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Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum.<\/i> Nature<\/i>, 328<\/b>, 811\u2013814 (1987).","DOI":"10.1038\/328811a0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Morris HR, Masento MS, Taylor GW, Jermyn KA, Kay RR. Structure elucidation of two differentiation inducing factors (DIF-2 and DIF-3) from the cellular slime mould Dictyostelium discoideum.<\/i> Biochem. J.<\/i>, 249<\/b>, 903\u2013906 (1988).","DOI":"10.1042\/bj2490903"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kay RR, Berks M, Traynor D. Morphogen hunting in Dictyostelium discoideum.<\/i> Development<\/i> (Suppl.), l81\u2013l190 (1989).","DOI":"10.1242\/dev.107.Supplement.81"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Kay RR, Flatman P, Thompson CRL. DIF signalling and cell fate. Semin. Cell Dev. Biol.<\/i>, 10<\/b>, 577\u2013585 (1999).","DOI":"10.1006\/scdb.1999.0341"},{"key":"5","unstructured":"5) Dictyostelium discoideum<\/i> (dictybase). \u2039http:\/\/dictybase.org\/\u203a"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Asahi K, Sakurai A, Takahashi N, Kubohara Y, Okamoto K, Tanaka Y. DIF-1, morphogen of Dictyostelium discoideum<\/i>, induces the erythroid differentiation in murine and human leukemia cells. Biochem. Biophys. Res. Commun.<\/i>, 208<\/b>, 1036\u20131039 (1995).","DOI":"10.1006\/bbrc.1995.1438"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kubohara Y, Saito Y, Tatemoto K. Differentiation-inducing factor of D. discoideum<\/i> raises intracellular calcium concentration and suppresses cell growth in rat pancreatic AR42J cells. FEBS Lett.<\/i>, 359<\/b>, 119\u2013122 (1995).","DOI":"10.1016\/0014-5793(95)00022-2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kubohara Y. 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Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1\/2 activity. Eur. J. Pharmacol.<\/i>, 485<\/b>, 21\u201329 (2004).","DOI":"10.1016\/j.ejphar.2003.11.041"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Shimizu K, Murata T, Tagawa T, Takahashi K, Ishikawa R, Abe Y, Hosaka K, Kubohara Y. Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.<\/i> Cancer Res.<\/i>, 64<\/b>, 2568\u20132571 (2004).","DOI":"10.1158\/0008-5472.CAN-03-3551"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y. Structural requirements of Dictyostelium<\/i> differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium<\/i> cells and anti-proliferative activity in K562 human leukemic cells. Biochem. Pharmacol.<\/i>, 70<\/b>, 676\u2013685 (2005).","DOI":"10.1016\/j.bcp.2005.06.002"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Omata W, Shibata H, Nagasawa M, Kojima I, Kikuchi H, Oshima Y, Hosaka K, Kubohara Y. Dictyostelium<\/i> differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells. FEBS J.<\/i>, 274<\/b>, 3392\u20133404 (2007).","DOI":"10.1111\/j.1742-4658.2007.05872.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kubohara Y, Kikuchi H, Oshima Y. Exploitation of the derivatives of Dictyostelium<\/i> differentiation-inducing factor-1, which promote glucose consumption in mammalian cells. Life Sci.<\/i>, 83<\/b>, 608\u2013612 (2008).","DOI":"10.1016\/j.lfs.2008.08.012"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kawaharada R, Nakamura A, Takahashi K, Kikuchi H, Oshima Y, Kubohara Y. Oral administration of Dictyostelium<\/i> differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin-induced diabetic rats. Life Sci.<\/i>, 155<\/b>, 56\u201362 (2016).","DOI":"10.1016\/j.lfs.2016.04.032"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y. Regulation of IL-2 production in Jurkat cells by Dictyostelium<\/i>-derived factors. Life Sci.<\/i>, 85<\/b>, 438\u2013443 (2009).","DOI":"10.1016\/j.lfs.2009.07.008"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Takahashi K, Murakami M, Kikuchi K, Oshima Y, Kubohara Y. Derivatives of Dictyostelium<\/i> differentiation-inducing factors promote mitogen-activated IL-2 production via<\/i> AP-1 in Jurkat cells. Life Sci.<\/i>, 88<\/b>, 480\u2013485 (2011).","DOI":"10.1016\/j.lfs.2011.01.004"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Nguyen VH, Kikuchi H, Kubohara Y, Takahashi K, Katou Y, Oshima Y. Development of novel DIF-1 derivatives that selectively suppress innate immune responses. Bioorg. Med. Chem.<\/i>, 23<\/b>, 4311\u20134315 (2015).","DOI":"10.1016\/j.bmc.2015.06.027"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Nakajima-Shimada J, Hatabu T, Hosoi Y, Onizuka Y, Kikuchi H, Oshima Y, Kubohara Y. Derivatives of Dictyostelium discoideum<\/i> differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro<\/i> and in vivo.<\/i> Biochem. Pharmacol.<\/i>, 85<\/b>, 1603\u20131610 (2013).","DOI":"10.1016\/j.bcp.2013.03.007"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, Homma Y. 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A specific DIF binding protein in Dictyostelium.<\/i> EMBO J.<\/i>, 9<\/b>, 3323\u20133328 (1990).","DOI":"10.1002\/j.1460-2075.1990.tb07532.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Morandini P, Offer J, Traynor D, Nayler O, Neuhaus D, Taylor GW, Kay RR. The proximal pathway of metabolism of the chlorinated signal molecule differentiation-inducing factor-1 (DIF-1) in the cellular slime mould Dictyostelium.<\/i> Biochem. J.<\/i>, 306<\/b>, 735\u2013743 (1995).","DOI":"10.1042\/bj3060735"}],"container-title":["Biological & Pharmaceutical Bulletin","Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/11\/40_b17-00484\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:26:53Z","timestamp":1659745613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/40\/11\/40_b17-00484\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b17-00484","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}