{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:05:00Z","timestamp":1789992300925,"version":"4.0.1"},"reference-count":35,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1248\/bpb.b17-00589","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T22:11:31Z","timestamp":1511907091000},"page":"172-181","source":"Crossref","is-referenced-by-count":27,"title":["Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents"],"prefix":"10.1248","volume":"41","author":[{"given":"Sol-Ji","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hee","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Yeon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Physiology, School of Dentistry, Dental Research Institute, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Gu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Hern","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin J.","family":"Beitz","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyun","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Eikermann-Haerter K, Moskowitz MA. Animal models of migraine headache and aura. <i>Curr. Opin. Neurol.<\/i>, <b>21<\/b>, 294\u2013300 (2008).","DOI":"10.1097\/WCO.0b013e3282fc25de"},{"key":"2","unstructured":"2) Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. <i>Pain<\/i>, <b>154<\/b> (Suppl. 1), S44\u2013S53 (2013)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptacek LJ, Ahn AH. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. <i>Cephalalgia<\/i>, <b>30<\/b>, 170\u2013178 (2010).","DOI":"10.1111\/j.1468-2982.2009.01864.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Christiansen I, Thomsen L, Daugaard D, Ulrich V, Olesen J. Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migraine with aura. <i>Cephalalgia<\/i>, <b>19<\/b>, 660\u2013667, discussion, 626 (1999).","DOI":"10.1046\/j.1468-2982.1999.019007660.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Tassorelli C, Joseph SA. Systemic nitroglycerin induces Fos immunoreactivity in brainstem and forebrain structures of the rat. <i>Brain Res.<\/i>, <b>682<\/b>, 167\u2013181 (1995).","DOI":"10.1016\/0006-8993(95)00348-T"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Galeotti N, Ghelardini C. St. John\u2019s wort relieves pain in an animal model of migraine. <i>Eur. J. Pain<\/i>, <b>17<\/b>, 369\u2013381 (2013).","DOI":"10.1002\/j.1532-2149.2012.00196.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A. Characterization of a novel model of chronic migraine. <i>Pain<\/i>, <b>155<\/b>, 269\u2013274 (2014).","DOI":"10.1016\/j.pain.2013.10.004"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Sufka KJ, Staszko SM, Johnson AP, Davis ME, Davis RE, Smitherman TA. Clinically relevant behavioral endpoints in a recurrent nitroglycerin migraine model in rats. <i>J. Headache Pain<\/i>, <b>17<\/b>, 40 (2016).","DOI":"10.1186\/s10194-016-0624-y"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Meents JE, Neeb L, Reuter U. TRPV1 in migraine pathophysiology. <i>Trends Mol. Med.<\/i>, <b>16<\/b>, 153\u2013159 (2010).","DOI":"10.1016\/j.molmed.2010.02.004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Diener HC, Charles A, Goadsby PJ, Holle D. New therapeutic approaches for the prevention and treatment of migraine. <i>Lancet Neurol.<\/i>, <b>14<\/b>, 1010\u20131022 (2015).","DOI":"10.1016\/S1474-4422(15)00198-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Meents JE, Hoffmann J, Chaplan SR, Neeb L, Schuh-Hofer S, Wickenden A, Reuter U. Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. <i>J. Headache Pain<\/i>, <b>16<\/b>, 57 (2015).","DOI":"10.1186\/s10194-015-0539-z"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Pyun K, Son JS, Kwon YB. Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats. <i>Pharmacol. Biochem. Behav.<\/i>, <b>124<\/b>, 278\u2013283 (2014).","DOI":"10.1016\/j.pbb.2014.06.023"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Summ O, Holland PR, Akerman S, Goadsby PJ. TRPV1 receptor blockade is ineffective in different <i>in vivo<\/i> models of migraine. <i>Cephalalgia<\/i>, <b>31<\/b>, 172\u2013180 (2011).","DOI":"10.1177\/0333102410375626"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Jancs\u00f3 G, Kiraly E, Jancso-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. <i>Nature<\/i>, <b>270<\/b>, 741\u2013743 (1977).","DOI":"10.1038\/270741a0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Nagy JI, van der Kooy D. Effects of neonatal capsaicin treatment on nociceptive thresholds in the rat. <i>J. Neurosci.<\/i>, <b>3<\/b>, 1145\u20131150 (1983).","DOI":"10.1523\/JNEUROSCI.03-06-01145.1983"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Szallasi A, Blumberg PM. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. <i>Neuroscience<\/i>, <b>30<\/b>, 515\u2013520 (1989).","DOI":"10.1016\/0306-4522(89)90269-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Szallasi A, Joo F, Blumberg PM. Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog. <i>Brain Res.