{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:40:05Z","timestamp":1790203205699,"version":"4.1.0"},"reference-count":49,"publisher":"Pharmaceutical Society of Japan","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1248\/bpb.b16-01026","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T22:07:51Z","timestamp":1493590071000},"page":"557-563","source":"Crossref","is-referenced-by-count":33,"title":["The Role of mPGES-1 in Inflammatory Brain Diseases"],"prefix":"10.1248","volume":"40","author":[{"given":"Yuri","family":"Ikeda-Matsuo","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokuriku University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Cowley TR, Fahey B, O\u2019Mara SM. COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning <i>in vivo.<\/i> <i>Eur. J. Neurosci.<\/i>, <b>27<\/b>, 2999\u20133008 (2008).","DOI":"10.1111\/j.1460-9568.2008.06251.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Chen C, Bazan NG. Endogenous PGE<sub>2<\/sub> regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. <i>J. Neurophysiol.<\/i>, <b>93<\/b>, 929\u2013941 (2005).","DOI":"10.1152\/jn.00696.2004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Wong CT, Ussyshkin N, Ahmad E, Rai-Bhogal R, Li H, Crawford DA. Prostaglandin E<sub>2<\/sub> promotes neural proliferation and differentiation and regulates Wnt target gene expression. <i>J. Neurosci. Res.<\/i>, <b>94<\/b>, 759\u2013775 (2016).","DOI":"10.1002\/jnr.23759"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Amateau SK, McCarthy MM. A novel mechanism of dendritic spine plasticity involving estradiol induction of prostaglandin-E<sub>2<\/sub>. <i>J. Neurosci.<\/i>, <b>22<\/b>, 8586\u20138596 (2002).","DOI":"10.1523\/JNEUROSCI.22-19-08586.2002"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Yagami T, Koma H, Yamamoto Y. Pathophysiological roles of cyclooxygenases and prostaglandins in the central nervous system. <i>Mol. Neurobiol.<\/i>, <b>53<\/b>, 4754\u20134771 (2016).","DOI":"10.1007\/s12035-015-9355-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K. Neuroprotective function of the PGE<sub>2<\/sub> EP2 receptor in cerebral ischemia. <i>J. Neurosci.<\/i>, <b>24<\/b>, 257\u2013268 (2004).","DOI":"10.1523\/JNEUROSCI.4485-03.2004"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ikeda-Matsuo Y, Tanji H, Ota A, Hirayama Y, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E<sub>2<\/sub> EP3 receptors. <i>Br. J. Pharmacol.<\/i>, <b>160<\/b>, 847\u2013859 (2010).","DOI":"10.1111\/j.1476-5381.2010.00711.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Andreasson K. Emerging roles of PGE<sub>2<\/sub> receptors in models of neurological disease. <i>Prostaglandins Other Lipid Mediat.<\/i>, <b>91<\/b>, 104\u2013112 (2010).","DOI":"10.1016\/j.prostaglandins.2009.04.003"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kaufmann WE, Andreasson KI, Isakson PC, Worley PF. Cyclooxygenases and the central nervous system. <i>Prostaglandins<\/i>, <b>54<\/b>, 601\u2013624 (1997).","DOI":"10.1016\/S0090-6980(97)00128-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>96<\/b>, 7220\u20137225 (1999).","DOI":"10.1073\/pnas.96.13.7220"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Samuelsson B, Morgenstern R, Jakobsson PJ. Membrane prostaglandin E synthase-1: A novel therapeutic target. <i>Pharmacol. Rev.<\/i>, <b>59<\/b>, 207\u2013224 (2007).","DOI":"10.1124\/pr.59.3.1"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Chaudhry U, Zhuang H, Dor\u00e9 S. Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer\u2019s disease. <i>Exp. Neurol.<\/i>, <b>223<\/b>, 359\u2013365 (2010).","DOI":"10.1016\/j.expneurol.2009.07.027"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Mattila S, Tuominen H, Koivukangas J, Stenb\u00e4ck F. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. <i>Neuropathology<\/i>, <b>29<\/b>, 156\u2013165 (2009).","DOI":"10.1111\/j.1440-1789.2008.00963.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>103<\/b>, 11790\u201311795 (2006).","DOI":"10.1073\/pnas.0604400103"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) O\u2019Banion MK. Prostaglandin E<sub>2<\/sub> synthases in neurologic homeostasis and disease. <i>Prostaglandins Other Lipid Mediat.<\/i>, <b>91<\/b>, 113\u2013117 (2010).","DOI":"10.1016\/j.prostaglandins.2009.04.008"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Murakami M, Nakatani Y, Tanioka T, Kudo I. Prostaglandin E synthase. <i>Prostaglandins Other Lipid Mediat.<\/i>, <b>68-69<\/b>, 383\u2013399 (2002).","DOI":"10.1016\/S0090-6980(02)00043-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S, O\u2019Banion MK. Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression. <i>J. Neurochem.<\/i>, <b>114<\/b>, 247\u2013258 (2010).","DOI":"10.1111\/j.1471-4159.2010.06759.