS\/MS and the application to saliva of healthy volunteers and diabetic patients. Anal. Bioanal. Chem.<\/i>, 407<\/b>, 1003\u20131014 (2015).","DOI":"10.1007\/s00216-014-8275-9"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97) Mochizuki T, Takayama T, Todoroki K, Inoue K, Min JZ, Toyo\u2019oka T. Towards the chiral metabolomics: Liquid chromatography-mass spectrometry based DL-amino acid analysis after labeling with a new chiral reagent, (S<\/i>)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate, and the application to saliva of healthy volunteers. Anal. Chim. Acta<\/i>, 875<\/b>, 73\u201382 (2015).","DOI":"10.1016\/j.aca.2015.02.054"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98) Mochizuki T, Taniguchi S, Tsutsui H, Min JZ, Inoue K, Todoroki K, Toyo\u2019oka T. Relative quantification of enantiomers of chiral amines by high-throughput LC-ESI-MS\/MS using isotopic variants of light and heavy L-pyroglutamic acids as the derivatization reagents. Anal. Chim. Acta<\/i>, 773<\/b>, 76\u201382 (2013).","DOI":"10.1016\/j.aca.2013.02.026"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99) Mochizuki T, Todoroki K, Inoue K, Min JZ, Toyo\u2019oka T. Isotopic variants of light and heavy L-pyroglutamic acid succinimidyl esters as the derivatization reagents for DL-amino acid chiral metabolomics identification by liquid chromatography and electrospray ionization mass spectrometry. Anal. Chim. Acta<\/i>, 811<\/b>, 51\u201359 (2014).","DOI":"10.1016\/j.aca.2013.12.016"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100) Inagaki S, Noda T, Min JZ, Toyo\u2019oka T. Metabolic profiling of rat hair and screening biomarkers using ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. J. Chromatogr. A<\/i>, 1176<\/b>, 94\u201399 (2007).","DOI":"10.1016\/j.chroma.2007.10.065"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101) Toyo\u2019oka T, Kumaki Y, Kanbori M, Kato M, Nakahara Y. Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma by reversed-phase liquid chromatography with electrospray ionization mass spectrometry. J. Pharm. Biomed. Anal.<\/i>, 30<\/b>, 1773\u20131787 (2003).","DOI":"10.1016\/S0731-7085(02)00520-4"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102) Toyo\u2019oka T, Kanbori M, Kumaki Y, Nakahara Y. Determination of triazolam involving the hydroxy metabolites in hair shaft and hair root by reversed-phase liquid chromatography with electrospray ionization mass spectrometry and application to human hair analysis. Anal. Biochem.<\/i>, 295<\/b>, 172\u2013179 (2001).","DOI":"10.1006\/abio.2001.5203"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103) Toyo\u2019oka T, Yano M, Kato M, Nakahara Y. Simultaneous determination of morphine and its glucuronides in rat hair and rat plasma by reversed-phase liquid chromatography with electrospray ionization mass spectrometry. Analyst<\/i>, 126<\/b>, 1339\u20131345 (2001).","DOI":"10.1039\/b103590h"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104) Toyo\u2019oka T, Kanbori M, Kumaki Y, Oe T, Miyahara T, Nakahara Y. Detection of triazolam and its hydroxy metabolites in rat hair by reversed-phase liquid chromatography with electrospray ionization mass spectrometry. J. Anal. Toxicol.<\/i>, 24<\/b>, 194\u2013201 (2000).","DOI":"10.1093\/jat\/24.3.194"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105) Inagaki S, Makino H, Fukushima T, Min JZ, Toyo\u2019oka T. Rapid detection of ketamine and norketamine in rat hair using micropulverized extraction and ultra-performance liquid chromatography-electrospray ionization mass spectrometry. Biomed. Chromatogr.<\/i>, 23<\/b>, 1245\u20131250 (2009).","DOI":"10.1002\/bmc.1256"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106) Nakahara Y, Takahashi K, Kikura R. Hair analysis for drugs of abuse. X. Effect of physicochemical properties of drugs on the incorporation rates into hair. Biol. Pharm. Bull.