{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:20:10Z","timestamp":1783808410492,"version":"3.55.0"},"reference-count":36,"publisher":"Pharmaceutical Society of Japan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1248\/bpb.b16-00773","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:30:28Z","timestamp":1488328228000},"page":"297-302","source":"Crossref","is-referenced-by-count":8,"title":["An Activatable Fluorescent \u03b3-Polyglutamic Acid Complex for Sentinel Lymph Node Imaging"],"prefix":"10.1248","volume":"40","author":[{"given":"Masayori","family":"Hagimori","sequence":"first","affiliation":[{"name":"Department of Biophysical Chemistry, Kobe Pharmaceutical University"},{"name":"Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Hatabe","sequence":"additional","affiliation":[{"name":"Department of Biophysical Chemistry, Kobe Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Biophysical Chemistry, Kobe Pharmaceutical University"},{"name":"Radioisotopes Research Laboratory, Kyoto University Hospital"},{"name":"Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Biophysical Chemistry, Kobe Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Biophysical Chemistry, Kobe Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Hoffman RM. The multiple uses of fluorescent proteins to visualize cancer <i>in vivo.<\/i> <i>Nat. Rev. Cancer<\/i>, <b>5<\/b>, 796\u2013806 (2005).","DOI":"10.1038\/nrc1717"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Weissleder R, Pittet MJ. Imaging in the era of molecular oncology. <i>Nature<\/i>, <b>452<\/b>, 580\u2013589 (2008).","DOI":"10.1038\/nature06917"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Yuan Y, Zhang J, Cao Q, An L, Liang G. Intracellular disassembly of self-quenched nanoparticles turns NIR fluorescence on for sensing furin activity in cells and in tumors. <i>Anal. Chem.<\/i>, <b>87<\/b>, 6180\u20136185 (2015).","DOI":"10.1021\/acs.analchem.5b01656"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Kobayashi H, Longmire MR, Ogawa M, Choyke PL. Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals. <i>Chem. Soc. Rev.<\/i>, <b>40<\/b>, 4626\u20134648 (2011).","DOI":"10.1039\/c1cs15077d"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) James TA, Edge SB. Sentinel lymph node in breast cancer. <i>Curr. Opin. Obstet. Gynecol.<\/i>, <b>18<\/b>, 53\u201358 (2006).","DOI":"10.1097\/01.gco.0000192975.38858.4b"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Takeuchi H, Kitajima M, Kitagawa Y. Sentinel lymph node as a target of molecular diagnosis of lymphatic micrometastasis and local immunoresponse to malignant cells. <i>Cancer Sci.<\/i>, <b>99<\/b>, 441\u2013450 (2008).","DOI":"10.1111\/j.1349-7006.2007.00672.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Dowlatshahi K, Fan M, Snider HC, Habib FA. Lymph node micrometastases from breast carcinoma: reviewing the dilemma. <i>Cancer<\/i>, <b>80<\/b>, 1188\u20131197 (1997).","DOI":"10.1002\/(SICI)1097-0142(19971001)80:7<1188::AID-CNCR2>3.0.CO;2-H"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Mart\u00ednez A, Zerdoud S, Mery E, Bouissou E, Ferron G, Querleu D. Hybrid imaging by SPECT\/CT for sentinel lymph node detection in patients with cancer of the uterine cervix. <i>Gynecol. Oncol.<\/i>, <b>119<\/b>, 431\u2013435 (2010).","DOI":"10.1016\/j.ygyno.2010.08.001"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Goldberg BB, Merton DA, Liu JB, Forsberg F, Zhang K, Thakur M, Schulz S, Schanche R, Murphy GF, Waldman SA. Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model. <i>J. Ultrasound Med.