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Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese\/diabetic mice. <i>PLoS ONE<\/i>, <b>8<\/b>, e83264 (2013).","DOI":"10.1371\/journal.pone.0083264"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kopelman PG. Obesity as a medical problem. <i>Nature<\/i>, <b>404<\/b>, 635\u2013643 (2000).","DOI":"10.1038\/35007508"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Susanti VY, Sasaki T, Yokota-Hashimoto H, Matsui S, Lee YS, Kikuchi O, Shimpuku M, Kim HJ, Kobayashi M, Kitamura T. Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice. <i>Obesity<\/i>, <b>22<\/b>, 2115\u20132119 (2014).","DOI":"10.1002\/oby.20838"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Park HK, Ahima RS. Leptin signaling. <i>F 1000 Prime Reports<\/i>, <b>6<\/b>, 73 (2014).","DOI":"10.12703\/P6-73"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) White MF. IRS proteins and the common path to diabetes. <i>Am. J. Physiol. Endocrinol. Metab.<\/i>, <b>283<\/b>, E413\u2013E422 (2002).","DOI":"10.1152\/ajpendo.00514.2001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. <i>Nat. Rev. Mol. Cell Biol.<\/i>, <b>12<\/b>, 21\u201335 (2011).","DOI":"10.1038\/nrm3025"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Rimando AM, Perkins-Veazie P. Determination of citrulline in watermelon rind. <i>J. Chromatogr. A<\/i>, <b>1078<\/b>, 196\u2013200 (2005).","DOI":"10.1016\/j.chroma.2005.05.009"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Hayashi T, Packiasamy ARJ, Matsui-Hirai H, Miyazaki A, Fukatsu A, Funami J, Iguchi A, Ignarro LJ. 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Disruption of the p70(s6k)\/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. <i>EMBO J.<\/i>, <b>17<\/b>, 6649\u20136659 (1998).","DOI":"10.1093\/emboj\/17.22.6649"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. <i>Nature<\/i>, <b>431<\/b>, 200\u2013205 (2004).","DOI":"10.1038\/nature02866"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Um S, D\u2019Alessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. <i>Cell Metab.<\/i>, <b>3<\/b>, 393\u2013402 (2006).","DOI":"10.1016\/j.cmet.2006.05.003"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) An HM, Park S, Lee D, Kim J, Cha M, Lee S, Lim H, Kim K, Ha N. 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