<\/i>, 18<\/b>, 1223\u20131227 (1995).","DOI":"10.1248\/bpb.18.1223"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107) P\u00f6tsch L, Skopp G, Moeller M. Influence of pigmentation on the codeine content of hair fibers in guinea pigs. J. Forensic Sci.<\/i>, 42<\/b>, 1095\u20131098 (1997).","DOI":"10.1520\/JFS14266J"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108) Gygi SP, Joseph RE Jr, Cone EJ, Wilkins DG, Rollins DE. Incorporation of codeine and metabolites into hair. Role of pigmentation. Drug Metab. Dispos.<\/i>, 24<\/b>, 495\u2013501 (1996).","DOI":"10.1016\/S0090-9556(25)07378-7"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109) Slawson MH, Wilkins DG, Rollins DE. The incorporation of drugs into hair: Relationship of hair color and melanin concentration to phencyclidine incorporation. J. Anal. Toxicol.<\/i>, 22<\/b>, 406\u2013413 (1998).","DOI":"10.1093\/jat\/22.6.406"},{"key":"110","doi-asserted-by":"crossref","unstructured":"110) Sugiura K, Min JZ, Toyo\u2019oka T, Inagaki S. Rapid, sensitive and simultaneous determination of fluorescence-labeled polyamines in human hair by high-pressure liquid chromatography coupled with electrospray-ionization time-of-flight mass spectrometry. J. Chromatogr. A<\/i>, 1205<\/b>, 94\u2013102 (2008).","DOI":"10.1016\/j.chroma.2008.08.026"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111) Kawanishi H, Toyo\u2019oka T, Ito K, Maeda M, Hamada T, Fukushima T, Kato M, Inagaki S. Rapid determination of histamine and its metabolites in mice hair by ultra-performance liquid chromatography with time-of-flight mass spectrometry. J. Chromatogr. A<\/i>, 1132<\/b>, 148\u2013156 (2006).","DOI":"10.1016\/j.chroma.2006.07.086"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112) Kawanishi H, Toyo\u2019oka T, Ito K, Maeda M, Hamada T, Fukushima T, Kato M, Inagaki S. Hair analysis of histamine and several metabolites in C3H\/HeNCrj mice by ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry (UPLC-ESI-TOF-MS): Influence of hair cycle and age. Clin. Chim. Acta<\/i>, 378<\/b>, 122\u2013127 (2007).","DOI":"10.1016\/j.cca.2006.11.007"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113) Toyo\u2019oka T, Suzuki A, Fukushima T, Kato M. Hair analysis of histamine after fluorescence labeling by column-switching reversed-phase liquid chromatography with electrospray ionization mass spectrometry and application to human hair. Anal. Biochem.<\/i>, 333<\/b>, 236\u2013245 (2004).","DOI":"10.1016\/j.ab.2004.06.037"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114) Min JZ, Tomiyasu Y, Morotomi T, Jiang Y-Z, Li G, Shi Q, Yu H, Inoue K, Todoroki K, Toyo\u2019oka T. First observation of N<\/i>-acetyl leucine and N<\/i>-acetyl isoleucine in diabetic patient hair and quantitative analysis by UPLC-ESI-MS\/MS. Clin. Chim. Acta<\/i>, 444<\/b>, 143\u2013148 (2015).","DOI":"10.1016\/j.cca.2015.02.006"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115) Tsutsui H, Maeda T, Toyo\u2019oka T, Min JZ, Inagaki S, Higashi T, Kagawa Y. Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultra-performance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry. J. Proteome Res.<\/i>, 9<\/b>, 3912\u20133922 (2010).","DOI":"10.1021\/pr100121k"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116) Tsutsui H, Maeda T, Min JZ, Inagaki S, Higashi T, Kagawa Y, Toyo\u2019oka T. Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Clin. Chim. Acta<\/i>, 412<\/b>, 861\u2013872 (2011).","DOI":"10.1016\/j.cca.2010.12.023"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117) Daniel CR 3rd, Piraccini BM, Tosti A. The nail and hair in forensic science. J. Am. Acad. Dermatol.