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) de Oliveira AC, Candelario-Jalil E, Bhatia HS, Lieb K, Hull M, Fiebich BL. Regulation of prostaglandin E<sub>2<\/sub> synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2. <i>Glia<\/i>, <b>56<\/b>, 844\u2013855 (2008).","DOI":"10.1002\/glia.20658"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y. Microglia-specific expression of microsomal prostaglandin E<sub>2<\/sub> synthase-1 contributes to lipopolysaccharide-induced prostaglandin E<sub>2<\/sub> production. <i>J. Neurochem.<\/i>, <b>94<\/b>, 1546\u20131558 (2005).","DOI":"10.1111\/j.1471-4159.2005.03302.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Naraba H, Yokoyama C, Tago N, Murakami M, Kudo I, Fueki M, Oh-Ishi S, Tanabe T. Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1. <i>J. Biol. Chem.<\/i>, <b>277<\/b>, 28601\u201328608 (2002).","DOI":"10.1074\/jbc.M203618200"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Korotkova M, Jakobsson PJ. Characterization of microsomal prostaglandin E synthase 1 inhibitors. <i>Basic Clin. Pharmacol. Toxicol.<\/i>, <b>114<\/b>, 64\u201369 (2014).","DOI":"10.1111\/bcpt.12162"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Sang N, Zhang J, Marcheselli V, Bazan NG, Chen C. Postsynaptically synthesized prostaglandin E<sub>2<\/sub> (PGE<sub>2<\/sub>) modulates hippocampal synaptic transmission <i>via<\/i> a presynaptic PGE<sub>2<\/sub> EP2 receptor. <i>J. Neurosci.<\/i>, <b>25<\/b>, 9858\u20139870 (2005).","DOI":"10.1523\/JNEUROSCI.2392-05.2005"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Vazquez-Tello A, Fan L, Hou X, Joyal JS, Mancini JA, Quiniou C, Clyman RI, Gobeil F Jr, Varma DR, Chemtob S. Intracellular-specific colocalization of prostaglandin E<sub>2<\/sub> synthases and cyclooxygenases in the brain. <i>Am. J. Physiol. Regul. Integr. Comp. Physiol.<\/i>, <b>287<\/b>, R1155\u2013R1163 (2004).","DOI":"10.1152\/ajpregu.00077.2004"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Eskilsson A, Tachikawa M, Hosoya K, Blomqvist A. Distribution of microsomal prostaglandin E synthase-1 in the mouse brain. <i>J. Comp. Neurol.<\/i>, <b>522<\/b>, 3229\u20133244 (2014).","DOI":"10.1002\/cne.23593"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Chaudhry UA, Zhuang H, Crain BJ, Dor\u00e9 S. Elevated microsomal prostaglandin-E synthase-1 in Alzheimer\u2019s disease. <i>Alzheimer\u2019s Dement.<\/i>, <b>4<\/b>, 6\u201313 (2008).","DOI":"10.1016\/j.jalz.2007.10.015"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Anrather J, Iadecola C. Inflammation and Stroke: An Overview. <i>Neurotherapeutics<\/i>, <b>13<\/b>, 661\u2013670 (2016).","DOI":"10.1007\/s13311-016-0483-x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME. Reduced susceptibility to ischemic brain injury and <i>N<\/i>-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>98<\/b>, 1294\u20131299 (2001).","DOI":"10.1073\/pnas.98.3.1294"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. <i>Br. J. Pharmacol.<\/i>, <b>159<\/b>, 1174\u20131186 (2010).","DOI":"10.1111\/j.1476-5381.2009.00595.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Dor\u00e9 S, Otsuka T, Mito T, Sugo N, Hand T, Wu L, Hurn PD, Traystman RJ, Andreasson K. Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. <i>Ann. Neurol.<\/i>, <b>54<\/b>, 155\u2013162 (2003).","DOI":"10.1002\/ana.10612"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y. Inhibition of prostaglandin E2 EP3 receptors improves stroke injury <i>via<\/i> anti-inflammatory and anti-apoptotic mechanisms. <i>J. Neuroimmunol.<\/i>, <b>238<\/b>, 34\u201343 (2011).","DOI":"10.1016\/j.jneuroim.2011.06.014"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Alam Q, Alam MZ, Mushtaq G, Damanhouri GA, Rasool M, Kamal MA, Haque A. Inflammatory process in Alzheimer\u2019s and Parkinson\u2019s diseases: Central role of cytokines. <i>Curr. Pharm. Des.<\/i>, <b>22<\/b>, 541\u2013548 (2016).","DOI":"10.2174\/1381612822666151125000300"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) McGeer PL, McGeer EG. NSAIDs and Alzheimer\u2019s disease: epidemiological, animal model and clinical studies. <i>Neurobiol. Aging<\/i>, <b>28<\/b>, 639\u2013647 (2007).","DOI":"10.1016\/j.neurobiolaging.2006.03.013"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer\u2019s disease. <i>J. Neurosci.<\/i>, <b>23<\/b>, 7504\u20137509 (2003).","DOI":"10.1523\/JNEUROSCI.23-20-07504.2003"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ 2nd, Morrow JD. Elevated CSF prostaglandin E<sub>2<\/sub> levels in patients with probable AD. <i>Neurology<\/i>, <b>53<\/b>, 1495\u20131498 (1999).","DOI":"10.1212\/WNL.53.7.1495"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M. Microsomal prostaglandin E synthase-1 is induced in Alzheimer\u2019s disease and its deletion mitigates Alzheimer\u2019s disease-like pathology in a mouse model. <i>J. Neurosci. Res.