<\/i>, <b>30<\/b>, 441\u2013453 (2011).","DOI":"10.7863\/jum.2011.30.4.441"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Noh YW, Jang YS, Ahn KJ, Lim YT, Chung BH. Simultaneous <i>in vivo<\/i> tracking of dendritic cells and priming of an antigen-specific immune response. <i>Biomaterials<\/i>, <b>32<\/b>, 6254\u20136263 (2011).","DOI":"10.1016\/j.biomaterials.2011.05.013"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Noh YW, Kong SH, Choi DY, Park HS, Yang HK, Lee HJ, Kim HC, Kang KW, Sung MH, Lim YT. Near-infrared emitting polymer nanogels for efficient sentinel lymph node mapping. <i>ACS Nano<\/i>, <b>6<\/b>, 7820\u20137831 (2012).","DOI":"10.1021\/nn301949y"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Sano K, Iwamiya Y, Kurosaki T, Ogawa M, Magata Y, Sasaki H, Ohshima T, Maeda M, Mukai T. Radiolabeled \u03b3-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging. <i>J. Control. Release<\/i>, <b>194<\/b>, 310\u2013315 (2014).","DOI":"10.1016\/j.jconrel.2014.08.025"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Fr\u00f6hlich E. The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. <i>Int. J. Nanomedicine<\/i>, <b>7<\/b>, 5577\u20135591 (2012).","DOI":"10.2147\/IJN.S36111"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Di Bona KR, Xu Y, Ramirez PA, DeLaine J, Parker C, Bao Y, Rasco JF. Surface charge and dosage dependent potential developmental toxicity and biodistribution of iron oxide nanoparticles in pregnant CD-1 mice. <i>Reprod. Toxicol.<\/i>, <b>50<\/b>, 36\u201342 (2014).","DOI":"10.1016\/j.reprotox.2014.09.010"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Xiao K, Li Y, Luo J, Lee JS, Xiao W, Gonik AM, Agarwal RG, Lam KS. The effect of surface charge on <i>in vivo<\/i> biodistribution of PEG-oligocholic acid based micellar nanoparticles. <i>Biomaterials<\/i>, <b>32<\/b>, 3435\u20133446 (2011).","DOI":"10.1016\/j.biomaterials.2011.01.021"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Bhattacharjee S, de Haan LH, Evers NM, Jiang X, Marcelis AT, Zuilhof H, Rietjens IM, Alink GM. Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells. <i>Part. Fibre Toxicol.<\/i>, <b>7<\/b>, 25 (2010).","DOI":"10.1186\/1743-8977-7-25"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kurosaki T, Kitahara T, Fumoto S, Nishida K, Nakamura J, Niidome T, Kodama Y, Nakagawa H, To H, Sasaki H. Ternary complexes of pDNA, polyethylenimine, and gamma-polyglutamic acid for gene delivery systems. <i>Biomaterials<\/i>, <b>30<\/b>, 2846\u20132853 (2009).","DOI":"10.1016\/j.biomaterials.2009.01.055"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Chang HH, Wang YL, Chiang YC, Chen YL, Chuang YH, Tsai SJ, Heish KH, Lin FH, Lin CP. A novel chitosan\u2013\u03b3PGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction. <i>PLoS ONE<\/i>, <b>9<\/b>, e92362 (2014).","DOI":"10.1371\/journal.pone.0092362"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Tsai WB, Lai HY, Lee JL, Lo CW, Chen WS. Enhancement of the cytotoxicity and selectivity of doxorubicin to hepatoma cells by synergistic combination of galactose-decorated \u03b3-poly(glutamic acid) nanoparticles and low-intensity ultrasound. <i>Langmuir<\/i>, <b>30<\/b>, 5510\u20135517 (2014).","DOI":"10.1021\/la500352g"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Cho EC, Xie JW, Wurm PA, Xia YN. Understanding the role of surface charges in cellular adsorption <i>versus<\/i> internalization by selectively removing gold nanoparticles on the cell surface with a I2\/KI etchant. <i>Nano Lett.<\/i>, <b>9<\/b>, 1080\u20131084 (2009).","DOI":"10.1021\/nl803487r"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Harush-Frenkel O, Debotton N, Benita S, Altschuler Y. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>353<\/b>, 26\u201332 (2007).","DOI":"10.1016\/j.bbrc.2006.11.135"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Toh U, Iwakuma N, Mishima M, Okabe M, Nakagawa S, Akagi Y. Navigation surgery for intraoperative sentinel lymph node detection using Indocyanine green (ICG) fluorescence real-time imaging in breast cancer. <i>Breast Cancer Res. Treat.<\/i>, <b>153<\/b>, 337\u2013344 (2015).","DOI":"10.1007\/s10549-015-3542-9"},{"key":"23","unstructured":"23) Nakamura T, Kogashiwa Y, Nagafuji H, Yamauchi K, Kohno N. Validity of sentinel lymph node biopsy by ICG fluorescence for early head and neck cancer. <i>Anticancer Res.