{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T10:14:31Z","timestamp":1772532871843,"version":"3.50.1"},"reference-count":36,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1248\/bpb.b16-00651","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T17:21:57Z","timestamp":1485883317000},"page":"169-173","source":"Crossref","is-referenced-by-count":25,"title":["Intrathecal Dexmedetomidine Alleviates Shivering during Cesarean Delivery under Spinal Anesthesia"],"prefix":"10.1248","volume":"40","author":[{"given":"Liang","family":"He","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Hospital of Guilin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Mei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Xiangya Hospital of Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Xiangya Hospital of Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Hospital of Guilin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Xiangya Hospital of Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Xiangya Hospital of Central South University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Moya F, Smith B. Spinal anesthesia for Cesarean section. Clinical and biochemical studies of effects on maternal physiology. <i>JAMA<\/i>, <b>179<\/b>, 609\u2013614 (1962).","DOI":"10.1001\/jama.1962.03050080021005"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Simon L, Boulay G, Ziane AF, Noblesse E, Mathiot JL, Toubas MF, Hamaza J. Effect of injection rate on hypotension associated with spinal anesthesia for Cesarean section. <i>Int. J. Obstet. Anesth.<\/i>, <b>9<\/b>, 10\u201314 (2000).","DOI":"10.1054\/ijoa.1999.0348"},{"key":"3","unstructured":"3) Sayg\u0131 A\u0130, \u00d6zdamar \u00d6, G\u00fcn \u0130, Emirkad\u0131 H, M\u00fcngen E, Akpak YK. Comparison of maternal and fetal outcomes among patients undergoing Cesarean section under general and spinal anesthesia: a randomized clinical trial. <i>Sao Paulo Med. J.<\/i>, <b>133<\/b>, 227\u2013234 (2015)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Roy JD, Girard M, Drolet P. Intrathecal meperidine decreases shivering during Cesarean delivery under spinal anesthesia. <i>Anesth. Analg.<\/i>, <b>98<\/b>, 230\u2013234 (2004).","DOI":"10.1213\/01.ANE.0000093251.42341.74"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Tsai YC, Chu KS. A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients. <i>Anesth. Analg.<\/i>, <b>93<\/b>, 1288\u20131292 (2001).","DOI":"10.1097\/00000539-200111000-00052"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Hong JY, Lee IH. Comparison of the effects of intrathecal morphine and pethidine on shivering after Caesarean delivery under combined-spinal epidural anaesthesia. <i>Anaesthesia<\/i>, <b>60<\/b>, 1168\u20131172 (2005).","DOI":"10.1111\/j.1365-2044.2005.04158.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Blaine Easley R, Brady KM, Tobias JD. Dexmedetomidine for the treatment of postanesthesia shivering in children. <i>Paediatr. Anaesth.<\/i>, <b>17<\/b>, 341\u2013346 (2007).","DOI":"10.1111\/j.1460-9592.2006.02100.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Usta B, Gozdemir M, Demircioglu RI, Muslu B, Sert H, Yaldiz A. Dexmedetomidine for the prevention of shivering during spinal anesthesia. <i>Clinics<\/i>, <b>66<\/b>, 1187\u20131191 (2011).","DOI":"10.1590\/S1807-59322011000700011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Liu ZX, Xu FY, Liang X, Zhou M, Wu L, Wu JR, Xia JH, Zou Z. Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials. <i>Can. J. Anaesth.<\/i>, <b>62<\/b>, 816\u2013829 (2015).","DOI":"10.1007\/s12630-015-0368-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Toyama H, Wagatsuma T, Ejima Y, Matsubara M, Kurosawa S. Cesarean section and primary pulmonary hypertension: the role of intravenous dexmedetomidine. <i>Int. J. Obstet. Anesth.<\/i>, <b>18<\/b>, 262\u2013267 (2009).","DOI":"10.1016\/j.ijoa.2008.08.001"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Neumann MM, Davio MB, Macknet MR, Applegate RL 2nd. Dexmedetomidine for awake fiberoptic intubation in a parturient with spinal muscular atrophy type III for Cesarean delivery. <i>Int. J. Obstet. Anesth.