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Experimental squalene adjuvant. II. Harmlessness and local reactogenity. <i>Vaccine<\/i>, <b>22<\/b>, 3470\u20133474 (2004).","DOI":"10.1016\/j.vaccine.2004.02.024"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Reynolds JA, Harrington DG, Crabbs CL, Peters CJ, Di Luzio NM. Adjuvant activity of a novel metabolisable lipid emulsion with inactivated viral vaccines. <i>Infect. Immun.<\/i>, <b>28<\/b>, 937\u2013943 (1980).","DOI":"10.1128\/iai.28.3.937-943.1980"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Mori A, Oleszycka E, Sharp FA, Coleman M, Ozasa Y, Singh M, O\u2019Hagan DT, Tajber L, Corrigan OI, McNeela EA, Lavelle EC. The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signalling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses. <i>Eur. J. Immunol.<\/i>, <b>42<\/b>, 2709\u20132719 (2012).","DOI":"10.1002\/eji.201242372"},{"key":"4","unstructured":"4) Tomljenovic L, Shaw CA. Aluminium vaccine adjuvants: are they safe? <i>Curr. Med. Chem.<\/i>, <b>18<\/b>, 2630\u20132637 (2011)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Iyer V, Cayatte C, Guzman B, Schneider-Ohrum K, Matuszak R, Snell A, Rajani GM, Mccarthy MP, Muralidhara B. Impact of formulation and particle size on stability and immunogenicity of oil-in-water emulsion adjuvants. <i>Hum. Vaccin. Immunother.<\/i>, <b>11<\/b>, 1853\u20131864 (2015).","DOI":"10.1080\/21645515.2015.1046660"},{"key":"6","unstructured":"6) Kelly GS. Squalene and its potential clinical uses. <i>Altern. Med. Rev.<\/i>, <b>4<\/b>, 29\u201336 (1999)."},{"key":"7","unstructured":"7) Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. <i>Molecules<\/i>, <b>14<\/b>, 540\u2013554 (2009)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ryu A, Arakane K, Koide C, Arai H, Nagano T. Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. <i>Biol. Pharm. Bull.<\/i>, <b>32<\/b>, 1504\u20131509 (2009).","DOI":"10.1248\/bpb.32.1504"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Roland I, Piel G, Delattre L, Evrard B. Systematic characterization of oil-in-water emulsions for formulation design. <i>Int. J. Pharm.<\/i>, <b>263<\/b>, 85\u201394 (2003).","DOI":"10.1016\/S0378-5173(03)00364-8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Fox CB. Squalene emulsions for parenteral vaccine and drug delivery. <i>Molecules<\/i>, <b>14<\/b>, 3286\u20133312 (2009).","DOI":"10.3390\/molecules14093286"},{"key":"11","unstructured":"11) Amarowicz R. Squalene: A natural antioxidant? <i>Eur. J. Lipid Sci. Technol.<\/i>, <b>111<\/b>, 411\u2013412 (2009)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mueller L, Boehm V. Antioxidant activity of \u03b2-carotene compounds in different <i>in vitro<\/i> assays. <i>Molecules<\/i>, <b>16<\/b>, 1055\u20131069 (2011).","DOI":"10.3390\/molecules16021055"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Allison AC. Squalene and squalane emulsions as adjuvants. <i>Methods<\/i>, <b>19<\/b>, 87\u201393 (1999).","DOI":"10.1006\/meth.1999.0832"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) S\u00fcli J, Ben\u00ed\u0161ek Z, Eli\u00e1\u0161 D, \u0160vr\u010dek \u0160, Ondrejkov\u00e1 A, Ondrejka R, Bajov\u00e1 V. Experimental squalene adjuvant. I. Preparation and testing of its effectiveness. <i>Vaccine<\/i>, <b>22<\/b>, 3464\u20133469 (2004).","DOI":"10.1016\/j.vaccine.2004.02.023"},{"key":"15","unstructured":"15) S\u00fcli J, Lov\u00e1sov\u00e1 M, Sobekov\u00e1 A. Antioxidative protection of squalene vaccination adjuvants. <i>Folia Vet.<\/i>, <b>56<\/b> (Suppl. II), 56\u201358 (2012)."},{"key":"16","unstructured":"16) Slepeck\u00e1 E, S\u00fcli J, Radov\u00e1 J, Ondrejkov\u00e1 A, Ondrejka R, Proke\u0161 M, Koryt\u00e1r \u013d, \u010cechvala P, Harvanov\u00e1 J. Stanovenie fyzik\u00e1lno-chemick\u00fdch vlastnost\u00ed a sledovanie stability skval\u00e9nov\u00fdch emulzi\u00ed. <i>Chem. Listy<\/i>, <b>107<\/b>, 659\u2013664 (2013)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Wiktor TJ, Aaslestad HG, Kaplan MM. Immunogenicity of rabies virus inactivated by \u03b2-propiolactone, acetylethyleneimine, and ionizing irradiation. <i>Appl. Microbiol.<\/i>, <b>23<\/b>, 914\u2013918 (1972).","DOI":"10.1128\/AEM.23.5.914-918.1972"},{"key":"18","unstructured":"18) WHO Expert Consultation on Rabies. <i>First report. WHO Technical Report Series No. 931<\/i>. World Health Organization Geneva (2005)."