<\/i>, <b>35<\/b>, 1669\u20131674 (2015)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Brouwer OR, van den Berg NS, Math\u00e9ron HM, van der Poel HG, van Rhijn BW, Bex A, van Tinteren H, Vald\u00e9s Olmos RA, van Leeuwen FW, Horenblas S. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye. <i>Eur. Urol.<\/i>, <b>65<\/b>, 600\u2013609 (2014).","DOI":"10.1016\/j.eururo.2013.11.014"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Hnatowich DJ, Layne WW, Childs RL, Lanteigne D, Davis MA, Griffin TW, Doherty PW. Radioactive labeling of antibody: a simple and efficient method. <i>Science<\/i>, <b>220<\/b>, 613\u2013615 (1983).","DOI":"10.1126\/science.6836304"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Ogawa M, Kosaka N, Longmire MR, Urano Y, Choyke PL, Kobayashi H. Fluorophore-quencher based activatable targeted optical probes for detecting <i>in vivo<\/i> cancer metastases. <i>Mol. Pharm.<\/i>, <b>6<\/b>, 386\u2013395 (2009).","DOI":"10.1021\/mp800115t"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Christie RJ, Tadiello CJ, Chamberlain LM, Grainger DW. Optical properties and application of a reactive and bioreducible thiol-containing tetramethylrhodamine dimer. <i>Bioconjug. Chem.<\/i>, <b>20<\/b>, 476\u2013480 (2009).","DOI":"10.1021\/bc800367e"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kong WH, Sung DK, Kim KS, Jung HS, Gho EJ, Yun SH, Hahn SK. Self-assembled complex of probe peptide\u2013<i>E. coli<\/i> RNA I conjugate and nano graphene oxide for apoptosis diagnosis. <i>Biomaterials<\/i>, <b>33<\/b>, 7556\u20137564 (2012).","DOI":"10.1016\/j.biomaterials.2012.06.086"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Chan LN, Hart C, Guo L, Nyberg T, Davies BS, Fong LG, Young SG, Agnew BJ, Tamanoi F. A novel approach to tag and identify geranylgeranylated proteins. <i>Electrophoresis<\/i>, <b>30<\/b>, 3598\u20133606 (2009).","DOI":"10.1002\/elps.200900259"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Vogel SS, Thaler C, Koushik SV. Fanciful FRET. <i>Sci. STKE<\/i>, <b>2006<\/b>, re2 (2006).","DOI":"10.1126\/stke.3312006re2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Wang W, Kong T, Zhang D, Zhang J, Cheng G. Label-free microRNA detection based on fluorescence quenching of gold nanoparticles with a competitive hybridization. <i>Anal. Chem.<\/i>, <b>87<\/b>, 10822\u201310829 (2015).","DOI":"10.1021\/acs.analchem.5b01930"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Chevalier A, Renard PY, Romieu A. Straightforward synthesis of bioconjugatable azo dyes. Part 2: Black Hole Quencher-2 (BHQ-2) and BlackBerry Quencher 650 (BBQ-650) scaffolds. <i>Tetrahedron Lett.<\/i>, <b>55<\/b>, 6764\u20136768 (2014).","DOI":"10.1016\/j.tetlet.2014.10.054"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Lewis JS, Meeke K, Osipo C, Ross EA, Kidawi N, Li T, Bell E, Chandel NS, Jordan VC. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. <i>J. Natl. Cancer Inst.<\/i>, <b>97<\/b>, 1746\u20131759 (2005).","DOI":"10.1093\/jnci\/dji400"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Guth E, Farris M, Bovee M, Francklyn CS. Asymmetric amino acid activation by class II histidyl-tRNA synthetase from <i>Escherichia coli.<\/i> <i>J. Biol. Chem.<\/i>, <b>284<\/b>, 20753\u201320762 (2009).","DOI":"10.1074\/jbc.M109.021311"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Bagby TR, Cai S, Duan S, Thati S, Aires DJ, Forrest L. Impact of molecular weight on lymphatic drainage of a biopolymer-based imaging agent. <i>Pharmaceutics<\/i>, <b>4<\/b>, 276\u2013295 (2012).","DOI":"10.3390\/pharmaceutics4020276"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Sahay G, Alakhova DY, Kabanov AV. Endocytosis of nanomedicines. <i>J. Control. Release<\/i>, <b>145<\/b>, 182\u2013195 (2010).","DOI":"10.1016\/j.jconrel.2010.01.036"}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/3\/40_b16-00773\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T11:35:34Z","timestamp":1498390534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/3\/40_b16-00773\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b16-00773","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}