<\/i>, <b>18<\/b>, 403\u2013407 (2009).","DOI":"10.1016\/j.ijoa.2009.05.002"},{"key":"12","unstructured":"12) Gupta M, Gupta P, Singh DK. Effect of 3 different doses of intrathecal dexmedetomidine (2.5\u2009\u00b5g, 5\u2009\u00b5g, and 10\u2009\u00b5g) on subarachnoid block characteristics: A prospective randomized double blind dose-response trial. <i>Pain Physician<\/i>, <b>19<\/b>, E411\u2013E420 (2016)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Qi X, Chen D, Li G, Huang X, Li Y, Wang X, Li Y. Comparison of intrathecal dexmedetomidine with morphine as adjuvants in Cesarean sections. <i>Biol. Pharm. Bull.<\/i>, <b>39<\/b>, 1455\u20131460 (2016).","DOI":"10.1248\/bpb.b16-00145"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Vanderstappen I, Vandermeersch E, Vanacker B, Mattheussen M, Herijgers P, Van Aken H. The effect of prophylactic clonidine on postoperative shivering. A large prospective double-blind study. <i>Anaesthesia<\/i>, <b>51<\/b>, 351\u2013355 (1996).","DOI":"10.1111\/j.1365-2044.1996.tb07747.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Bajwa SJ, Gupta S, Kaur J, Singh A, Parmar S. Reduction in the incidence of shivering with perioperative dexmedetomidine: A randomized prospective study. <i>J. Anaesthesiol. Clin. Pharmacol.<\/i>, <b>28<\/b>, 86\u201391 (2012).","DOI":"10.4103\/0970-9185.92452"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Bozgeyik S, Mizrak A, K\u0131l\u0131\u00e7 E, Yendi F, Ugur BK. The effects of preemptive tramadol and dexmedetomidine on shivering during arthroscopy. <i>Saudi J. Anaesth.<\/i>, <b>8<\/b>, 238\u2013243 (2014).","DOI":"10.4103\/1658-354X.130729"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Mittal G, Gupta K, Katyal S, Kaushal S. Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering. <i>Indian J. Anaesth.<\/i>, <b>58<\/b>, 257\u2013262 (2014).","DOI":"10.4103\/0019-5049.135031"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. <i>Anesthesiology<\/i>, <b>87<\/b>, 835\u2013841 (1997).","DOI":"10.1097\/00000542-199710000-00017"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Lewis SR, Nicholson A, Smith AF, Alderson P. Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia. <i>Cochrane Database Syst. Rev.<\/i>, <b>10<\/b>, CD011107 (2015).","DOI":"10.1002\/14651858.CD011107.pub2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Doufas AG, Lin CM, Suleman MI, Liem EB, Lenhardt R, Morioka N, Ak\u00e7a O, Shah YM, Bjorksten AR, Sessler DI. Dexmedetomidine and meperidine additively reduce the shivering threshold in humans. <i>Stroke<\/i>, <b>34<\/b>, 1218\u20131223 (2003).","DOI":"10.1161\/01.STR.0000068787.76670.A4"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Bicer C, Esmaoglu A, Akin A, Boyaci A. Dexmedetomidine and meperidine prevent postanaesthetic shivering. <i>Eur. J. Anaesthesiol.<\/i>, <b>23<\/b>, 149\u2013153 (2006).","DOI":"10.1017\/S0265021505002061"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Elvan EG, O\u00e7 B, Uzun S, Karabulut E, Co\u015fkun F, Aypar U. Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy. <i>Eur. J. Anaesthesiol.<\/i>, <b>25<\/b>, 357\u2013364 (2008).","DOI":"10.1017\/S0265021507003110"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kim YS, Kim YI, Seo KH, Kang HR. Optimal dose of prophylactic dexmedetomidine for preventing postoperative shivering. <i>Int. J. Med. Sci.<\/i>, <b>10<\/b>, 1327\u20131332 (2013).","DOI":"10.7150\/ijms.6531"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Callaway CW, Elmer J, Guyette FX, Molyneaux BJ, Anderson KB, Empey PE, Gerstel SJ, Holquist K, Repine MJ, Rittenberger JC. Dexmedetomidine reduces shivering during mild hypothermia in waking subjects. <i>PLoS ONE<\/i>, <b>10<\/b>, e0129709 (2015).","DOI":"10.1371\/journal.pone.0129709"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Mahendru V, Tewari A, Katyal S, Grewal A, Singh MR, Katyal R. A comparison of intrathecal dexmedetomidine, clonidine, and fentanyl as adjuvants to hyperbaric bupivacaine for lower limb surgery: A double blind controlled study. <i>J. Anaesthesiol. Clin. Pharmacol.