<\/i>, <b>503<\/b>, 68\u201372 (1989).","DOI":"10.1016\/0006-8993(89)91705-8"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. <i>Science<\/i>, <b>288<\/b>, 306\u2013313 (2000).","DOI":"10.1126\/science.288.5464.306"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yeo JH, Yoon SY, Kim SJ, Oh SB, Lee JH, Beitz AJ, Roh DH. Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension. <i>Int. J. Cancer<\/i>, <b>138<\/b>, 2466\u20132476 (2016).","DOI":"10.1002\/ijc.29980"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Han HJ, Beitz AJ, Lee JH. Depletion of capsaicin-sensitive afferents prevents lamina-dependent increases in spinal <i>N<\/i>-methyl-D-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats. <i>Eur. J. Pain<\/i>, <b>12<\/b>, 552\u2013563 (2008).","DOI":"10.1016\/j.ejpain.2007.09.002"},{"key":"21","unstructured":"21) Lee MG, Lee DK, Huh BK, Choi SS, Kim HZ, Lim BG, Kim HS, Choi YS, Hur WS, Lee MK. The effect of clonidine pretreatment on epidural resiniferatoxin in a neuropathic pain rat model. <i>Acta Med. Okayama<\/i>, <b>69<\/b>, 95\u2013103 (2015)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kwon SG, Roh DH, Yoon SY, Moon JY, Choi SR, Choi HS, Kang SY, Han HJ, Beitz AJ, Oh SB, Lee JH. Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain. <i>Mol. Pain<\/i>, <b>10<\/b>, 1744-8069-10-2 (2014).","DOI":"10.1186\/1744-8069-10-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kang SY, Roh DH, Park JH, Lee HJ, Lee JH. Activation of spinal alpha2-adrenoceptors using diluted bee venom stimulation reduces cold allodynia in neuropathic pain rats. <i>Evid. Based Complement. Alternat. Med.<\/i>, <b>2012<\/b>, 784713 (2012).","DOI":"10.1155\/2012\/784713"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Moon JY, Choi SR, Roh DH, Yoon SY, Kwon SG, Choi HS, Kang SY, Han HJ, Kim HW, Beitz AJ, Oh SB, Lee JH. Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain. <i>Pharmacol. Res.<\/i>, <b>100<\/b>, 353\u2013364 (2015).","DOI":"10.1016\/j.phrs.2015.08.019"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Harriott AM, Schwedt TJ. Migraine is associated with altered processing of sensory stimuli. <i>Curr. Pain Headache Rep.<\/i>, <b>18<\/b>, 458 (2014).","DOI":"10.1007\/s11916-014-0458-8"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Guy N, Marques AR, Orliaguet T, Lanteri-Minet M, Dallel R, Clavelou P. Are there differences between cephalic and extracephalic cutaneous allodynia in migraine patients? <i>Cephalalgia<\/i>, <b>30<\/b>, 881\u2013886 (2010).","DOI":"10.1111\/j.1468-2982.2009.02008.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Landy S, Rice K, Lobo B. Central sensitisation and cutaneous allodynia in migraine. <i>CNS Drugs<\/i>, <b>18<\/b>, 337\u2013342 (2004).","DOI":"10.2165\/00023210-200418060-00001"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. <i>Ann. Neurol.<\/i>, <b>47<\/b>, 614\u2013624 (2000).","DOI":"10.1002\/1531-8249(200005)47:5<614::AID-ANA9>3.3.CO;2-E"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Ossipov MH, Bian D, Malan TP Jr, Lai J, Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve\u2013ligation injury induced tactile allodynia in rats. <i>Pain<\/i>, <b>79<\/b>, 127\u2013133 (1999).","DOI":"10.1016\/S0304-3959(98)00187-0"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Khan GM, Chen SR, Pan HL. Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats. <i>Neuroscience<\/i>, <b>114<\/b>, 291\u2013299 (2002).","DOI":"10.1016\/S0306-4522(02)00372-X"},{"key":"31","unstructured":"31) Pan HL, Khan GM, Alloway KD, Chen SR. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. <i>J. Neurosci.<\/i>, <b>23<\/b>, 2911\u20132919 (2003)."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Back SK, Jeong KY, Li C, Lee J, Lee SB, Na HS. Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis. <i>J. Dermatol. Sci.<\/i>, <b>67<\/b>, 111\u2013119 (2012).","DOI":"10.1016\/j.jdermsci.2012.05.006"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Diamond S, Freitag F, Phillips S, Bernstein J, Saper J. Intranasal civamide for the acute treatment of migraine headache. <i>Cephalalgia<\/i>, <b>20<\/b>, 597\u2013602 (2000).","DOI":"10.1046\/j.1468-2982.2000.00088.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Dux M, Santha P, Jancso G. Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat. <i>J. Physiol.<\/i>, <b>552<\/b>, 859\u2013867 (2003).","DOI":"10.1113\/jphysiol.2003.050633"},{"key":"35","unstructured":"35) Zakharov A, Vitale C, Kilinc E, Koroleva K, Fayuk D, Shelukhina I, Naumenko N, Skorinkin A, Khazipov R, Giniatullin R. Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers. <i>Front. Cell. Neurosci.<\/i>, <b>9<\/b>, 287 (2015)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/2\/41_b17-00589\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T01:38:35Z","timestamp":1570412315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/2\/41_b17-00589\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b17-00589","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}