{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:21:18Z","timestamp":1777738878723,"version":"3.51.4"},"reference-count":21,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1248\/bpb.b17-00151","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T22:17:06Z","timestamp":1496269026000},"page":"910-915","source":"Crossref","is-referenced-by-count":3,"title":["Co-administration of Magnesium Ion Prevents Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rats"],"prefix":"10.1248","volume":"40","author":[{"given":"Noriaki","family":"Nagai","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Kindai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akina","family":"Ueno","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadatoshi","family":"Tanino","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Oka","sequence":"additional","affiliation":[{"name":"Yokohama University of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Ito","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Hultqvist M, Olofsson P, Gelderman KA, Holmberg J, Holmdahl R. A new arthritis therapy with oxidative burst inducers. <i>PLoS Med.<\/i>, <b>3<\/b>, e348 (2006).","DOI":"10.1371\/journal.pmed.0030348"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kato S, Takeuchi K. Alteration of gastric ulcerogenic and healing responses in rats with adjuvant-induced arthritis. <i>Jpn. J. Pharmacol.<\/i>, <b>89<\/b>, 1\u20136 (2002).","DOI":"10.1254\/jjp.89.1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Fries JF, Miller SR, Spitz PW, Williams CA, Hubert HB, Bloch DA. Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use. <i>Gastroenterology<\/i>, <b>96<\/b> (Suppl.), 647\u2013655 (1989).","DOI":"10.1016\/S0016-5085(89)80061-7"},{"key":"4","unstructured":"4) Kato S, Ito Y, Nishio H, Aoi Y, Amagase K, Takeuchi K. Increased susceptibility of small intestine to NSAID-provoked ulceration in rats with adjuvant-induced arthritis: involvement of enhanced expression of TLR4. <i>Life Sci.<\/i>, <b>81<\/b>, 1309\u20131316 (2007)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. <i>Nat. New Biol.<\/i>, <b>231<\/b>, 232\u2013235 (1971).","DOI":"10.1038\/newbio231232a0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Whittle BJ. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. <i>Gastroenterology<\/i>, <b>80<\/b>, 94\u201398 (1981).","DOI":"10.1016\/0016-5085(81)90196-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Weissenborn U, Maedge S, Buettner D, Sewing KF. Indomethacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat. <i>Pharmacology<\/i>, <b>30<\/b>, 32\u201339 (1985).","DOI":"10.1159\/000138047"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Asako H, Kubes P, Wallace J, Gaginella T, Wolf RE, Granger DN. Indomethacin-induced leukocyte adhesion in mesenteric venules; role of lipoxygenase products. <i>Am. J. Physiol.<\/i>, <b>262<\/b>, G903\u2013G908 (1992).","DOI":"10.1152\/ajpgi.1992.262.5.G903"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yamada T, Deitch E, Specian RD, Perry MA, Sartor RB, Grisham MB. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. <i>Inflammation<\/i>, <b>17<\/b>, 641\u2013662 (1993).","DOI":"10.1007\/BF00920471"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Whittle BJ, Laszlo F, Evans SM, Moncada S. Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin. <i>Br. J. Pharmacol.<\/i>, <b>116<\/b>, 2286\u20132290 (1995).","DOI":"10.1111\/j.1476-5381.1995.tb15066.x"},{"key":"11","unstructured":"11) Konaka A, Nishijima M, Tanaka A, Kunikata T, Kato S, Takeuchi K. Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats. <i>J. Physiol. Pharmacol.<\/i>, <b>50<\/b>, 25\u201338 (1999)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Nagai N, Fukuhata T, Ito Y, Usui S, Hirano K. Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat. <i>Biol. Pharm. Bull.<\/i>, <b>32<\/b>, 116\u2013120 (2009).","DOI":"10.1248\/bpb.32.116"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nagai N, Takeda A, Itanami Y, Ito Y. Co-administration of water containing magnesium ion prevents loxoprofen-induced lesions in gastric mucosa of adjuvant-induced arthritis rat. <i>Biol. Pharm. Bull.<\/i>, <b>35<\/b>, 2230\u20132237 (2012).","DOI":"10.1248\/bpb.b12-00703"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Billingham ME. Models of arthritis and the search for anti-arthritic drugs. <i>Pharmacol. Ther.<\/i>, <b>21<\/b>, 389\u2013428 (1983).","DOI":"10.1016\/0163-7258(83)90062-1"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sakuma S, Nishigaki F, Magari K, Ogawa T, Miyata S, Ohkubo Y, Goto T. FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis. <i>Inflamm. Res.<\/i>, <b>50<\/b>, 509\u2013514 (2001).","DOI":"10.1007\/PL00000227"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kato N, Mashita Y, Kato S, Mitsufuji S, Yoshikawa T, Takeuchi K. Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats <i>via<\/i> a NO\/cGMP-dependent mechanism. <i>Dig. Dis. Sci.<\/i>, <b>54<\/b>, 2346\u20132356 (2009).","DOI":"10.1007\/s10620-008-0646-7"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Nagai N, Fukuhata T, Ito Y, Tai H, Hataguchi Y, Nakagawa K. Preventive effect of water containing magnesium ion on paw edema in adjuvant-induced arthritis rat. <i>Biol. Pharm. Bull.<\/i>, <b>30<\/b>, 1934\u20131937 (2007).","DOI":"10.1248\/bpb.30.1934"},{"key":"18","unstructured":"18) Tanaka A, Kunikata T, Mizoguchi H, Kato S, Takeuchi K. Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. <i>J. Physiol. Pharmacol.<\/i>, <b>50<\/b>, 405\u2013417 (1999)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yokoyama T, Oono H, Miyamoto A, Ishiguro S, Nishio A. Magnesium-deficient medium enhances NO production in alveolar macrophages isolated from rats. <i>Life Sci.<\/i>, <b>72<\/b>, 1247\u20131257 (2003).","DOI":"10.1016\/S0024-3205(02)02371-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Nagai N, Fukuhata T, Ito Y. Effect of magnesium deficiency on intracellular ATP levels in human lens epithelial cells. <i>Biol. Pharm. Bull.<\/i>, <b>30<\/b>, 6\u201310 (2007).","DOI":"10.1248\/bpb.30.6"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Nagai N, Tanino T, Ito Y. Excessive interleukin 18 relate the aggravation of indomethacin-induced intestinal ulcerogenic lesions in adjuvant-induced arthritis rat. <i>Biol. Pharm. Bull.<\/i>, <b>38<\/b>, 1580\u20131590 (2015).","DOI":"10.1248\/bpb.b15-00375"}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/6\/40_b17-00151\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T09:57:57Z","timestamp":1569405477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/6\/40_b17-00151\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b17-00151","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}