{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:25:02Z","timestamp":1792661102309,"version":"4.5.0"},"reference-count":32,"publisher":"Pharmaceutical Society of Japan","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1248\/bpb.b17-00313","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T22:09:48Z","timestamp":1498082988000},"page":"1490-1498","source":"Crossref","is-referenced-by-count":32,"title":["A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1\u03b1\/Nrf2\/HO-1 Pathway"],"prefix":"10.1248","volume":"40","author":[{"given":"Xiaojing","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixing","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luchen","family":"Shan","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Fihn SD, Blankenship JC, Alexander KP, Bittl JA, Byrne JG, Fletcher BJ, Fonarow GC, Lange RA, Levine GN, Maddox TM, Naidu SS, Ohman EM, Smith PK, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Guyton RA, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK. 2014 ACC\/AHA\/AATS\/PCNA\/SCAI\/ STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. <i>J. Thorac. Cardiovasc. Surg.<\/i>, <b>149<\/b>, e5\u2013e23 (2015)."},{"key":"2","unstructured":"2) Neri M, Riezzo I, Pascale N, Pomara C, Turillazzi E. Ischemia\/reperfusion injury following acute myocardial infarction: A critical issue for clinicians and forensic pathologists. <i>Mediators Inflamm.<\/i>, <b>2017<\/b>, 7018393 (2017)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Lejay A, Fang F, John R, Van JA, Barr M, Thaveau F, Chakfe N, Geny B, Scholey JW. Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus. <i>J. Mol. Cell. Cardiol.<\/i>, <b>91<\/b>, 11\u201322 (2016).","DOI":"10.1016\/j.yjmcc.2015.12.020"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Chang W, Zhang M, Li J, Meng Z, Xiao D, Wei S, Chen L, Wang CY, Hatch GM. Berberine attenuates ischemia\u2013reperfusion injury <i>via<\/i> regulation of adenosine-5\u2032-monophosphate kinase activity in both non-ischemic and ischemic areas of the rat heart. <i>Cardiovasc. Drugs Ther.<\/i>, <b>26<\/b>, 467\u2013478 (2012).","DOI":"10.1007\/s10557-012-6422-0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Li X, Liu J, Lin L, Guo Y, Lin C, Zhang C, Yang B. Traditional chinese medicine shuang shen ning xin attenuates myocardial ischemia\/reperfusion injury by preserving of mitochondrial function. <i>Evid. Based Complement. Alternat. Med.<\/i>, <b>2014<\/b>, 180965 (2014).","DOI":"10.1155\/2014\/180965"},{"key":"6","unstructured":"6) Guo M, Liu Y, Shi D. Cardiovascular actions and therapeutic potential of tetramethylpyrazine (active component isolated from rhizoma chuanxiong): Roles and mechanisms. <i>Biomed. Res. Int.<\/i>, <b>2016<\/b>, 2430329 (2016)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Zhao GR, Zhang HM, Ye TX, Xiang ZJ, Yuan YJ, Guo ZX, Zhao LB. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B. <i>Food Chem. Toxicol.<\/i>, <b>46<\/b>, 73\u201381 (2008).","DOI":"10.1016\/j.fct.2007.06.034"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Cui Q, Chen Y, Zhang M, Shan L, Sun Y, Yu P, Zhang G, Wang D, Zhao Z, Xu Q, Xu B, Wang Y. Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives. <i>Chem. Biol. Drug Des.<\/i>, <b>84<\/b>, 282\u2013291 (2014).","DOI":"10.1111\/cbdd.12312"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Cui G, Shan L, Hung M, Lei S, Choi I, Zhang Z, Yu P, Hoi P, Wang Y, Lee SM. A novel Danshensu derivative confers cardioprotection <i>via<\/i> PI3K\/Akt and Nrf2 pathways. <i>Int. J. Cardiol.<\/i>, <b>168<\/b>, 1349\u20131359 (2013).","DOI":"10.1016\/j.ijcard.2012.12.012"},{"key":"10","unstructured":"10) Li S, Shan L, Zhang Z, Li W, Liao K, Li S, Sheng X, Yu P, Wang Y. Pharmacokinetic and metabolic studies of ADTM: A novel Danshensu derivative confers cardioprotection by HPLC-UV and LC-MS\/MS. <i>J. Chromatogr. Sci.<\/i>, <b>53<\/b>, 872\u2013878 (2015)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Xu C, Deng H, Chen H, Cui Q, Shan L-C, Yu P, Sun Y-W, Wang Y-Q. Design, synthesis and biological evaluations of novel conjugates of Danshensu, tetramethylpyrazine and hydrogen sulfide donors as cardioprotective agents. <i>Asian J. Chem.<\/i>, <b>28<\/b>, 2555\u20132561 (2016).","DOI":"10.14233\/ajchem.2016.20101"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Wang Y, Zhang X, Xu C, Zhang G, Zhang Z, Yu P, Shan L, Sun Y, Wang Y. Synthesis and biological evaluation of Danshensu and tetramethylpyrazine conjugates as cardioprotective agents. <i>Chem. Pharm. Bull.<\/i>, <b>65<\/b>, 381\u2013388 (2017).","DOI":"10.1248\/cpb.c16-00839"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Wang L, Zhang X, Cui G, Chan JY, Wang L, Li C, Shan L, Xu C, Zhang Q, Wang Y, Di L, Lee SM. A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II. <i>Oncotarget<\/i>, <b>7<\/b>, 32054\u201332064 (2016).","DOI":"10.18632\/oncotarget.8410"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hu S, Wang L, Mak S, Zhang Z, Xu D, Li H, Li Y, Hu Y, Lee SM, Wang Y, Han Y. Potent protection against MPP+-induced neurotoxicity <i>via<\/i> activating transcription factor MEF2D by a novel derivative of naturally occurring Danshensu\/tetramethylpyrazine. <i>Neuromolecular Med.