<\/i>, <b>91<\/b>, 909\u2013919 (2013).","DOI":"10.1002\/jnr.23217"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Kuroki Y, Sasaki Y, Kamei D, Akitake Y, Takahashi M, Uematsu S, Akira S, Nakatani Y, Kudo I, Hara S. Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of \u03b2-amyloid peptide fragment 31\u201335. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>424<\/b>, 409\u2013413 (2012).","DOI":"10.1016\/j.bbrc.2012.06.121"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S. Cyclooxygenase-2 is instrumental in Parkinson\u2019s disease neurodegeneration. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>100<\/b>, 5473\u20135478 (2003).","DOI":"10.1073\/pnas.0837397100"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Herrera AJ, Casta\u00f1o A, Venero JL, Cano J, Machado A. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. <i>Neurobiol. Dis.<\/i>, <b>7<\/b>, 429\u2013447 (2000).","DOI":"10.1006\/nbdi.2000.0289"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Vezzani A, Aronica E, Mazarati A, Pittman QJ. Epilepsy and brain inflammation. <i>Exp. Neurol.<\/i>, <b>244<\/b>, 11\u201321 (2013).","DOI":"10.1016\/j.expneurol.2011.09.033"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Takemiya T, Maehara M, Matsumura K, Yasuda S, Sugiura H, Yamagata K. Prostaglandin E<sub>2<\/sub> produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region. <i>Neurosci. Res.<\/i>, <b>56<\/b>, 103\u2013110 (2006).","DOI":"10.1016\/j.neures.2006.06.003"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K. Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. <i>J. Neurosci. Res.<\/i>, <b>88<\/b>, 381\u2013390 (2010).","DOI":"10.1002\/jnr.22195"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Takemiya T, Matsumura K, Sugiura H, Yasuda S, Uematsu S, Akira S, Yamagata K. Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca<sup>2+<\/sup> levels. <i>Neurochem. Int.<\/i>, <b>58<\/b>, 489\u2013496 (2011).","DOI":"10.1016\/j.neuint.2011.01.003"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Myung J, Cho BK, Kim YS, Park SH. Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas. <i>Neuropathology<\/i>, <b>30<\/b>, 224\u2013231 (2010).","DOI":"10.1111\/j.1440-1789.2009.01072.x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Xu K, Wang L, Shu HK. COX-2 overexpression increases malignant potential of human glioma cells through Id1. <i>Oncotarget<\/i>, <b>5<\/b>, 1241\u20131252 (2014).","DOI":"10.18632\/oncotarget.1370"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Lalier L, Cartron PF, Pedelaborde F, Olivier C, Loussouarn D, Martin SA, Meflah K, Menanteau J, Vallette FM. Increase in PGE<sub>2<\/sub> biosynthesis induces a Bax dependent apoptosis correlated to patients\u2019 survival in glioblastoma multiforme. <i>Oncogene<\/i>, <b>26<\/b>, 4999\u20135009 (2007).","DOI":"10.1038\/sj.onc.1210303"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Payner T, Leaver HA, Knapp B, Whittle IR, Trifan OC, Miller S, Rizzo MT. Microsomal prostaglandin E synthase-1 regulates human glioma cell growth <i>via<\/i> prostaglandin E(2)-dependent activation of type II protein kinase A. <i>Mol. Cancer Ther.<\/i>, <b>5<\/b>, 1817\u20131826 (2006).","DOI":"10.1158\/1535-7163.MCT-05-0548"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Larsson K, Kock A, Idborg H, Arsenian Henriksson M, Martinsson T, Johnsen JI, Korotkova M, Kogner P, Jakobsson PJ. COX\/mPGES-1\/PGE<sub>2<\/sub> pathway depicts an inflammatory-dependent high-risk neuroblastoma subset. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>112<\/b>, 8070\u20138075 (2015).","DOI":"10.1073\/pnas.1424355112"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Nakano Y, Kuroda E, Kito T, Uematsu S, Akira S, Yokota A, Nishizawa S, Yamashita U. Induction of prostaglandin E<sub>2<\/sub> synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation. <i>J. Neurosurg.<\/i>, <b>108<\/b>, 311\u2013319 (2008).","DOI":"10.3171\/JNS\/2008\/108\/2\/0311"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Leclerc P, Idborg H, Spahiu L, Larsson C, Nekhotiaeva N, Wannberg J, Stenberg P, Korotkova M, Jakobsson PJ. Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation. <i>Prostaglandins Other Lipid Mediat.<\/i>, <b>107<\/b>, 26\u201334 (2013).","DOI":"10.1016\/j.prostaglandins.2013.09.001"}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/5\/40_b16-01026\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T15:34:14Z","timestamp":1569166454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/5\/40_b16-01026\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b16-01026","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}