},{"key":"19","unstructured":"19) Smith JS, Yager PA, Baer GM. A rapid reproducible test for determining rabies neutralizing antibody. <i>Bull. World Health Organ.<\/i>, <b>48<\/b>, 535\u2013541 (1973)."},{"key":"20","unstructured":"20) StatSoft, Inc. STATISTICA (dataanalysissoftware system), version8.0. \u2039www.statsoft.com.\u203a accessed 25.10.15. (2007)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) G\u00fcne\u015f FM. Medical use of squalene as a natural antioxidant. <i>J. Marmara Univ. Inst. Health Sci.<\/i>, <b>3<\/b>, 220\u2013228 (2013).","DOI":"10.5455\/musbed.20131213100404"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ekanayake-Mudiyanselage S, Hamburger M, Elsner P, Thiele JJ. Ultraviolet A induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids <i>in vitro<\/i> and <i>in vivo.<\/i> <i>J. Invest. Dermatol.<\/i>, <b>120<\/b>, 915\u2013922 (2003).","DOI":"10.1046\/j.1523-1747.2003.12233.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Nakagawa K, Ibusuki D, Suzuki Y, Yamashita S, Higuchi O, Oikawa S, Miyazawa T. Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight exposed human skin. <i>J. Lipid Res.<\/i>, <b>48<\/b>, 2779\u20132787 (2007).","DOI":"10.1194\/jlr.D700016-JLR200"},{"key":"24","unstructured":"24) Thiele JJ, Ekanayake-Mudiyanselage S. Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. <i>Mol. Aspects Med.<\/i>, <b>28<\/b>, 646\u2013667 (2007)."},{"key":"25","unstructured":"25) Popa I, B\u0103beanu NE, Ni\u021b\u0103 S, Popa O, Dinu-P\u00e2rvu CE. Squalene-natural resources and applications. <i>Farmacia<\/i>, <b>62<\/b>, 840\u2013862 (2014)."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Herbert V. Prooxidant effects of antioxidant vitamins. <i>J. Nutr.<\/i>, <b>126<\/b> (Suppl.), 1197S\u20131200S (1996).","DOI":"10.1093\/jn\/126.suppl_4.1197S"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Kohno Y, Egawa Y, Itoh S, Nagaoka S, Takahashi M, Mukai K. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in <i>n<\/i>-butanol. <i>Biochim. Biophys. Acta<\/i>, <b>1256<\/b>, 52\u201356 (1995).","DOI":"10.1016\/0005-2760(95)00005-W"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Psomiadou E, Tsimidou M. Stability of virgin olive oil. 2. Photo-oxidation studies. <i>J. Agric. Food Chem.<\/i>, <b>50<\/b>, 722\u2013727 (2002).","DOI":"10.1021\/jf010847u"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Tengerdy RP, Ameghino E, Riemann H. Serological responses of rams to a Brucella ovis-vitamin E adjuvant vaccine. <i>Vaccine<\/i>, <b>9<\/b>, 273\u2013276 (1991).","DOI":"10.1016\/0264-410X(91)90111-I"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Franchini A, Bertuzzi S, Tosarelli C, Manfreda G. Vitamin E in viral inactivated vaccines. <i>Poult. Sci.<\/i>, <b>74<\/b>, 666\u2013671 (1995).","DOI":"10.3382\/ps.0740666"},{"key":"31","unstructured":"31) Green H, Mellanby E. Carotene and vitamin A: The anti-infective action of carotene. <i>Br. J. Exp. Pathol.<\/i>, <b>11<\/b>, 81\u201389 (1930)."},{"key":"32","unstructured":"32) Clausen SW. Carotenemia and resistance to infection. <i>Trans. Am. Ped. Soc.<\/i>, <b>43<\/b>, 27\u201330 (1931)."},{"key":"33","unstructured":"33) WHO Expert Committee on Rabies. <i>8th Report. Techn. Report Series, No. 824<\/i>. Geneva WHO p. 87 (1992)."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) van der Horst-Graat JM, Kok FJ, Schouten EG. Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people. <i>Br. J. Nutr.<\/i>, <b>92<\/b>, 113\u2013118 (2004).","DOI":"10.1079\/BJN20041155"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Murray MT. Beta-carotene and other carotenoids. <i>Textbook of Natural Medicine.<\/i> (Pizzorno JE, Murray MT eds.) 4th ed. Chapter 69. Elsevier, St. Louis, pp. 602\u2013610 (2013).","DOI":"10.1016\/B978-1-4377-2333-5.00069-9"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Bendich A. Carotenoids and the immune response. <i>J. Nutr.<\/i>, <b>119<\/b>, 112\u2013115 (1989).","DOI":"10.1093\/jn\/119.1.112"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Bendich A. \u03b2-Carotene and the immune response. <i>Proc. Nutr. Soc.<\/i>, <b>50<\/b>, 263\u2013274 (1991).","DOI":"10.1079\/PNS19910036"},{"key":"38","unstructured":"38) Vel\u00ed\u0161ek J. <i>The Chemistry of Food<\/i>. 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