<\/i>, 50<\/b>, 258\u2013261 (2004).","DOI":"10.1016\/j.jaad.2003.06.008"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118) Greaves M, Moll JMH. Amino acid composition of human nail, as measured by gas-liquid chromatography. Clin. Chem.<\/i>, 22<\/b>, 1608\u20131613 (1976).","DOI":"10.1093\/clinchem\/22.10.1608"},{"key":"119","doi-asserted-by":"crossref","unstructured":"119) Irving RC, Dickson SJ. The detection of sedatives in hair and nail samples using tandem LC-MS-MS. Forensic Sci. Int.<\/i>, 166<\/b>, 58\u201367 (2007).","DOI":"10.1016\/j.forsciint.2006.03.027"},{"key":"120","doi-asserted-by":"crossref","unstructured":"120) Li XL, Li G, Jiang YZ, Kang D, Jin CH, Shi Q, Jin T, Inoue K, Todoroki K, Toyo\u2019oka T, Min JZ. Human nails metabolite analysis: A rapid and simple method for quantification of uric acid in human fingernail by high-performance liquid chromatography with UV-detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 1002<\/b>, 394\u2013398 (2015).","DOI":"10.1016\/j.jchromb.2015.08.044"},{"key":"121","doi-asserted-by":"crossref","unstructured":"121) Min JZ, Yano H, Matsumoto A, Yu H, Shi Q, Higashi T, Inagaki S, Toyo\u2019oka T. Simultaneous determination of polyamines in human nail as 4-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole derivatives by nanoflow chip LC coupled with quadrupole time-of-flight tandem mass spectrometry. Clin. Chim. Acta<\/i>, 412<\/b>, 98\u2013106 (2011).","DOI":"10.1016\/j.cca.2010.09.018"},{"key":"122","doi-asserted-by":"crossref","unstructured":"122) Min JZ, Morota Y, Jiang YZ, Li G, Kang D, Yu HF, Inoue K, Todoroki K, Toyo\u2019oka T. Rapid and sensitive determination of diacetylpolyamines in human fingernail by ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Eur. J. Mass Spectrom.<\/i>, 20<\/b>, 477\u2013486 (2014).","DOI":"10.1255\/ejms.1301"},{"key":"123","doi-asserted-by":"crossref","unstructured":"123) Min JZ, Matsumoto A, Li G, Jiang YZ, Yu HF, Todoroki K, Inoue K, Toyo\u2019oka T. A quantitative analysis of the polyamine in lung cancer patient fingernails by LC-ESI-MS\/MS. Biomed. Chromatogr.<\/i>, 28<\/b>, 492\u2013499 (2014).","DOI":"10.1002\/bmc.3059"},{"key":"124","doi-asserted-by":"crossref","unstructured":"124) Min JZ, Hatanaka S, Yu HF, Higashi T, Inagaki S, Toyo\u2019oka T. First detection of free D-amino acids in human nails by combination of derivatization and UPLC-ESI-TOF-MS. Anal. Methods<\/i>, 2<\/b>, 1233\u20131235 (2010).","DOI":"10.1039\/c0ay00373e"},{"key":"125","doi-asserted-by":"crossref","unstructured":"125) Min JZ, Hatanaka S, Yu H, Higashi T, Inagaki S, Toyo\u2019oka T. Determination of DL-amino acids, derivatized with R<\/i>(\u2212)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N<\/i>,N<\/i>-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 879<\/b>, 3220\u20133228 (2011).","DOI":"10.1016\/j.jchromb.2011.02.016"},{"key":"126","unstructured":"126) Jakus V, Bauerova K, Michalkova D, Carsky J. Serum levels of advanced glycation end products in poorly metabolically controlled children with diabetes mellitus: relation to HbA1c. Diabetes Nutr. Metab.<\/i>, 14<\/b>, 207\u2013211 (2001)."},{"key":"127","doi-asserted-by":"crossref","unstructured":"127) Hamada Y, Nakamura J, Fujisawa H, Yago H, Nakashima E, Koh N, Hotta N. Effects of glycemic control on plasma 3-deoxyglucosone levels in NIDDM patients. Diabetes Care<\/i>, 20<\/b>, 1466\u20131469 (1997).","DOI":"10.2337\/diacare.20.9.1466"},{"key":"128","doi-asserted-by":"crossref","unstructured":"128) Min JZ, Yamamoto M, Yu HF, Higashi T, Toyo\u2019oka T. Rapid and sensitive determination of the intermediates of advanced glycation end products in human nail by ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Anal. Biochem.