<\/i>, <b>29<\/b>, 496\u2013502 (2013).","DOI":"10.4103\/0970-9185.119151"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Das A, Halder S, Chattopadhyay S, Mandal P, Chhaule S, Banu R. Effect of two different doses of dexmedetomidine as adjuvant in vupivacaine induced subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind, randomized controlled study. <i>Oman Med. J.<\/i>, <b>30<\/b>, 257\u2013263 (2015).","DOI":"10.5001\/omj.2015.52"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Kim JE, Kim NY, Lee HS, Kil HK. Effects of intrathecal dexmedetomidine on low-dose bupivacaine spinal anesthesia in elderly patients undergoing transurethral prostatectomy. <i>Biol. Pharm. Bull.<\/i>, <b>36<\/b>, 959\u2013965 (2013).","DOI":"10.1248\/bpb.b12-01067"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Sun Y, Xu Y, Wang GN. Comparative evaluation of intrathecal bupivacaine alone, bupivacaine-fentanyl, and bupivacaine-dexmedetomidine in Caesarean section. <i>Drug Res.<\/i> (Stuttg), <b>65<\/b>, 468\u2013472 (2015).","DOI":"10.1055\/s-0034-1387740"},{"key":"29","unstructured":"29) Itagaki T, Uchisaki S, Adachi Y, Suzuki K, Obata Y, Doi M, Sato S. apnea and severe respiratory depression induced by dexmedetomidine after general anesthesia in intensive care unit. <i>Masui<\/i>, <b>58<\/b>, 1534\u20131537 (2009)."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kurhekar P, Kumar SM, Sampath D. Comparative evaluation of intrathecal morphine and intrathecal dexmedetomidine in patients undergoing gynaecological surgeries under spinal anaesthesia: A prospective randomised double blind study. <i>Indian J. Anaesth.<\/i>, <b>60<\/b>, 382\u2013387 (2016).","DOI":"10.4103\/0019-5049.183387"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Wu Y, Zhang Y, Hu X, Qian C, Zhou Y, Xie J. A comparison of propofol <i>vs.<\/i> dexmedetomidine for sedation, haemodynamic control and satisfaction, during esophagogastroduodenoscopy under conscious sedation. <i>J. Clin. Pharm. Ther.<\/i>, <b>40<\/b>, 419\u2013425 (2015).","DOI":"10.1111\/jcpt.12282"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Niu XY, Ding XB, Guo T, Chen MH, Fu SK, Li Q. Effects of intravenous and intrathecal dexmedetomidine in spinal anesthesia: a meta-analysis. <i>CNS Neurosci. Ther.<\/i>, <b>19<\/b>, 897\u2013904 (2013).","DOI":"10.1111\/cns.12172"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Erdivanli B, Altun M, Sezen OK, Colako\u011flu SA. Anti-nociceptive, analgesic and pathohistological effects of intrathecal dexmedetomidine and bupivacaine in rats. <i>Braz. J. Anesthesiol.<\/i>, <b>63<\/b>, 183\u2013187 (2013).","DOI":"10.1016\/j.bjane.2012.02.006"},{"key":"34","unstructured":"34) Al-Mustafa MM, Abu-Halaweh SA, Aloweidi AS, Murshidi MM, Ammari BA, Awwad ZM, Al-Edwan GM, Ramsay MA. Effect of dexmedetomidine added to spinal bupivacaine for urological procedures. <i>Saudi Med. J.<\/i>, <b>30<\/b>, 365\u2013370 (2009)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kanazi GE, Aouad MT, Jabbour-Khoury SI, Al Jazzar MD, Alameddine MM, Al-Yaman R, Bulbul M, Baraka AS. Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. <i>Acta Anaesthesiol. Scand.<\/i>, <b>50<\/b>, 222\u2013227 (2006).","DOI":"10.1111\/j.1399-6576.2006.00919.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Shukla U, Prabhakar T, Malhotra K, Srivastava D. Dexmedetomidine <i>versus<\/i> midazolam as adjuvants to intrathecal bupivacaine: A clinical comparison. <i>J. Anaesthesiol. Clin. Pharmacol.<\/i>, <b>32<\/b>, 214\u2013219 (2016).","DOI":"10.4103\/0970-9185.182105"}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/2\/40_b16-00651\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:23:26Z","timestamp":1568766206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/2\/40_b16-00651\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b16-00651","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}