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Neurohumoral activation in heart failure: the role of adrenergic receptors. <i>An. Acad. Bras. Cienc.<\/i>, <b>78<\/b>, 485\u2013503 (2006)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Floras JS. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. <i>J. Am. Coll. Cardiol.<\/i>, <b>54<\/b>, 375\u2013385 (2009).","DOI":"10.1016\/j.jacc.2009.03.061"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. <i>Circulation<\/i>, <b>82<\/b>, 1730\u20131736 (1990).","DOI":"10.1161\/01.CIR.82.5.1730"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hori Y, Yoshioka K, Kanai K, Hoshi F, Itoh N, Higuchi S-I. Spironolactone decreases isoproterenol-induced ventricular fibrosis and matrix metalloproteinase-2 in rats. <i>Biol. Pharm. Bull.<\/i>, <b>34<\/b>, 61\u201365 (2011).","DOI":"10.1248\/bpb.34.61"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Qin W, Rudolph AE, Bond BR, Rocha R, Blomme EA, Goellner JJ, Funder JW, McMahon EG. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. <i>Circ. Res.<\/i>, <b>93<\/b>, 69\u201376 (2003).","DOI":"10.1161\/01.RES.0000080521.15238.E5"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Veliotes DG, Woodiwiss AJ, Deftereos DA, Gray D, Osadchii O, Norton GR. Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by beta-adrenoreceptor activation. <i>Hypertension<\/i>, <b>45<\/b>, 914\u2013920 (2005).","DOI":"10.1161\/01.HYP.0000164567.62172.c5"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Sauzeau V, Sevilla MA, Rivas-Elena JV, de Alava E, Montero MJ, Lopez-Novoa JM, Bustelo XR. Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. <i>Nat. Med.<\/i>, <b>12<\/b>, 841\u2013845 (2006).","DOI":"10.1038\/nm1426"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) De L\u00e9an A, Racz K, McNicoll N, Desrosiers ML. 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Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats. <i>Pharmacol. Res.<\/i>, <b>44<\/b>, 311\u2013315 (2001).","DOI":"10.1006\/phrs.2001.0865"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Rogerson FM, Yao Y, Smith BJ, Fuller PJ. Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor. <i>Clin. Exp. Pharmacol. Physiol.<\/i>, <b>31<\/b>, 704\u2013709 (2004).","DOI":"10.1111\/j.1440-1681.2004.04079.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Enomoto S, Yoshiyama M, Omura T, Matsumoto R, Kusuyama T, Kim S, Izumi Y, Akioka K, Iwao H, Takeuchi K, Yoshikawa J. 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