<\/i>, 424<\/b>, 187\u2013194 (2012).","DOI":"10.1016\/j.ab.2012.02.025"},{"key":"129","doi-asserted-by":"crossref","unstructured":"129) Gr\u00f6schl M. Current status of salivary hormone analysis. Clin. Chem.<\/i>, 54<\/b>, 1759\u20131769 (2008).","DOI":"10.1373\/clinchem.2008.108910"},{"key":"130","doi-asserted-by":"crossref","unstructured":"130) Chiappin S, Antonelli G, Gatti R, De Palo EF. Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clin. Chim. Acta<\/i>, 383<\/b>, 30\u201340 (2007).","DOI":"10.1016\/j.cca.2007.04.011"},{"key":"131","doi-asserted-by":"crossref","unstructured":"131) Suzuki M, Furuhashi M, Sesoko S, Kosuge K, Maeda T, Todoroki K, Inoue K, Min JZ, Toyo\u2019oka T. Determination of creatinine-related molecules in saliva by reversed-phase liquid chromatography with tandem mass spectrometry and the evaluation of hemodialysis in chronic kidney disease patients. Anal. Chim. Acta<\/i>, 911<\/b>, 92\u201399 (2016).","DOI":"10.1016\/j.aca.2016.01.032"},{"key":"132","doi-asserted-by":"crossref","unstructured":"132) Fujii S, Maeda T, Noge I, Kitagawa Y, Todoroki K, Inoue K, Min JZ, Toyo\u2019oka T. Determination of acetone in saliva by reversed-phase liquid chromatography with fluorescence detection and the monitoring of diabetes mellitus patients with ketoacidosis. Clin. Chim. Acta<\/i>, 430<\/b>, 140\u2013144 (2014).","DOI":"10.1016\/j.cca.2014.01.006"},{"key":"133","doi-asserted-by":"crossref","unstructured":"133) Higashi T, Ichikawa T, Shimizu C, Nagai S, Inagaki S, Min JZ, Chiba H, Ikegawa S, Toyo\u2019oka T. Stable isotope-dilution liquid chromatography\/tandem mass spectrometry method for determination of thyroxine in saliva. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, 879<\/b>, 1013\u20131017 (2011).","DOI":"10.1016\/j.jchromb.2011.02.048"},{"key":"134","doi-asserted-by":"crossref","unstructured":"134) Higashi T, Nagura Y, Shimada K, Toyo\u2019oka T. Studies on neurosteroids XXVI. Fluoxetine-evoked changes in rat brain and serum levels on neuroactive androgen, 5\u03b1-androstane-3\u03b1,17\u03b2-diol. Biol. Pharm. Bull.<\/i>, 32<\/b>, 1636\u20131638 (2009).","DOI":"10.1248\/bpb.32.1636"},{"key":"135","doi-asserted-by":"crossref","unstructured":"135) Higashi T, Suzuki M, Hanai J, Inagaki S, Min JZ, Shimada K, Toyo\u2019oka T. A specific LC\/ESI-MS\/MS method for determination of 25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi<\/i>-25-hydroxyvitamin D3. J. Sep. Sci.<\/i>, 34<\/b>, 725\u2013732 (2011).","DOI":"10.1002\/jssc.201000911"},{"key":"136","doi-asserted-by":"crossref","unstructured":"136) Tsutsui H, Mochizuki T, Inoue K, Toyama T, Yoshimoto N, Endo Y, Todoroki K, Min JZ, Toyo\u2019oka T. High-throughput LC-MS\/MS based simultaneous determination of polyamines including N<\/i>-acetylated forms in human saliva and the diagnostic approach to breast cancer patients. Anal. Chem.<\/i>, 85<\/b>, 11835\u201311842 (2013).","DOI":"10.1021\/ac402526c"},{"key":"137","doi-asserted-by":"crossref","unstructured":"137) Takayama T, Tsutsui H, Shimizu I, Toyama T, Yoshimoto N, Endo Y, Inoue K, Todoroki K, Min JZ, Mizuno H, Toyo\u2019oka T. Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry. Clin. Chim. Acta<\/i>, 452<\/b>, 18\u201326 (2016).","DOI":"10.1016\/j.cca.2015.10.032"},{"key":"138","doi-asserted-by":"crossref","unstructured":"138) McLellan AC, Phillips SA, Thornalley PJ. Fluorimetric assay of D-lactate. Anal. Biochem.<\/i>, 206<\/b>, 12\u201316 (1992).","DOI":"10.1016\/S0003-2697(05)80004-1"},{"key":"139","doi-asserted-by":"crossref","unstructured":"139) Thornalley PJ, Hooper NI, Jennings PE, Florkowski CM, Jones AF, Lunec J, Barnett AH. The human red blood cell glyoxalase system in diabetes mellitus. Diabetes Res. Clin. Pract.