<\/i>, <b>18<\/b>, 561\u2013572 (2016).","DOI":"10.1007\/s12017-016-8399-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Walters JW, Amos D, Ray K, Santanam N. Mitochondrial redox status as a target for cardiovascular disease. <i>Curr. Opin. Pharmacol.<\/i>, <b>27<\/b>, 50\u201355 (2016).","DOI":"10.1016\/j.coph.2016.01.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Shoag J, Arany Z. Regulation of hypoxia-inducible genes by PGC-1 alpha. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, <b>30<\/b>, 662\u2013666 (2010).","DOI":"10.1161\/ATVBAHA.108.181636"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Goffart S, Wiesner RJ. Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis. <i>Exp. Physiol.<\/i>, <b>88<\/b>, 33\u201340 (2003).","DOI":"10.1113\/eph8802500"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Rowe GC, Jiang A, Arany Z. PGC-1 coactivators in cardiac development and disease. <i>Circ. Res.<\/i>, <b>107<\/b>, 825\u2013838 (2010).","DOI":"10.1161\/CIRCRESAHA.110.223818"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Chai W, Zhang W, Jin Z, Feng Y, Kuang Y, Zhi J. Angiotensin II type I receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-\u03b1. <i>Acta Biochim. Biophys. Sin.<\/i>, <b>44<\/b>, 984\u2013990 (2012).","DOI":"10.1093\/abbs\/gms087"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Sun Y, Yu P, Zhang G, Wang L, Zhong H, Zhai Z, Wang L, Wang Y. Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models. <i>J. Neurosci. Res.<\/i>, <b>90<\/b>, 1662\u20131669 (2012).","DOI":"10.1002\/jnr.23034"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Baran\u010d\u00edk M, Gre\u0161ov\u00e1 L, Bartekov\u00e1 M, Dovinov\u00e1 I. Nrf2 as a key player of redox regulation in cardiovascular diseases. <i>Physiol. Res.<\/i>, <b>65<\/b> (Suppl. 1), S1 (2016).","DOI":"10.33549\/physiolres.933403"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Zuo L, Zhou T, Pannell BK, Ziegler AC, Best TM. Biological and physiological role of reactive oxygen species\u2014the good, the bad and the ugly. <i>Acta Physiol.<\/i>, <b>214<\/b>, 329\u2013348 (2015).","DOI":"10.1111\/apha.12515"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Lee Y, Gustafsson AB. Role of apoptosis in cardiovascular disease. <i>Apoptosis<\/i>, <b>14<\/b>, 536\u2013548 (2009).","DOI":"10.1007\/s10495-008-0302-x"},{"key":"24","unstructured":"24) Ventura-Clapier R, Garnier A, Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. <i>Cardiovasc. Res.<\/i>, <b>79<\/b>, 208\u2013217 (2008)."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Wu ZD, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. <i>Cell<\/i>, <b>98<\/b>, 115\u2013124 (1999).","DOI":"10.1016\/S0092-8674(00)80611-X"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) McLeod CJ, Jeyabalan AP, Minners JO, Clevenger R, Hoyt RF Jr, Sack MN. Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced post-anoxic mitochondrial respiratory recovery. <i>Circulation<\/i>, <b>110<\/b>, 534\u2013539 (2004).","DOI":"10.1161\/01.CIR.0000136997.53612.6C"},{"key":"27","unstructured":"27) Sun L, Zhao M, Yu X, Wang H, He X, Liu J, Zang W. Cardioprotection by acetylcholine: a novel mechanism <i>via<\/i> mitochondrial biogenesis and function involving the PGC-1\u03b1 pathway. <i>J. Cell. Physiol.<\/i>, <b>228<\/b>, 1238\u20131248 (2013)."},{"key":"28","unstructured":"28) Yang Y, Zhang H, Li X, Yang T, Jiang Q. Effects of PPAR\u03b1\/PGC-1\u03b1 on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes <i>in vitro.<\/i> <i>Int. J. Clin. Exp. Pathol.<\/i>, <b>8<\/b>, 12216\u201312224 (2015)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Yang H, Yang R, Liu H, Ren Z, Wang C, Li D, Ma X. Knockdown of peroxisome proliferator-activated receptor gamma coactivator-1 alpha increased apoptosis of human endometrial cancer HEC-1A cells. <i>OncoTargets and Therapy<\/i>, <b>9<\/b>, 5329\u20135338 (2016).","DOI":"10.2147\/OTT.S102816"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. <i>Genes Dev.<\/i>, <b>13<\/b>, 76\u201386 (1999).","DOI":"10.1101\/gad.13.1.76"},{"key":"31","unstructured":"31) Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. <i>Free Radic. Biol. Med.<\/i>, <b>47<\/b>, 1304\u20131309 (2009)."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. <i>J. Biol. Chem.<\/i>, <b>284<\/b>, 13291\u201313295 (2009).","DOI":"10.1074\/jbc.R900010200"}],"container-title":["Biological &amp; Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/9\/40_b17-00313\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T16:44:42Z","timestamp":1602348282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/9\/40_b17-00313\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b17-00313","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}