<\/i>, 7<\/b>, 115\u2013120 (1989).","DOI":"10.1016\/0168-8227(89)90101-0"},{"key":"140","doi-asserted-by":"crossref","unstructured":"140) McLellan AC, Thornalley PJ, Benn J, Sonksen PH. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clin. Sci.<\/i>, 87<\/b>, 21\u201329 (1994).","DOI":"10.1042\/cs0870021"},{"key":"141","doi-asserted-by":"crossref","unstructured":"141) Thornalley PJ, McLellan AC, Lo TW, Benn J, S\u00f6nksen PH. Negative association between erythrocyte reduced glutathione concentration and diabetic complications. Clin. Sci.<\/i>, 91<\/b>, 575\u2013582 (1996).","DOI":"10.1042\/cs0910575"},{"key":"142","doi-asserted-by":"crossref","unstructured":"142) Kuwabara T, Takayama T, Todoroki K, Inoue K, Min JZ, Toyo\u2019oka T. Evaluation of a series of prolylamidepyridine as the chiral derivatization reagents for enantioseparation of carboxylic acids by LC-ESI-MS\/MS and the application to human saliva. Anal. Bioanal. Chem.<\/i>, 406<\/b>, 2641\u20132649 (2014).","DOI":"10.1007\/s00216-014-7637-7"},{"key":"143","doi-asserted-by":"crossref","unstructured":"143) Numako M, Takayama T, Noge I, Kitagawa Y, Todoroki K, Mizuno H, Min JZ, Toyo\u2019oka T. Dried saliva spot (DSS) as a convenient and reliable sampling for bioanalysis: An application for the diagnosis of diabetes mellitus. Anal. Chem.<\/i>, 88<\/b>, 635\u2013639 (2016).","DOI":"10.1021\/acs.analchem.5b04059"},{"key":"144","doi-asserted-by":"crossref","unstructured":"144) P\u00e9rez-Trujillo M, Lindon JC, Parella T, Keun HC, Nicholson JK, Athersuch TJ. Chiral metabonomics: 1<\/sup>H-NMR-based enantiospecific differentiation of metabolites in human urine via<\/i> direct cosolvation with \u03b2-cyclodextrin. Anal. Chem.<\/i>, 84<\/b>, 2868\u20132874 (2012).","DOI":"10.1021\/ac203291d"},{"key":"145","doi-asserted-by":"crossref","unstructured":"145) Fukushima T, Kawai J, Imai K, Toyo\u2019oka T. Simultaneous determination of D- and L-serine in rat brain microdialysis sample using a column-switching HPLC with fluorimetric detection. Biomed. Chromatogr.<\/i>, 18<\/b>, 813\u2013819 (2004).","DOI":"10.1002\/bmc.394"},{"key":"146","doi-asserted-by":"crossref","unstructured":"146) Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, Shinoda N, Nakazato M, Kumakiri C, Okada S, Hasegawa H, Imai K, Iyo M. Decreased serum levels of D-serine in patients with schizophrenia. Arch. Gen. Psychiatry<\/i>, 60<\/b>, 572\u2013576 (2003).","DOI":"10.1001\/archpsyc.60.6.572"},{"key":"147","doi-asserted-by":"crossref","unstructured":"147) Tsai GE, Yang P, Chang Y-C, Chong M-Y. D-Alanine added to antipsychotics for the treatment of schizophrenia. Biol. Psychiatry<\/i>, 59<\/b>, 230\u2013234 (2006).","DOI":"10.1016\/j.biopsych.2005.06.032"},{"key":"148","doi-asserted-by":"crossref","unstructured":"148) Nishikawa T. Metabolism and functional roles of endogenous D-serine in mammalian brains. Biol. Pharm. Bull.<\/i>, 28<\/b>, 1561\u20131565 (2005).","DOI":"10.1248\/bpb.28.1561"},{"key":"149","doi-asserted-by":"crossref","unstructured":"149) Takayama T, Mochizuki T, Todoroki K, Min JZ, Mizuno H, Inoue K, Akatsu H, Noge I, Toyo\u2019oka T. A novel approach for LC-MS\/MS-based chiral metabolomics fingerprinting and chiral metabolomics extraction using a pair of enantiomers of chiral derivatization reagents. Anal. Chim. Acta<\/i>, 898<\/b>, 73\u201384 (2015).","DOI":"10.1016\/j.aca.2015.10.010"}],"container-title":["Biological & Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/39\/9\/39_b16-00453\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T15:52:37Z","timestamp":1749570757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/39\/9\/39_b16-00453\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":149,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b16-00453","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}